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DE3585657D1 - Gegenseitige trennung von proteinen. - Google Patents

Gegenseitige trennung von proteinen.

Info

Publication number
DE3585657D1
DE3585657D1 DE8585306559A DE3585657A DE3585657D1 DE 3585657 D1 DE3585657 D1 DE 3585657D1 DE 8585306559 A DE8585306559 A DE 8585306559A DE 3585657 A DE3585657 A DE 3585657A DE 3585657 D1 DE3585657 D1 DE 3585657D1
Authority
DE
Germany
Prior art keywords
proteins
mutual separation
mutual
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585306559A
Other languages
English (en)
Other versions
DE3585657A1 (de
Inventor
Koichi Kato
Takao Yamada
Kenji Kawahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1984/000460 external-priority patent/WO1986002068A1/ja
Priority claimed from PCT/JP1985/000274 external-priority patent/WO1986007063A1/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE3585657A1 publication Critical patent/DE3585657A1/de
Publication of DE3585657D1 publication Critical patent/DE3585657D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/24Extraction; Separation; Purification by electrochemical means
    • C07K1/26Electrophoresis
    • C07K1/28Isoelectric focusing
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/55IL-2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/56IFN-alpha

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE8585306559A 1984-09-26 1985-09-16 Gegenseitige trennung von proteinen. Expired - Lifetime DE3585657D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP1984/000460 WO1986002068A1 (en) 1984-09-26 1984-09-26 Mutual separation of proteins
PCT/JP1985/000274 WO1986007063A1 (en) 1985-05-21 1985-05-21 Mutual separation of proteins

Publications (2)

Publication Number Publication Date
DE3585657A1 DE3585657A1 (de) 1992-04-23
DE3585657D1 true DE3585657D1 (de) 1992-04-23

Family

ID=26425064

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585306559A Expired - Lifetime DE3585657D1 (de) 1984-09-26 1985-09-16 Gegenseitige trennung von proteinen.

Country Status (8)

Country Link
EP (1) EP0176299B1 (de)
JP (1) JPH0694476B2 (de)
KR (1) KR860002526A (de)
AU (1) AU599575B2 (de)
DE (1) DE3585657D1 (de)
DK (1) DK431485A (de)
IL (1) IL76360A0 (de)
NZ (1) NZ213615A (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3526096A1 (de) * 1985-07-22 1987-01-22 Basf Ag Verfahren zur reinigung von htnf
CN86104525A (zh) * 1985-07-31 1987-02-25 武田药品工业株式会社 人类白细胞介素-2的分析方法和试剂
DK585886A (da) * 1985-12-24 1987-06-25 Takeda Chemical Industries Ltd Immunstimulerende middel og anvendelse deraf
US5451662A (en) * 1987-10-23 1995-09-19 Schering Corporation Method of purifying protein
EP0391934A1 (de) * 1987-10-23 1990-10-17 Schering Corporation Verfahren zur proteinreinigung
US5250296A (en) * 1990-11-29 1993-10-05 Takeda Chemical Industries, Ltd. Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine
US5416071A (en) * 1991-03-12 1995-05-16 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release containing epo and hyaluronic acid
CA2442210C (en) 2001-03-29 2009-09-08 Schering Corporation Aryl oxime-piperazines useful as ccr5 antagonists
WO2004085406A1 (en) 2003-03-24 2004-10-07 F. Hoffmann-La Roche Ag Benzyl-pyridazinons as reverse transcriptase inhibitors
KR20080056220A (ko) 2005-10-19 2008-06-20 에프. 호프만-라 로슈 아게 페닐-아세트아마이드 nnrt 저해제
PT2057125E (pt) 2006-08-16 2011-05-31 Hoffmann La Roche Inibidores n?o nucle?sidos de transcriptase inversa
AU2007332654B2 (en) 2006-12-13 2013-06-20 F. Hoffmann-La Roche Ag 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors
MX2009012704A (es) 2007-05-30 2009-12-08 Hoffmann La Roche Inhibidores de transcriptasa inversa de no nucleosidos.
WO2009080534A1 (en) 2007-12-21 2009-07-02 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
EP2475678B1 (de) 2009-09-10 2014-10-08 Lonza Biologics Plc. Verfahren und System zur Polypeptidreinigung

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60184A (en) * 1979-05-31 1984-05-31 Schering Ag Process for the specific cleavage of protein sequences from proteins
GR73557B (de) * 1980-01-08 1984-03-15 Biogen Inc
CH651308A5 (de) 1980-07-01 1985-09-13 Hoffmann La Roche Interferone und deren herstellung.
JPS58116498A (ja) * 1981-12-28 1983-07-11 Takeda Chem Ind Ltd Il‐2をコードする新規伝令rnaの製造法
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
CA1341562C (en) * 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell
DE3377363D1 (en) 1982-03-31 1988-08-18 Ajinomoto Kk Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells
EP0092163B1 (de) * 1982-04-20 1988-09-28 Sloan-Kettering Institute For Cancer Research Reinigung von Interleukin-2
JPS58198293A (ja) * 1982-05-12 1983-11-18 Shionogi & Co Ltd インタ−ロイキン等免疫調節因子の製造方法
IE56026B1 (en) 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
IL90047A (en) 1982-10-19 1992-12-01 Cetus Oncology Corp Cysteine-depleted biologically active muteins other than interferon - '
JPS59116231A (ja) * 1982-12-13 1984-07-05 スロ−ン−ケツタリング・インステイテユ−ト・フオ−・キヤンサ−・リサ−チ 抗−インタ−ロイキン−2単クロ−ン抗体
ZA841395B (en) * 1983-03-03 1984-10-31 Hoffmann La Roche Purification of interferon
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
WO1985000606A1 (en) 1983-07-19 1985-02-14 Takeda Chemical Industries, Ltd. Human il-2 and process for its preparation
JPS60115528A (ja) 1983-11-28 1985-06-22 Takeda Chem Ind Ltd ヒトインタ―ロイキン―2蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物
JPS60126088A (ja) 1983-12-13 1985-07-05 Takeda Chem Ind Ltd 新規dνaおよびその用途
JPS60172999A (ja) * 1983-12-20 1985-09-06 Suntory Ltd 新規な塩基性ポリペプチドおよびその製造法
ZA849910B (en) * 1983-12-23 1985-09-25 Hoffmann La Roche Purification of recombinant interleukin-2
AU591464B2 (en) * 1984-08-16 1989-12-07 Savient Pharmaceuticals, Inc. Method of removing n-terminal amino acid residues using aeromonas aminopeptidases

Also Published As

Publication number Publication date
DE3585657A1 (de) 1992-04-23
DK431485D0 (da) 1985-09-24
AU4749685A (en) 1986-04-10
EP0176299B1 (de) 1992-03-18
DK431485A (da) 1986-03-27
JPS6178799A (ja) 1986-04-22
EP0176299A3 (en) 1987-07-15
NZ213615A (en) 1989-08-29
JPH0694476B2 (ja) 1994-11-24
EP0176299A2 (de) 1986-04-02
KR860002526A (ko) 1986-04-26
IL76360A0 (en) 1986-01-31
AU599575B2 (en) 1990-07-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee