DK1471142T3 - Heterodimere receptor-biblioteker under anvendelse af fagemider - Google Patents

Heterodimere receptor-biblioteker under anvendelse af fagemider

Info

Publication number: DK1471142T3
Authority: DK; Denmark
Prior art keywords: domain; terminal; polypeptide; libraries; heterodimeric receptor
Prior art date: 1991-04-10

Application number

DK04076718T

Other languages

English (en)

Inventor

Angray Kang

Richard A Lerner

Carlos Barbas

Original Assignee

Scripps Research Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-10

Filing date

1992-04-10

Publication date

2009-03-09

1992-04-10 Application filed by Scripps Research Inst filed Critical Scripps Research Inst

2009-03-09 Application granted granted Critical

2009-03-09 Publication of DK1471142T3 publication Critical patent/DK1471142T3/da

Links

229920001184 polypeptide Polymers 0.000 abstract 5
108090000765 processed proteins & peptides Proteins 0.000 abstract 5
102000004196 processed proteins & peptides Human genes 0.000 abstract 5
241000724791 Filamentous phage Species 0.000 abstract 4
108700005091 Immunoglobulin Genes Proteins 0.000 abstract 2
239000003446 ligand Substances 0.000 abstract 2
239000002773 nucleotide Substances 0.000 abstract 2
125000003729 nucleotide group Chemical group 0.000 abstract 2
240000004307 Citrus medica Species 0.000 abstract 1
108020004414 DNA Proteins 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
230000004927 fusion Effects 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Cell Biology (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Crystallography & Structural Chemistry (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

DK04076718T 1991-04-10 1992-04-10 Heterodimere receptor-biblioteker under anvendelse af fagemider DK1471142T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US68360291A	1991-04-10	1991-04-10
US82662392A	1992-01-27	1992-01-27
PCT/US1992/003091 WO1992018619A1 (en)	1991-04-10	1992-04-10	Heterodimeric receptor libraries using phagemids

Publications (1)

Publication Number	Publication Date
DK1471142T3 true DK1471142T3 (da)	2009-03-09

Family

ID=27103149

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK04076718T DK1471142T3 (da)	1991-04-10	1992-04-10	Heterodimere receptor-biblioteker under anvendelse af fagemider
DK92910558T DK0580737T3 (da)	1991-04-10	1992-04-10	Heterodimere receptorbiblioteker ved anvendelse af phagemider

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK92910558T DK0580737T3 (da)	1991-04-10	1992-04-10	Heterodimere receptorbiblioteker ved anvendelse af phagemider

Country Status (14)

Country	Link
US (6)	US5658727A (da)
EP (2)	EP1471142B1 (da)
JP (4)	JP3672306B2 (da)
AT (2)	ATE414768T1 (da)
AU (1)	AU662148B2 (da)
CA (1)	CA2108147C (da)
DE (2)	DE69233367T2 (da)
DK (2)	DK1471142T3 (da)
ES (2)	ES2315612T3 (da)
FI (1)	FI120309B (da)
IE (1)	IE921169A1 (da)
NO (1)	NO319371B1 (da)
PT (1)	PT100379B (da)
WO (1)	WO1992018619A1 (da)

Families Citing this family (1288)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5427908A (en) *	1990-05-01	1995-06-27	Affymax Technologies N.V.	Recombinant library screening methods
GB9015198D0 (en) *	1990-07-10	1990-08-29	Brien Caroline J O	Binding substance
US6172197B1 (en)	1991-07-10	2001-01-09	Medical Research Council	Methods for producing members of specific binding pairs
US7063943B1 (en)	1990-07-10	2006-06-20	Cambridge Antibody Technology	Methods for producing members of specific binding pairs
US6916605B1 (en)	1990-07-10	2005-07-12	Medical Research Council	Methods for producing members of specific binding pairs
GB9206318D0 (en) *	1992-03-24	1992-05-06	Cambridge Antibody Tech	Binding substances
ATE164395T1 (de) *	1990-12-03	1998-04-15	Genentech Inc	Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
ATE414768T1 (de) *	1991-04-10	2008-12-15	Scripps Research Inst	Bibliotheken heterodimerer rezeptoren mittels phagemiden
US5858657A (en) *	1992-05-15	1999-01-12	Medical Research Council	Methods for producing members of specific binding pairs
DE69230142T2 (de) *	1991-05-15	2000-03-09	Cambridge Antibody Technology Ltd.	Verfahren zur herstellung von spezifischen bindungspaargliedern
US6492160B1 (en)	1991-05-15	2002-12-10	Cambridge Antibody Technology Limited	Methods for producing members of specific binding pairs
US6225447B1 (en)	1991-05-15	2001-05-01	Cambridge Antibody Technology Ltd.	Methods for producing members of specific binding pairs
US5962255A (en) *	1992-03-24	1999-10-05	Cambridge Antibody Technology Limited	Methods for producing recombinant vectors
US5733731A (en) *	1991-10-16	1998-03-31	Affymax Technologies N.V.	Peptide library and screening method
US5270170A (en) *	1991-10-16	1993-12-14	Affymax Technologies N.V.	Peptide library and screening method
DK1024191T3 (da)	1991-12-02	2008-12-08	Medical Res Council	Fremstilling af autoantistoffer fremvist på fag-overflader ud fra antistofsegmentbiblioteker
US7067284B1 (en) *	1992-01-27	2006-06-27	The Scripps Research Institute	Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
US5733743A (en) *	1992-03-24	1998-03-31	Cambridge Antibody Technology Limited	Methods for producing members of specific binding pairs
EP0732404A4 (en) *	1993-12-03	1997-07-30	Asahi Chemical Ind	NEW EXPRESSION DETECTION VECTOR
WO1995020401A1 (en) *	1994-01-31	1995-08-03	Trustees Of Boston University	Polyclonal antibody libraries
US20060078561A1 (en) *	1994-01-31	2006-04-13	The Trustees Of Boston University	Polyclonal antibody libraries
US6576236B1 (en)	1994-07-01	2003-06-10	Dana Farber Cancer Institute	Methods for stimulating T cell responses by manipulating a common cytokine receptor γ chain
US7820798B2 (en) *	1994-11-07	2010-10-26	Human Genome Sciences, Inc.	Tumor necrosis factor-gamma
US7597886B2 (en)	1994-11-07	2009-10-06	Human Genome Sciences, Inc.	Tumor necrosis factor-gamma
US6326155B1 (en) *	1995-03-20	2001-12-04	Dyax Corp.	Engineering affinity ligands for macromolecules
US7429646B1 (en)	1995-06-05	2008-09-30	Human Genome Sciences, Inc.	Antibodies to human tumor necrosis factor receptor-like 2
US5702892A (en) *	1995-05-09	1997-12-30	The United States Of America As Represented By The Department Of Health And Human Services	Phage-display of immunoglobulin heavy chain libraries
US6475806B1 (en) *	1995-06-07	2002-11-05	Praecis Pharmaceuticals, Inc.	Anchor libraries and identification of peptide binding sequences
US7368111B2 (en)	1995-10-06	2008-05-06	Cambridge Antibody Technology Limited	Human antibodies specific for TGFβ2
US6090382A (en)	1996-02-09	2000-07-18	Basf Aktiengesellschaft	Human antibodies that bind human TNFα
US6713279B1 (en)	1995-12-07	2004-03-30	Diversa Corporation	Non-stochastic generation of genetic vaccines and enzymes
US20030219752A1 (en) *	1995-12-07	2003-11-27	Diversa Corporation	Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof
US6939689B2 (en)	1995-12-07	2005-09-06	Diversa Corporation	Exonuclease-mediated nucleic acid reassembly in directed evolution
US6358709B1 (en)	1995-12-07	2002-03-19	Diversa Corporation	End selection in directed evolution
US5830696A (en)	1996-12-05	1998-11-03	Diversa Corporation	Directed evolution of thermophilic enzymes
US6537776B1 (en)	1999-06-14	2003-03-25	Diversa Corporation	Synthetic ligation reassembly in directed evolution
US6740506B2 (en)	1995-12-07	2004-05-25	Diversa Corporation	End selection in directed evolution
US6764835B2 (en) *	1995-12-07	2004-07-20	Diversa Corporation	Saturation mutageneis in directed evolution
US7888466B2 (en)	1996-01-11	2011-02-15	Human Genome Sciences, Inc.	Human G-protein chemokine receptor HSATU68
DE19629143A1 (de) *	1996-07-19	1998-01-22	Bayer Ag	Vorrichtung zum Separieren von Mikroobjekten
US5876925A (en) *	1996-10-11	1999-03-02	The Trustees Of The University Of Pennsylvania	Magnetically activated cell sorting for production of proteins
US5985543A (en) *	1996-10-11	1999-11-16	The Trustees Of The University Of Pennsylvania	Compositions and methods for detection of antibody binding to cells
IL119587A (en) *	1996-11-07	2000-12-06	Univ Ramot	Method of preparing and for obtaining bimolecular interactions
US5817497A (en) *	1996-11-26	1998-10-06	Incyte Pharmaceuticals	Glutathione s-transferase
EP0977886A4 (en) *	1997-03-07	2002-10-23	Sunol Molecular Corp	FUSION PROTEINS, WHICH CONTAIN A BACTERIOPHAGE ENVELOPE PROTEIN AND A SINGLE CHAIN T-CELL RECEPTOR
US6555310B1 (en) *	1997-04-04	2003-04-29	Biosite Diagnostics, Inc.	Polyclonal libraries
US6057098A (en) *	1997-04-04	2000-05-02	Biosite Diagnostics, Inc.	Polyvalent display libraries
EP0985033A4 (en) *	1997-04-04	2005-07-13	Biosite Inc	POLYVALENT AND POLYCLONAL LIBRARIES
ATE349470T1 (de)	1997-04-07	2007-01-15	Genentech Inc	Anti-vefg antibodies
US7365166B2 (en)	1997-04-07	2008-04-29	Genentech, Inc.	Anti-VEGF antibodies
DE69832970T2 (de) *	1997-04-07	2006-08-10	Genentech, Inc., South San Francisco	Humanisierte antikörper und verfahren zu ihrer herstellung
CA2288430C (en)	1997-04-16	2013-04-09	Millennium Biotherapeutics, Inc.	Crsp protein (cysteine-rich secreted proteins), nucleic acid molecules encoding them and uses therefor
NZ516848A (en)	1997-06-20	2004-03-26	Ciphergen Biosystems Inc	Retentate chromatography apparatus with applications in biology and medicine
CA2309679C (en) *	1997-11-17	2010-07-20	Peter Kufer	Method of identifying binding site domains that retain the capacity of binding to an epitope
WO1999031265A1 (en) *	1997-12-12	1999-06-24	Way Jeffrey C	Compounds and methods for the inhibition of protein-protein interactions
US7390619B1 (en)	1998-02-11	2008-06-24	Maxygen, Inc.	Optimization of immunomodulatory properties of genetic vaccines
WO1999047538A1 (en)	1998-03-19	1999-09-23	Human Genome Sciences, Inc.	Cytokine receptor common gamma chain like
US6344330B1 (en)	1998-03-27	2002-02-05	The Regents Of The University Of California	Pharmacophore recombination for the identification of small molecule drug lead compounds
US7163682B2 (en)	1998-04-13	2007-01-16	The Forsyth Institute	Glucan binding protein and glucosyltransferase immunogens
US7056517B2 (en)	1998-04-13	2006-06-06	The Forsyth Institute	Glucosyltransferase immunogens
WO2000002584A2 (en)	1998-07-13	2000-01-20	Board Of Regents, The University Of Texas System	Cancer treatment methods using antibodies to aminophospholipids
WO2000006717A2 (en)	1998-07-27	2000-02-10	Genentech, Inc.	Improved transformation efficiency in phage display through modification of a coat protein
US6190908B1 (en)	1998-08-12	2001-02-20	The Scripps Research Institute	Modulation of polypeptide display on modified filamentous phage
US6420110B1 (en)	1998-10-19	2002-07-16	Gpc Biotech, Inc.	Methods and reagents for isolating biologically active peptides
IL127127A0 (en) *	1998-11-18	1999-09-22	Peptor Ltd	Small functional units of antibody heavy chain variable regions
US20090130718A1 (en) *	1999-02-04	2009-05-21	Diversa Corporation	Gene site saturation mutagenesis
WO2000050443A2 (en)	1999-02-26	2000-08-31	Millennium Pharmaceutcals, Inc.	Secreted proteins and uses thereof
EP1161451A4 (en)	1999-02-26	2006-05-17	Human Genome Sciences Inc	HUMAN ALPHA ENDOKIN AND METHOD FOR ITS USE
CN100439399C (zh)	1999-03-25	2008-12-03	艾博特股份有限两合公司	结合人il-12的人抗体及其生产方法
DE19915057A1 (de)	1999-04-01	2000-10-19	Forschungszentrum Borstel	Monoklonale Antikörper gegen das humane Mcm3 Protein, Verfahren zu ihrer Herstellung und ihre Verwendung
US6492497B1 (en)	1999-04-30	2002-12-10	Cambridge Antibody Technology Limited	Specific binding members for TGFbeta1
DK2067788T3 (da) *	1999-05-18	2015-10-19	Dyax Corp	Fab-fragmentbiblioteker og fremgangsmåder til anvendelse deraf
US20020102613A1 (en) *	1999-05-18	2002-08-01	Hoogenboom Hendricus Renerus Jacobus Mattheus	Novel Fab fragment libraries and methods for their use
US20040001826A1 (en) *	1999-06-30	2004-01-01	Millennium Pharmaceuticals, Inc.	Glycoprotein VI and uses thereof
US7291714B1 (en)	1999-06-30	2007-11-06	Millennium Pharmaceuticals, Inc.	Glycoprotein VI and uses thereof
WO2001014557A1 (en)	1999-08-23	2001-03-01	Dana-Farber Cancer Institute, Inc.	Pd-1, a receptor for b7-4, and uses therefor
US6673346B1 (en)	1999-08-31	2004-01-06	The Regents Of The University Of Michigan	Compositions and methods for the treatment of sepsis
US20070111259A1 (en) *	1999-10-02	2007-05-17	Medarex, Inc.	Human antibodies
US7135287B1 (en)	1999-10-02	2006-11-14	Biosite, Inc.	Human antibodies
US6794132B2 (en)	1999-10-02	2004-09-21	Biosite, Inc.	Human antibodies
US6680209B1 (en) *	1999-12-06	2004-01-20	Biosite, Incorporated	Human antibodies as diagnostic reagents
AU784983B2 (en) *	1999-12-15	2006-08-17	Genentech Inc.	Shotgun scanning, a combinatorial method for mapping functional protein epitopes
WO2001049717A2 (en)	1999-12-30	2001-07-12	President And Fellows Of Harvard College	Methods and compositions relating to modulation of hepatocyte growth, plasma cell differentiation or t cell subset activity by modulation of xbp-1 activity
AU2002219944B2 (en)	2000-11-28	2008-02-21	Medimmune, Llc	Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
SK12942002A3 (sk)	2000-02-10	2003-05-02	Abbott Laboratories	Protilátky viažuce ľudský interleukín-18, spôsoby ich výroby a použitia
PT1259547E (pt) *	2000-03-01	2012-10-15	Medimmune Inc	Anticorpos recombinantes de alta potência e método para a sua produção
EP1276856A4 (en)	2000-04-12	2004-06-09	Human Genome Sciences Inc	ALBUMIN FUSION PROTEINS
US8288322B2 (en)	2000-04-17	2012-10-16	Dyax Corp.	Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
AU2001253589B2 (en) *	2000-04-17	2007-08-16	Dyax Corp	Methods of constructing display libraries of genetic packages for members of a diverse family of peptides
JP2004528802A (ja) *	2000-04-24	2004-09-24	イエール・ユニバーシテイ	Ｄｎａおよびタンパク質を結合する小型タンパク質
US7495070B2 (en) *	2000-04-24	2009-02-24	Yale University	Protein binding miniature proteins
EP1714661A3 (en)	2000-05-19	2012-03-14	The Center for Blood Research, INC.	Methods for diagnosing and treating hemostatic disorders by modulating p-selectin activity
US20030031675A1 (en)	2000-06-06	2003-02-13	Mikesell Glen E.	B7-related nucleic acids and polypeptides useful for immunomodulation
CA2410458A1 (en)	2000-06-08	2001-12-13	The Center For Blood Research, Inc.	Methods and compositions for inhibiting immunoglobulin-mediated__reperfusion injury
WO2001096528A2 (en)	2000-06-15	2001-12-20	Human Genome Sciences, Inc.	Human tumor necrosis factor delta and epsilon
MXPA02012434A (es)	2000-06-16	2004-09-06	Cambridge Antibody Tech	Anticuerpos que se unen inmunoespecificamente a estimulador de linfocitos ii.
NZ543512A (en)	2000-06-28	2008-12-24	Genetics Inst Llc	Interaction of PD-L2 with PD-1 transmits a negative signal to immune cells, downregulating immune responses
WO2002028893A2 (en)	2000-07-14	2002-04-11	Cropdesign N.V.	Plant cyclin-dependent kinase inhibitors
US7288390B2 (en)	2000-08-07	2007-10-30	Centocor, Inc.	Anti-dual integrin antibodies, compositions, methods and uses
US6902734B2 (en)	2000-08-07	2005-06-07	Centocor, Inc.	Anti-IL-12 antibodies and compositions thereof
UA81743C2 (uk)	2000-08-07	2008-02-11	Центокор, Инк.	МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
GB0022978D0 (en)	2000-09-19	2000-11-01	Oxford Glycosciences Uk Ltd	Detection of peptides
JP2004515233A (ja)	2000-11-01	2004-05-27	イルーシスセラポーティクス，インコーポレーテッド	タンパク質トランススプライシングによる二重特異性分子の作製方法
US6821731B2 (en)	2000-11-28	2004-11-23	Wyeth	Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis of prostate cancer
JP2004526426A (ja)	2000-11-28	2004-09-02	ワイス	前立腺癌の診断および治療に有用なｋｉａａ核酸およびポリペプチドの発現分析
WO2002046434A2 (en) *	2000-12-08	2002-06-13	Alexion Pharmaceuticals, Inc.	Plasmid vectors
US7083784B2 (en)	2000-12-12	2006-08-01	Medimmune, Inc.	Molecules with extended half-lives, compositions and uses thereof
US6979556B2 (en) *	2000-12-14	2005-12-27	Genentech, Inc.	Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
DK2316940T3 (da) *	2000-12-18	2013-11-04	Dyax Corp	Fokuserede biblioteker af genpakker
SK9062003A3 (en) *	2000-12-22	2004-04-06	Ortho Mcneil Pharm Inc	Substituted triazole diamine derivatives as kinase inhibitors
WO2002051438A2 (en)	2000-12-22	2002-07-04	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Use of repulsive guidance molecule (rgm) and its modulators
AU2002231368C1 (en)	2001-01-05	2018-08-16	Amgen Fremont Inc.	Antibodies to insulin-like growth factor I receptor
CA2437811A1 (en)	2001-02-09	2002-08-22	Human Genome Sciences, Inc.	Human g-protein chemokine receptor (ccr5) hdgnr10
US7323327B2 (en)	2001-02-23	2008-01-29	Dsm Ip Assets B.V.	Genes encoding novel proteolytic enzymes
US20030165873A1 (en)	2001-03-02	2003-09-04	Come Jon H.	Three hybrid assay system
AU2002250236A1 (en) *	2001-03-02	2002-09-19	Medimmune, Inc.	Cd2 antagonists for treatment of autoimmune or inflammatory disease
US8981061B2 (en)	2001-03-20	2015-03-17	Novo Nordisk A/S	Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
US20090081199A1 (en) *	2001-03-20	2009-03-26	Bioxell S.P.A.	Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
US8231878B2 (en)	2001-03-20	2012-07-31	Cosmo Research & Development S.P.A.	Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
CA2342376C (en) *	2001-03-20	2013-11-12	Marco Colonna	A receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
EP1379125A4 (en)	2001-03-22	2004-12-08	Abbott Gmbh & Co Kg	TRANSGENIC ANIMALS THAT EXPRESS SPECIFIC ANTIBODIES FOR INTERESTING GENES AND THEIR USE
EP1383912A4 (en)	2001-04-02	2007-11-28	Wyeth Corp	PD-1, B7-4 RECEPTOR, AND ITS USES
KR20030093316A (ko)	2001-04-13	2003-12-06	휴먼 게놈 사이언시즈, 인코포레이티드	혈관 내피 성장 인자 ２
EP2277897A1 (en)	2001-04-16	2011-01-26	Wyeth Holdings Corporation	Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
US6803230B2 (en) *	2001-04-27	2004-10-12	Alexion Pharmaceuticals, Inc.	Phagemid vectors
KR100942393B1 (ko)	2001-05-25	2010-02-17	휴먼 게놈 사이언시즈, 인코포레이티드	Ｔｒａｉｌ 수용체에 면역특이적으로 결합하는 항체
US20060239533A1 (en) *	2001-06-04	2006-10-26	Triantafyllos Tafas	Method for detecting infectious agents using computer controlled automated image analysis
CA2868614A1 (en)	2001-06-08	2002-12-08	Abbott Laboratories (Bermuda) Ltd.	Methods of administering anti-tnf.alpha. antibodies
US20030124144A1 (en) *	2001-06-21	2003-07-03	Larry Cosenza	Chimeric capsid proteins and uses thereof
US20040002058A1 (en) *	2001-06-21	2004-01-01	Uab Research Foundation	Chimeric capsid proteins and uses thereof
EP2270184A3 (en)	2001-06-22	2012-04-11	Pioneer Hi-Bred International, Inc.	Defensin polynucleotides and methods of use
WO2003004604A2 (en) *	2001-07-06	2003-01-16	Genentech, Inc.	Phage displayed pdz domain ligands
US6867189B2 (en)	2001-07-26	2005-03-15	Genset S.A.	Use of adipsin/complement factor D in the treatment of metabolic related disorders
CA2454731C (en) *	2001-08-27	2010-11-02	Genentech, Inc.	A system for antibody expression and assembly
AU2002347404A1 (en) *	2001-09-14	2003-04-01	Cytos Biotechnology Ag	In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
US20040142325A1 (en)	2001-09-14	2004-07-22	Liat Mintz	Methods and systems for annotating biomolecular sequences
US7414111B2 (en) *	2001-09-19	2008-08-19	Alexion Pharmaceuticals, Inc.	Engineered templates and their use in single primer amplification
US7306906B2 (en) *	2001-09-19	2007-12-11	Alexion Pharmaceuticals, Inc.	Engineered templates and their use in single primer amplification
DE60232672D1 (de)	2001-10-01	2009-07-30	Dyax Corp	Mehrkettige eukaryontische display-vektoren und deren verwendungen
WO2003035842A2 (en) *	2001-10-24	2003-05-01	Dyax Corporation	Hybridization control of sequence variation
AR039067A1 (es)	2001-11-09	2005-02-09	Pfizer Prod Inc	Anticuerpos para cd40
KR100450864B1 (ko) *	2001-11-23	2004-10-01	한국과학기술연구원	Ｒｎａ 표적 분자에 대해 특이성이 향상된네오마이신-클로람페니콜 헤테로 이합체 및 그의 제조방법
ES2337989T3 (es)	2001-12-18	2010-05-03	Endocube Sas	Nuevas proteinas asociadas a la muerte de la familia thap y rutas par4 relacionadas implicadas en el control de la apoptosis.
US7858297B2 (en)	2001-12-18	2010-12-28	Centre National De La Recherche Scientifique Cnrs	Chemokine-binding protein and methods of use
EP1463807A4 (en)	2001-12-19	2006-04-12	Bristol Myers Squibb Co	FORMATHYDROGENASE FROM PICHIA PASTORIS AND USES THEREOF
AU2002364586A1 (en)	2001-12-21	2003-07-30	Delta Biotechnology Limited	Albumin fusion proteins
US20040009498A1 (en) *	2002-01-14	2004-01-15	Diversa Corporation	Chimeric antigen binding molecules and methods for making and using them
JP2005523688A (ja) *	2002-01-18	2005-08-11	ブリストル−マイヤーズ　スクイブ　カンパニー	タンパク質チロシンキナーゼおよび／またはタンパク質チロシンキナーゼ経路と相互作用する化合物の活性を予測するためのポリヌクレオチドおよびポリペプチドの同定
US7094579B2 (en)	2002-02-13	2006-08-22	Xoma Technology Ltd.	Eukaryotic signal sequences for prokaryotic expression
WO2003072054A2 (en) *	2002-02-25	2003-09-04	Cabot Corporation	Custom ligand design for biomolecular filtration and purification for bioseperation
DE60326214D1 (de) *	2002-03-01	2009-04-02	Siemens Healthcare Diagnostics	Assays zur überwachung von krebspatienten auf grundlage der spiegel von analytenkomponenten des plasminogen-aktivator-systems in proben von körperflüssigkeiten
AU2003212415A1 (en)	2002-03-01	2003-09-16	Bayer Corporation	Assays to monitor levels of epidermal growth factor receptor (egfr) extracellular domain (ecd) in cancer patients
JP2005531511A (ja)	2002-03-07	2005-10-20	ザフォーシスインスティチュート	グルカン結合タンパク質の免疫原性
AU2003218456A1 (en) *	2002-04-01	2003-10-20	Human Genome Sciences, Inc.	Antibodies that specifically bind to gmad
GB0207533D0 (en)	2002-04-02	2002-05-08	Oxford Glycosciences Uk Ltd	Protein
US7745192B2 (en)	2002-04-03	2010-06-29	Venomics Pty Limited	Prothrombin activating protein
AU2003226065B2 (en)	2002-04-12	2009-02-26	Ludwig Institute For Cancer Research, Ltd	Recombinant anti-interleukin-9 antibodies
US20030206898A1 (en)	2002-04-26	2003-11-06	Steven Fischkoff	Use of anti-TNFalpha antibodies and another drug
EA008607B1 (ru)	2002-05-21	2007-06-29	ДСМ Ай Пи ЭССЕТС Б.В.	Полинуклеотид, кодирующий фосфолипазу aspergillus niger, фосфолипаза aspergillus niger и способы получения и применения полинуклеотида и фосфолипазы
NZ556507A (en) *	2002-06-03	2010-03-26	Genentech Inc	Synthetic antibody phage libraries
EP2305710A3 (en)	2002-06-03	2013-05-29	Genentech, Inc.	Synthetic antibody phage libraries
AU2003274463B2 (en) *	2002-06-10	2009-10-29	University Of Rochester	Gene differentially expressed in breast and bladder cancer and encoded polypeptides
US7425618B2 (en)	2002-06-14	2008-09-16	Medimmune, Inc.	Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
AU2003240005B2 (en) *	2002-06-14	2010-08-12	Takeda Pharmaceutical Company Limited	Recombination of nucleic acid library members
MX337052B (es)	2002-07-15	2016-02-11	Univ Texas	Peptidos que se enlazan a fosfatidiletanolamina y sus usos en el tratamiento de infecciones virales y del cancer.
USRE47770E1 (en)	2002-07-18	2019-12-17	Merus N.V.	Recombinant production of mixtures of antibodies
ATE514717T1 (de)	2002-07-18	2011-07-15	Merus B V	Rekombinante produktion von antikörpermischungen
MY151032A (en)	2002-07-19	2014-03-31	Abbott Lab S A	Treatment of tnf? related disorders
US7250551B2 (en)	2002-07-24	2007-07-31	President And Fellows Of Harvard College	Transgenic mice expressing inducible human p25
EA200500330A1 (ru)	2002-08-10	2006-06-30	Йейл Юниверсити	Антагонисты nogo рецепторов
US20040067532A1 (en) *	2002-08-12	2004-04-08	Genetastix Corporation	High throughput generation and affinity maturation of humanized antibody
DK1534335T4 (da)	2002-08-14	2015-10-05	Macrogenics Inc	Fcgammariib-specifikke antistoffer og fremgangsmåder til anvendelse deraf
WO2004018660A2 (en)	2002-08-19	2004-03-04	Dsm Ip Assets B.V.	Novel lipases and uses thereof
WO2004018505A1 (en)	2002-08-20	2004-03-04	Yeda Research And Development Co. Ltd.	Akap84 and its use for visualization of biological structures
CN101044247B (zh)	2002-08-20	2011-06-22	千年药品公司	用于鉴定,评估,预防和治疗子宫颈癌的组合物,试剂盒及方法
EP1536820B2 (en)	2002-09-04	2013-10-23	Biopolymer Engineering, Inc.	Cancer therapy using whole glucan particles and antibodies
EP1539234A4 (en) *	2002-09-05	2006-02-15	Medimmune Inc	METHOD FOR PREVENTING OR TREATING CELL MALIGNITY BY ADMINISTERING CD2 ANTAGONISTS
AU2003272491B2 (en) *	2002-09-18	2008-10-02	The Trustees Of The University Of Pennsylvania	Compositions, methods and kits for detection of an antigen on a cell and in a biological mixture
AU2003294232A1 (en)	2002-10-16	2004-05-04	Euro-Celtique S.A.	Antibodies that bind cell-associated CA 125/O722P and methods of use thereof
US7427469B2 (en) *	2002-11-05	2008-09-23	Institut Pasteur	Method of treating cytomegalovirus with DC-SIGN blockers
US20060134100A1 (en) *	2002-11-05	2006-06-22	Ali Amara	Dc-sign blockers and their use for preventing or treating viral infections
AU2003287622A1 (en) *	2002-11-06	2004-06-03	Fraunhofer Usa	Expression of foreign sequences in plants using trans-activation system
US7491509B2 (en)	2003-02-03	2009-02-17	Fraunhofer Usa, Inc.	System for expression of genes in plants
US7692063B2 (en) *	2002-11-12	2010-04-06	Ibio, Inc.	Production of foreign nucleic acids and polypeptides in sprout systems
US7683238B2 (en) *	2002-11-12	2010-03-23	iBio, Inc. and Fraunhofer USA, Inc.	Production of pharmaceutically active proteins in sprouted seedlings
AU2003302470A1 (en) *	2002-11-26	2004-06-18	Dyax Corporation	Methods and compositions for controlling valency of phage display
DE10256669B4 (de) *	2002-12-04	2006-03-09	Universitätsklinikum Charité an der Humboldt-Universität zu Berlin Technologietransferstelle	Gemisch mindestens zweier Fusionsproteine sowie ihre Herstellung und Verwendung
AU2004204095B2 (en) *	2003-01-07	2009-07-30	Dyax Corporation	Kunitz domain library
EP1585767A2 (en) *	2003-01-16	2005-10-19	Genentech, Inc.	Synthetic antibody phage libraries
MXPA05007615A (es) *	2003-01-21	2005-09-30	Bristol Myers Squibb Co	Polinucleotido que codifica una novedosa acil coenzima a, monoacilglicerol aciltransferasa-3 (mgat3), y usos del mismo.
DE10303974A1 (de)	2003-01-31	2004-08-05	Abbott Gmbh & Co. Kg	Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
EP1947116B1 (en)	2003-02-10	2017-06-21	2-BBB Medicines B.V.	Differentially expressed nucleic acids in the blood-brain barrier under inflammatory conditions
WO2006113909A2 (en)	2005-04-19	2006-10-26	Seattle Genetics, Inc.	Humanized anti-cd70 binding agents and uses thereof
ES2347959T3 (es)	2003-02-20	2010-11-26	Seattle Genetics, Inc.	Conjugados de anticuerpos anti-cd70-farmaco y su uso para el tratamiento del cancer.
US20040180387A1 (en)	2003-03-13	2004-09-16	Fujirebio Diagnostics, Inc.	Detection of urinary mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of ovarian cancer
HUE025347T2 (en)	2003-03-19	2016-02-29	Biogen Ma Inc	NOGO receptor binding protein
US7294701B2 (en) *	2003-04-02	2007-11-13	Technion Research & Development Foundation Ltd.	Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same
JP4764818B2 (ja)	2003-04-11	2011-09-07	メディミューン，エルエルシー	組換えｉｌ−９抗体およびその使用
US20050014932A1 (en)	2003-05-15	2005-01-20	Iogenetics, Llc	Targeted biocides
ES2427641T3 (es)	2003-05-22	2013-10-31	Ibio, Inc.	Molécula vehículo recombinante para la expresión, el suministro y la purificación de polipéptidos diana
US9708410B2 (en)	2003-05-30	2017-07-18	Janssen Biotech, Inc.	Anti-tissue factor antibodies and compositions
ES2408582T3 (es)	2003-05-30	2013-06-21	Merus B.V.	Biblioteca de Fab para la preparación de una mezcla de anticuerpos
US20100069614A1 (en)	2008-06-27	2010-03-18	Merus B.V.	Antibody producing non-human mammals
CA2542232A1 (en)	2003-06-09	2005-01-20	Alnylam Pharmaceuticals, Inc.	Method for treating neurodegenerative disease by inhibiting alpha-synuclein
WO2005010163A2 (en) *	2003-07-15	2005-02-03	Barros Research Institute	Compositions and methods for immunotherapy of human immunotherapy of human immunodeficiency virus (hiv)
US7393534B2 (en)	2003-07-15	2008-07-01	Barros Research Institute	Compositions and methods for immunotherapy of cancer and infectious diseases
WO2005011580A2 (en) *	2003-07-25	2005-02-10	Board Of Regents, The University Of Texas System	Compositions and methods for herpes simplex prophylaxis and treatment
CA2445420A1 (en)	2003-07-29	2005-01-29	Invitrogen Corporation	Kinase and phosphatase assays
US7619059B2 (en)	2003-07-29	2009-11-17	Life Technologies Corporation	Bimolecular optical probes
US20050106667A1 (en) *	2003-08-01	2005-05-19	Genentech, Inc	Binding polypeptides with restricted diversity sequences
CA2534055A1 (en) *	2003-08-01	2005-02-10	Genentech, Inc.	Antibody cdr polypeptide sequences with restricted diversity
US7758859B2 (en) *	2003-08-01	2010-07-20	Genentech, Inc.	Anti-VEGF antibodies
HN2004000285A (es)	2003-08-04	2006-04-27	Pfizer Prod Inc	ANTICUERPOS DIRIGIDOS A c-MET
CA2534661A1 (en)	2003-08-08	2005-02-17	Genenews Inc.	Osteoarthritis biomarkers and uses thereof
US20050048617A1 (en)	2003-08-18	2005-03-03	Medimmune, Inc.	Humanization of antibodies
AR045563A1 (es)	2003-09-10	2005-11-02	Warner Lambert Co	Anticuerpos dirigidos a m-csf
IL158287A0 (en)	2003-10-07	2004-05-12	Yeda Res & Dev	Antibodies to nik, their preparation and use
CA2761987A1 (en)	2003-10-07	2005-04-21	Millennium Pharmaceuticals, Inc.	Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
US20070274988A1 (en) *	2003-10-10	2007-11-29	Five Prime Therapeautics, Inc.	Kiaa0779, Splice Variants Thereof, and Methods of Their Use
US7329725B1 (en) *	2003-10-29	2008-02-12	Nastech Pharmaceutical Company Inc.	Phage displayed Trp cage ligands
JP2005139011A (ja) *	2003-11-04	2005-06-02	Nof Corp	火薬原料及びその製造方法
GB0325836D0 (en) *	2003-11-05	2003-12-10	Celltech R&D Ltd	Biological products
US20050100965A1 (en)	2003-11-12	2005-05-12	Tariq Ghayur	IL-18 binding proteins
SI1983000T1 (sl)	2003-11-21	2015-12-31	Ucb Biopharma Sprl	Postopek za zdravljenje multiple skleroze z zaviranjem aktivnosti il-17
NZ547591A (en) *	2003-12-04	2009-11-27	Vaccinex Inc	Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells
GB0329825D0 (en)	2003-12-23	2004-01-28	Celltech R&D Ltd	Biological products
US20050266425A1 (en) *	2003-12-31	2005-12-01	Vaccinex, Inc.	Methods for producing and identifying multispecific antibodies
DOP2005000002A (es)	2004-01-09	2005-08-15	Pfizer	"anticuerpos contra madcam"
DK1737971T3 (da)	2004-01-20	2017-11-13	Merus Nv	Blandinger af bindingsproteiner
US20060014211A1 (en)	2004-01-21	2006-01-19	Fujirebio Diagnostics, Inc.	Detection of mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of the peritoneum and the peritoneal cavity
CN102816241B (zh)	2004-02-09	2015-07-22	人类基因科学公司	清蛋白融合蛋白
AU2005214382B2 (en)	2004-02-19	2011-08-04	Genentech, Inc.	CDR-repaired antibodies
EP1769068B1 (en) *	2004-02-20	2014-12-31	iBio, Inc.	Systems and methods for clonal expression in plants
US7442783B2 (en)	2004-03-01	2008-10-28	The Cbr Institute For Biomedical Research, Inc.	Natural IgM antibodies and inhibitors thereof
KR20080075045A (ko)	2004-03-24	2008-08-13	트리패스 이미징, 인코포레이티드	자궁경부 질환의 검사 방법 및 조성물
EP1786463A4 (en) *	2004-03-26	2009-05-20	Human Genome Sciences Inc	ANTIBODY AGAINST NOGO RECEPTOR
US7785903B2 (en) *	2004-04-09	2010-08-31	Genentech, Inc.	Variable domain library and uses
TWI439284B (zh)	2004-04-09	2014-06-01	Abbvie Biotechnology Ltd	用於治療ＴＮＦα相關失調症之多重可變劑量療法
EP2207033B1 (en)	2004-04-15	2014-06-18	University of Florida Research Foundation, Inc.	Neural proteins as biomarkers for nervous system injury and other neural disorders
US8318905B2 (en)	2004-04-23	2012-11-27	Richard Kroczek	Antibodies for depletion of ICOS-positive cells in vivo
AU2005250369A1 (en) *	2004-05-18	2005-12-15	Genentech, Inc.	M13 virus major coat protein variants for C-terminal and BI-terminal display of a heterologous protein
EP2270034A3 (en)	2004-06-03	2011-06-01	Athlomics Pty Ltd	Agents and methods for diagnosing stress
GB0414054D0 (en)	2004-06-23	2004-07-28	Owen Mumford Ltd	Improvements relating to automatic injection devices
EP1776136B1 (en)	2004-06-24	2012-10-03	Biogen Idec MA Inc.	Treatment of conditions involving demyelination
US7241598B2 (en) *	2004-06-29	2007-07-10	The Chinese University Of Hong Kong	Frame-shifting PCR for germline immunoglobulin genes retrieval and antibody engineering
US6986264B1 (en) *	2004-07-15	2006-01-17	Carrier Corporation	Economized dehumidification system
EP2322215A3 (en)	2004-07-16	2011-09-28	Pfizer Products Inc.	Combination treatment for non-hematologic malignancies using an anti-IGF-1R antibody
US7342093B2 (en)	2004-07-23	2008-03-11	University Of Massachusetts	Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins
EP1789070B1 (en)	2004-08-03	2012-10-24	Biogen Idec MA Inc.	Taj in neuronal function
CA2576195A1 (en) *	2004-08-05	2006-02-16	Biosite Incorporated	Compositions and methods for phage display of polypeptides
DK3530673T3 (da) *	2004-09-03	2022-04-19	Genentech Inc	Humaniserede anti-beta7-antagonister og anvendelser deraf
US7700720B2 (en)	2004-09-21	2010-04-20	Medimmune, Llc	Antibodies against and methods for producing vaccines for respiratory syncytial virus
US7435804B2 (en) *	2004-10-19	2008-10-14	Phage Biotechnology, Inc.	Method for obtaining single chain antibodies to human interferon α2b
WO2006047417A2 (en)	2004-10-21	2006-05-04	University Of Florida Research Foundation, Inc.	Detection of cannabinoid receptor biomarkers and uses thereof
EP1809326A4 (en)	2004-10-27	2009-11-04	Medimmune Inc	MODULATION OF ANTIBODY SPECIFICITY BY MEASURING ADAPTATION OF ITS AFFINITY TO AN APPARENT ANTIGEN
GB0426146D0 (en)	2004-11-29	2004-12-29	Bioxell Spa	Therapeutic peptides and method
SI1772465T1 (sl)	2005-01-05	2009-06-30	F Star Biotech Forsch & Entw	Sintetične imunoglobulinske domene z modificiranimi vezavnimi lastnostmi v regijah molekule, ki se razlikujejo od komplementarnost dolučujočih regij
GT200600031A (es)	2005-01-28	2006-08-29		Formulacion anticuerpo anti a beta
CA2599589A1 (en)	2005-02-07	2006-08-17	Genenews,Inc.	Mild osteoarthritis biomarkers and uses thereof
DK1853718T3 (da)	2005-02-15	2015-11-09	Univ Duke	Anti-cd19-antistoffer og deres anvendelse inden for onkologi
GB0503546D0 (en) *	2005-02-21	2005-03-30	Hellenic Pasteur Inst	Antibody
US20090142338A1 (en) *	2005-03-04	2009-06-04	Curedm, Inc.	Methods and Compositions for Treating Type 1 and Type 2 Diabetes Mellitus and Related Conditions
JP2008531730A (ja) *	2005-03-04	2008-08-14	キュアーディーエム、インク．	Ｉ型真性糖尿病及び他の症状を治療するための方法及び薬学的組成物
CA2602035C (en)	2005-03-18	2015-06-16	Medimmune, Inc.	Framework-shuffling of antibodies
NZ586780A (en)	2005-03-23	2012-02-24	Genmab As	Antibodies against CD38 for treatment of multiple myeloma
GB0506912D0 (en)	2005-04-05	2005-05-11	Celltech R&D Ltd	Biological products
ES2971647T3 (es)	2005-04-15	2024-06-06	Macrogenics Inc	Diacuerpos covalentes y usos de los mismos
US20060269556A1 (en) *	2005-04-18	2006-11-30	Karl Nocka	Mast cell activation using siglec 6 antibodies
AR053067A1 (es)	2005-04-25	2007-04-18	Pfizer	Anticuerpos contra miostatina
EP2444419A1 (en)	2005-04-26	2012-04-25	Pfizer Inc.	P-Cadherin antibodies
US7595380B2 (en)	2005-04-27	2009-09-29	Tripath Imaging, Inc.	Monoclonal antibodies and methods for their use in the detection of cervical disease
WO2006121852A2 (en)	2005-05-05	2006-11-16	Duke University	Anti-cd19 antibody therapy for autoimmune disease
CN101500607B (zh)	2005-05-16	2013-11-27	阿布维生物技术有限公司	TNFα抑制剂治疗腐蚀性多关节炎的用途
MX2007014474A (es)	2005-05-17	2008-02-07	Univ Connecticut	Composiciones y metodos para inmunomodulacion en un organismo.
WO2006128083A2 (en)	2005-05-25	2006-11-30	Curedm, Inc.	Human proislet peptide, derivatives and analogs thereof, and methods of using same
CN103242447B (zh)	2005-05-27	2016-04-27	比奥根Ma公司	结合tweak的抗体
US7767789B2 (en) *	2005-06-02	2010-08-03	University Hopitals of Cleveland	Truncated proteins as cancer markers
MY144484A (en)	2005-06-17	2011-09-30	Wyeth Corp	Methods of purifying anti a beta antibodies
CA2613512A1 (en)	2005-06-23	2007-01-04	Medimmune, Inc.	Antibody formulations having optimized aggregation and fragmentation profiles
KR20130080058A (ko) *	2005-06-30	2013-07-11	아보트 러보러터리즈	Ｉｌ-12/ｐ40 결합 단백질
EP2476761A3 (en)	2005-07-07	2012-10-17	Athlomics Pty Ltd	Polynucleotide marker genes and their expression, for diagnosis of endotoxemia
HRP20131066T1 (hr)	2005-07-08	2013-12-06	Biogen Idec Ma Inc.	Sp35 antitijela i njihova upotreba
EP1904652A2 (en) *	2005-07-08	2008-04-02	Brystol-Myers Squibb Company	Single nucleotide polymorphisms associated with dose-dependent edema and methods of use thereof
CN109187944A (zh)	2005-08-02	2019-01-11	埃克斯生物科技公司	使用IL-1α自身抗体诊断、治疗和预防血管疾病
JP2009502180A (ja)	2005-08-03	2009-01-29	アデレイドリサーチアンドイノベーションピーティーワイリミテッド	多糖シンターゼ
BRPI0614475B8 (pt) *	2005-08-03	2021-05-25	Fraunhofer Usa Inc	polipeptídeo, anticorpo, ácido nucleico, vetores, célula hospedeira, composição e processos de produção de anticorpo
US20090215992A1 (en) *	2005-08-19	2009-08-27	Chengbin Wu	Dual variable domain immunoglobulin and uses thereof
US7612181B2 (en) *	2005-08-19	2009-11-03	Abbott Laboratories	Dual variable domain immunoglobulin and uses thereof
US20070041905A1 (en)	2005-08-19	2007-02-22	Hoffman Rebecca S	Method of treating depression using a TNF-alpha antibody
US20070202512A1 (en) *	2005-08-19	2007-08-30	Bristol-Myers Squibb Company	Human single nucleotide polymorphisms associated with dose-dependent weight gain and methods of use thereof
EP2500359A3 (en)	2005-08-19	2012-10-17	Abbott Laboratories	Dual variable domain immunoglobulin and uses thereof
CA2618482C (en)	2005-08-19	2014-10-07	Abbott Laboratories	Dual variable domain immunoglobin and uses thereof
ZA200802971B (en)	2005-09-07	2009-10-28	Amgen Fremont Inc	Human monoclonal antibodies to activin receptor-like kinase-1
ATE546160T1 (de) *	2005-09-14	2012-03-15	Ucb Pharma Sa	Antikörper-kammpolymer-konjugat
JP2009510002A (ja)	2005-09-30	2009-03-12	アボットゲゼルシャフトミットベシュレンクテルハフツングウントコンパニーコマンディトゲゼルシャフト	反発誘導分子（ｒｇｍ）タンパク質ファミリーのタンパク質の結合ドメイン、及びその機能的断片、及びそれらの使用
GB0520169D0 (en) *	2005-10-04	2005-11-09	Celltech R&D Ltd	Biological products
WO2007048074A1 (en)	2005-10-21	2007-04-26	Genenews Inc.	Method and apparatus for correlating levels of biomarker products with disease
US8597646B2 (en)	2005-10-25	2013-12-03	The Johns Hopkins University	Methods and compositons featuring TGF-beta antagonists for the treatment of marfan syndrome and associated disorders
US7989395B2 (en)	2005-10-28	2011-08-02	Glaxosmithkline Llc	Methods for identifying compounds of interest using encoded libraries
AU2006337105B2 (en)	2005-11-01	2013-05-02	Abbvie Biotechnology Ltd	Methods and compositions for diagnosing ankylosing spondylitis using biomarkers
WO2007056161A1 (en)	2005-11-04	2007-05-18	Biogen Idec Ma Inc.	Methods for promoting neurite outgrowth and survival of dopaminergic neurons
CA2628238A1 (en)	2005-11-07	2007-05-18	The Scripps Research Institute	Compositions and methods for controlling tissue factor signaling specificity
EP1957531B1 (en)	2005-11-07	2016-04-13	Genentech, Inc.	Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
UA96139C2 (uk)	2005-11-08	2011-10-10	Дженентек, Інк.	Антитіло до нейропіліну-1 (nrp1)
EP1949109B1 (en)	2005-11-14	2012-02-29	MetaMol Theranostics, LLC	Peptide sequence that promotes tumor invasion
US20070122413A1 (en)	2005-11-28	2007-05-31	Sivakumar Pallavur V	Il-21 antagonists
AU2006350038B2 (en)	2005-11-30	2011-09-15	Massachusetts Institute Of Technology	Pathogen detection biosensor
JP5486808B2 (ja)	2005-11-30	2014-05-07	アッヴィ・インコーポレイテッド	アミロイドベータタンパク質に対するモノクローナル抗体及びその使用
BRPI0619249A2 (pt)	2005-11-30	2011-09-20	Abbott Lab	anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos
WO2007064919A2 (en) *	2005-12-02	2007-06-07	Genentech, Inc.	Binding polypeptides with restricted diversity sequences
WO2007064882A2 (en)	2005-12-02	2007-06-07	Biogen Idec Ma Inc.	Treatment of conditions involving demyelination
JP5808070B2 (ja) *	2005-12-02	2015-11-10	ジェネンテック，インコーポレイテッド	結合ポリペプチド及びその使用
ZA200804594B (en)	2005-12-09	2010-08-25	Ucb Pharma Sa	Antibody molecules having specificity for human IL-6
US10183986B2 (en)	2005-12-15	2019-01-22	Industrial Technology Research Institute	Trimeric collagen scaffold antibodies
US20070264687A1 (en)	2005-12-15	2007-11-15	Min-Yuan Chou	Recombinant triplex scaffold-based polypeptides
US8014957B2 (en)	2005-12-15	2011-09-06	Fred Hutchinson Cancer Research Center	Genes associated with progression and response in chronic myeloid leukemia and uses thereof
US7632498B2 (en)	2005-12-19	2009-12-15	Tripath Imaging, Inc.	MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disease
EP1987360B1 (en)	2006-01-27	2012-03-07	Tripath Imaging, Inc.	Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor
BRPI0707276B1 (pt)	2006-01-27	2021-08-31	Biogen Ma Inc	Polipeptídeo de fusão antagonista de receptor nogo
WO2007090126A2 (en) *	2006-01-30	2007-08-09	Invitrogen Corporation	Compositions and methods for detecting and quantifying toxic substances in disease states
US20070175313A1 (en) *	2006-01-31	2007-08-02	Kevin Vandervliet	MP3 player holder assembly
WO2007095320A2 (en) *	2006-02-13	2007-08-23	Fraunhofer Usa, Inc.	Hpv antigens, vaccine compositions, and related methods
US8277816B2 (en) *	2006-02-13	2012-10-02	Fraunhofer Usa, Inc.	Bacillus anthracis antigens, vaccine compositions, and related methods
KR20080106433A (ko) *	2006-02-13	2008-12-05	프라운호퍼 유에스에이, 인코포레이티드	인플루엔자 항원, 백신 조성물 및 관련 방법
TW200744634A (en)	2006-02-21	2007-12-16	Wyeth Corp	Methods of using antibodies against human IL-22
TWI417301B (zh)	2006-02-21	2013-12-01	Wyeth Corp	對抗人類介白素-２２（ｉｌ-２２）之抗體及其用途
EP1999148B8 (en)	2006-03-06	2014-03-05	Medlmmune, LLC	Humanized anti-cd22 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
EP2010569A4 (en)	2006-03-20	2009-09-09	Xoma Technology Ltd	HUMAN ANTIBODIES SPECIFIC TO GASTRINE MATERIALS AND METHODS
EP2738179A1 (en)	2006-04-05	2014-06-04	AbbVie Biotechnology Ltd	Antibody purification
EP2703010A3 (en)	2006-04-10	2014-08-06	AbbVie Biotechnology Ltd	Uses and compositions for treatment of rheumatoid arthritis
EP2007426A4 (en)	2006-04-10	2010-06-16	Abbott Biotech Ltd	COMPOSITIONS FOR THE TREATMENT OF PSORIASTIC POLYARTHRITIS AND THEIR APPLICATIONS
CA2564435A1 (en)	2006-04-10	2007-10-10	Abbott Biotechnology Ltd.	Methods for monitoring and treating intestinal disorders
US7702468B2 (en)	2006-05-03	2010-04-20	Population Diagnostics, Inc.	Evaluating genetic disorders
US10522240B2 (en)	2006-05-03	2019-12-31	Population Bio, Inc.	Evaluating genetic disorders
CA2651567A1 (en) *	2006-05-09	2007-11-22	Genentech, Inc.	Binding polypeptides with optimized scaffolds
US20090318308A1 (en) *	2006-05-30	2009-12-24	Millegen	Highly diversified antibody libraries
GB0611116D0 (en)	2006-06-06	2006-07-19	Oxford Genome Sciences Uk Ltd	Proteins
SG177907A1 (en)	2006-06-14	2012-02-28	Macrogenics Inc	Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity
HUE030269T2 (en)	2006-06-26	2017-04-28	Macrogenics Inc	FC RIIB-specific antibodies and methods for their use
NZ572765A (en)	2006-06-30	2012-08-31	Abbott Biotech Ltd	Automatic injection device with rod driving syringe longitudinally split with radially compressible pair of wings along its length
US7572618B2 (en)	2006-06-30	2009-08-11	Bristol-Myers Squibb Company	Polynucleotides encoding novel PCSK9 variants
EP2402437B1 (en) *	2006-07-05	2016-06-01	Catalyst Biosciences, Inc.	Protease screening methods and proteases identified thereby
AT503889B1 (de)	2006-07-05	2011-12-15	Star Biotechnologische Forschungs Und Entwicklungsges M B H F	Multivalente immunglobuline
US20100003189A1 (en)	2006-07-14	2010-01-07	The Regents Of The University Of California	Cancer biomarkers and methods of use thereof
KR101528939B1 (ko)	2006-07-18	2015-06-15	사노피	암 치료를 위한 ｅｐｈａ2에 대한 길항제 항체
ES2613957T3 (es)	2006-08-04	2017-05-29	Medimmune Limited	Anticuerpos contra ERBB2
TWI405771B (zh)	2006-08-28	2013-08-21	Kyowa Hakko Kirin Co Ltd	具拮抗性之人類ｌｉｇｈｔ專一性人類單株抗體
EP3910065B1 (en)	2006-09-08	2025-07-23	AbbVie Bahamas Ltd.	Interleukin -13 binding proteins
TR201910145T4 (tr)	2006-09-26	2019-08-21	Genmab As	Tümörlerin tedavi edilmesine yönelik anti-CD38 artı kortikosteroidler artı bir kortikosteroid-olmayan kemoterapötik.
BRPI0719250A2 (pt)	2006-10-12	2015-06-16	Wyeth Corp	Métodos e composições com opalescência reduzida.
AU2007324135B2 (en) *	2006-10-12	2013-06-27	Genentech, Inc.	Antibodies to lymphotoxin-alpha
CA2665826A1 (en)	2006-10-16	2008-04-24	Medimmune, Llc	Molecules with reduced half-lives, compositions and uses thereof
GB0620729D0 (en)	2006-10-18	2006-11-29	Ucb Sa	Biological products
EP1914242A1 (en)	2006-10-19	2008-04-23	Sanofi-Aventis	Novel anti-CD38 antibodies for the treatment of cancer
WO2008055260A2 (en)	2006-11-03	2008-05-08	Wyeth	Glycolysis-inhibiting substances in cell culture
EP1921142A1 (en) *	2006-11-07	2008-05-14	Cytos Biotechnology AG	Selection of human monoclonal antibodies by eukaryotic cell display
JP2010509354A (ja)	2006-11-09	2010-03-25	アイアールエム・リミテッド・ライアビリティ・カンパニー	アゴニストｔｒｋｂ抗体およびその使用
EP2094282A4 (en)	2006-11-15	2010-05-05	Functional Genetics Inc	ANTI-TSG101 ANTIBODIES AND USES THEREOF FOR THE TREATMENT OF VIRAL INFECTIONS
US7488807B2 (en)	2006-11-22	2009-02-10	3M Innovative Properties Company	Antibody with protein A selectivity
WO2008064306A2 (en)	2006-11-22	2008-05-29	Curedm, Inc.	Methods and compositions relating to islet cell neogenesis
US8455626B2 (en)	2006-11-30	2013-06-04	Abbott Laboratories	Aβ conformer selective anti-aβ globulomer monoclonal antibodies
PT2099823E (pt)	2006-12-01	2014-12-22	Seattle Genetics Inc	Agentes de ligação ao alvo variantes e suas utilizações
CN101678100A (zh)	2006-12-06	2010-03-24	米迪缪尼有限公司	治疗系统性红斑狼疮的方法
EP2094306A2 (en)	2006-12-20	2009-09-02	XOMA Technology Ltd.	Treatment of il-1-beta related diseases
CA2947292C (en)	2006-12-27	2019-07-23	Emory University	Compositions and methods for the treatment of infections and tumors
US8128926B2 (en)	2007-01-09	2012-03-06	Biogen Idec Ma Inc.	Sp35 antibodies and uses thereof
JP2010515456A (ja)	2007-01-09	2010-05-13	バイオジェン・アイデック・エムエイ・インコーポレイテッド	Ｓｐ３５抗体およびその使用
US7776331B1 (en)	2007-01-16	2010-08-17	Abbott Laboratories	Methods of treating plaque psoriasis
MX2009008461A (es)	2007-02-07	2009-08-17	Decode Genetics Ehf	Variantes geneticas que contribuyen a riesgo de cancer de prostata.
US7834154B2 (en)	2007-02-09	2010-11-16	Genentech, Inc.	Anti-ROBO4 antibodies and uses therefor
WO2008101184A2 (en)	2007-02-16	2008-08-21	The Board Of Trustees Of Southern Illinois University	Arl-1 specific antibodies
US8685666B2 (en) *	2007-02-16	2014-04-01	The Board Of Trustees Of Southern Illinois University	ARL-1 specific antibodies and uses thereof
JP5646179B2 (ja)	2007-02-21	2014-12-24	デコード・ジェネティクス・イーエイチエフ	循環器疾患に関連する遺伝的感受性変異体
DK2447719T3 (da)	2007-02-26	2016-10-10	Oxford Biotherapeutics Ltd	Proteiner
WO2008104803A2 (en)	2007-02-26	2008-09-04	Oxford Genome Sciences (Uk) Limited	Proteins
EP2486928A1 (en)	2007-02-27	2012-08-15	Abbott GmbH & Co. KG	Method for the treatment of amyloidoses
PL2125894T3 (pl)	2007-03-22	2019-08-30	Biogen Ma Inc.	Białka wiążące, w tym przeciwciała, pochodne przeciwciał i fragmenty przeciwciał, które swoiście wiążą się z CD154 i ich zastosowania
ES2381780T3 (es)	2007-03-22	2012-05-31	Heptares Therapeutics Limited	Receptores acoplados a proteínas G mutantes y métodos para seleccionarlos
KR101540823B1 (ko)	2007-03-30	2015-07-30	메디뮨 엘엘씨	항체 제제
CA2682927A1 (en)	2007-04-02	2008-10-16	Amgen Fremont Inc.	Anti-ige antibodies
WO2008122310A1 (en) *	2007-04-04	2008-10-16	Chimera Biotec Gmbh	Method for the detection of an analyte in biological matrix
US7807168B2 (en) *	2007-04-10	2010-10-05	Vaccinex, Inc.	Selection of human TNFα specific antibodies
EP2147096B1 (en)	2007-04-13	2015-03-25	Catalyst Biosciences, Inc.	Modified factor VII polypeptides and uses thereof
TW200902708A (en)	2007-04-23	2009-01-16	Wyeth Corp	Methods of protein production using anti-senescence compounds
CN101687024A (zh) *	2007-04-28	2010-03-31	美国弗劳恩霍夫股份有限公司	锥虫抗原、疫苗组合物和相关方法
EP2164868B1 (en)	2007-05-04	2015-03-25	Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA	Engineered rabbit antibody variable domains and uses thereof
EP2068925A4 (en)	2007-05-07	2011-08-31	Medimmune Llc	ANTI-ICOS ANTIBODIES AND THEIR USE FOR THE TREATMENT OF CANCER, TRANSPLANTATIONS AND AUTOIMMUNE DISEASES
PL3072525T3 (pl)	2007-05-14	2018-07-31	Astrazeneca Ab	Sposoby redukcji poziomów bazofili
US8318163B2 (en) *	2007-05-17	2012-11-27	Genentech, Inc.	Anti-pan neuropilin antibody and binding fragments thereof
AU2008256219B2 (en)	2007-05-25	2014-06-05	Decode Genetics Ehf.	Genetic variants on Chr 5p12 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment
US20090232801A1 (en) *	2007-05-30	2009-09-17	Abbot Laboratories	Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof
PE20090329A1 (es) *	2007-05-30	2009-03-27	Abbott Lab	Anticuerpos humanizados contra el globulomero ab(20-42) y sus usos
EP2171451A4 (en)	2007-06-11	2011-12-07	Abbott Biotech Ltd	METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS
PT2170956E (pt)	2007-06-15	2015-02-05	Medigene Ag	Tratamento de tumores utilizando um anticorpo anti-l1 específico
CA2691434C (en)	2007-06-21	2020-07-21	Macrogenics, Inc.	Covalent diabodies and uses thereof
US8921279B2 (en) *	2007-06-26	2014-12-30	F-Star Biotechnologische Forschungs—und Entwicklungsges. m.b.H	Display of binding agents
CA2692933C (en) *	2007-07-11	2016-10-18	Fraunhofer Usa, Inc.	Yersinia pestis antigens, vaccine compositions, and related methods
PL2474557T3 (pl)	2007-07-16	2015-02-27	Genentech Inc	Przeciwciała anty- CD79b i immunokoniugaty i sposoby stosowania
PE20090481A1 (es)	2007-07-16	2009-05-18	Genentech Inc	Anticuerpos anti-cd79b e inmunoconjugados humanizados y metodos de uso
WO2009018449A1 (en)	2007-07-31	2009-02-05	Verenium Corporation	Tailored multi-site combinatorial assembly
US20100273722A1 (en) *	2007-08-06	2010-10-28	Yale University	Modified miniature proteins
WO2009026397A2 (en) *	2007-08-20	2009-02-26	Fraunhofer Usa, Inc.	Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods
SG185940A1 (en) *	2007-08-30	2012-12-28	Curedm Group Holdings Llc	Compositions and methods of using proislet peptides and analogs thereof
GB0717337D0 (en)	2007-09-06	2007-10-17	Ucb Pharma Sa	Method of treatment
WO2009036379A2 (en) *	2007-09-14	2009-03-19	Adimab, Inc.	Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en)	2007-09-14	2014-11-04	Adimab, Llc	Rationally designed, synthetic antibody libraries and uses therefor
CN101842387B (zh)	2007-09-26	2014-05-07	Ucb医药有限公司	双特异性抗体融合物
CA2704494A1 (en) *	2007-11-02	2009-05-14	The Scripps Research Institute	Directed evolution using proteins comprising unnatural amino acids
JP5767475B2 (ja)	2007-11-05	2015-08-19	メディミューン，エルエルシー	強皮症の治療方法
EP2614837A1 (en)	2007-11-09	2013-07-17	Affitech Research AS	Anti-VEGF antibody compositions and methods
CA2705486C (en)	2007-11-19	2019-04-02	Celera Corporation	Lung cancer markers and uses thereof
US9308257B2 (en) *	2007-11-28	2016-04-12	Medimmune, Llc	Protein formulation
US8697360B2 (en)	2007-11-30	2014-04-15	Decode Genetics Ehf.	Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition
AR069501A1 (es)	2007-11-30	2010-01-27	Genentech Inc	Anticuerpos anti- vegf (factor de crecimiento endotelial vascular)
GB0724051D0 (en)	2007-12-08	2008-01-16	Medical Res Council	Mutant proteins and methods for producing them
WO2009085462A1 (en)	2007-12-19	2009-07-09	Centocor, Inc.	Design and generation of human de novo pix phage display libraries via fusion to pix or pvii, vectors, antibodies and methods
GB0724860D0 (en)	2007-12-20	2008-01-30	Heptares Therapeutics Ltd	Screening
JP5536666B2 (ja)	2007-12-20	2014-07-02	ゾーマ（ユーエス）リミテッドライアビリティカンパニー	痛風の治療のための方法
EP2237792B1 (en)	2007-12-26	2017-05-24	Vaccinex, Inc.	Anti-c35 antibody combination therapies and methods
JP5730020B2 (ja)	2007-12-28	2015-06-03	ネオトープバイオサイエンシーズリミテッド	アミロイドーシスの処置および予防
GB0800277D0 (en)	2008-01-08	2008-02-13	Imagination Tech Ltd	Video motion compensation
CA2711771C (en)	2008-01-11	2017-01-24	Gene Techno Science Co., Ltd.	Humanized anti-.alpha.9 integrin antibodies and the uses thereof
US20110033378A1 (en)	2008-01-18	2011-02-10	Medlmmune, Llc.	Cysteine Engineered Antibodies For Site-Specific Conjugation
PT2247620T (pt)	2008-01-31	2016-08-23	Genentech Inc	Anticorpos e imunoconjugados anti-cd79b e métodos de utilização
CN101952454B (zh)	2008-02-08	2014-06-04	米迪缪尼有限公司	具有减弱的Fc配体亲和性的抗IFNAR1抗体
GB0802474D0 (en)	2008-02-11	2008-03-19	Heptares Therapeutics Ltd	Mutant proteins and methods for selecting them
AU2009213689B2 (en)	2008-02-14	2014-11-20	Decode Genetics Ehf.	Susceptibility variants for lung cancer
JP2011512817A (ja)	2008-02-28	2011-04-28	スリーエムイノベイティブプロパティズカンパニー	クロストリジウム・ディフィシル胞子に対する抗体及びその使用
US8962803B2 (en)	2008-02-29	2015-02-24	AbbVie Deutschland GmbH & Co. KG	Antibodies against the RGM A protein and uses thereof
WO2009114815A1 (en) *	2008-03-13	2009-09-17	Dyax Corp	Libraries of genetic packages comprising novel hc cdr3 designs
US8178092B2 (en)	2008-03-18	2012-05-15	Abbott Laboratories	Methods of treating psoriasis by administration of antibodies to the p40 subunit of IL-12 and/or IL-23
EP2260102A1 (en)	2008-03-25	2010-12-15	Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research	Treating cancer by down-regulating frizzled-4 and/or frizzled-1
EP2274450A2 (en)	2008-04-01	2011-01-19	Decode Genetics EHF	Susceptibility variants for peripheral arterial disease and abdominal aortic aneurysm
CN102046655B (zh)	2008-04-02	2016-09-14	宏观基因有限公司	Bcr-复合体-特异性抗体和其使用方法
CA2720368C (en)	2008-04-02	2017-08-22	Macrogenics, Inc.	Her2/neu-specific antibodies and methods of using same
KR101674097B1 (ko)	2008-04-11	2016-11-08	시애틀 지네틱스, 인크.	췌장, 난소 및 다른 암의 검출 및 치료
GB0807413D0 (en)	2008-04-23	2008-05-28	Ucb Pharma Sa	Biological products
US9388510B2 (en)	2008-04-24	2016-07-12	Dyax Corp.	Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs
WO2009131256A1 (en)	2008-04-24	2009-10-29	Gene Techno Science Co., Ltd.	Humanized antibodies specific for amino acid sequence rgd of an extracellular matrix protein and the uses thereof
SG10202105499WA (en) *	2008-04-25	2021-07-29	Dyax Corp	Antibodies Against Fcrn And Use Thereof
US20090269786A1 (en) *	2008-04-25	2009-10-29	The Board Of Trustees Of The University Of Illinois	RHO1-Gamma Amino Butyric Acid C Receptor-Specific Antibodies
CA2722466A1 (en)	2008-04-29	2009-11-05	Tariq Ghayur	Dual variable domain immunoglobulins and uses thereof
EP2113255A1 (en)	2008-05-02	2009-11-04	f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H.	Cytotoxic immunoglobulin
WO2009135181A2 (en)	2008-05-02	2009-11-05	Seattle Genetics, Inc.	Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
CA2723219A1 (en)	2008-05-09	2009-11-12	Abbott Gmbh & Co. Kg	Antibodies to receptor of advanced glycation end products (rage) and uses thereof
ES2533480T3 (es) *	2008-05-16	2015-04-10	F. Hoffmann-La Roche Ag	Uso de biomarcadores para evaluar el tratamiento de trastornos inflamatorios gastrointestinales con antagonistas de la integrina beta7
US20090291073A1 (en) *	2008-05-20	2009-11-26	Ward Keith W	Compositions Comprising PKC-theta and Methods for Treating or Controlling Ophthalmic Disorders Using Same
EP2304439A4 (en)	2008-05-29	2012-07-04	Nuclea Biotechnologies Llc	ANTI-phospho-AKT ANTIBODY
JP5723769B2 (ja)	2008-06-03	2015-05-27	アッヴィ・インコーポレイテッド	二重可変ドメイン免疫グロブリン及びその使用
BRPI0913406A2 (pt)	2008-06-03	2018-01-09	Abbott Lab	imunoglobulinas de domínio variável duplo e usos das mesmas
EP2282770B1 (en)	2008-06-04	2018-03-07	MacroGenics, Inc.	Antibodies with altered binding to fcrn and methods of using same
EP2303318A2 (en)	2008-06-20	2011-04-06	Wyeth LLC	Compositions and methods of use of orf1358 from beta-hemolytic streptococcal strains
AU2009269542A1 (en)	2008-07-07	2010-01-14	Decode Genetics Ehf	Genetic variants for breast cancer risk assessment
WO2010006060A2 (en)	2008-07-08	2010-01-14	Abbott Laboratories	Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
CN102143760B (zh)	2008-07-08	2015-06-17	Abbvie公司	前列腺素e2结合蛋白及其用途
WO2010005570A2 (en)	2008-07-09	2010-01-14	Biogen Idec Ma Inc.	Compositions comprising antibodies to lingo or fragments thereof
EP2326668B1 (en)	2008-08-14	2018-01-17	Teva Pharmaceuticals Australia Pty Ltd	Anti-il-12/il-23 antibodies
US9023594B2 (en)	2008-09-05	2015-05-05	President And Fellows Of Harvard College	Continuous directed evolution of proteins and nucleic acids
WO2010033237A2 (en) *	2008-09-22	2010-03-25	Calmune Corporation	Methods for creating diversity in libraries and libraries, display vectors and methods, and displayed molecules
AU2009293640A1 (en) *	2008-09-22	2010-03-25	Calmune Corporation	Methods and vectors for display of 2G12 -derived domain exchanged antibodies
US20100075329A1 (en)	2008-09-23	2010-03-25	O'toole Margot	Methods for predicting production of activating signals by cross-linked binding proteins
EP2352841A2 (en)	2008-09-23	2011-08-10	President and Fellows of Harvard College	Sirt4 and uses thereof
EP3133086B1 (en)	2008-09-26	2018-08-01	Dana-Farber Cancer Institute, Inc.	Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses thereof
US8313942B2 (en)	2008-09-26	2012-11-20	Wyeth Llc	Compatible display vector systems
US8734803B2 (en)	2008-09-28	2014-05-27	Ibio Inc.	Humanized neuraminidase antibody and methods of use thereof
EP3025727A1 (en)	2008-10-02	2016-06-01	The J. David Gladstone Institutes	Methods of treating liver disease
SMT202000101T1 (it)	2008-10-10	2020-03-13	Childrens Medical Center	Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente
JP2012505900A (ja)	2008-10-14	2012-03-08	ダイアクスコーポレーション	全身性強皮症に伴う肺線維症の治療および予防のためのｉｇｆ−ｉｉ／ｉｇｆ−ｉｉｅ結合タンパク質の使用
EP2921501A1 (en)	2008-10-20	2015-09-23	Abbvie Inc.	Isolation and purification of antibodies using Protein A affinity chromatography
AU2009308422B2 (en)	2008-10-24	2017-01-05	The Government of the United States of America as represented by The Secretary, Department of Health and Human Services, Center for Disease Control and Prevention	Human Ebola virus species and compositions and methods thereof
CN105646643A (zh)	2008-10-29	2016-06-08	阿布林克斯公司	单域抗原结合性分子的纯化方法
AU2009333791B2 (en)	2008-10-29	2013-04-04	Ablynx N.V.	Formulations of single domain antigen binding molecules
DK2346904T3 (da)	2008-10-29	2017-06-12	China Synthetic Rubber Corp	Fremgangsmåder og midler til diagnosen og behandling af hepatocellular carcinom
CN102438652B (zh)	2008-11-12	2014-08-13	米迪缪尼有限公司	抗体制剂
ATE523603T1 (de) *	2008-11-21	2011-09-15	Chimera Biotec Gmbh	Konjugatkomplexe zum analytnachweis
EP2361093A2 (en)	2008-11-26	2011-08-31	Five Prime Therapeutics, Inc.	Compositions and methods for regulating collagen and smooth muscle actin expression by serpine2
US9598491B2 (en)	2008-11-28	2017-03-21	Emory University	Methods for the treatment of infections and tumors
KR20110097913A (ko) *	2008-12-04	2011-08-31	아보트 러보러터리즈	이원 가변 도메인 면역글로불린 및 이의 용도
FI4209510T3 (fi)	2008-12-09	2024-03-22	Hoffmann La Roche	Anti-PD-L1-vasta-aineita ja niiden käyttö T-solutoiminnan tehostamiseksi
CA2745460C (en)	2008-12-19	2021-07-13	Macrogenics, Inc.	Covalent diabodies and uses thereof
US20120003235A1 (en)	2008-12-31	2012-01-05	Biogen Idec Ma Inc.	Anti-lymphotoxin antibodies
US9181315B2 (en)	2009-01-08	2015-11-10	Dana-Farber Cancer Institute, Inc.	Compositions and methods for induced brown fat differentiation
GB0900425D0 (en)	2009-01-12	2009-02-11	Ucb Pharma Sa	Biological products
EP2387584A1 (en)	2009-01-14	2011-11-23	IQ Therapeutics BV	Combination antibodies for the treatment and prevention of disease caused by bacillus anthracis and related bacteria and their toxins
BRPI1007345A2 (pt)	2009-01-20	2019-04-16	H. ZADEH Homayoun	regeneração óssea de anticorpo mediado
AU2010207552A1 (en)	2009-01-21	2011-09-01	Oxford Biotherapeutics Ltd.	PTA089 protein
US20110165063A1 (en) *	2009-01-29	2011-07-07	Abbott Laboratories	Il-1 binding proteins
RU2011135768A (ru)	2009-01-29	2013-03-10	Эбботт Лэборетриз	Белки, связывающие il-1
WO2010087702A1 (en)	2009-01-30	2010-08-05	Stichting Katholieke Universiteit	TET2 gene as a marker for diagnosing a myelodysuplastic syndrome (MDS) or an acute myeloid leukemia (AML) and determining the prognosis in a subject
US8852608B2 (en)	2009-02-02	2014-10-07	Medimmune, Llc	Antibodies against and methods for producing vaccines for respiratory syncytial virus
WO2010093993A2 (en)	2009-02-12	2010-08-19	Human Genome Sciences, Inc.	Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance
JP5782385B2 (ja)	2009-02-17	2015-09-24	ユーシービーファーマソシエテアノニム	ヒトｏｘ４０に対する特異性を有する抗体分子
US8030026B2 (en)	2009-02-24	2011-10-04	Abbott Laboratories	Antibodies to troponin I and methods of use thereof
SG173705A1 (en)	2009-03-05	2011-09-29	Abbott Lab	Il-17 binding proteins
EP2403880A1 (en)	2009-03-05	2012-01-11	Tripath Imaging, Inc.	Matrix metalloproteinase-7 (mmp-7) monoclonal antibodies and methods for their use in the detection of ovarian cancer
EP2405920A1 (en)	2009-03-06	2012-01-18	Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research	Novel therapy for anxiety
CA2753713A1 (en)	2009-03-06	2010-09-10	Tripath Imaging, Inc	Glycodelin monoclonal antibodies and methods for their use in the detection of ovarian cancer
KR101667227B1 (ko)	2009-03-10	2016-10-18	가부시키가이샤 진 테크노 사이언스	인간화된 ｋ33ｎ 단일 클론 항체의 제조, 발현 및 해석
GB0904214D0 (en)	2009-03-11	2009-04-22	Ucb Pharma Sa	Biological products
BRPI1012676A2 (pt)	2009-04-01	2016-04-05	Genentech Inc	anticorpos anti-fcrh5 e imunoconjugados e métodos de uso
AU2010231494B2 (en)	2009-04-03	2016-01-07	Decode Genetics Ehf	Genetic markers for risk management of atrial fibrillation and stroke
EP2241323A1 (en)	2009-04-14	2010-10-20	Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research	Tenascin-W and brain cancers
DK2421898T3 (da)	2009-04-20	2016-05-30	Oxford Biotherapeutics Ltd	Cadherin-17-specifikke antistoffer
US8636704B2 (en)	2009-04-29	2014-01-28	Abbvie Biotechnology Ltd	Automatic injection device
US20110033389A1 (en) *	2009-04-29	2011-02-10	Zhifeng Chen	Modified antibodies for passive immunotherapy
US8765916B2 (en)	2009-04-29	2014-07-01	The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.	ERG monoclonal antibodies
EP2432878B2 (en) *	2009-05-20	2018-05-16	Novimmune SA	Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants
EP2261242A1 (en)	2009-06-10	2010-12-15	Universite Catholique De Louvain	Aspartate-N-acetyltransferase enzyme, diagnostic method and therapeutic method
GB0910725D0 (en)	2009-06-22	2009-08-05	Heptares Therapeutics Ltd	Mutant proteins and methods for producing them
MX2012000121A (es)	2009-06-22	2012-03-07	Medimmune Llc	Regiones fc modificadas para la conjugacion especifica del sitio.
EP2272979A1 (en)	2009-06-30	2011-01-12	Centre National de la Recherche Scientifique (CNRS)	Method for testing a subject thought to be predisposed to having cancer
SG177583A1 (en)	2009-07-09	2012-02-28	Hoffmann La Roche	In vivo tumor vasculature imaging
AU2010269841A1 (en)	2009-07-10	2012-02-23	Decode Genetics Ehf	Genetic markers associated with risk of diabetes mellitus
US9259476B2 (en)	2009-07-31	2016-02-16	Wayne State University	Monophosphorylated lipid A derivatives
US8809285B2 (en)	2009-07-31	2014-08-19	Wayne State University	Monophosphorylated lipid A derivatives
SG178335A1 (en)	2009-08-13	2012-03-29	Crucell Holland Bv	Antibodies against human respiratory syncytial virus (rsv) and methods of use
EP2292266A1 (en)	2009-08-27	2011-03-09	Novartis Forschungsstiftung, Zweigniederlassung	Treating cancer by modulating copine III
MX336152B (es)	2009-08-29	2016-01-08	Abbvie Inc	Proteinas terapeutico de union a dll4.
US20110059111A1 (en)	2009-09-01	2011-03-10	Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center	Mammalian receptors as targets for antibody and active vaccination therapy against mold infections
AU2010289527C1 (en)	2009-09-01	2014-10-30	Abbvie Inc.	Dual variable domain immunoglobulins and uses thereof
ES2667258T3 (es)	2009-09-10	2018-05-10	Ucb Biopharma Sprl	Anticuerpos multivalentes
US20110082054A1 (en) *	2009-09-14	2011-04-07	Dyax Corp.	Libraries of genetic packages comprising novel hc cdr3 designs
EP2478101A1 (en)	2009-09-16	2012-07-25	Stichting Het Nederlands Kanker Instituut	Fra-1 target genes as drug targets for treating cancer
US20110189183A1 (en)	2009-09-18	2011-08-04	Robert Anthony Williamson	Antibodies against candida, collections thereof and methods of use
EP2305717A1 (en)	2009-09-21	2011-04-06	Koninklijke Nederlandse Akademie van Wetenschappen	Inhibiting TNIK for treating colon cancer
US20120244170A1 (en)	2009-09-22	2012-09-27	Rafal Ciosk	Treating cancer by modulating mex-3
WO2011036555A1 (en)	2009-09-25	2011-03-31	University Of Oslo	Multivalent phage display systems and methods
US8926976B2 (en)	2009-09-25	2015-01-06	Xoma Technology Ltd.	Modulators
CA2772945A1 (en)	2009-09-25	2011-03-31	Xoma Technology Ltd.	Screening methods
AU2010298025B2 (en)	2009-09-25	2016-04-21	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Neutralizing antibodies to HIV-1 and their use
GB201005063D0 (en)	2010-03-25	2010-05-12	Ucb Pharma Sa	Biological products
EP2483307A1 (en)	2009-09-29	2012-08-08	Fraunhofer USA, Inc.	Influenza hemagglutinin antibodies, compositions, and related methods
WO2011041584A2 (en)	2009-09-30	2011-04-07	President And Fellows Of Harvard College	Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products
AR078470A1 (es)	2009-10-02	2011-11-09	Sanofi Aventis	Anticuerpos que se unen especificamente al receptor epha2
WO2011047083A1 (en)	2009-10-13	2011-04-21	Oxford Biotherapeutics Ltd.	Antibodies against epha10
WO2011045352A2 (en)	2009-10-15	2011-04-21	Novartis Forschungsstiftung	Spleen tyrosine kinase and brain cancers
US8716450B2 (en)	2009-10-15	2014-05-06	Abbvie Inc.	Dual variable domain immunoglobulins and uses thereof
MX341136B (es)	2009-10-20	2016-08-09	Abbvie Inc	Aislamiento y purificacion de los anticuerpos anti-il-13 al usar la cromatografia de afinidad con proteina a.
US9234037B2 (en)	2009-10-27	2016-01-12	Ucb Biopharma Sprl	Method to generate antibodies to ion channels
GB0922434D0 (en)	2009-12-22	2010-02-03	Ucb Pharma Sa	antibodies and fragments thereof
CA2778673A1 (en)	2009-10-27	2011-05-05	Karen Margrete Miller	Function modifying nav 1.7 antibodies
US20110098862A1 (en)	2009-10-27	2011-04-28	ExxonMobil Research Engineering Company Law Department	Multi-stage processes and control thereof
GB0922435D0 (en)	2009-12-22	2010-02-03	Ucb Pharma Sa	Method
UY32979A (es) *	2009-10-28	2011-02-28	Abbott Lab	Inmunoglobulinas con dominio variable dual y usos de las mismas
US20120213801A1 (en)	2009-10-30	2012-08-23	Ekaterina Gresko	Phosphorylated Twist1 and cancer
US8420083B2 (en)	2009-10-31	2013-04-16	Abbvie Inc.	Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof
EP2496605A1 (en)	2009-11-02	2012-09-12	Oxford Biotherapeutics Ltd.	Ror1 as therapeutic and diagnostic target
WO2011058087A1 (en)	2009-11-11	2011-05-19	Gentian As	Immunoassay for assessing related analytes of different origin
WO2011060272A2 (en)	2009-11-13	2011-05-19	Dana-Farber Cancer Institute, Inc.	Compositions, kits, and methods for the diagnosis, prognosis, monitoring, treatment and modulation of post-transplant lymphoproliferative disorders and hypoxia associated angiogenesis disorders using galectin-1
GB0920127D0 (en)	2009-11-17	2009-12-30	Ucb Pharma Sa	Antibodies
US8450086B2 (en)	2009-11-17	2013-05-28	Centocor Ortho Biotech Inc.	Bacterial membrane protein secretion
GB0920324D0 (en)	2009-11-19	2010-01-06	Ucb Pharma Sa	Antibodies
KR20120118002A (ko)	2009-12-08	2012-10-25	애보트 게엠베하 운트 콤파니 카게	망막 신경 섬유 층 변성의 치료에 사용하기 위한 ｒｇｍａ 단백질에 대한 모노클로날 항체
DK3459564T3 (da)	2010-01-06	2022-02-07	Takeda Pharmaceuticals Co	Plasmakallikreinbindende proteiner
GB201000467D0 (en)	2010-01-12	2010-02-24	Ucb Pharma Sa	Antibodies
WO2011088163A1 (en)	2010-01-14	2011-07-21	President And Fellows Of Harvard College	Methods for modulating skeletal remodeling and patterning by modulating shn2 activity, shn3 activity, or shn2 and shn3 activity in combination
EP2526424A2 (en)	2010-01-22	2012-11-28	Dana-Farber Cancer Institute, Inc.	Compositions,kits, and methods for identification, assessment, prevention, and therapy of metabolic disorders
WO2011097301A2 (en)	2010-02-02	2011-08-11	Abbott Biotechnology Ltd.	METHODS AND COMPOSITIONS FOR PREDICTING RESPONSIVENESS TO TREATMENT WITH TNF-α INHIBITOR
EP2354244A1 (en)	2010-02-04	2011-08-10	Stichting Top Institute Food and Nutrition	MBL2 as a marker of liver-specific insulin resistance
EP2354245A1 (en)	2010-02-04	2011-08-10	Stichting Top Institute Food and Nutrition	MBL2 as a marker of hepatic PPAR- activity
TWI518325B (zh)	2010-02-04	2016-01-21	自治醫科大學	對ａｌｋ抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
AU2011223919B2 (en)	2010-03-02	2015-03-19	Abbvie Inc.	Therapeutic DLL4 binding proteins
US9616120B2 (en) *	2010-03-04	2017-04-11	Vet Therapeutics, Inc.	Monoclonal antibodies directed to CD20
EP2542258A4 (en) *	2010-03-04	2013-08-21	Vet Therapeutics Inc	MONOCLONAL ANTIBODIES DIRECTED AGAINST CD52
WO2011107586A1 (en)	2010-03-05	2011-09-09	Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research,	Smoc1, tenascin-c and brain cancers
US10706955B2 (en)	2010-03-23	2020-07-07	Iogenetics, Llc	Bioinformatic processes for determination of peptide binding
WO2013040142A2 (en)	2011-09-16	2013-03-21	Iogenetics, Llc	Bioinformatic processes for determination of peptide binding
GB201005064D0 (en)	2010-03-25	2010-05-12	Ucb Pharma Sa	Biological products
EP2550297B1 (en)	2010-03-25	2019-01-23	UCB Biopharma SPRL	Disulfide stabilized dvd-lg molecules
US8987419B2 (en)	2010-04-15	2015-03-24	AbbVie Deutschland GmbH & Co. KG	Amyloid-beta binding proteins
LT2558577T (lt)	2010-04-16	2019-03-12	Nuevolution A/S	Bifunkciniai kompleksai ir tokių kompleksų gamybos ir naudojimo būdai
EP2561076A1 (en)	2010-04-19	2013-02-27	Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research	Modulating xrn1
EP2380909A1 (en)	2010-04-26	2011-10-26	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	PTK-7 protein involved in breast cancer
EP2564200B8 (en)	2010-04-27	2019-10-02	The Regents of The University of California	Cancer biomarkers and methods of use thereof
KR101863033B1 (ko)	2010-04-30	2018-06-01	얀센 바이오테크 인코포레이티드	안정화된 파이브로넥틴 도메인 조성물, 방법 및 용도
EA028899B1 (ru)	2010-04-30	2018-01-31	Алексион Фармасьютикалз, Инк.	АНТИ-C5a-АНТИТЕЛА И СПОСОБЫ ПРИМЕНЕНИЯ АНТИТЕЛ
WO2011141823A2 (en)	2010-05-14	2011-11-17	Orega Biotech	Methods of treating and/or preventing cell proliferation disorders with il-17 antagonists
DK2571532T3 (da)	2010-05-14	2017-08-28	Abbvie Inc	Il-1-bindende proteiner
HUE039740T2 (hu)	2010-06-03	2019-01-28	Abbvie Biotechnology Ltd	Alkalmazások és készítmények hidradenitis suppurativa (HS) kezelésére
EP2580239A1 (en)	2010-06-10	2013-04-17	Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research	Treating cancer by modulating mammalian sterile 20-like kinase 3
US9499813B2 (en)	2010-06-10	2016-11-22	President And Fellows Of Harvard College	Systems and methods for amplification and phage display
MX2012014838A (es)	2010-06-16	2013-02-07	Abbvie Inc	Comparacion de las muestras de proteina.
MY195217A (en) *	2010-06-22	2023-01-11	Regeneron Pharma	MICE Expressing An Immunoglobulin Hybrid Light Chain
US20120009196A1 (en)	2010-07-08	2012-01-12	Abbott Laboratories	Monoclonal antibodies against hepatitis c virus core protein
TWI627964B (zh)	2010-07-09	2018-07-01	傑森疫苗防護公司	抗-人類呼吸道融合性病毒（ｒｓｖ）抗體及其使用方法
EP2591004A1 (en)	2010-07-09	2013-05-15	F.Hoffmann-La Roche Ag	Anti-neuropilin antibodies and methods of use
UY33492A (es)	2010-07-09	2012-01-31	Abbott Lab	Inmunoglobulinas con dominio variable dual y usos de las mismas
CA2805572A1 (en)	2010-07-16	2012-01-19	Martin Hegen	Modified single domain antigen binding molecules and uses thereof
US9354228B2 (en)	2010-07-16	2016-05-31	Adimab, Llc	Antibody libraries
CN103392182B (zh)	2010-08-02	2017-07-04	众有生物有限公司	用于发现遗传疾病中致病突变的系统和方法
AU2011286024B2 (en)	2010-08-02	2014-08-07	Macrogenics, Inc.	Covalent diabodies and uses thereof
EP2601218A4 (en)	2010-08-03	2015-02-18	Abbvie Inc	VARIABLE DOUBLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
WO2012019061A2 (en)	2010-08-05	2012-02-09	Stem Centrx, Inc.	Novel effectors and methods of use
EP2420250A1 (en)	2010-08-13	2012-02-22	Universitätsklinikum Münster	Anti-Syndecan-4 antibodies
JP6147665B2 (ja)	2010-08-14	2017-06-14	アッヴィ・インコーポレイテッド	アミロイドベータ結合タンパク質
ES2599645T3 (es)	2010-08-17	2017-02-02	Stichting Katholieke Universiteit	Método innovador para diagnosticar la fiebre Q utilizando una prueba inmunológica celular
AU2011291462A1 (en)	2010-08-19	2013-03-14	Zoetis Belgium S.A.	Anti-NGF antibodies and their use
GB201014033D0 (en)	2010-08-20	2010-10-06	Ucb Pharma Sa	Biological products
TW201211252A (en)	2010-08-26	2012-03-16	Abbott Lab	Dual variable domain immunoglobulins and uses thereof
JP2013539468A (ja)	2010-08-27	2013-10-24	ステムセントリックス，インコーポレイテッド	Ｎｏｔｕｍタンパク質モジュレーターおよび使用法
KR20140014064A (ko)	2010-09-03	2014-02-05	스템 센트알엑스 인코포레이티드	신규한 조절 인자 및 사용 방법
WO2012032143A1 (en)	2010-09-10	2012-03-15	Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research	Phosphorylated twist1 and metastasis
MX2013003182A (es)	2010-09-20	2013-04-24	Abbvie Inc	Purificacion de anticuerpos por cromatografia de lecho movil simulada.
RU2013118307A (ru)	2010-09-21	2014-10-27	Стихтинг Катхолике Юниверситейт	Новый способ диагностики белезни лайма с использованием теста клеточного иммунного ответа
WO2012044921A1 (en)	2010-10-01	2012-04-05	St. Jude Children's Research Hospital	Methods and compositions for typing molecular subgroups of medulloblastoma
WO2012052391A1 (en)	2010-10-19	2012-04-26	Glaxo Group Limited	Polypeptide with jmjd3 catalytic activity
EP2632489B1 (en)	2010-10-27	2020-01-15	The Research Foundation for The State University of New York	Compositions targeting the soluble extracellular domain of e-cadherin and related methods for cancer therapy
EP2640738A1 (en)	2010-11-15	2013-09-25	Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research	Anti-fungal agents
WO2012068463A2 (en)	2010-11-18	2012-05-24	Beth Israel Deaconess Medicall Center, Inc.	Methods of treating obesity by inhibiting nicotinamide n-methyl transferase (nnmt)
NZ611428A (en)	2010-12-08	2015-07-31	Stemcentrx Inc	Novel modulators and methods of use
EP2465928A1 (en)	2010-12-16	2012-06-20	Academisch Medisch Centrum bij de Universiteit van Amsterdam	Treatment of Th17-mediated diseases
CA2821976A1 (en)	2010-12-21	2012-09-13	Abbvie Inc.	Il-1 -alpha and -beta bispecific dual variable domain immunoglobulins and their use
US20120275996A1 (en)	2010-12-21	2012-11-01	Abbott Laboratories	IL-1 Binding Proteins
EP2654790B1 (en)	2010-12-22	2019-02-06	Teva Pharmaceuticals Australia Pty Ltd	Modified antibody with improved half-life
AU2011348204B2 (en)	2010-12-22	2017-03-02	President And Fellows Of Harvard College	Continuous directed evolution
WO2012092323A1 (en)	2010-12-28	2012-07-05	Xoma Technology Ltd.	Cell surface display using pdz domains
WO2012089814A1 (en)	2010-12-30	2012-07-05	INSERM (Institut National de la Santé et de la Recherche Médicale)	Antigen binding formats for use in therapeutic treatments or diagnostic assays
US10208349B2 (en)	2011-01-07	2019-02-19	Ucb Biopharma Sprl	Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy
GB201100282D0 (en)	2011-01-07	2011-02-23	Ucb Pharma Sa	Biological methods
ES2632583T3 (es)	2011-01-14	2017-09-14	Ucb Biopharma Sprl	Anticuerpo que se une a IL-17A e IL-17F
BR112013018905B1 (pt)	2011-01-24	2021-07-13	Abbvie Biotechnology Ltd	Dispositivos de injeção automática que têm superfícies de pega sobremoldadas.
EP3763740A1 (en)	2011-01-26	2021-01-13	Celldex Therapeutics, Inc.	Anti-kit antibodies and uses thereof
WO2012109238A2 (en)	2011-02-07	2012-08-16	President And Fellows Of Harvard College	Methods for increasing immune responses using agents that directly bind to and activate ire-1
SA112330278B1 (ar)	2011-02-18	2015-10-09	ستيم سينتركس، انك.	مواد ضابطة جديدة وطرق للاستخدام
ES2777894T3 (es)	2011-03-02	2020-08-06	Berg Llc	Ensayos por interrogación basados en células y usos de los mismos
WO2012122219A2 (en)	2011-03-07	2012-09-13	University Of Louisville Research Foundation	Predictive marker of dnmt1 inhibitor therapeutic efficacy and methods of using the marker
WO2012125735A1 (en)	2011-03-15	2012-09-20	Abott Laboratories	An integrated approach to the isolation and purification of antibodies
WO2012128810A1 (en)	2011-03-23	2012-09-27	Abbott Laboratories	Methods and systems for the analysis of protein samples
WO2012131053A1 (en)	2011-03-30	2012-10-04	Ablynx Nv	Methods of treating immune disorders with single domain antibodies against tnf-alpha
WO2012134813A1 (en)	2011-03-31	2012-10-04	St. Jude Children's Research Hospital	Methods and compositions for identifying minimal residual disease in acute lymphoblastic leukemia
CA2832565A1 (en)	2011-04-08	2012-10-11	Biogen Idec Ma Inc.	Biomarkers predictive of therapeutic responsiveness to ifn.beta. and uses thereof
WO2012142164A1 (en)	2011-04-12	2012-10-18	The United States Of America, As Represented By The Secretary, Department Of Health & Human Services	Human monoclonal antibodies that bind insulin-like growth factor (igf) i and ii
SI2699264T1 (en)	2011-04-20	2018-08-31	Medimmune Llc	Antibodies and other molecules that bind b7-h1 and pd-1
WO2012162068A2 (en)	2011-05-21	2012-11-29	Macrogenics, Inc.	Deimmunized serum-binding domains and their use for extending serum half-life
CA2837527C (en)	2011-06-02	2019-05-28	Dyax Corp.	Fc receptor binding proteins
LT2714735T (lt)	2011-06-03	2021-12-10	Xoma Technology Ltd.	Tgf beta specifiniai antikūnai
US9181553B2 (en)	2011-06-06	2015-11-10	Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute For Biomedical Research	Method of treatment of breast cancers over-expressing the SHP2 signature genes
US9244074B2 (en)	2011-06-07	2016-01-26	University Of Hawaii	Biomarker of asbestos exposure and mesothelioma
US9561274B2 (en)	2011-06-07	2017-02-07	University Of Hawaii	Treatment and prevention of cancer with HMGB1 antagonists
RU2014100111A (ru)	2011-06-10	2015-07-20	МЕДИММЬЮН, ЭлЭлСи	МОЛЕКУЛЫ, СВЯЗЫВАЮЩИЕСЯ С Psl Pseudomonas, И ПУТИ ИХ ПРИМЕНЕНИЯ
GEP201706667B (en)	2011-06-28	2017-05-25	Berlin - Chemie Ag	Antibodies to adp-ribosyl cyclase 2
US9447178B2 (en)	2011-06-28	2016-09-20	Oxford Biotherapeutics Ltd.	Therapeutic and diagnostic target
JP2014520847A (ja)	2011-07-13	2014-08-25	アッヴィ・インコーポレイテッド	抗ｉｌ−１３抗体を使用して喘息を治療するための方法および組成物
GB201112056D0 (en)	2011-07-14	2011-08-31	Univ Leuven Kath	Antibodies
US10323236B2 (en)	2011-07-22	2019-06-18	President And Fellows Of Harvard College	Evaluation and improvement of nuclease cleavage specificity
JP6120848B2 (ja)	2011-08-15	2017-04-26	メディミューン，エルエルシー	抗ｂ７−ｈ４抗体およびその使用
AU2012298884B2 (en)	2011-08-23	2017-11-16	Foundation Medicine, Inc.	Novel KIF5B-RET fusion molecules and uses thereof
US20130058947A1 (en)	2011-09-02	2013-03-07	Stem Centrx, Inc	Novel Modulators and Methods of Use
WO2013034579A1 (en)	2011-09-05	2013-03-14	Rheinische Friedrich-Wilhelms-Universität Bonn	Biosynthetic gene cluster for the production of peptide/protein analogues
US9447192B2 (en)	2011-09-09	2016-09-20	Medimmune Limited	Anti-Siglec-15 antibodies and uses thereof
CA2848368C (en)	2011-09-13	2023-02-14	Dana-Farber Cancer Institute, Inc.	Compositions and methods for brown fat induction and activity using fndc5
US10221454B2 (en)	2011-10-10	2019-03-05	The Hospital For Sick Children	Methods and compositions for screening and treating developmental disorders
WO2013056178A2 (en)	2011-10-14	2013-04-18	Foundation Medicine, Inc.	Novel estrogen receptor mutations and uses thereof
UY34409A (es)	2011-10-24	2013-05-31	Abbvie Inc	Inmunoenlazadores dirigidos contra el tnf
SG11201401791WA (en)	2011-10-24	2014-08-28	Abbvie Inc	Immunobinders directed against sclerostin
US9221907B2 (en)	2011-11-01	2015-12-29	Bionomics Inc.	Anti-GPR49 monoclonal antibodies
US10598653B2 (en)	2011-11-01	2020-03-24	Bionomics Inc.	Methods of blocking cancer stem cell growth
AU2012332590B2 (en)	2011-11-01	2016-10-20	Bionomics, Inc.	Anti-GPR49 antibodies
AU2012332587B2 (en)	2011-11-01	2017-02-23	Bionomics, Inc.	Antibodies and methods of treating cancer
EP2773390B1 (en)	2011-11-03	2020-12-30	Tripath Imaging, Inc.	Methods and compositions for preparing samples for immunostaining
EP2773779B1 (en)	2011-11-04	2020-10-14	Population Bio, Inc.	Methods and compositions for diagnosing, prognosing, and treating neurological conditions
SMT202000542T1 (it)	2011-11-07	2020-11-10	Medimmune Ltd	Terapie di combinazione utilizzando molecole di legame anti-psl e pcrv di pseudomonas
EP2776838A1 (en)	2011-11-08	2014-09-17	Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research	Early diagnostic of neurodegenerative diseases
IN2014CN04183A (da)	2011-11-08	2015-07-17	Pfizer
US20140314787A1 (en)	2011-11-08	2014-10-23	Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute	Treatment for neurodegenerative diseases
SG11201401649VA (en)	2011-11-11	2014-07-30	Ucb Pharma Sa	Albumin binding antibodies and binding fragments thereof
US20140017174A1 (en)	2011-11-30	2014-01-16	Raja Atreya	Methods and compositions for determining responsiveness to treatment with a tnf-alpha inhibitor
JP6342812B2 (ja)	2011-12-14	2018-06-13	アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー	鉄関連障害を診断および治療するための組成物および方法
CN104136462B (zh)	2011-12-14	2017-06-09	艾伯维德国有限责任两合公司	用于诊断和治疗铁相关病症的组合物和方法
EP3050900A1 (en)	2011-12-19	2016-08-03	Xoma (Us) Llc	Methods for treating acne
RU2664181C2 (ru)	2011-12-20	2018-08-15	Регенерон Фармасьютикалз, Инк.	Мыши с гуманизированной легкой цепью
ES3027182T3 (en)	2011-12-23	2025-06-13	Pfizer	Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
AU2012362326A1 (en)	2011-12-30	2014-07-24	Abbvie Inc.	Dual variable domain immunoglobulins against IL-13 and/or IL-17
WO2013102825A1 (en)	2012-01-02	2013-07-11	Novartis Ag	Cdcp1 and breast cancer
GB201201332D0 (en)	2012-01-26	2012-03-14	Imp Innovations Ltd	Method
RS57603B1 (sr)	2012-01-27	2018-11-30	Abbvie Deutschland	Sastav i metod za dijagnozu i tretiranje bolesti povezanih sa degeneracijom neurita
CA2863887C (en)	2012-02-09	2023-01-03	Population Diagnostics, Inc.	Methods of screening low frequency gdna variation biomarkers for pervasive developmental disorder (pdd) or pervasive developmental disorder - not otherwise specified (pdd_nos)
WO2013119990A2 (en)	2012-02-10	2013-08-15	Seattle Genetics, Inc.	Detection and treatment of cd30+ cancers
US9550830B2 (en)	2012-02-15	2017-01-24	Novo Nordisk A/S	Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
LT2814842T (lt)	2012-02-15	2018-11-12	Novo Nordisk A/S	Antikūnai, kurie suriša peptidoglikaną atpažįstantį baltymą 1
TWI605061B (zh)	2012-02-15	2017-11-11	諾佛儂迪克股份有限公司	會結合及阻斷表現在骨髓細胞上觸發受體－１（ｔｒｅｍ－１）之抗體
GB201203051D0 (en)	2012-02-22	2012-04-04	Ucb Pharma Sa	Biological products
GB201203071D0 (en)	2012-02-22	2012-04-04	Ucb Pharma Sa	Biological products
ME02928B (me)	2012-02-24	2018-04-20	Abbvie Stemcentrx Llc	Dll3 modulatori i metode upotrebe
KR101721678B1 (ko)	2012-03-08	2017-03-31	할로자임, 아이엔씨	조건부 활성 항-표피 성장 인자 수용체 항체 및 이의 사용 방법
WO2013138522A2 (en)	2012-03-16	2013-09-19	Genelux Corporation	Methods for assessing effectiveness and monitoring oncolytic virus treatment
WO2013142808A1 (en)	2012-03-23	2013-09-26	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Pathogenic phlebovirus isolates and compositions and methods of use
WO2013144240A1 (en)	2012-03-29	2013-10-03	Friedrich Miescher Institute For Biomedical Research	Inhibition of interleukin- 8 and/or its receptor cxcrl in the treatment her2/her3 -overexpressing breast cancer
EA038600B1 (ru)	2012-04-02	2021-09-21	Берг Ллк	Основанные на клетках перекрестные анализы и их применение
WO2013151649A1 (en)	2012-04-04	2013-10-10	Sialix Inc	Glycan-interacting compounds
WO2013158275A1 (en)	2012-04-20	2013-10-24	Abbvie Inc.	Cell culture methods to reduce acidic species
US9150645B2 (en)	2012-04-20	2015-10-06	Abbvie, Inc.	Cell culture methods to reduce acidic species
WO2013158273A1 (en)	2012-04-20	2013-10-24	Abbvie Inc.	Methods to modulate c-terminal lysine variant distribution
SI2838917T1 (sl)	2012-04-20	2019-11-29	Merus Nv	Postopki in sredstva za produkcijo heterodimernih IG-podobnih molekul
HK1206252A1 (en)	2012-05-14	2016-01-08	Biogen Ma Inc.	Lingo-2 antagonists for treatment of conditions involving motor neurons
JP6122948B2 (ja)	2012-05-15	2017-04-26	モルフォテック，インコーポレイテッド	胃癌の治療のための方法
US20130336957A1 (en)	2012-05-21	2013-12-19	Abbvie, Inc.	Novel purification of human, humanized, or chimeric antibodies using protein a affinity chromatography
WO2013176754A1 (en)	2012-05-24	2013-11-28	Abbvie Inc.	Novel purification of antibodies using hydrophobic interaction chromatography
EP2859018B1 (en)	2012-06-06	2021-09-22	Zoetis Services LLC	Caninized anti-ngf antibodies and methods thereof
EP2867674B1 (en)	2012-06-28	2018-10-10	UCB Biopharma SPRL	A method for identifying compounds of therapeutic interest
EP2866831A1 (en)	2012-06-29	2015-05-06	Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research	Treating diseases by modulating a specific isoform of mkl1
EP2870242A1 (en)	2012-07-05	2015-05-13	Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research	New treatment for neurodegenerative diseases
WO2014006115A1 (en)	2012-07-06	2014-01-09	Novartis Ag	Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the il-8/cxcr interaction
AR091755A1 (es)	2012-07-12	2015-02-25	Abbvie Inc	Proteinas de union a il-1
GB201213652D0 (en)	2012-08-01	2012-09-12	Oxford Biotherapeutics Ltd	Therapeutic and diagnostic target
US10457733B2 (en)	2012-08-03	2019-10-29	Dana-Farber Cancer Institute, Inc.	Agents that modulate immune cell activation and methods of use thereof
WO2014039860A2 (en)	2012-09-07	2014-03-13	University Of Louisville Research Foundation, Inc.	Compositions and methods for modulating dnmt1 inhibitor activity
EP2895621B1 (en)	2012-09-14	2020-10-21	Population Bio, Inc.	Methods and compositions for diagnosing, prognosing, and treating neurological conditions
CA2922005A1 (en)	2012-09-27	2014-04-03	Population Diagnostics, Inc.	Methods and compositions for screening and treating developmental disorders
US9365641B2 (en)	2012-10-01	2016-06-14	The Trustees Of The University Of Pennsylvania	Compositions and methods for targeting stromal cells for the treatment of cancer
AU2013329421A1 (en)	2012-10-09	2015-04-30	Biogen Ma Inc.	Combination therapies and uses for treatment of demyelinating disorders
KR102229873B1 (ko)	2012-10-12	2021-03-19	더 브리검 앤드 우먼즈 하스피털, 인크.	면역 반응의 향상
BR112015009961B1 (pt)	2012-11-01	2020-10-20	Abbvie Inc.	proteína de ligação capaz de se ligar a dll4 e vegf, bem como composição que a compreende como composição que a compreende
US20150291953A1 (en) *	2012-11-02	2015-10-15	Enzymatics Inc.	Methods and kits for nucleic acid sample preparation for sequencing
WO2014071358A2 (en)	2012-11-05	2014-05-08	Foundation Medicine, Inc.	Novel ntrk1 fusion molecules and uses thereof
WO2014074942A1 (en)	2012-11-08	2014-05-15	Illumina, Inc.	Risk variants of alzheimer's disease
CN104903349B (zh)	2012-11-08	2018-10-19	十一生物治疗股份有限公司	Il-6拮抗剂及其应用
AU2013359419B2 (en)	2012-12-10	2018-03-15	Biogen Ma Inc.	Anti-blood dendritic cell antigen 2 antibodies and uses thereof
GB201223276D0 (en)	2012-12-21	2013-02-06	Ucb Pharma Sa	Antibodies and methods of producing same
US9550986B2 (en)	2012-12-21	2017-01-24	Abbvie Inc.	High-throughput antibody humanization
KR20150100715A (ko)	2012-12-21	2015-09-02	앰플리뮨, 인크.	항-h7cr 항체
AU2013202668B2 (en)	2012-12-24	2014-12-18	Adelaide Research & Innovation Pty Ltd	Inhibition of cancer growth and metastasis
US10717965B2 (en)	2013-01-10	2020-07-21	Gloriana Therapeutics, Inc.	Mammalian cell culture-produced neublastin antibodies
EP2945652B1 (en)	2013-01-18	2021-07-07	Foundation Medicine, Inc.	Methods of treating cholangiocarcinoma
GB201302447D0 (en)	2013-02-12	2013-03-27	Oxford Biotherapeutics Ltd	Therapeutic and diagnostic target
CN105164159A (zh)	2013-02-22	2015-12-16	施特姆森特克斯股份有限公司	新的抗体缀合物及其用途
WO2014142646A1 (en)	2013-03-13	2014-09-18	Stichting Katholieke Universiteit	Q-fever diagnostic
BR112015023355A8 (pt)	2013-03-14	2018-01-30	Abbott Lab	antígenos recombinantes ns3 de hcv e mutantes dos mesmos para detecção de anticorpos aprimorada.
CA2899449A1 (en)	2013-03-14	2014-10-02	Abbvie Inc.	Low acidic species compositions and methods for producing the same using displacement chromatography
CA2906417C (en)	2013-03-14	2022-06-21	Robert Ziemann	Hcv core lipid binding domain monoclonal antibodies
KR20150129033A (ko)	2013-03-14	2015-11-18	애브비 인코포레이티드	저 산성 종 조성물 및 이의 제조 및 사용 방법
EP2968526A4 (en)	2013-03-14	2016-11-09	Abbott Lab	ANTIGEN-ANTIBODY COMBINATION ASSAY OF HEPATITIS C VIRUS AND METHODS AND COMPOSITIONS FOR USE THEREWITH
US20160185853A1 (en)	2013-03-14	2016-06-30	Parkash Gill	Cancer treatment using antibodies that bind cell surface grp78
WO2014142882A1 (en)	2013-03-14	2014-09-18	Abbvie Inc.	Protein purification using displacement chromatography
US9469686B2 (en)	2013-03-15	2016-10-18	Abbott Laboratories	Anti-GP73 monoclonal antibodies and methods of obtaining the same
EP2968508B1 (en)	2013-03-15	2022-04-27	Sanofi Pasteur Biologics, LLC	Antibodies against clostridium difficile toxins and methods of using the same
RU2015144186A (ru)	2013-03-15	2017-04-24	Эббви Инк.	Очистка конъюгата антитело-лекарственное средство (аdс)
CA2903546A1 (en)	2013-03-15	2014-09-25	Biogen Ma Inc.	Treatment and prevention of acute kidney injury using anti-alpha v beta 5 antibodies
PT2968588T (pt)	2013-03-15	2019-05-08	Abbvie Inc	Formulações de conjugado de fármaco-anticorpo anti-egfr
BR112015023797A2 (pt)	2013-03-15	2017-10-24	Abbvie Inc	proteínas de ligação de especificidade dupla dirigidas contra il-1b e/ou il-17
US9499621B2 (en)	2013-04-08	2016-11-22	Cytodyn, Inc.	Felinized antibodies and methods of treating retroviral infections in felines
WO2014178715A1 (en)	2013-05-02	2014-11-06	Stichting Katholieke Universiteit	Personalised medicine
LT2981822T (lt)	2013-05-06	2020-12-28	Scholar Rock, Inc.	Kompozicijos ir būdai, skirti augimo faktoriaus moduliacijai
JP6416224B2 (ja)	2013-05-17	2018-10-31	セントルナショナルデラルシュルシュサイエンティフィーク（シーエヌアールエス）	抗ｃｘｃｌ１抗体、抗ｃｘｃｌ７抗体および抗ｃｘｃｌ８抗体ならびにそれらの用途
SG11201509618QA (en)	2013-05-24	2015-12-30	Medimmune Llc	Anti-b7-h5 antibodies and their uses
US10100123B2 (en)	2013-06-06	2018-10-16	Pierre Fabre Medicament	Anti-C10orf54 antibodies and uses thereof
WO2014197369A1 (en)	2013-06-06	2014-12-11	Dana-Farber Cancer Institute, Inc.	Compositions and methods for identification, assessment prevention, and treatment of cancer using pd-l1 isoforms
EP3003372B1 (en)	2013-06-07	2019-10-09	Duke University	Inhibitors of complement factor h
AU2014296288B2 (en)	2013-07-31	2020-02-13	Dana-Farber Cancer Institute, Inc.	Compositions and methods for modulating thermogenesis using PTH-related and EGF-related molecules
US20160178610A1 (en)	2013-08-07	2016-06-23	Friedrich Miescher Institute For Biomedical Research	New screening method for the treatment Friedreich's ataxia
US20150044192A1 (en)	2013-08-09	2015-02-12	President And Fellows Of Harvard College	Methods for identifying a target site of a cas9 nuclease
DK3036320T4 (da)	2013-08-19	2024-05-06	Biogen Ma Inc	Styring af proteinglycosylering ved hjælp af dyrkningsmedietilsætning og cellekulturprocesparametre
KR102313341B1 (ko)	2013-08-26	2021-10-18	바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드	시알릴-루이스 ａ에 대한 사람 항체 코드화 핵산
EP3038634A4 (en)	2013-08-28	2017-10-11	AbbVie Stemcentrx LLC	Novel sez6 modulators and methods of use
AU2014312215B2 (en)	2013-08-28	2020-02-27	Abbvie Stemcentrx Llc	Site-specific antibody conjugation methods and compositions
US9340800B2 (en)	2013-09-06	2016-05-17	President And Fellows Of Harvard College	Extended DNA-sensing GRNAS
EA201600252A1 (ru)	2013-09-12	2017-05-31	Галозим, Инк.	Модифицированные антитела к рецепторам антиэпидермального фактора роста и способы их использования
WO2015048330A2 (en)	2013-09-25	2015-04-02	Biogen Idec Ma Inc.	On-column viral inactivation methods
EP3049521B1 (en)	2013-09-25	2019-03-06	Cornell University	Compounds for inducing anti-tumor immunity and methods thereof
US10570204B2 (en)	2013-09-26	2020-02-25	The Medical College Of Wisconsin, Inc.	Methods for treating hematologic cancers
WO2015057939A1 (en)	2013-10-18	2015-04-23	Biogen Idec Ma Inc.	Anti-s1p4 antibodies and uses thereof
CN105849323A (zh)	2013-10-28	2016-08-10	多茨设备公司	过敏原检测
WO2015066190A1 (en)	2013-10-29	2015-05-07	President And Fellows Of Harvard College	Methods and compositions for inhibting oxidative stress
EP2871189A1 (en)	2013-11-07	2015-05-13	Institut Pasteur	High-affinity monoclonal anti-strep-tag antibody
US20160272673A1 (en)	2013-11-07	2016-09-22	Abbvie Inc.	Isolation and purification of dvd-igs
DK3511422T3 (da)	2013-11-12	2023-02-06	Population Bio Inc	Fremgangsmåder og sammensætninger til diagnosticering, prognose og behandling af endometriose
KR102283408B1 (ko)	2013-11-15	2021-07-29	앵스티띠 파스퇴르	플라스모듐 팔시파룸 아르테미시닌 내성의 분자 마커
US9067998B1 (en)	2014-07-15	2015-06-30	Kymab Limited	Targeting PD-1 variants for treatment of cancer
US8992927B1 (en)	2014-07-15	2015-03-31	Kymab Limited	Targeting human NAV1.7 variants for treatment of pain
US9914769B2 (en)	2014-07-15	2018-03-13	Kymab Limited	Precision medicine for cholesterol treatment
US9045545B1 (en)	2014-07-15	2015-06-02	Kymab Limited	Precision medicine by targeting PD-L1 variants for treatment of cancer
US8986694B1 (en)	2014-07-15	2015-03-24	Kymab Limited	Targeting human nav1.7 variants for treatment of pain
CA3225453A1 (en)	2013-12-19	2015-06-25	Novartis Ag	Human mesothelin chimeric antigen receptors and uses thereof
US20160289633A1 (en)	2013-12-20	2016-10-06	Biogen Ma Inc.	Use of Perfusion Seed Cultures to Improve Biopharmaceutical Fed-Batch Production Capacity and Product Quality
US11708411B2 (en)	2013-12-20	2023-07-25	Wake Forest University Health Sciences	Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines
EP2960252A1 (en)	2014-06-26	2015-12-30	Institut Pasteur	Phospholipase for treatment of immunosuppression
CN119775416A (zh)	2013-12-24	2025-04-08	杨森制药公司	抗vista抗体及片段
US10238700B2 (en)	2014-01-02	2019-03-26	Genelux Corporation	Oncolytic virus adjunct therapy with agents that increase virus infectivity
WO2015108907A2 (en)	2014-01-14	2015-07-23	Dana-Farber Cancer Institute, Inc.	Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
US10179911B2 (en)	2014-01-20	2019-01-15	President And Fellows Of Harvard College	Negative selection and stringency modulation in continuous evolution systems
JOP20200094A1 (ar)	2014-01-24	2017-06-16	Dana Farber Cancer Inst Inc	جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar)	2014-01-31	2017-06-16	Children’S Medical Center Corp	جزيئات جسم مضاد لـ tim-3 واستخداماتها
SG11201606624WA (en)	2014-02-11	2016-09-29	Visterra Inc	Antibody moleules to dengue virus and uses thereof
BR112016018891A2 (pt)	2014-02-21	2017-10-10	Abbvie Stemcentrx Llc	anticorpos anti-dll3 e conjugados de fármacos para uso em melanoma
GB201403775D0 (en)	2014-03-04	2014-04-16	Kymab Ltd	Antibodies, uses & methods
US9738702B2 (en)	2014-03-14	2017-08-22	Janssen Biotech, Inc.	Antibodies with improved half-life in ferrets
US20150259420A1 (en)	2014-03-14	2015-09-17	Novartis Ag	Antibody molecules to lag-3 and uses thereof
DK3122869T3 (da)	2014-03-24	2019-09-09	Biogen Ma Inc	Fremgangsmåder til afhjælpning af glutamindeprivation under pattedyrecellekultur
NZ724815A (en)	2014-04-04	2017-11-24	Bionomics Inc	Humanized antibodies that bind lgr5
IL248511B (en)	2014-05-13	2022-07-01	Bavarian Nordic As	Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and a monoclonal antibody against tim-3
WO2015175874A2 (en)	2014-05-16	2015-11-19	Medimmune, Llc	Molecules with altered neonate fc receptor binding having enhanced therapeutic and diagnostic properties
DK3148579T3 (da)	2014-05-28	2021-03-08	Agenus Inc	Anti-gitr antistoffer og fremgangsmåder til anvendelse deraf
GB201409558D0 (en)	2014-05-29	2014-07-16	Ucb Biopharma Sprl	Method
SG10201703965SA (en)	2014-06-03	2017-06-29	Xbiotech Inc	Compositions and methods for treating and preventing staphylococcus aureus infections
AU2015271685B2 (en)	2014-06-04	2021-02-18	Biontech Research And Development, Inc.	Human monoclonal antibodies to ganglioside GD2
US20170137824A1 (en)	2014-06-13	2017-05-18	Indranil BANERJEE	New treatment against influenza virus
WO2015198202A1 (en)	2014-06-23	2015-12-30	Friedrich Miescher Institute For Biomedical Research	Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small rnas
GB201411320D0 (en)	2014-06-25	2014-08-06	Ucb Biopharma Sprl	Antibody construct
WO2016001830A1 (en)	2014-07-01	2016-01-07	Friedrich Miescher Institute For Biomedical Research	Combination of a brafv600e inhibitor and mertk inhibitor to treat melanoma
US9139648B1 (en)	2014-07-15	2015-09-22	Kymab Limited	Precision medicine by targeting human NAV1.9 variants for treatment of pain
GB201412659D0 (en)	2014-07-16	2014-08-27	Ucb Biopharma Sprl	Molecules
GB201412658D0 (en)	2014-07-16	2014-08-27	Ucb Biopharma Sprl	Molecules
MY178347A (en)	2014-07-17	2020-10-08	Novo Nordisk As	Site directed mutagenesis of trem-1 antibodies for decreasing viscosity
TWI719942B (zh)	2014-07-21	2021-03-01	瑞士商諾華公司	使用ｃｄ３３嵌合抗原受體治療癌症
WO2016012623A1 (en)	2014-07-25	2016-01-28	Theravectys	Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule
US10077453B2 (en)	2014-07-30	2018-09-18	President And Fellows Of Harvard College	CAS9 proteins including ligand-dependent inteins
US10851149B2 (en)	2014-08-14	2020-12-01	The Trustees Of The University Of Pennsylvania	Treatment of cancer using GFR α-4 chimeric antigen receptor
PL3183268T3 (pl)	2014-08-19	2020-09-07	Novartis Ag	Chimeryczny receptor antygenowy (CAR) anty-CD123 do zastosowania w leczeniu nowotworu złośliwego
EP3186281B1 (en)	2014-08-28	2019-04-10	Halozyme, Inc.	Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
US10724096B2 (en)	2014-09-05	2020-07-28	Population Bio, Inc.	Methods and compositions for inhibiting and treating neurological conditions
KR20170060042A (ko)	2014-09-13	2017-05-31	노파르티스 아게	Alk 억제제의 조합 요법
IL250902B (en)	2014-09-16	2022-08-01	Symphogen As	Anti-met antibodies and compositions
EP3197557A1 (en)	2014-09-24	2017-08-02	Friedrich Miescher Institute for Biomedical Research	Lats and breast cancer
SI3200822T1 (sl)	2014-09-30	2021-10-29	Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts	Vezavne molekule, posebno antiteles, vezanih na L1CAM (CD171)
US9982061B2 (en)	2014-10-01	2018-05-29	Medimmune Limited	Antibodies to ticagrelor and methods of use
US20170209574A1 (en)	2014-10-03	2017-07-27	Novartis Ag	Combination therapies
MA40035A (fr)	2014-10-14	2016-04-21	Dana Farber Cancer Inst Inc	Molécules d'anticorps de pd-l1 et leurs utilisations
MA41685A (fr)	2014-10-17	2017-08-22	Biogen Ma Inc	Supplémentation en cuivre pour la régulation de la glycosylation dans un procédé de culture cellulaire de mammifère
WO2016077052A2 (en)	2014-10-22	2016-05-19	President And Fellows Of Harvard College	Evolution of proteases
MA40864A (fr)	2014-10-31	2017-09-05	Biogen Ma Inc	Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères
SI3215527T1 (sl)	2014-11-05	2025-04-30	Annexon, Inc.	Humanizirana protitelesa proti komplementnemu faktorju C1q in njihova uporaba
WO2016073894A1 (en)	2014-11-07	2016-05-12	Eleven Biotherapeutics, Inc.	Therapeutic agents with increased ocular retention
SI3215530T1 (sl)	2014-11-07	2020-02-28	Sesen Bio, Inc.	Izboljšana protitelesa IL-6
FI3218005T3 (fi)	2014-11-12	2023-03-31	Seagen Inc	Glykaanin kanssa vuorovaikutteisia yhdisteitä ja käyttömenetelmiä
US9879087B2 (en)	2014-11-12	2018-01-30	Siamab Therapeutics, Inc.	Glycan-interacting compounds and methods of use
US11033637B2 (en)	2014-11-21	2021-06-15	University Of Maryland, Baltimore	Targeted structure-specific particulate delivery systems
EP3227687A4 (en)	2014-12-05	2018-10-24	Prelude, Inc.	Dcis recurrence and invasive breast cancer
ES3015000T3 (en)	2014-12-08	2025-04-28	Dana Farber Cancer Inst Inc	Methods for upregulating immune responses using combinations of anti-rgmb and anti-pd-1 agents
EP3229838B1 (en)	2014-12-11	2020-09-09	Pierre Fabre Médicament	Anti-c10orf54 antibodies and uses thereof
WO2016094881A2 (en)	2014-12-11	2016-06-16	Abbvie Inc.	Lrp-8 binding proteins
EP3233918A1 (en)	2014-12-19	2017-10-25	Novartis AG	Combination therapies
US10221248B2 (en)	2014-12-22	2019-03-05	The Rockefeller University	Anti-MERTK agonistic antibodies and uses thereof
EP3242893A1 (en)	2015-01-08	2017-11-15	Biogen MA Inc.	Lingo-1 antagonists and uses for treatment of demyelinating disorders
JP2018507254A (ja)	2015-02-02	2018-03-15	アイツーファーマシューティカルズ，インコーポレーテッド	抗代替軽鎖抗体
DE112016001013T5 (de)	2015-03-03	2017-12-21	Kymab Limited	Antikörper, verwendungen und verfahren
EP3265491A1 (en)	2015-03-03	2018-01-10	Xoma (Us) Llc	Treatment of post-prandial hyperinsulinemia and hypoglycemia after bariatric surgery
US20180042998A1 (en)	2015-03-10	2018-02-15	University Of Massachusetts	Targeting gdf6 and bmp signaling for anti-melanoma therapy
US11136401B2 (en)	2015-03-27	2021-10-05	University Of Southern California	Car t-cell therapy directed to LHR for the treatment of solid tumors
CN116327915A (zh)	2015-04-03	2023-06-27	佐马技术有限公司	使用TGF-β抑制剂和PD-1抑制剂治疗癌症
WO2016168631A1 (en)	2015-04-17	2016-10-20	President And Fellows Of Harvard College	Vector-based mutagenesis system
EP3283512A4 (en)	2015-04-17	2018-10-03	Distributed Bio Inc	Method for mass humanization of non-human antibodies
EP3285811A1 (en)	2015-04-21	2018-02-28	Institut Gustave Roussy	Therapeutic methods, products and compositions inhibiting znf555
GB201506869D0 (en)	2015-04-22	2015-06-03	Ucb Biopharma Sprl	Method
GB201506870D0 (en)	2015-04-22	2015-06-03	Ucb Biopharma Sprl	Method
EP3288542B1 (en)	2015-04-29	2021-12-29	University Of South Australia	Compositions and methods for administering antibodies
CA2988001C (en)	2015-04-30	2023-09-26	Abcheck S.R.O.	Method for mass humanization of rabbit antibodies
CN107847594B (zh)	2015-05-06	2022-04-15	詹森生物科技公司	前列腺特异性膜抗原(psma)双特异性结合剂及其用途
EP3292152A1 (en)	2015-05-07	2018-03-14	Agenus Inc.	Anti-ox40 antibodies and methods of use thereof
CA2987146A1 (en)	2015-05-27	2016-12-01	Ucb Biopharma Sprl	Method for the treatment of neurological disease
PE20180672A1 (es)	2015-05-29	2018-04-19	Agenus Inc	Anticuerpos anti-ctla-4 y metodos de uso de los mismos
HRP20200262T1 (hr)	2015-05-29	2020-05-29	Abbvie Inc.	Protutijela protiv cd40 i njihova upotreba
JP7010473B2 (ja)	2015-06-04	2022-02-10	ユニバーシティオブサザンカリフォルニア	Ｌｙｍ－１およびｌｙｍ－２標的化ｃａｒ細胞免疫療法
TW201710286A (zh)	2015-06-15	2017-03-16	艾伯維有限公司	抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
GB201510758D0 (en)	2015-06-18	2015-08-05	Ucb Biopharma Sprl	Novel TNFa structure for use in therapy
CN107922497B (zh)	2015-06-24	2022-04-12	詹森药业有限公司	抗vista抗体和片段
GB201601073D0 (en)	2016-01-20	2016-03-02	Ucb Biopharma Sprl	Antibodies
GB201601075D0 (en)	2016-01-20	2016-03-02	Ucb Biopharma Sprl	Antibodies molecules
GB201601077D0 (en)	2016-01-20	2016-03-02	Ucb Biopharma Sprl	Antibody molecule
US10392674B2 (en)	2015-07-22	2019-08-27	President And Fellows Of Harvard College	Evolution of site-specific recombinases
WO2017015559A2 (en)	2015-07-23	2017-01-26	President And Fellows Of Harvard College	Evolution of bt toxins
WO2017019896A1 (en)	2015-07-29	2017-02-02	Novartis Ag	Combination therapies comprising antibody molecules to pd-1
WO2017019897A1 (en)	2015-07-29	2017-02-02	Novartis Ag	Combination therapies comprising antibody molecules to tim-3
PL3317301T3 (pl)	2015-07-29	2021-11-15	Novartis Ag	Terapie skojarzone zawierające cząsteczki przeciwciał przeciw lag-3
WO2017019895A1 (en)	2015-07-30	2017-02-02	President And Fellows Of Harvard College	Evolution of talens
CA2994841A1 (en)	2015-08-06	2017-02-09	Xoma (Us) Llc	Antibody fragments against the insulin receptor and uses thereof to treat hypoglycemia
EP3932953A1 (en)	2015-08-28	2022-01-05	F. Hoffmann-La Roche AG	Anti-hypusine antibodies and uses thereof
AU2016317915B2 (en)	2015-09-01	2021-02-18	Agenus Inc.	Anti-PD-1 antibodies and methods of use thereof
EP3350220B1 (en)	2015-09-15	2021-05-19	Scholar Rock, Inc.	Anti-pro/latent-myostatin antibodies and uses thereof
CN108137681B (zh)	2015-09-23	2024-06-18	豪夫迈·罗氏有限公司	抗-vegf抗体的优化的变体
JP7054924B2 (ja)	2015-09-23	2022-04-15	サイトイミューンセラピューティクス，インコーポレイテッド	免疫療法のためのｆｌｔ３指向ｃａｒ細胞
US11207393B2 (en)	2015-10-16	2021-12-28	President And Fellows Of Harvard College	Regulatory T cell PD-1 modulation for regulating T cell effector immune responses
SG10202104041PA (en)	2015-10-23	2021-06-29	Harvard College	Nucleobase editors and uses thereof
SG11201802887PA (en)	2015-10-27	2018-05-30	Ucb Biopharma Sprl	Methods of treatment using anti-il-17a/f antibodies
US20180348224A1 (en)	2015-10-28	2018-12-06	Friedrich Miescher Institute For Biomedical Resear Ch	Tenascin-w and biliary tract cancers
WO2017075329A2 (en)	2015-10-29	2017-05-04	Dana-Farber Cancer Institute, Inc.	Methods for identification, assessment, prevention, and treatment of metabolic disorders using pm20d1 and n-lipidated amino acids
CN108473559A (zh)	2015-11-10	2018-08-31	威特拉公司	特异性结合脂多糖的抗体分子-药物共轭物及其应用
CN108463248B (zh)	2015-11-12	2022-10-21	西雅图基因公司	聚糖相互作用化合物及使用方法
JP2019506363A (ja)	2015-11-25	2019-03-07	ビステラ，インコーポレイテッド	Ａｐｒｉｌに対する抗体分子およびその使用
EP3383911B1 (en)	2015-12-02	2021-01-20	STCube & Co. Inc.	Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
JP7227007B2 (ja)	2015-12-02	2023-02-21	ストサイエンシス，インコーポレイテッド	グリコシル化ｂｔｌａ（ｂ－及びｔ－リンパ球減弱因子）に特異的な抗体
GB201521391D0 (en)	2015-12-03	2016-01-20	Ucb Biopharma Sprl	Antibodies
GB201521382D0 (en)	2015-12-03	2016-01-20	Ucb Biopharma Sprl	Antibodies
GB201521383D0 (en)	2015-12-03	2016-01-20	Ucb Biopharma Sprl And Ucb Celltech	Method
GB201521389D0 (en)	2015-12-03	2016-01-20	Ucb Biopharma Sprl	Method
GB201521393D0 (en)	2015-12-03	2016-01-20	Ucb Biopharma Sprl	Antibodies
EP3386542B1 (en)	2015-12-10	2020-11-18	Katholieke Universiteit Leuven	Anti adamts13 antibodies and their use for treatment or prevention of haemorrhagic disorders due to ventricular assist device
JP2019502695A (ja)	2015-12-17	2019-01-31	ノバルティスアーゲー	ＰＤ−１に対する抗体分子とＣ−Ｍｅｔ阻害剤との組合せおよびその使用
BR112018012138A2 (pt)	2015-12-17	2018-12-04	Novartis Ag	moléculas de anticorpo para pd-1 e usos das mesmas
US10287345B2 (en)	2016-01-08	2019-05-14	Scholar Rock, Inc.	Methods for inhibiting myostatin activation by administering anti-pro/latent myostatin antibodies
GB201602413D0 (en)	2016-02-10	2016-03-23	Nascient Ltd	Method
MX2018009800A (es)	2016-02-12	2018-11-09	Janssen Pharmaceutica Nv	Anticuerpos y fragmentos anti-vista, usos de los mismos y procedimientos de identificacion de los mismos.
BR112018017031A2 (pt)	2016-02-23	2019-01-22	Sesen Bio Inc	formulações de antagonista de il-6 e usos das mesmas
KR20180119632A (ko)	2016-02-29	2018-11-02	제넨테크, 인크.	암에 대한 치료 및 진단 방법
JP2019509282A (ja)	2016-02-29	2019-04-04	ファウンデーション・メディシン・インコーポレイテッド	癌の治療方法
SG11201807523PA (en)	2016-03-10	2018-09-27	Viela Bio Inc	Ilt7 binding molecules and methods of using the same
KR20230088508A (ko)	2016-03-11	2023-06-19	스칼러 락, 인크.	TGFβ1-결합 이뮤노글로불린 및 그의 용도
WO2017160599A1 (en)	2016-03-14	2017-09-21	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Use of cd300b antagonists to treat sepsis and septic shock
WO2017161206A1 (en)	2016-03-16	2017-09-21	Halozyme, Inc.	Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use
US11186641B2 (en)	2016-03-17	2021-11-30	Oslo Universitetssykehus Hf	Fusion proteins targeting tumour associated macrophages for treating cancer
AU2017238172B2 (en)	2016-03-21	2024-06-27	Marengo Therapeutics, Inc.	Multispecific and multifunctional molecules and uses thereof
EP3432925A4 (en)	2016-03-22	2019-11-06	Bionomics Limited	ADMINISTRATION OF A MONOCLONAL ANTI-LGR5 ANTIBODY
US11034992B2 (en)	2016-03-23	2021-06-15	The General Hospital Corporation	Assays and methods for detecting UDP-glucose
CA3018216A1 (en)	2016-03-25	2017-09-28	Visterra, Inc.	Formulations of antibody molecules to dengue virus
MA44510A (fr)	2016-03-29	2021-03-31	Janssen Biotech Inc	Methode de traitement du psoriasis avec dosage intervalle augmenté d'anticorps anti-il12 et/ou -23
WO2017175058A1 (en)	2016-04-07	2017-10-12	Janssen Pharmaceutica Nv	Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
EP3439692A4 (en)	2016-04-08	2020-01-22	ITI Health, Inc.	ANTIBODIES BINDING PLECTIN-1 AND USES THEREOF
WO2017181098A2 (en)	2016-04-15	2017-10-19	Visterra, Inc.	Antibody molecules to zika virus and uses thereof
CN116333130A (zh)	2016-05-24	2023-06-27	英斯梅德股份有限公司	抗体及其制备方法
EP3464360A1 (en)	2016-05-27	2019-04-10	Agenus Inc.	Anti-tim-3 antibodies and methods of use thereof
IL263834B2 (en)	2016-06-20	2024-01-01	Kymab Ltd	Anti-pd-l1 antibodies
MA45491A (fr)	2016-06-27	2019-05-01	Juno Therapeutics Inc	Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
CN110291402B (zh)	2016-06-27	2023-09-01	朱诺治疗学股份有限公司	鉴定肽表位的方法、结合此类表位的分子和相关用途
AR108975A1 (es)	2016-07-06	2018-10-17	Celgene Corp	Anticuerpos con baja inmunogenicidad y sus usos
JP2019525772A (ja)	2016-07-08	2019-09-12	スターテン・バイオテクノロジー・ベー・フェー	抗ａｐｏｃ３抗体およびその使用方法
MA45668A (fr)	2016-07-13	2019-05-22	Biogen Ma Inc	Schémas posologiques d'antagonistes de lingo-1 et leurs utilisations pour le traitement de troubles de démyélinisation
CA3030837A1 (en)	2016-07-15	2018-01-18	Novartis Ag	Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
WO2018017964A2 (en)	2016-07-21	2018-01-25	Emory University	Ebola virus antibodies and binding agents derived therefrom
WO2018022479A1 (en)	2016-07-25	2018-02-01	Biogen Ma Inc.	Anti-hspa5 (grp78) antibodies and uses thereof
WO2018026748A1 (en)	2016-08-01	2018-02-08	Xoma (Us) Llc	Parathyroid hormone receptor 1 (pth1r) antibodies and uses thereof
WO2018052556A1 (en)	2016-08-02	2018-03-22	Visterra, Inc.	Engineered polypeptides and uses thereof
IL264565B2 (en)	2016-08-03	2024-07-01	Harvard College	Adenosine nuclear base editors and their uses
CA3032146A1 (en)	2016-08-03	2018-02-08	Bio-Techne Corporation	Identification of vsig3/vista as a novel immune checkpoint and use thereof for immunotherapy
CN109804066A (zh)	2016-08-09	2019-05-24	哈佛大学的校长及成员们	可编程cas9-重组酶融合蛋白及其用途
US11542509B2 (en)	2016-08-24	2023-01-03	President And Fellows Of Harvard College	Incorporation of unnatural amino acids into proteins using base editing
EP3512965B1 (en)	2016-09-15	2024-03-13	ArcherDX, LLC	Methods of nucleic acid sample preparation for analysis of cell-free dna
JP6997772B2 (ja)	2016-09-15	2022-01-18	アーチャーディーエックス，エルエルシー	核酸サンプル調製の方法
AU2017331277B2 (en)	2016-09-23	2024-05-30	Marengo Therapeutics, Inc.	Multispecific antibody molecules comprising lambda and kappa light chains
JP2019534710A (ja)	2016-09-28	2019-12-05	ゾーマ（ユーエス）リミテッドライアビリティカンパニー	インターロイキン２に結合する抗体およびその使用
GB201616596D0 (en)	2016-09-29	2016-11-16	Nascient Limited	Epitope and antibodies
WO2018064436A1 (en)	2016-09-30	2018-04-05	Janssen Biotech, Inc.	Safe and effective method of treating psoriasis with anti-il23 specific antibody
EP4521116A3 (en)	2016-10-03	2025-05-28	Abbott Laboratories	Improved methods of assessing uch-l1 status in patient samples
KR20240153612A (ko)	2016-10-07	2024-10-23	노파르티스 아게	암의 치료를 위한 키메라 항원 수용체
CA3037380A1 (en)	2016-10-11	2018-04-19	Agenus Inc.	Anti-lag-3 antibodies and methods of use thereof
KR102622411B1 (ko)	2016-10-14	2024-01-10	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	핵염기 에디터의 aav 전달
WO2018071576A1 (en)	2016-10-14	2018-04-19	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Treatment of tumors by inhibition of cd300f
CN110300600A (zh)	2016-11-02	2019-10-01	伊缪诺金公司	利用抗体-药物缀合物和parp抑制剂的组合治疗
US11779604B2 (en)	2016-11-03	2023-10-10	Kymab Limited	Antibodies, combinations comprising antibodies, biomarkers, uses and methods
KR102539159B1 (ko)	2016-11-07	2023-06-02	주식회사 뉴라클사이언스	서열 유사성을 가진 항-패밀리 19, 멤버 a5 항체 및 그것의 사용 방법
DE102016121899A1 (de)	2016-11-15	2018-05-17	Immatics Biotechnologies Gmbh	Verfahren zur Herstellung von elektrokompetenten Hefezellen und Verfahren zur Verwendung dieser Zellen
WO2018093841A1 (en)	2016-11-16	2018-05-24	Janssen Biotech, Inc.	Method of treating psoriasis with anti-il-23 specific antibody
EP3541847A4 (en)	2016-11-17	2020-07-08	Seattle Genetics, Inc.	COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE
MD3551660T2 (ro)	2016-12-07	2024-03-31	Agenus Inc	Anticorpi anti-CTLA-4 și procedee de utilizare a acestora
CN110300599B (zh)	2016-12-07	2024-07-02	艾吉纳斯公司	抗体和其使用方法
WO2018111976A1 (en)	2016-12-14	2018-06-21	Janssen Biotech, Inc.	Pd-l1 binding fibronectin type iii domains
EP3932432A1 (en)	2016-12-14	2022-01-05	Janssen Biotech, Inc.	Cd8a-binding fibronectin type iii domains
US10611823B2 (en)	2016-12-14	2020-04-07	Hanssen Biotech, Inc	CD137 binding fibronectin type III domains
GB201621635D0 (en)	2016-12-19	2017-02-01	Ucb Biopharma Sprl	Crystal structure
IL267565B2 (en)	2016-12-23	2025-02-01	Visterra Inc	Methods of producing binding polypeptides containing covalently linked heavy chains and light chains
WO2018119359A1 (en)	2016-12-23	2018-06-28	President And Fellows Of Harvard College	Editing of ccr5 receptor gene to protect against hiv infection
DK3565592T5 (da)	2017-01-06	2024-09-02	Scholar Rock Inc	Behandling af stofskiftesygdomme ved inhibering af myostatinaktivering
BR112019013908A2 (pt)	2017-01-06	2020-02-04	Scholar Rock Inc	inibidores de tgfss1 isoforma-específicos, contexto-permissivos, e seus usos
PT3565592T (pt)	2017-01-06	2023-05-31	Scholar Rock Inc	Tratamento de doenças metabólicas através da inibição da ativação da miostatina
CN110312530A (zh)	2017-01-13	2019-10-08	中央研究院	用以治疗心肌梗塞的可重复装载的水胶系统
WO2018130661A1 (en)	2017-01-13	2018-07-19	Academia Sinica	Reloadable hydrogel system for treating brain conditions
ES2994374T3 (en)	2017-01-18	2025-01-23	Visterra Inc	Antibody molecule-drug conjugates and uses thereof
WO2018140121A1 (en)	2017-01-30	2018-08-02	Janssen Biotech, Inc.	Anti-tnf antibodies, compositions, and methods for the treatment of active psoriatic arthritis
US10240205B2 (en)	2017-02-03	2019-03-26	Population Bio, Inc.	Methods for assessing risk of developing a viral disease using a genetic test
US11623945B2 (en)	2017-02-06	2023-04-11	The United States Of America, As Represented By The Secretary Of Agriculture	Immunostimulating compositions and uses therefore
MX2019009377A (es)	2017-02-07	2019-12-11	Janssen Biotech Inc	Anticuerpos anti-tnf, composiciones y metodos para el tratamiento de la espondilitis anquilosante activa.
WO2018151820A1 (en)	2017-02-16	2018-08-23	Elstar Therapeutics, Inc.	Multifunctional molecules comprising a trimeric ligand and uses thereof
CN110382529B (zh)	2017-03-02	2024-03-08	诺华股份有限公司	工程化的异源二聚体蛋白质
JP2020510671A (ja)	2017-03-03	2020-04-09	シアトルジェネティックス，インコーポレイテッド	グリカン相互作用化合物および使用の方法
US11898179B2 (en)	2017-03-09	2024-02-13	President And Fellows Of Harvard College	Suppression of pain by gene editing
JP2020510439A (ja)	2017-03-10	2020-04-09	プレジデントアンドフェローズオブハーバードカレッジ	シトシンからグアニンへの塩基編集因子
CA3057192A1 (en)	2017-03-23	2018-09-27	President And Fellows Of Harvard College	Nucleobase editors comprising nucleic acid programmable dna binding proteins
JP7346300B2 (ja)	2017-03-23	2023-09-19	アボット・ラボラトリーズ	早期バイオマーカーであるユビキチンカルボキシ末端ヒドロラーゼｌ１を使用する、ヒト対象における外傷性脳損傷の程度の診断及び決定の一助となるための方法
EP3599843A4 (en)	2017-03-24	2021-01-13	The Regents of the University of California	PROTEOGLYCAN IRREGULARITIES IN ABNORMAL FIBROBLASTS AND THERAPIES BASED ON THEM
AU2018249493A1 (en)	2017-04-03	2019-09-19	Oncxerna Therapeutics, Inc.	Methods for treating cancer using PS-targeting antibodies with immuno-oncology agents
EP3609915A1 (en)	2017-04-12	2020-02-19	Pfizer Inc	Antibodies having conditional affinity and methods of use thereof
AU2018253176B2 (en)	2017-04-13	2023-02-02	Agenus Inc.	Anti-CD137 antibodies and methods of use thereof
CN110546513A (zh)	2017-04-15	2019-12-06	雅培实验室	使用早期生物标记物帮助超急性诊断和确定人类受试者中的创伤性脑损伤的方法
WO2018195283A1 (en)	2017-04-19	2018-10-25	Elstar Therapeutics, Inc.	Multispecific molecules and uses thereof
KR20190141659A (ko)	2017-04-21	2019-12-24	스태튼 바이오테크놀로지 비.브이.	항-apoc3 항체 및 이의 사용 방법
BR112019022476A2 (pt)	2017-04-28	2020-05-12	Abbott Laboratories	Métodos para o auxílio no diagnóstico e determinação hiperagudos de lesão cerebral traumática usando biomarcadores iniciais em pelo menos duas amostras a partir do mesmo ser humano
EP3615566B1 (en)	2017-04-28	2023-12-20	Marengo Therapeutics, Inc.	Multispecific molecules comprising a non-immunoglobulin heterodimerization domain and uses thereof
PL3618863T3 (pl)	2017-05-01	2023-11-06	Agenus Inc.	Przeciwciała anty- tigit i sposoby ich zastosowania
US10865238B1 (en)	2017-05-05	2020-12-15	Duke University	Complement factor H antibodies
JOP20190256A1 (ar)	2017-05-12	2019-10-28	Icahn School Med Mount Sinai	فيروسات داء نيوكاسل واستخداماتها
WO2018209320A1 (en)	2017-05-12	2018-11-15	President And Fellows Of Harvard College	Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
CN110753703B (zh)	2017-05-23	2024-04-09	德国亥姆霍兹慕尼黑中心健康与环境研究中心（有限公司）	新的cd73抗体、其制备和用途
US10866251B2 (en)	2017-05-25	2020-12-15	Abbott Laboratories	Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
BR112019025313A2 (pt)	2017-05-30	2020-06-23	Abbott Laboratories	Métodos para auxílio no diagnóstico e avaliação de uma lesão cerebral traumática leve em um indivíduo humano usando troponina cardíaca i
CN111051346A (zh)	2017-05-31	2020-04-21	斯特库伯株式会社	使用免疫特异性结合btn1a1的抗体和分子治疗癌症的方法
JP2020522254A (ja)	2017-05-31	2020-07-30	エルスターセラピューティクス，インコーポレイテッド	骨髄増殖性白血病（ｍｐｌ）タンパク質に結合する多特異性分子およびその使用
WO2018222689A1 (en)	2017-05-31	2018-12-06	Stcube & Co., Inc.	Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
WO2018226671A1 (en)	2017-06-06	2018-12-13	Stcube & Co., Inc.	Methods of treating cancer using antibodies and molecules that bind to btn1a1 or btn1a1-ligands
BR112019024291A2 (pt)	2017-06-09	2020-07-28	Providence Health & Services-Oregon	utilização de cd39 e de cd103 para a identificação de células t tumorais humanas reativas para o tratamento do câncer
GB201709379D0 (en)	2017-06-13	2017-07-26	Univ Leuven Kath	Humanised ADAMTS13 binding antibodies
WO2018236904A1 (en)	2017-06-19	2018-12-27	Surface Oncology, Inc.	COMBINATION OF ANTI-CD47 ANTIBODIES AND CELL DEATH INDUCING AGENTS, AND USES THEREOF
EP3642240A1 (en)	2017-06-22	2020-04-29	Novartis AG	Antibody molecules to cd73 and uses thereof
WO2019005817A2 (en)	2017-06-26	2019-01-03	Bio-Techne Corporation	HYBRIDOMIC CLONES, MONOCLONAL ANTIBODIES DIRECTED AGAINST VSIG-4, AND METHODS OF MAKING AND USING SAME
CN111050791A (zh)	2017-06-27	2020-04-21	诺华股份有限公司	用于抗tim-3抗体的给药方案及其用途
CA3068041C (en)	2017-07-03	2024-06-25	Abbott Laboratories	Improved methods for measuring ubiquitin carboxy-terminal hydrolase l1 levels in blood
US11447809B2 (en)	2017-07-06	2022-09-20	President And Fellows Of Harvard College	Evolution of tRNA synthetases
CN118812712A (zh)	2017-07-11	2024-10-22	指南针制药有限责任公司	结合人cd137的激动剂抗体及其用途
BR112020000698A2 (pt)	2017-07-14	2020-07-14	Pfizer Inc.	anticorpos contra madcam
EP3431496A1 (en)	2017-07-19	2019-01-23	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Anti- isoasp7 amyloid beta antibodies and uses thereof
CA3070095A1 (en)	2017-07-20	2019-01-24	Novartis Ag	Dosage regimens of anti-lag-3 antibodies and uses thereof
EP3658583A1 (en)	2017-07-28	2020-06-03	Scholar Rock, Inc.	Ltbp complex-specific inhibitors of tgf-beta 1 and uses thereof
JP2020534795A (ja)	2017-07-28	2020-12-03	プレジデントアンドフェローズオブハーバードカレッジ	ファージによって支援される連続的進化（ｐａｃｅ）を用いて塩基編集因子を進化させるための方法および組成物
WO2019035938A1 (en)	2017-08-16	2019-02-21	Elstar Therapeutics, Inc.	MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
EP3684811A2 (en)	2017-08-17	2020-07-29	Massachusetts Institute of Technology	Multiple specificity binders of cxc chemokines and uses thereof
JP2020534025A (ja)	2017-08-25	2020-11-26	プレジデントアンドフェローズオブハーバードカレッジ	ＢｏＮＴペプチダーゼの進化
EP3672990A1 (en)	2017-08-25	2020-07-01	Five Prime Therapeutics, Inc.	B7-h4 antibodies and methods of use thereof
US11319532B2 (en)	2017-08-30	2022-05-03	President And Fellows Of Harvard College	High efficiency base editors comprising Gam
US11624130B2 (en)	2017-09-18	2023-04-11	President And Fellows Of Harvard College	Continuous evolution for stabilized proteins
TW201922780A (zh)	2017-09-25	2019-06-16	美商健生生物科技公司	以抗ｉｌ１２／ｉｌ２３抗體治療狼瘡之安全且有效之方法
CN119192374A (zh)	2017-10-02	2024-12-27	威特拉公司	Cd138抗体分子及其用途
ES2759622T3 (es)	2017-10-02	2020-05-11	Certest Biotec S L	Anticuerpos anti-Dps y dispositivos de prueba para la detección de bacterias del género Campylobacter
CN112020648A (zh)	2017-10-04	2020-12-01	赫斯佩瑞克斯股份公司	针对癌症个体化疗法的制品和方法
JP7256796B2 (ja)	2017-10-13	2023-04-12	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｔｈｏｍｓｅｎ－ｎｏｕｖｅｌｌｅ（ｔｎ）抗原に対するヒト抗体
KR20200121782A (ko)	2017-10-16	2020-10-26	더 브로드 인스티튜트, 인코퍼레이티드	아데노신 염기 편집제의 용도
EP3697816A1 (en)	2017-10-19	2020-08-26	Debiopharm International S.A.	Combination product for the treatment of cancer
WO2019077165A1 (en)	2017-10-20	2019-04-25	Institut Curie	DAP10 / 12-BASED CHIMERIC ANTIGENIC RECEPTORS (CAR) ADAPTED FOR RUSH
MX2020004512A (es)	2017-10-31	2020-08-13		Anticuerpos anti apolipoproteina c-iii (anti-apoc3) y metodos de uso de los mismos.
WO2019089594A1 (en)	2017-10-31	2019-05-09	Immunogen, Inc.	Combination treatment with antibody-drug conjugates and cytarabine
US11718679B2 (en)	2017-10-31	2023-08-08	Compass Therapeutics Llc	CD137 antibodies and PD-1 antagonists and uses thereof
WO2019094595A2 (en)	2017-11-09	2019-05-16	Pinteon Therapeutics Inc.	Methods and compositions for the generation and use of humanized conformation-specific phosphorylated tau antibodies
CA3081602A1 (en)	2017-11-16	2019-05-23	Novartis Ag	Combination therapies
WO2019100052A2 (en)	2017-11-20	2019-05-23	Compass Therapeutics Llc	Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
EP3717069A1 (en)	2017-11-27	2020-10-07	Purdue Pharma L.P.	Humanized antibodies targeting human tissue factor
US20200377571A1 (en)	2017-12-08	2020-12-03	Elstar Therapeutics, Inc.	Multispecific molecules and uses thereof
EP3721234A1 (en)	2017-12-09	2020-10-14	Abbott Laboratories	Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of gfap and uch-l1
WO2019113525A2 (en)	2017-12-09	2019-06-13	Abbott Laboratories	Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1)
WO2019139987A1 (en)	2018-01-09	2019-07-18	Elstar Therapeutics, Inc.	Calreticulin binding constructs and engineered t cells for the treatment of diseases
WO2019150309A1 (en)	2018-02-02	2019-08-08	Hammack Scott	Modulators of gpr68 and uses thereof for treating and preventing diseases
EP3746477A1 (en)	2018-02-02	2020-12-09	Bio-Techne Corporation	Compounds that modulate the interaction of vista and vsig3 and methods of making and using
GB201802486D0 (en)	2018-02-15	2018-04-04	Ucb Biopharma Sprl	Methods
WO2019168897A2 (en)	2018-02-28	2019-09-06	Dana-Farber Cancer Institute, Inc.	Methods for treating cancer using combinations of anti-btnl2 and immune checkpoint blockade agents
AU2019228600A1 (en)	2018-03-02	2020-09-24	Five Prime Therapeutics, Inc.	B7-H4 antibodies and methods of use thereof
KR20200129125A (ko)	2018-03-05	2020-11-17	얀센 바이오테크 인코포레이티드	항-il23 특이적 항체로 크론병을 치료하는 방법
CA3093772C (en)	2018-03-12	2024-04-16	Zoetis Services Llc	Anti-ngf antibodies and methods thereof
EP3765517A1 (en)	2018-03-14	2021-01-20	Elstar Therapeutics, Inc.	Multifunctional molecules that bind to calreticulin and uses thereof
KR20230020023A (ko)	2018-03-14	2023-02-09	서피스 온콜로지, 인크.	Cd39에 결합하는 항체 및 이의 용도
US20210009711A1 (en)	2018-03-14	2021-01-14	Elstar Therapeutics, Inc.	Multifunctional molecules and uses thereof
MX2020009879A (es)	2018-03-22	2021-01-08	Surface Oncology Inc	Anticuerpos anti-il-27 y sus usos.
WO2019180272A1 (en)	2018-03-23	2019-09-26	Fundación Instituto De Investigación Sanitaria De Santiago De Compostela	Anti-leptin affinity reagents for use in the treatment of obesity and other leptin-resistance associated diseases
HRP20230744T1 (hr)	2018-03-26	2023-10-27	Glycanostics S.R.O.	Sredstva i metode glikoprofiliranja proteina
CR20200450A (es)	2018-04-02	2021-02-11	Bristol Myers Squibb Co	Anticuerpos anti-trem-l y usos de los mismos
WO2019200357A1 (en)	2018-04-12	2019-10-17	Surface Oncology, Inc.	Biomarker for cd47 targeting therapeutics and uses therefor
US20210147547A1 (en)	2018-04-13	2021-05-20	Novartis Ag	Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
EP3784274A1 (en)	2018-04-27	2021-03-03	Fondazione Ebri Rita Levi-Montalcini	Antibody directed against a tau-derived neurotoxic peptide and uses thereof
AU2019265888A1 (en)	2018-05-10	2020-11-26	Neuracle Science Co., Ltd.	Anti-family with sequence similarity 19, member A5 antibodies and method of use thereof
TW202003048A (zh)	2018-05-15	2020-01-16	美商伊繆諾金公司	用抗體-藥物偶聯物及flt3抑制劑之組合治療
WO2019226658A1 (en)	2018-05-21	2019-11-28	Compass Therapeutics Llc	Multispecific antigen-binding compositions and methods of use
CN112384534A (zh)	2018-05-21	2021-02-19	指南针制药有限责任公司	用于增强nk细胞对靶细胞的杀死的组合物和方法
EP3797160A1 (en)	2018-05-23	2021-03-31	The Broad Institute Inc.	Base editors and uses thereof
TWI869346B (zh)	2018-05-30	2025-01-11	瑞士商諾華公司	Ｅｎｔｐｄ２抗體、組合療法、及使用該等抗體和組合療法之方法
WO2019241649A1 (en)	2018-06-14	2019-12-19	President And Fellows Of Harvard College	Evolution of cytidine deaminases
BR112020025661A2 (pt)	2018-06-18	2021-03-23	UCB Biopharma SRL	antagonista anti-grem1, agente anticâncer, métodos de tratamento de um câncer e de prognosticar um câncer, composição ou kit, métodos para a detecção de câncer, para determinar se um paciente com ou com suspeita de ter ou com risco de desenvolver câncer é ou não susceptível de responder ao tratamento com um agente quimioterápico, e para determinar se um paciente com ou com suspeita de ter ou com risco de desenvolver câncer tem probabilidade de responder ao tratamento com um antagonista de grem1
EP3810269A2 (en)	2018-06-19	2021-04-28	Atarga, LLC	Antibody molecules to complement component 5 and uses thereof
US12129298B2 (en)	2018-06-21	2024-10-29	Daiichi Sankyo Company, Limited	Compositions including CD3 antigen binding fragments and uses thereof
EP3814376A4 (en)	2018-06-26	2022-07-06	Mor Research Applications Ltd.	ANTI-TRANSTHYRETIN ANTIBODIES AND THEIR USES
AU2019297451A1 (en)	2018-07-03	2021-01-28	Marengo Therapeutics, Inc.	Anti-TCR antibody molecules and uses thereof
WO2020008083A1 (es)	2018-07-05	2020-01-09	Consejo Superior De Investigaciones Científicas	Diana terapéutica en receptores de quimiocinas para la selección de compuestos útiles para el tratamiento de procesos patológicos que implican la señalización de quimiocinas
MX2021000347A (es)	2018-07-11	2021-04-19	Scholar Rock Inc	Inhibidores de tgf?1 selectivos de isoforma, de alta afinidad y usos de los mismos.
TW202019957A (zh)	2018-07-11	2020-06-01	美商供石公司	TGFβ1抑制劑及其用途
EP4019046A1 (en)	2018-07-11	2022-06-29	Scholar Rock, Inc.	Isoform selective tgfbeta1 inhibitors and use thereof
US20200025776A1 (en)	2018-07-18	2020-01-23	Janssen Biotech, Inc.	Sustained Response Predictors After Treatment With Anti-IL23 Specific Antibody
KR102767692B1 (ko)	2018-07-20	2025-02-17	피에르 파브르 메디카먼트	Vista의 수용체
WO2020021465A1 (en)	2018-07-25	2020-01-30	Advanced Accelerator Applications (Italy) S.R.L.	Method of treatment of neuroendocrine tumors
HRP20221504T1 (hr)	2018-08-08	2023-03-31	Pml Screening, Llc	Postupci procjene rizika od razvoja progresivne multifokalne leukoencefalopatije uzrokovane john cunningham virusom pomoću genetskog testiranja
EP3833442A2 (en)	2018-08-09	2021-06-16	Compass Therapeutics LLC	Antibodies that bind cd277 and uses thereof
WO2020033923A1 (en)	2018-08-09	2020-02-13	Compass Therapeutics Llc	Antigen binding agents that bind cd277 and uses thereof
WO2020033925A2 (en)	2018-08-09	2020-02-13	Compass Therapeutics Llc	Antibodies that bind cd277 and uses thereof
US11492645B2 (en) *	2018-08-29	2022-11-08	Shanghaitech University	Composition and use of Cas protein inhibitors
WO2020056338A1 (en)	2018-09-14	2020-03-19	Prelude Corporation	Method of selection for treatment of subjects at risk of invasive breast cancer
DK3883606T5 (da)	2018-09-24	2024-08-05	Janssen Biotech Inc	Sikker og effektiv fremgangsmåde til behandling af colitis ulcerosa med anti-il12/il23-antistof
AU2019346645A1 (en)	2018-09-27	2021-04-29	Marengo Therapeutics, Inc.	CSF1R/CCR2 multispecific antibodies
US20210380675A1 (en)	2018-09-28	2021-12-09	Kyowa Kirin Co., Ltd.	Il-36 antibodies and uses thereof
MA53811A (fr)	2018-10-03	2022-03-16	Staten Biotechnology B V	Anticorps spécifiques à l'apoc3 humaine et du cynomolgus et procédés pour leur utilisation
IL281988B2 (en)	2018-10-05	2025-03-01	Bavarian Nordic As	Combination therapy for treating cancer with an intravenous administration of a recombinant mva and an immune checkpoint antagonist or agonist
UY38407A (es)	2018-10-15	2020-05-29	Novartis Ag	Anticuerpos estabilizadores de trem2
BR112021007765A2 (pt)	2018-10-23	2021-08-03	Scholar Rock, Inc.	inibidores seletivos de rgmc e uso dos mesmos
GB201817311D0 (en)	2018-10-24	2018-12-05	Ucb Biopharma Sprl	Antibodies
GB201817309D0 (en)	2018-10-24	2018-12-05	Ucb Biopharma Sprl	Antibodies
WO2020086408A1 (en)	2018-10-26	2020-04-30	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	A high-yield perfusion-based transient gene expression bioprocess
US12281338B2 (en)	2018-10-29	2025-04-22	The Broad Institute, Inc.	Nucleobase editors comprising GeoCas9 and uses thereof
BR112021008795A2 (pt)	2018-11-13	2021-08-31	Compass Therapeutics Llc	Construtos de ligação multiespecíficos contra moléculas de ponto de verificação e seus usos
MX2021005560A (es)	2018-11-20	2021-06-23	Bavarian Nordic As	Terapia para el tratamiento del cancer con administracion intratumoral y/o intravenosa de un virus vaccinia ankara (mva) recombinante que codifica ligando 4-1bbl (cd137l) y/o ligando del cumulo o grupo de diferenciacion 40 (cd40l).
CN113395979A (zh)	2018-11-20	2021-09-14	詹森生物科技公司	用抗il-23特异性抗体治疗银屑病的安全且有效的方法
MX2021006980A (es)	2018-12-13	2021-07-15	Surface Oncology Inc	Anticuerpos anti-il-27 y usos de estos.
JP2022514561A (ja)	2018-12-18	2022-02-14	ヤンセンバイオテツク，インコーポレーテツド	抗ｉｌ１２／ｉｌ２３抗体でループスを治療する安全かつ有効な方法
TW202031684A (zh)	2018-12-20	2020-09-01	日商協和麒麟股份有限公司	Fn14抗體及其用途
US20220281970A1 (en)	2018-12-20	2022-09-08	Novartis Ag	Pharmaceutical Combinations
US20220153827A1 (en)	2019-01-15	2022-05-19	Janssen Biotech, Inc.	Anti-TNF Antibody Compositions and Methods for the Treatment of Juvenile Idiopathic Arthritis
MX2021008453A (es)	2019-01-16	2021-08-19	Compass Therapeutics Llc	Formulaciones de anticuerpos que se unen a cd137 humano y usos de los mismos.
GB201900732D0 (en)	2019-01-18	2019-03-06	Ucb Biopharma Sprl	Antibodies
AU2020210962A1 (en)	2019-01-23	2021-07-22	Janssen Biotech, Inc.	anti-TNF antibody compositions for use in methods for the treatment of Psoriatic Arthritis
US12351837B2 (en)	2019-01-23	2025-07-08	The Broad Institute, Inc.	Supernegatively charged proteins and uses thereof
US12084500B2 (en)	2019-01-23	2024-09-10	New York University	Antibodies specific to delta 1 chain of T cell receptor
AR117918A1 (es)	2019-01-30	2021-09-01	Scholar Rock Inc	COMPLEJOS-ESPECÍFICOS LTBP INHIBIDORES DE TGFb Y SUS USOS
US11738050B2 (en)	2019-02-01	2023-08-29	Regents Of The University Of Minnesota	Compounds binding to fibroblast activation protein alpha
EP3693063A1 (en)	2019-02-06	2020-08-12	Diaccurate	Methods and compositions for treating cancer
EP3696191A1 (en)	2019-02-14	2020-08-19	Fundación Instituto de Investigación contra la Leucemia Josep Carreras (IJC)	Car t-cells for the treatment of cd1a-positive cancer
US10871640B2 (en)	2019-02-15	2020-12-22	Perkinelmer Cellular Technologies Germany Gmbh	Methods and systems for automated imaging of three-dimensional objects
EP3927745A1 (en)	2019-02-21	2021-12-29	Marengo Therapeutics, Inc.	Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders
CN114127113A (zh)	2019-02-21	2022-03-01	马伦戈治疗公司	与钙网蛋白结合的多功能分子及其用途
SG11202108955QA (en)	2019-02-21	2021-09-29	Marengo Therapeutics Inc	Antibody molecules that bind to nkp30 and uses thereof
CA3130754A1 (en)	2019-02-21	2020-08-27	Marengo Therapeutics, Inc.	Multifunctional molecules that bind to t cell related cancer cells and uses thereof
CN114126714A (zh)	2019-02-21	2022-03-01	马伦戈治疗公司	抗tcr抗体分子及其用途
EP4378958A3 (en)	2019-02-26	2024-09-04	Inspirna, Inc.	High-affinity anti-mertk antibodies and uses thereof
US20220177581A1 (en)	2019-03-11	2022-06-09	Memorial Sloan Kettering Cancer Center	Cd22 antibodies and methods of using the same
EP3938390A1 (en)	2019-03-14	2022-01-19	Janssen Biotech, Inc.	Manufacturing methods for producing anti-tnf antibody compositions
EP3938392A1 (en)	2019-03-14	2022-01-19	Janssen Biotech, Inc.	Methods for producing anti-tnf antibody compositions
EA202192505A1 (ru)	2019-03-14	2022-03-29	Янссен Байотек, Инк.	Способы получения композиций антитела к фно
CN113825765A (zh)	2019-03-14	2021-12-21	詹森生物科技公司	用于制备抗il12/il23抗体组合物的制造方法
WO2020188466A1 (en)	2019-03-18	2020-09-24	Janssen Biotech, Inc.	Method of treating psoriasis in pediatric subjects with anti-il12/il23 antibody
JP7669281B2 (ja)	2019-03-19	2025-04-28	ザブロードインスティテュート，インコーポレーテッド	編集ヌクレオチド配列を編集するための方法および組成物
EP3947442A2 (en)	2019-03-28	2022-02-09	Danisco US Inc.	Engineered antibodies
SG11202110732XA (en)	2019-03-29	2021-10-28	Atarga Llc	Anti fgf23 antibody
EP3962529A4 (en)	2019-04-30	2023-11-01	Dana-Farber Cancer Institute, Inc.	Methods for treating cancer using combinations of anti-cx3cr1 and immune checkpoint blockade agents
EP3972690A4 (en)	2019-05-23	2023-07-05	Janssen Biotech, Inc.	METHOD OF TREATMENT OF INFLAMMATORY BOWEL DISEASE USING COMBINATION THERAPY OF ANTIBODIES TO IL-23 AND TNF-ALPHA
WO2020245677A1 (en)	2019-06-03	2020-12-10	Janssen Biotech, Inc.	Anti-tnf antibodies, compositions, and methods for the treatment of active ankylosing spondylitis
CN113939531A (zh)	2019-06-03	2022-01-14	詹森生物科技公司	用于治疗银屑病关节炎的抗tnf抗体组合物和方法
WO2020257289A2 (en)	2019-06-17	2020-12-24	Visterra, Inc.	Humanized antibody molecules to cd138 and uses thereof
EP4004025A1 (en)	2019-07-26	2022-06-01	Visterra, Inc.	Interleukin-2 agents and uses thereof
PL4007777T3 (pl)	2019-08-02	2024-03-11	Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS)	(CAR)T-komórki przeciw BCMA do leczenia szpiczaka mnogiego
WO2021023860A1 (en)	2019-08-07	2021-02-11	Db Biotech, As	Improved horseradish peroxidase polypeptides
JP7691138B2 (ja)	2019-08-12	2025-06-11	アプティーボリサーチアンドデベロップメントエルエルシー	４－１ｂｂおよび０ｘ４０結合タンパク質ならびに関連する組成物および方法、４－１ｂｂに対する抗体、０ｘ４０に対する抗体
WO2021028752A1 (en)	2019-08-15	2021-02-18	Janssen Biotech, Inc.	Anti-tfn antibodies for treating type i diabetes
PH12022550460A1 (en)	2019-08-30	2023-02-27	Agenus Inc	Anti-cd96 antibodies and methods of use thereof
JP2022546768A (ja)	2019-09-04	2022-11-08	ワイ－バイオロジクス・インコーポレイテッド	抗ｖｓｉｇ４抗体または抗原結合フラグメントおよびその使用
WO2021044009A1 (en)	2019-09-04	2021-03-11	Deutsches Zentrum Für Neurodegenerative Erkrankungen E.V. (Dzne)	Herv inhibitors for use in treating tauopathies
KR20220062500A (ko)	2019-09-16	2022-05-17	서피스 온콜로지, 인크.	항-cd39 항체 조성물 및 방법
US20220348651A1 (en)	2019-09-18	2022-11-03	Novartis Ag	Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
TW202124446A (zh)	2019-09-18	2021-07-01	瑞士商諾華公司	與ｅｎｔｐｄ２抗體之組合療法
CA3151078A1 (en)	2019-09-25	2021-04-01	Surface Oncology, Inc.	Anti-il-27 antibodies and uses thereof
JP2022549504A (ja)	2019-09-26	2022-11-25	エスティーキューブアンドカンパニー	グリコシル化ｃｔｌａ－４に対して特異的な抗体およびその使用方法
KR20220088438A (ko)	2019-10-09	2022-06-27	주식회사 에스티큐브앤컴퍼니	글리코실화된 lag3에 대해 특이적인 항체 및 이의 사용 방법
EP4045061A4 (en)	2019-10-14	2024-04-17	ARO Biotherapeutics Company	FIBRONECTIN TYPE III DOMAINS BINDING TO CD137
WO2021076574A2 (en)	2019-10-14	2021-04-22	Aro Biotherapeutics Company	Fn3 domain-sirna conjugates and uses thereof
KR20220103947A (ko)	2019-10-21	2022-07-25	노파르티스 아게	베네토클락스 및 tim-3 억제제를 사용한 조합 요법
MX2022004769A (es)	2019-10-21	2022-05-16	Novartis Ag	Inhibidores de tim-3 y sus usos.
WO2021080682A1 (en)	2019-10-24	2021-04-29	Massachusetts Institute Of Technology	Monoclonal antibodies that bind human cd161 and uses thereof
IL293009A (en)	2019-11-20	2022-07-01	Bavarian Nordic As	Recombinant mva viruses for intratumoral and/or intravenous administration for treating cancer
GB201917480D0 (en)	2019-11-29	2020-01-15	Univ Oxford Innovation Ltd	Antibodies
GB201919061D0 (en)	2019-12-20	2020-02-05	Ucb Biopharma Sprl	Multi-specific antibody
GB201919062D0 (en)	2019-12-20	2020-02-05	Ucb Biopharma Sprl	Antibody
EP4077389A1 (en)	2019-12-20	2022-10-26	Novartis AG	Combination of anti tim-3 antibody mbg453 and anti tgf-beta antibody nis793, with or without decitabine or the anti pd-1 antibody spartalizumab, for treating myelofibrosis and myelodysplastic syndrome
GB201919058D0 (en)	2019-12-20	2020-02-05	Ucb Biopharma Sprl	Multi-specific antibodies
TWI877278B (zh)	2019-12-30	2025-03-21	美商思進公司	以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法
WO2021138407A2 (en)	2020-01-03	2021-07-08	Marengo Therapeutics, Inc.	Multifunctional molecules that bind to cd33 and uses thereof
KR102821932B1 (ko)	2020-01-06	2025-06-17	백시넥스 인코포레이티드	항-ccr8 항체 및 이의 용도
JP2023510793A (ja)	2020-01-11	2023-03-15	スカラーロックインコーポレイテッド	ＴＧＦβ阻害剤およびその使用
WO2021142448A2 (en)	2020-01-11	2021-07-15	Scholar Rock,Inc.	Tgf-beta inhibitors and use thereof
TWI869528B (zh)	2020-01-13	2025-01-11	美商威特拉公司	C5ar1抗體分子及其用途
US20230058489A1 (en)	2020-01-17	2023-02-23	Novartis Ag	Combination comprising a tim-3 inhibitor and a hypomethylating agent for use in treating myelodysplastic syndrome or chronic myelomonocytic leukemia
US20230075965A1 (en)	2020-01-24	2023-03-09	Constantine S. Mitsiades	Uses of biomarkers for improving immunotherapy
CA3167027A1 (en)	2020-02-05	2021-08-12	Larimar Therapeutics, Inc.	Tat peptide binding proteins and uses thereof
ES2975410T3 (es)	2020-02-13	2024-07-05	UCB Biopharma SRL	Anticuerpos biespecíficos que se unen a HVEM y CD9
EP4103610A1 (en)	2020-02-13	2022-12-21	UCB Biopharma SRL	Anti cd44-ctla4 bispecific antibodies
WO2021160268A1 (en)	2020-02-13	2021-08-19	UCB Biopharma SRL	Bispecific antibodies against cd9
WO2021160265A1 (en)	2020-02-13	2021-08-19	UCB Biopharma SRL	Bispecific antibodies against cd9 and cd137
EP4103609A1 (en)	2020-02-13	2022-12-21	UCB Biopharma SRL	Bispecific antibodies against cd9 and cd7
BR112022016368A2 (pt)	2020-02-18	2023-01-10	Alector Llc	Anticorpos pilra e seus métodos de uso
IL295979A (en)	2020-03-06	2022-10-01	Ona Therapeutics S L	Anti-cd36 antibodies and their use for cancer treatment
AU2021232853A1 (en)	2020-03-10	2022-09-22	Massachusetts Institute Of Technology	Compositions and methods for immunotherapy of NPM1c-positive cancer
US20230139885A1 (en)	2020-03-11	2023-05-04	Fundació Institut De Recerca Contra La Leucèmia Josep Carreras	Cd22 targeting-moiety for the treatment of b-cell acute lymphoblastic leukemia (b-all)
PL4045533T3 (pl)	2020-03-26	2024-04-15	Vanderbilt University	Ludzkie przeciwciała monoklonalne przeciwko ciężkiemu ostremu zespołowi oddechowemu wywołanemu koronawirusem 2 (sars-cov-2)
US20230203191A1 (en)	2020-03-30	2023-06-29	Danisco Us Inc	Engineered antibodies
US11969476B2 (en)	2020-04-03	2024-04-30	Visterra, Inc.	Antibody molecule-drug conjugates and uses thereof
WO2021211331A1 (en)	2020-04-13	2021-10-21	Abbott Point Of Care Inc.	METHODS, COMPLEXES AND KITS FOR DETECTING OR DETERMINING AN AMOUNT OF A ß-CORONAVIRUS ANTIBODY IN A SAMPLE
GB2612450A (en)	2020-04-24	2023-05-03	Marengo Therapeutics Inc	Multifunctional molecules that bind to T cell related cancer cells and uses thereof
CN115461363A (zh)	2020-05-01	2022-12-09	诺华股份有限公司	免疫球蛋白变体
WO2021220215A1 (en)	2020-05-01	2021-11-04	Novartis Ag	Engineered immunoglobulins
AU2021267940A1 (en)	2020-05-08	2022-12-08	President And Fellows Of Harvard College	Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
EP4149548A4 (en)	2020-05-13	2024-05-08	Disc Medicine, Inc.	ANTI-HEMOJUVELIN ANTIBODIES (HJV) FOR THE TREATMENT OF MYELOFIBROSIS
CR20220646A (es)	2020-05-17	2023-10-23	Astrazeneca Uk Ltd	Anticuerpos contra el sars-cov-2 y métodos de selección y uso de los mismos
US12258393B2 (en)	2020-05-21	2025-03-25	Janssen Biotech, Inc.	Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha
WO2021239666A1 (en)	2020-05-26	2021-12-02	Diaccurate	Therapeutic methods
US20230235080A1 (en)	2020-06-03	2023-07-27	Bionecure Therapeutics, Inc.	Trophoblast cell-surface antigen-2 (trop-2) antibodies
TW202216195A (zh)	2020-06-24	2022-05-01	美商威特拉公司	April抗體分子及其用途
CN116390772A (zh)	2020-07-07	2023-07-04	博泰康医药公司	新型美登素类似物作为adc有效载荷及其在癌症治疗中的用途
IL299757A (en)	2020-07-20	2023-03-01	Astrazeneca Uk Ltd	SARS-COV-2 proteins, antibodies against SARS-COV-2, and methods of using them
WO2022026592A2 (en)	2020-07-28	2022-02-03	Celltas Bio, Inc.	Antibody molecules to coronavirus and uses thereof
CA3190230A1 (en)	2020-07-30	2022-02-03	Janssen Biotech, Inc.	Method of treating psoriasis in pediatric subjects with anti-il12/il23 antibody
KR20230042301A (ko)	2020-08-04	2023-03-28	애벗트 라보라토리이즈	샘플에서 sars-cov-2 단백질을 검출하기 위한 개선된 방법 및 키트
HRP20250221T1 (hr)	2020-08-18	2025-04-11	Cephalon Llc	Anti-par-2 protutijela i postupci njihove primjene
CA3190755A1 (en)	2020-08-26	2022-03-03	Andreas Loew	Multifunctional molecules that bind to calreticulin and uses thereof
CN116917316A (zh)	2020-08-26	2023-10-20	马伦戈治疗公司	与NKp30结合的抗体分子及其用途
GB2616354A (en)	2020-08-26	2023-09-06	Marengo Therapeutics Inc	Methods of detecting TRBC1 or TRBC2
EP4204020A1 (en)	2020-08-31	2023-07-05	Advanced Accelerator Applications International S.A.	Method of treating psma-expressing cancers
EP4204021A1 (en)	2020-08-31	2023-07-05	Advanced Accelerator Applications International S.A.	Method of treating psma-expressing cancers
EP4228764A1 (en)	2020-10-14	2023-08-23	Five Prime Therapeutics, Inc.	Anti-c-c chemokine receptor 8 (ccr8) antibodies and methods of use thereof
IL301859A (en)	2020-10-15	2023-06-01	UCB Biopharma SRL	Binding molecules that multimerise cd45
EP4229081A1 (en)	2020-10-15	2023-08-23	The United States of America, as represented by The Secretary, Department of Health and Human Services	Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods
WO2022087274A1 (en)	2020-10-21	2022-04-28	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Antibodies that neutralize type-i interferon (ifn) activity
EP4251647A1 (en)	2020-11-24	2023-10-04	Bio-Techne Corporation	Anti-severe acute respiratory syndrome coronavirus antibodies
WO2023102384A1 (en)	2021-11-30	2023-06-08	Abbott Laboratories	Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
CA3200314A1 (en)	2020-12-01	2022-06-09	Peter Pavlik	Tumor-associated antigens and cd-3 binding proteins, related compositions, and methods
CA3198161A1 (en)	2020-12-01	2022-06-09	Beth MCQUISTON	Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
MX2023006599A (es)	2020-12-04	2023-06-19	Visterra Inc	Metodos de uso de agentes de interleucina-2.
CA3202339A1 (en)	2020-12-18	2022-06-23	Mei Jang	Protein compositions and methods for producing and using the same
EP4271998A1 (en)	2020-12-30	2023-11-08	Abbott Laboratories	Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample
CN117425500A (zh)	2021-01-13	2024-01-19	纪念斯隆凯特琳癌症中心	抗dll3抗体-药物缀合物
WO2022153194A1 (en)	2021-01-13	2022-07-21	Memorial Sloan Kettering Cancer Center	Antibody-pyrrolobenzodiazepine derivative conjugate
MX2023008598A (es)	2021-01-20	2023-08-10	Visterra Inc	Agentes de interleuquina-2 y usos de los mismos.
US20240141060A1 (en)	2021-01-29	2024-05-02	Novartis Ag	Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof
US20240230671A9 (en)	2021-02-24	2024-07-11	Alladapt Immunotherapeutics, Inc.	Compositions and methods for identification of cross-reactive allergenic proteins and treatment of allergies
WO2022187440A1 (en)	2021-03-03	2022-09-09	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	La protien as a novel regulator of osteoclastogenesis
WO2022184853A1 (en)	2021-03-03	2022-09-09	Pierre Fabre Medicament	Anti-vsig4 antibody or antigen binding fragment and uses thereof
WO2022190034A1 (en)	2021-03-12	2022-09-15	Janssen Biotech, Inc.	Method of treating psoriatic arthritis patients with inadequate response to tnf therapy with anti-il23 specific antibody
EP4305061A1 (en)	2021-03-12	2024-01-17	Janssen Biotech, Inc.	Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody
US20240310266A1 (en)	2021-03-18	2024-09-19	Novartis Ag	Biomarkers for cancer and methods of use thereof
WO2022204581A2 (en)	2021-03-26	2022-09-29	Scholar Rock, Inc.	Tgf-beta inhibitors and use thereof
EP4067381A1 (en)	2021-04-01	2022-10-05	Julius-Maximilians-Universität Würzburg	Novel tnfr2 binding molecules
TW202304979A (zh)	2021-04-07	2023-02-01	瑞士商諾華公司	抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
EP4320147A4 (en)	2021-04-08	2025-06-18	Marengo Therapeutics, Inc.	TCR-BINDING MULTIFUNCTIONAL MOLECULES AND USES THEREOF
IL307595A (en)	2021-04-14	2023-12-01	Aro Biotherapeutics Company	FN3 RNA-silencing region conjugates and their uses
KR20240034160A (ko)	2021-04-14	2024-03-13	에이알오 바이오테라퓨틱스 컴패니	Cd71 결합 피브로넥틴 3형 도메인
IL308198A (en)	2021-05-07	2024-01-01	Surface Oncology Llc	Anti-IL-27 antibodies and uses thereof
JP2024519858A (ja)	2021-05-18	2024-05-21	アボット・ラボラトリーズ	小児対象における脳損傷を査定する方法
US20250199013A1 (en)	2021-05-28	2025-06-19	Alexion Pharmaceuticals, Inc.	Methods for detecting cm-tma biomarkers
EP4348260A2 (en)	2021-06-03	2024-04-10	Scholar Rock, Inc.	Tgf-beta inhibitors and therapeutic use thereof
BR112023022097A2 (pt)	2021-06-07	2023-12-19	Agonox Inc	Cxcr5, pd-1 e icos expressando células t cd4 reativas de tumor e seu uso
US20240280561A1 (en)	2021-06-08	2024-08-22	Dana-Farber Cancer Institute, Inc.	Compositions and methods for treating and/or identifying an agent for treating intestinal cancers
AU2022293999A1 (en)	2021-06-14	2023-11-30	argenx BV	Anti-il-9 antibodies and methods of use thereof
US20240118279A1 (en)	2021-06-14	2024-04-11	Abbott Laboratories	Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind
MX2023014840A (es)	2021-06-23	2024-02-12	Scholar Rock Inc	Un inhibidor de la vía de la miostatina en combinación con un activador de la vía de la glp-1 para su uso en el tratamiento de trastornos metabólicos.
EP4362977A1 (en)	2021-06-29	2024-05-08	Seagen Inc.	Methods of treating cancer with a combination of a nonfucosylated anti-cd70 antibody and a cd47 antagonist
EP4367137A1 (en)	2021-07-09	2024-05-15	Janssen Biotech, Inc.	Manufacturing methods for producing anti-tnf antibody compositions
JP2024527586A (ja)	2021-07-09	2024-07-25	ヤンセンバイオテツク，インコーポレーテツド	抗－ｔｎｆ抗体組成物を産生するための製造方法
US20230038355A1 (en)	2021-07-09	2023-02-09	Janssen Biotech, Inc.	Manufacturing Methods for Producing Anti-IL12/IL23 Antibody Compositions
WO2023285878A1 (en)	2021-07-13	2023-01-19	Aviation-Ophthalmology	Methods for detecting, treating, and preventing gpr68-mediated ocular diseases, disorders, and conditions
AU2022310862A1 (en)	2021-07-14	2024-02-01	Regeneron Pharmaceuticals, Inc.	Engineered t cell receptors fused to binding domains from antibodies
AU2022320051A1 (en)	2021-07-30	2024-01-25	ONA Therapeutics S.L.	Anti-cd36 antibodies and their use to treat cancer
AU2022328390A1 (en)	2021-08-10	2024-03-21	Adimab, Llc	Anti-gdf15 antibodies, compositions and uses thereof
EP4392780A1 (en)	2021-08-26	2024-07-03	Glycanostics s.r.o.	Glycoprotein biomarkers for diagnosing cancer
CN118715440A (zh)	2021-08-31	2024-09-27	雅培实验室	诊断脑损伤的方法和系统
AU2022339759A1 (en)	2021-08-31	2024-03-07	Abbott Laboratories	Methods and systems of diagnosing brain injury
US20240391979A1 (en) *	2021-09-13	2024-11-28	Achelois Biopharma, Inc.	Hepatitis b virus antivirus (hbv-antivirus) compositions and methods of use
IL310815A (en)	2021-09-14	2024-04-01	Glycanostics S R O	Glycoprotein biomarkers for breast cancer diagnosis
EP4405478A1 (en)	2021-09-20	2024-07-31	Alnylam Pharmaceuticals, Inc.	Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof
US20250223376A1 (en)	2021-09-20	2025-07-10	Voyager Therapeutics, Inc.	Compositions and methods for the treatment of her2 positive cancer
EP4409294A1 (en)	2021-09-30	2024-08-07	Abbott Laboratories	Methods and systems of diagnosing brain injury
CN118451101A (zh)	2021-10-18	2024-08-06	百欧麦斯公司	抗激活素a抗体、组合物及其用途
JP2024541946A (ja)	2021-10-29	2024-11-13	ヤンセンバイオテツク，インコーポレーテツド	抗ｉｌ２３特異的抗体を用いてクローン病を治療する方法
EP4177266A1 (en)	2021-11-05	2023-05-10	Katholieke Universiteit Leuven	Neutralizing anti-sars-cov-2 human antibodies
IL312778A (en)	2021-11-15	2024-07-01	Janssen Biotech Inc	Methods of treating crohn's disease with anti-il23 specific antibody
WO2023092004A1 (en)	2021-11-17	2023-05-25	Voyager Therapeutics, Inc.	Compositions and methods for the treatment of tau-related disorders
EP4436997A1 (en)	2021-11-23	2024-10-02	Janssen Biotech, Inc.	Method of treating ulcerative colitis with anti-il23 specific antibody
WO2023097254A1 (en)	2021-11-24	2023-06-01	Visterra, Inc.	Engineered antibody molecules to cd138 and uses thereof
WO2023097119A2 (en)	2021-11-29	2023-06-01	Dana-Farber Cancer Institute, Inc.	Methods and compositions to modulate riok2
MX2024006746A (es)	2021-12-01	2024-08-09	Visterra Inc	Métodos de uso de agentes de interleucina-2.
AU2022413677A1 (en)	2021-12-17	2024-06-27	Abbott Laboratories	Systems and methods for determining uch-l1, gfap, and other biomarkers in blood samples
EP4452316A1 (en)	2021-12-22	2024-10-30	BYOMass Inc.	Targeting gdf15-gfral pathway
EP4452305A1 (en)	2021-12-23	2024-10-30	Bavarian Nordic A/S	Recombinant mva viruses for intraperitoneal administration for treating cancer
US20250109190A1 (en)	2022-01-31	2025-04-03	Byomass Inc.	Myeloproliferative conditions
WO2023150652A1 (en)	2022-02-04	2023-08-10	Abbott Laboratories	Lateral flow methods, assays, and devices for detecting the presence or measuring the amount of ubiquitin carboxy-terminal hydrolase l1 and/or glial fibrillary acidic protein in a sample
TW202342548A (zh)	2022-02-07	2023-11-01	美商威特拉公司	抗獨特型(anti-idiotype)抗體分子及其用途
TW202342510A (zh)	2022-02-18	2023-11-01	英商Ｒｑ生物科技有限公司	抗體
AU2023247337A1 (en)	2022-03-30	2024-11-14	Janssen Biotech, Inc.	Method of treating mild to moderate psoriasis with il-23 specific antibody
WO2023192436A1 (en)	2022-03-31	2023-10-05	Alexion Pharmaceuticals, Inc.	Singleplex or multiplexed assay for complement markers in fresh biological samples
GB202205200D0 (en)	2022-04-08	2022-05-25	Ucb Biopharma Sprl	Combination with chemotherapy
GB202205203D0 (en)	2022-04-08	2022-05-25	UCB Biopharma SRL	Combination with inhibitor
JP2025514142A (ja)	2022-04-25	2025-05-02	ビステラ，インコーポレイテッド	Ａｐｒｉｌに対する抗体分子およびその使用
WO2023209177A1 (en)	2022-04-29	2023-11-02	Astrazeneca Uk Limited	Sars-cov-2 antibodies and methods of using the same
WO2023220695A2 (en)	2022-05-13	2023-11-16	Voyager Therapeutics, Inc.	Compositions and methods for the treatment of her2 positive cancer
KR20250011938A (ko)	2022-05-18	2025-01-22	얀센 바이오테크 인코포레이티드	Il23 항체에 의해 건선성 관절염을 평가 및 치료하기 위한 방법
EP4536836A1 (en)	2022-06-07	2025-04-16	Regeneron Pharmaceuticals, Inc.	Pseudotyped viral particles for targeting tcr-expressing cells
EP4296279A1 (en)	2022-06-23	2023-12-27	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Anti-transthyretin (ttr) binding proteins and uses thereof
AU2023298134A1 (en)	2022-06-29	2024-11-28	Abbott Laboratories	Magnetic point-of-care systems and assays for determining gfap in biological samples
CN119948051A (zh)	2022-07-15	2025-05-06	詹森生物科技公司	用于改善抗原结合可变区的生物工程化配对的材料和方法
EP4554619A1 (en)	2022-07-15	2025-05-21	Danisco US Inc.	Methods for producing monoclonal antibodies
TW202435912A (zh)	2022-08-03	2024-09-16	美商航海家醫療公司	用於穿過血腦屏障之組合物及方法
EP4580753A1 (en)	2022-08-31	2025-07-09	Washington University	Alphavirus antigen binding antibodies and uses thereof
EP4581052A1 (en)	2022-09-01	2025-07-09	University of Georgia Research Foundation, Inc.	Compositions and methods for directing apolipoprotein l1 to induce mammalian cell death
CN120035450A (zh)	2022-09-06	2025-05-23	阿雷克森制药公司	造血干细胞移植物相关血栓性微血管病（hsct-tma）患者的诊断和预后生物标志物谱
KR20250068723A (ko)	2022-09-15	2025-05-16	아보트 러보러터리즈	경증 및 초경증 외상성 뇌 손상을 구분하기 위한 바이오마커 및 방법
EP4590400A1 (en)	2022-09-21	2025-07-30	Elthera AG	Novel binding molecules binding to l1cam
US20240199734A1 (en)	2022-11-22	2024-06-20	Janssen Biotech, Inc.	Method of Treating Ulcerative Colitis with Anti-IL23 Specific Antibody
WO2024138076A1 (en)	2022-12-22	2024-06-27	Scholar Rock, Inc.	Selective and potent inhibitory antibodies of myostatin activation
WO2024168061A2 (en)	2023-02-07	2024-08-15	Ayan Therapeutics Inc.	Antibody molecules binding to sars-cov-2
WO2024188356A1 (en)	2023-03-16	2024-09-19	Inmagene Biopharmaceuticals (Hangzhou) Co., Ltd.	Ilt7-targeting antibodies and uses thereof
WO2024194685A2 (en)	2023-03-17	2024-09-26	Oxitope Pharma B.V.	Anti-phosphocholine antibodies and methods of use thereof
WO2024194686A2 (en)	2023-03-17	2024-09-26	Oxitope Pharma B.V.	Anti-phosphocholine antibodies and methods of use thereof
WO2024196814A1 (en)	2023-03-17	2024-09-26	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Methods for treatment of age-related macular degeneration
WO2024211475A1 (en)	2023-04-04	2024-10-10	Abbott Laboratories	Use of biomarkers to determine whether a subject has sustained, may have sustained or is suspected of sustaining a subacute acquired brain injury (abi)
WO2024226969A1 (en)	2023-04-28	2024-10-31	Abbott Point Of Care Inc.	Improved assays, cartridges, and kits for detection of biomarkers, including brain injury biomarkers
WO2024240634A1 (en)	2023-05-19	2024-11-28	Les Laboratoires Servier	Anti-met antibodies, antibody-drug conjugates, compositions and uses thereof
WO2024243578A1 (en)	2023-05-25	2024-11-28	Dispatch Biotherapeutics, Inc.	Synthetic cancer antigens as targets for treating cancers
EP4484445A1 (en)	2023-06-26	2025-01-01	Universität zu Köln	Hcmv neutralizing antibodies
WO2025068389A2 (en)	2023-09-27	2025-04-03	Elthera Ag	L1cam binding molecules for treating hematological malignancy diseases
WO2025072888A2 (en)	2023-09-28	2025-04-03	Novavax, Inc.	Anti-sars-cov-2 spike (s) antibodies and their use in treating covid-19
WO2025122634A1 (en)	2023-12-05	2025-06-12	Voyager Therapeutics, Inc.	Compositions and methods for the treatment of tau-related disorders
WO2025133707A1 (en)	2023-12-19	2025-06-26	Vectory Therapeutics B.V.	Anti-tdp-43 antibodies and uses thereof
WO2025147500A1 (en)	2024-01-03	2025-07-10	Kiniksa Pharmaceuticals, Gmbh	Method of reducing aggregation in the virus-inactivated preparation of anti-cd40 antibodies

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5618920A (en)	1985-11-01	1997-04-08	Xoma Corporation	Modular assembly of antibody genes, antibodies prepared thereby and use
DE3852304T3 (de) *	1987-03-02	1999-07-01	Enzon Labs Inc., Piscataway, N.J.	Organismus als Träger für "Single Chain Antibody Domain (SCAD)".
US5223409A (en) *	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
DE68913658T3 (de) *	1988-11-11	2005-07-21	Stratagene, La Jolla	Klonierung von Immunglobulin Sequenzen aus den variablen Domänen
CA2016841C (en) *	1989-05-16	1999-09-21	William D. Huse	A method for producing polymers having a preselected activity
AU627591B2 (en) *	1989-06-19	1992-08-27	Xoma Corporation	Chimeric mouse-human km10 antibody with specificity to a human tumor cell antigen
CA2025398A1 (en)	1989-09-20	1992-03-15	Timothy Gerard Dinan	Diagnosis and treatment of a disorder of the gastrointestinal tract
US5427908A (en) *	1990-05-01	1995-06-27	Affymax Technologies N.V.	Recombinant library screening methods
ATE160818T1 (de) *	1990-06-01	1997-12-15	Chiron Corp	Zusammensetzungen und verfahren zur identifizierung von molekülen mit biologischer wirksamkeit
US5723286A (en) *	1990-06-20	1998-03-03	Affymax Technologies N.V.	Peptide library and screening systems
GB9015198D0 (en) *	1990-07-10	1990-08-29	Brien Caroline J O	Binding substance
US6172197B1 (en)	1991-07-10	2001-01-09	Medical Research Council	Methods for producing members of specific binding pairs
GB9019812D0 (en)	1990-09-11	1990-10-24	Scotgen Ltd	Novel antibodies for treatment and prevention of infection in animals and man
IL99552A0 (en) *	1990-09-28	1992-08-18	Ixsys Inc	Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
US5871974A (en) *	1990-09-28	1999-02-16	Ixsys Inc.	Surface expression libraries of heteromeric receptors
GB9022190D0 (en) *	1990-10-12	1990-11-28	Perham Richard N	Immunogenic material
ATE164395T1 (de)	1990-12-03	1998-04-15	Genentech Inc	Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
AU1457992A (en) *	1991-03-01	1992-10-06	Stratagene	Pcr generated dicistronic dna molecules for producing antibodies
ATE414768T1 (de) *	1991-04-10	2008-12-15	Scripps Research Inst	Bibliotheken heterodimerer rezeptoren mittels phagemiden
ES2168277T3 (es) *	1992-09-04	2002-06-16	Scripps Research Inst	Fagemidos que coexpresan un receptor de superficie y una proteina heterologa de superficie.

1992
- 1992-04-10 AT AT04076718T patent/ATE414768T1/de active
- 1992-04-10 EP EP04076718A patent/EP1471142B1/en not_active Expired - Lifetime
- 1992-04-10 EP EP92910558A patent/EP0580737B1/en not_active Expired - Lifetime
- 1992-04-10 AU AU17856/92A patent/AU662148B2/en not_active Expired
- 1992-04-10 DE DE69233367T patent/DE69233367T2/de not_active Expired - Lifetime
- 1992-04-10 AT AT92910558T patent/ATE269401T1/de active
- 1992-04-10 US US08/133,011 patent/US5658727A/en not_active Expired - Lifetime
- 1992-04-10 IE IE116992A patent/IE921169A1/en not_active IP Right Cessation
- 1992-04-10 JP JP51064992A patent/JP3672306B2/ja not_active Expired - Lifetime
- 1992-04-10 ES ES04076718T patent/ES2315612T3/es not_active Expired - Lifetime
- 1992-04-10 ES ES92910558T patent/ES2223040T3/es not_active Expired - Lifetime
- 1992-04-10 DK DK04076718T patent/DK1471142T3/da active
- 1992-04-10 CA CA 2108147 patent/CA2108147C/en not_active Expired - Lifetime
- 1992-04-10 DK DK92910558T patent/DK0580737T3/da active
- 1992-04-10 PT PT100379A patent/PT100379B/pt not_active IP Right Cessation
- 1992-04-10 WO PCT/US1992/003091 patent/WO1992018619A1/en active IP Right Grant
- 1992-04-10 DE DE69233750T patent/DE69233750D1/de not_active Expired - Lifetime
1993
- 1993-10-08 NO NO19933610A patent/NO319371B1/no not_active IP Right Cessation
- 1993-10-08 FI FI934422A patent/FI120309B/fi not_active IP Right Cessation
1994
- 1994-10-12 US US08/322,730 patent/US5759817A/en not_active Expired - Lifetime
1997
- 1997-08-08 US US08/907,739 patent/US6235469B1/en not_active Expired - Fee Related
2000
- 2000-12-04 US US09/729,597 patent/US6468738B1/en not_active Expired - Fee Related
2002
- 2002-08-26 JP JP2002289257A patent/JP4108430B2/ja not_active Expired - Lifetime
- 2002-10-18 US US10/273,973 patent/US7118866B2/en not_active Expired - Fee Related
2005
- 2005-02-28 JP JP2005054302A patent/JP4118896B2/ja not_active Expired - Lifetime
- 2005-12-22 US US11/315,970 patent/US7985841B2/en not_active Expired - Fee Related
2007
- 2007-05-16 JP JP2007130665A patent/JP4118938B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0580737B1 (en)	2004-06-16
US7118866B2 (en)	2006-10-10
AU1785692A (en)	1992-11-17
DE69233750D1 (de)	2009-01-02
NO933610D0 (no)	1993-10-08
FI934422A0 (fi)	1993-10-08
FI934422L (fi)	1993-12-08
PT100379A (pt)	1993-08-31
JP3672306B2 (ja)	2005-07-20
CA2108147C (en)	2009-01-06
ATE414768T1 (de)	2008-12-15
EP0580737A4 (en)	1996-04-24
NO933610L (no)	1993-12-10
FI120309B (fi)	2009-09-15
US5759817A (en)	1998-06-02
JPH06506836A (ja)	1994-08-04
US20060257856A1 (en)	2006-11-16
US7985841B2 (en)	2011-07-26
US20040002057A1 (en)	2004-01-01
US5658727A (en)	1997-08-19
EP0580737A1 (en)	1994-02-02
JP2003204797A (ja)	2003-07-22
NO319371B1 (no)	2005-07-25
DE69233367D1 (de)	2004-07-22
US6468738B1 (en)	2002-10-22
JP2007222179A (ja)	2007-09-06
JP2005218449A (ja)	2005-08-18
ES2223040T3 (es)	2005-02-16
CA2108147A1 (en)	1992-10-11
US6235469B1 (en)	2001-05-22
ES2315612T3 (es)	2009-04-01
WO1992018619A1 (en)	1992-10-29
JP4118938B2 (ja)	2008-07-16
JP4108430B2 (ja)	2008-06-25
JP4118896B2 (ja)	2008-07-16
EP1471142B1 (en)	2008-11-19
DK0580737T3 (da)	2004-11-01
EP1471142A1 (en)	2004-10-27
PT100379B (pt)	1999-01-29
DE69233367T2 (de)	2005-05-25
ATE269401T1 (de)	2004-07-15
AU662148B2 (en)	1995-08-24
IE921169A1 (en)	1992-10-21

Publication	Publication Date	Title
DK1471142T3 (da)	2009-03-09	Heterodimere receptor-biblioteker under anvendelse af fagemider
Lewis et al.	1992	Sequence of a second human KDEL receptor
KR960704038A (ko)	1996-08-31	세포 표면 수용체 Hek와 결합하는 사이토킨(Cytokines That Bind the Cell Surface Receptor Hek)
EP3288582B1 (en)	2021-03-31	Nucleic acid construct
WO1996018105A1 (en)	1996-06-13	Single chain t-cell receptor
NZ515913A (en)	2004-01-30	Modified chimeric polypeptides with improved pharmacokinetic properties
US8003757B2 (en)	2011-08-23	Receptor-based interaction trap
Carrington et al.	1996	Implications of conserved structural motifs in disparate trypanosome surface proteins
NZ336929A (en)	2000-11-24	Purified receptor that binds TRAIL and antibodies thereof
CA2184059A1 (en)	1995-09-28	Human trk receptors and neurotrophic factor inhibitors
CA2339331A1 (en)	2000-03-02	Expression and export of angiogenesis inhibitors as immunofusins
WO2002002621A3 (en)	2002-08-15	Mammalian secreted proteins
IL142905A (en)	2009-12-24	Functional antagonists of hedgehog activity
Smiley et al.	1990	The trypanosome leucine repeat gene in the variant surface glycoprotein expression site encodes a putative metal-binding domain and a region resembling protein-binding domains of yeast, Drosophila, and mammalian proteins
AU632513B2 (en)	1993-01-07	Cdnas coding for the gamma subunit of the high-affinity receptor for immunoglobulin e
Zha et al.	2001	Cloning of cDNAs encoding C-type lectins from Elapidae snakes Bungarus fasciatus and Bungarus multicinctus
Hawlisch et al.	1998	Site-directed C3a receptor antibodies from phage display libraries
Muto et al.	1995	High-Affinity Chimeric Human Granulocyte-Macrophage Colony-Stimulating Factor-Receptor Carrying the Cytoplasmic Domain of the β Subunit But Not the α Subunit Transduces Growth-Promoting Signals in Ba/F3 Cells
Banfield et al.	1992	The isolation and characterization of rabbit motilin precursor cDNA
AU2001281784A1 (en)	2002-02-21	Receptor-based interaction trap
AU674523B2 (en)	1997-01-02	An interferon-alpha/beta binding protein its preparation and pharmaceutical compositions containing it
KR860006484A (ko)	1986-09-11	단백질 또는 당단백질의 제조방법
Morgan et al.	1993	Novel developmentally regulated exon identified in the rat fast skeletal muscle troponin T gene
Wittenbrink et al.	2009	Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino acid in the α2 domain
Ito et al.	1992	Development of a prokaryotic expression vector that exploits dicistronic gene organization