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MX382033B - Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma. - Google Patents

Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma.

Info

Publication number
MX382033B
MX382033B MX2016012021A MX2016012021A MX382033B MX 382033 B MX382033 B MX 382033B MX 2016012021 A MX2016012021 A MX 2016012021A MX 2016012021 A MX2016012021 A MX 2016012021A MX 382033 B MX382033 B MX 382033B
Authority
MX
Mexico
Prior art keywords
treatment
pi3k
gamma
heterocyclic compounds
mediated disorders
Prior art date
Application number
MX2016012021A
Other languages
English (en)
Other versions
MX2016012021A (es
Inventor
David G Winkler
Jeffery L Kutok
Vito J Palombella
Original Assignee
Infinity Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infinity Pharmaceuticals Inc filed Critical Infinity Pharmaceuticals Inc
Publication of MX2016012021A publication Critical patent/MX2016012021A/es
Publication of MX382033B publication Critical patent/MX382033B/es

Links

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En la presente se describen compuestos y composiciones farmacéuticas que modulan la actividad cinasa, incluida la actividad PI3 cinasa, y los compuestos, composiciones farmacéuticas y los métodos de tratamiento de enfermedades y estados asociados con la actividad cinasa, incluida la actividad PI3 cinasa.
MX2016012021A 2014-03-19 2015-03-18 Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma. MX382033B (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201461955717P 2014-03-19 2014-03-19
US201461980484P 2014-04-16 2014-04-16
US201462000923P 2014-05-20 2014-05-20
US201462033008P 2014-08-04 2014-08-04
US201462059766P 2014-10-03 2014-10-03
US201462075173P 2014-11-04 2014-11-04
US201562101980P 2015-01-09 2015-01-09
PCT/US2015/021200 WO2015143012A1 (en) 2014-03-19 2015-03-18 Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders

Publications (2)

Publication Number Publication Date
MX2016012021A MX2016012021A (es) 2017-04-13
MX382033B true MX382033B (es) 2025-03-13

Family

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Family Applications (1)

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MX2016012021A MX382033B (es) 2014-03-19 2015-03-18 Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma.

Country Status (16)

Country Link
US (4) US9775844B2 (es)
EP (2) EP4066834A1 (es)
JP (1) JP6701088B2 (es)
CN (3) CN113616656B (es)
AU (1) AU2015231413B2 (es)
CA (1) CA2943075C (es)
DK (1) DK3119397T3 (es)
EA (1) EA201691872A1 (es)
ES (1) ES2913486T3 (es)
IL (1) IL247841B (es)
MX (1) MX382033B (es)
NZ (1) NZ724368A (es)
PH (1) PH12016501809A1 (es)
PT (1) PT3119397T (es)
SG (2) SG11201607705XA (es)
WO (1) WO2015143012A1 (es)

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KR101897881B1 (ko) 2008-01-04 2018-09-12 인텔리카인, 엘엘씨 특정 화학 물질, 조성물 및 방법
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
EP3581574A1 (en) 2011-01-10 2019-12-18 Infinity Pharmaceuticals, Inc. A composition for oral administration for use in the treatment of cancer, an inflammatory disease or an auto-immune disease
CN103998442B (zh) 2011-08-29 2016-09-14 无限药品股份有限公司 杂环化合物及其用途
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
LT2908823T (lt) 2012-10-15 2019-10-25 Epizyme Inc Vėžio gydymo būdai
US10860683B2 (en) 2012-10-25 2020-12-08 The Research Foundation For The State University Of New York Pattern change discovery between high dimensional data sets
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
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