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DE3884529D1 - Leader-anteile zur produktion von rekombinanten proteinen. - Google Patents

Leader-anteile zur produktion von rekombinanten proteinen.

Info

Publication number
DE3884529D1
DE3884529D1 DE88902750T DE3884529T DE3884529D1 DE 3884529 D1 DE3884529 D1 DE 3884529D1 DE 88902750 T DE88902750 T DE 88902750T DE 3884529 T DE3884529 T DE 3884529T DE 3884529 D1 DE3884529 D1 DE 3884529D1
Authority
DE
Germany
Prior art keywords
production
recombinant proteins
leader
shares
leader shares
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88902750T
Other languages
English (en)
Other versions
DE3884529T2 (de
Inventor
Peter Keck
Charles Cohen
James Huston
Richard Ridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Creative Biomolecules Inc
Original Assignee
Creative Biomolecules Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Creative Biomolecules Inc filed Critical Creative Biomolecules Inc
Application granted granted Critical
Publication of DE3884529D1 publication Critical patent/DE3884529D1/de
Publication of DE3884529T2 publication Critical patent/DE3884529T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE88902750T 1987-03-20 1988-03-04 Leader-anteile zur produktion von rekombinanten proteinen. Expired - Fee Related DE3884529T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2850087A 1987-03-20 1987-03-20
PCT/US1988/000729 WO1988007086A1 (en) 1987-03-20 1988-03-04 Leader sequences for the production of recombinant proteins

Publications (2)

Publication Number Publication Date
DE3884529D1 true DE3884529D1 (de) 1993-11-04
DE3884529T2 DE3884529T2 (de) 1994-04-28

Family

ID=21843794

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88902750T Expired - Fee Related DE3884529T2 (de) 1987-03-20 1988-03-04 Leader-anteile zur produktion von rekombinanten proteinen.

Country Status (6)

Country Link
EP (1) EP0305481B1 (de)
JP (1) JP2535066B2 (de)
AU (1) AU601273B2 (de)
CA (1) CA1334943C (de)
DE (1) DE3884529T2 (de)
WO (1) WO1988007086A1 (de)

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US5869620A (en) * 1986-09-02 1999-02-09 Enzon, Inc. Multivalent antigen-binding proteins
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US6027725A (en) * 1991-11-25 2000-02-22 Enzon, Inc. Multivalent antigen-binding proteins
DE69332377T2 (de) * 1992-07-13 2003-07-03 Bionebraska, Inc. Verfahren zur modifizierung rekombinanter polypeptide
US5656456A (en) * 1992-07-13 1997-08-12 Bionebraska, Inc. Chemical method for selective modification of the N- and/or C-terminal amino acid α-carbon reactive group of a recombinant polypeptide or a portion thereof
AU5670194A (en) * 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
DE4336810A1 (de) * 1993-10-28 1995-05-18 Basf Ag Verfahren zur rekombinanten Herstellung von Proteinen in Hefe
CA2206848A1 (en) * 1994-12-07 1996-06-13 Bionebraska, Inc. Production of peptides using recombinant fusion protein constructs
AU4415796A (en) * 1994-12-07 1996-06-26 Bionebraska, Inc. Production of c-terminal amidated peptides from recombinant protein constructs
US6703484B2 (en) 1997-01-08 2004-03-09 Invitrogen Corporation Methods for production of proteins
KR100620554B1 (ko) 2004-06-05 2006-09-06 한국생명공학연구원 Ｔａｇ-72에 대한 인간화 항체
US20090087873A1 (en) 2006-07-21 2009-04-02 Invitrogen Corporation Sharply resolving labeled protein molecular weight standards
US7678883B2 (en) * 2007-07-25 2010-03-16 E.I. Du Pont De Nemours And Company Solubility tags for the expression and purification of bioactive peptides
KR101338517B1 (ko) 2011-04-18 2013-12-10 연세대학교 산학협력단 인간 간-카르복실에스터라제 １을 특이적으로 인식하는 단일클론 항체, 상기 항체를 생산하는 하이브리도마 세포주 및 이의 용도
US9115182B2 (en) 2011-06-21 2015-08-25 E I Du Pont De Nemours And Company Cysteine cross-linked structural peptides
US9580479B2 (en) 2012-07-20 2017-02-28 University—Industry Cooperation Group Of Kyung Hee University Peptide tag and uses thereof
CN104812773B (zh) 2012-07-20 2018-04-06 庆熙大学校产学协力团 表位标记用抗体、杂交瘤细胞株以及其用途
KR101453462B1 (ko) 2013-05-16 2014-10-23 앱클론(주) Her2에 특이적으로 결합하는 항체
KR101605421B1 (ko) 2014-03-05 2016-03-23 국립암센터 B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도
EP3783031B1 (de) 2014-12-03 2023-08-02 Aimed Bio Inc. Antikörper gegen neuropilin 1 und verwendung davon
KR102462811B1 (ko) 2015-04-27 2022-11-04 에이비온 주식회사 항체에 덴드론이 접합된 면역접합체 및 이의 용도
KR101896882B1 (ko) 2015-11-30 2018-09-11 앱클론(주) Vegfr2에 특이적으로 결합하는 항체
CN109476738A (zh) 2016-02-15 2019-03-15 社会福祉法人三星生命公益财团 抗EGFRvIII的抗体及其用途
MX2018014554A (es) 2016-05-27 2019-09-09 Orum Therapeutics Inc Anticuerpo penetrante de citosol y uso del mismo.
WO2017209554A2 (ko) 2016-06-03 2017-12-07 사회복지법인 삼성생명공익재단 항-nrp1 항체 스크리닝 방법
EP3480598A4 (de) 2016-06-03 2020-01-22 Samsung Life Public Welfare Foundation Verfahren zum antikörper-screening anhand von zellen aus patienten
EP3467508A4 (de) 2016-06-03 2020-04-29 Samsung Life Public Welfare Foundation Anti-nrp1-antikörper-screening-verfahren
WO2017209553A2 (ko) 2016-06-03 2017-12-07 사회복지법인 삼성생명공익재단 환자 유래 세포를 이용한 항체 스크리닝 방법
CN110072889B (zh) 2016-08-05 2023-06-13 Y生物股份有限公司 抗程序性细胞死亡配体1(pd-l1)的抗体及其用途
CN110049998B (zh) 2016-08-05 2023-04-11 Y生物股份有限公司 抗程序性细胞死亡1(pd-1)的抗体及其用途
WO2018026249A1 (ko) 2016-08-05 2018-02-08 주식회사 와이바이오로직스 프로그램화된 세포 사멸 단백질 리간드-1 (pd-l1)에 대한 항체 및 이의 용도
KR101757346B1 (ko) 2017-03-27 2017-07-26 아주대학교산학협력단 항-emap ii 항체 및 이의 용도
KR101970327B1 (ko) 2017-04-13 2019-04-18 고려대학교 산학협력단 검출 신호의 자가 증폭 원리를 이용한 정확, 신속, 편리한 단일 단계 질병 진단 방법
EP3630844A4 (de) 2017-05-30 2021-03-03 Chong Kun Dang Pharmaceutical Corp. Neuartiger anti-c-met-antikörper und verwendung davon
CN111278860B (zh) 2017-09-08 2024-03-29 Y生物股份有限公司 抗人dlk1的抗体及其用途
JP7009642B2 (ja) 2017-10-20 2022-01-25 ファーマブシン インコーポレイテッド 抗－ｖｉｓｔａ抗体及びその用途
KR102311838B1 (ko) 2017-12-27 2021-10-14 주식회사 파멥신 항-pd-l1 항체 및 이의 용도
KR102275930B1 (ko) 2018-03-14 2021-07-12 (주)알테오젠 Folr1에 특이적으로 결합하는 항체 및 그의 용도
JP7527641B2 (ja) 2018-04-18 2024-08-05 アブクロン・インコーポレイテッド スイッチ分子及びスイッチャブルキメラ抗原受容体
JP7062134B2 (ja) 2018-04-27 2022-05-16 アイメッド バイオ インコーポレーテッド 細胞の磁性ビーズ付着を用いた磁性基盤バイオパンニング方法
KR102115300B1 (ko) 2018-06-01 2020-05-26 재단법인 목암생명과학연구소 항체 라이브러리 및 이를 이용한 항체 스크리닝 방법
AU2019317229A1 (en) 2018-08-10 2021-02-18 Eutilex Co.,Ltd Chimeric Antigen Receptor that Binds HLA-DR, and CAR-T Cell
KR102353568B1 (ko) 2018-11-14 2022-01-20 주식회사 헬릭스미스 안정성이 향상된 항 c-Met 항체 또는 그의 항원 결합 단편
JP2022522547A (ja) 2019-03-06 2022-04-20 レゴケム バイオサイエンシズ， インク． ヒトｄｌｋ１に対する抗体を含む抗体薬物コンジュゲート及びその使用
KR102502287B1 (ko) 2020-04-17 2023-02-22 앱클론(주) 항-her2 어피바디 및 이를 스위치 분자로 이용하는 스위처블 키메라 항원 수용체
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WO2021251564A1 (ko) 2020-06-09 2021-12-16 국민대학교산학협력단 Grp94에 특이적으로 결합하는 항체 또는 그의 항원 결합 단편 및 이들의 용도
KR102757518B1 (ko) 2020-12-07 2025-01-21 (주)이노베이션바이오 Cd47에 특이적인 항체 및 이의 용도
WO2022154472A1 (ko) 2021-01-12 2022-07-21 에스지메디칼 주식회사 Cd55에 대한 신규 항체 및 이의 용도
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WO2023277281A1 (ko) 2021-06-30 2023-01-05 (주)이노베이션바이오 Cd47에 특이적인 인간화 항체 및 이를 포함하는 cd47 관련 질환의 예방 또는 치료용 약학적 조성물
CN118339181A (zh) 2021-11-05 2024-07-12 首尔大学医院 抵抗素特异性抗体及其用途
KR102530111B1 (ko) 2022-03-11 2023-05-10 앱클론(주) 코티닌을 표적하는 항체 또는 그의 항원 결합 단편, 이를 포함하는 키메라 항원 수용체 및 이들의 용도
AU2023238458A1 (en) 2022-03-25 2024-10-17 Hk Inno.N Corporation Hla-g-specific antibody and use thereof
KR20240008997A (ko) 2022-07-12 2024-01-22 (재) 스크립스코리아항체연구원 사스-코로나 바이러스 2 중화 항체

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE113985T1 (de) * 1987-03-20 1994-11-15 Creative Biomolecules Inc Verfahren zur reinigung von rekombinanten polypeptiden.

Also Published As

Publication number Publication date
CA1334943C (en) 1995-03-28
DE3884529T2 (de) 1994-04-28
JPH01503117A (ja) 1989-10-26
WO1988007086A1 (en) 1988-09-22
AU1482488A (en) 1988-10-10
EP0305481B1 (de) 1993-09-29
EP0305481A1 (de) 1989-03-08
AU601273B2 (en) 1990-09-06
JP2535066B2 (ja) 1996-09-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee