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MX2018014554A - Anticuerpo penetrante de citosol y uso del mismo. - Google Patents

Anticuerpo penetrante de citosol y uso del mismo.

Info

Publication number
MX2018014554A
MX2018014554A MX2018014554A MX2018014554A MX2018014554A MX 2018014554 A MX2018014554 A MX 2018014554A MX 2018014554 A MX2018014554 A MX 2018014554A MX 2018014554 A MX2018014554 A MX 2018014554A MX 2018014554 A MX2018014554 A MX 2018014554A
Authority
MX
Mexico
Prior art keywords
cytosol
chain variable
variable region
penetrating antibody
heavy chain
Prior art date
Application number
MX2018014554A
Other languages
English (en)
Inventor
Sung Kim Yong
Sun Kim Ji
Yeong Park Jae
Original Assignee
Orum Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020160065379A external-priority patent/KR20170133933A/ko
Priority claimed from KR1020160065365A external-priority patent/KR102000000B1/ko
Application filed by Orum Therapeutics Inc filed Critical Orum Therapeutics Inc
Priority claimed from KR1020170065670A external-priority patent/KR20180129514A/ko
Publication of MX2018014554A publication Critical patent/MX2018014554A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
    • C07K2317/82—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies functional in the cytoplasm, the inner aspect of the cell membrane, the nucleus or the mitochondria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente divulgación se refiere a un anticuerpo que penetra el citosol y su uso, y más específicamente a la identificación de un mecanismo estructural que induce el escape de los endosomas al citosol después de la internalización celular en células vivas a través de una proteína de membrana celular, una región variable de la cadena ligera y/o una región variable de la cadena pesada, que se basa en esta identificación y tiene una capacidad significativamente mejorada para escapar de los endosomas en el citosol, un anticuerpo que penetra el citosol que comprende el mismo, un método para producir el mismo y su uso.
MX2018014554A 2016-05-27 2017-05-26 Anticuerpo penetrante de citosol y uso del mismo. MX2018014554A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1020160065379A KR20170133933A (ko) 2016-05-27 2016-05-27 항체의 상보성 결정 영역의 구조적 변화를 유도하기 위한 방법
KR1020160065365A KR102000000B1 (ko) 2016-05-27 2016-05-27 항체에 엔도좀 탈출능을 부여하는 엔도좀 탈출 구조 모티프 및 이의 활용
PCT/KR2017/005559 WO2017204606A1 (ko) 2016-05-27 2017-05-26 세포질 침투 항체 및 이의 용도
KR1020170065670A KR20180129514A (ko) 2017-05-26 2017-05-26 세포질 침투 항체 및 이의 용도

Publications (1)

Publication Number Publication Date
MX2018014554A true MX2018014554A (es) 2019-09-09

Family

ID=60412784

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018014554A MX2018014554A (es) 2016-05-27 2017-05-26 Anticuerpo penetrante de citosol y uso del mismo.

Country Status (8)

Country Link
US (1) US11155641B2 (es)
JP (1) JP2019520086A (es)
AU (1) AU2017271189B2 (es)
BR (1) BR112018074275A2 (es)
CA (1) CA3025757A1 (es)
IL (1) IL263242A (es)
MX (1) MX2018014554A (es)
WO (1) WO2017204606A1 (es)

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KR101602870B1 (ko) 2014-07-22 2016-03-21 아주대학교산학협력단 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용
KR101602876B1 (ko) 2014-07-22 2016-03-11 아주대학교산학협력단 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용
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WO2019132579A2 (ko) * 2017-12-28 2019-07-04 오름테라퓨틱 주식회사 세포질 침투 항체에 융합된 rna 분해효소를 포함하는 면역독소
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AR124471A1 (es) * 2020-12-23 2023-03-29 Chugai Pharmaceutical Co Ltd Moléculas de unión a antígeno con actividad de penetración en el citosol mejorada
KR102623211B1 (ko) 2021-07-20 2024-01-11 아주대학교산학협력단 세포 내부에 침투하여 표적단백질을 분해하여 제거하는 세포침투 분해항체 및 이의 용도

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KR101602870B1 (ko) 2014-07-22 2016-03-21 아주대학교산학협력단 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용
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Also Published As

Publication number Publication date
NZ749020A (en) 2020-11-27
US20190144566A1 (en) 2019-05-16
BR112018074275A2 (pt) 2019-10-01
CA3025757A1 (en) 2017-11-30
US11155641B2 (en) 2021-10-26
IL263242A (en) 2018-12-31
JP2019520086A (ja) 2019-07-18
WO2017204606A1 (ko) 2017-11-30
AU2017271189B2 (en) 2020-02-20

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