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ATE457313T1 - Bicyclische heterocyclische p-38-kinase- inhibitoren - Google Patents

Bicyclische heterocyclische p-38-kinase- inhibitoren

Info

Publication number
ATE457313T1
ATE457313T1 AT04815697T AT04815697T ATE457313T1 AT E457313 T1 ATE457313 T1 AT E457313T1 AT 04815697 T AT04815697 T AT 04815697T AT 04815697 T AT04815697 T AT 04815697T AT E457313 T1 ATE457313 T1 AT E457313T1
Authority
AT
Austria
Prior art keywords
kinase inhibitors
bicyclic heterocyclic
kinase
disorders
compounds
Prior art date
Application number
AT04815697T
Other languages
English (en)
Inventor
Qing Dong
Jianqiang Wang
Jiong Lan
Hengyuan Lang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE457313T1 publication Critical patent/ATE457313T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
AT04815697T 2003-12-23 2004-12-23 Bicyclische heterocyclische p-38-kinase- inhibitoren ATE457313T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53252903P 2003-12-23 2003-12-23
US57511304P 2004-05-28 2004-05-28
PCT/US2004/043682 WO2005063766A2 (en) 2003-12-23 2004-12-23 Bicyclic heterocyclic p-38 kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE457313T1 true ATE457313T1 (de) 2010-02-15

Family

ID=34743022

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04815697T ATE457313T1 (de) 2003-12-23 2004-12-23 Bicyclische heterocyclische p-38-kinase- inhibitoren

Country Status (14)

Country Link
US (2) US7569571B2 (de)
EP (1) EP1699800B1 (de)
JP (1) JP2007517052A (de)
KR (1) KR100899245B1 (de)
AT (1) ATE457313T1 (de)
AU (1) AU2004309420B2 (de)
BR (1) BRPI0418112A (de)
CA (1) CA2548326A1 (de)
DE (1) DE602004025504D1 (de)
ES (1) ES2339670T3 (de)
PL (1) PL1699800T3 (de)
PT (1) PT1699800E (de)
RU (1) RU2006126791A (de)
WO (1) WO2005063766A2 (de)

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MXPA06000554A (es) 2003-07-14 2006-07-03 Arena Pharm Inc Derivados arilo y heteroarilo fusionados como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con los mismos.
JP2007526339A (ja) * 2004-03-02 2007-09-13 ニューロジェン・コーポレーション アリール置換プリン類縁体
US9512125B2 (en) 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
KR101011957B1 (ko) 2005-08-25 2011-01-31 에프. 호프만-라 로슈 아게 Ｐ３８ ｍαｐ 키나아제 저해제 및 이의 사용 방법
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WO2008074676A1 (en) 2006-12-19 2008-06-26 F. Hoffmann-La Roche Ag Pyrazolo [3, 4 -d] pyrimidine p38 map kinase inhibitors
US8022085B2 (en) 2007-05-07 2011-09-20 Amgen Inc. Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof
EP1992344A1 (de) 2007-05-18 2008-11-19 Institut Curie P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind
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WO2010006072A2 (en) 2008-07-08 2010-01-14 The Regents Of The University Of California Mtor modulators and uses thereof
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WO2010045542A2 (en) 2008-10-16 2010-04-22 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
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JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン， エルエルシー 複素環式化合物およびその使用
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
ES2593256T3 (es) 2010-05-21 2016-12-07 Infinity Pharmaceuticals, Inc. Compuestos químicos, composiciones y métodos para las modulaciones de cinasas
CA2804744C (en) 2010-07-14 2019-05-28 Novartis Ag Ip receptor agonist 1,8-naphthyridinyl and 7,8-dihydropyrido[3,2-b]pyrazinyl heterocyclic compounds
AU2011326071A1 (en) 2010-11-08 2013-05-23 Lycera Corporation N- sulfonylated tetrahydroquinolines and related bicyclic compounds inhibition of RORy activity and the treatment of diseases
CN103298474B (zh) 2010-11-10 2016-06-29 无限药品股份有限公司 杂环化合物及其用途
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WO2005063766A3 (en) 2005-09-09
EP1699800A2 (de) 2006-09-13
US20070142405A1 (en) 2007-06-21
KR20060103272A (ko) 2006-09-28
US20090264409A1 (en) 2009-10-22
AU2004309420B2 (en) 2008-10-30
ES2339670T3 (es) 2010-05-24
PL1699800T3 (pl) 2010-07-30
PT1699800E (pt) 2010-04-12
WO2005063766A2 (en) 2005-07-14
DE602004025504D1 (de) 2010-03-25
AU2004309420A1 (en) 2005-07-14
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CA2548326A1 (en) 2005-07-14
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