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CY1113324T1 - Υποκατεστημενα αμιδικα παραγωγα ως αναστολεις πρωτεϊνικων κινασων - Google Patents

Υποκατεστημενα αμιδικα παραγωγα ως αναστολεις πρωτεϊνικων κινασων

Info

Publication number
CY1113324T1
CY1113324T1 CY20121101137T CY121101137T CY1113324T1 CY 1113324 T1 CY1113324 T1 CY 1113324T1 CY 20121101137 T CY20121101137 T CY 20121101137T CY 121101137 T CY121101137 T CY 121101137T CY 1113324 T1 CY1113324 T1 CY 1113324T1
Authority
CY
Cyprus
Prior art keywords
diseases
suspensions
protein kinase
amide derivatives
substituted amide
Prior art date
Application number
CY20121101137T
Other languages
English (en)
Inventor
Tae-Seong Kim
David Bauer
Steven Bellon
Alessandro Boezio
Shon Booker
Deborah Choquette
Derin D´AMICO
Noel D´Angelo
Celia Dominguez
Ingrid M Fellows
Julie Germain
Russel Graceffa
Jean-Cristophe Harmange
Satoko Hirai
Daniel La
Matthew Lee
Longbin Liu
Mark H Normal
Michele Pothashman
Philip Roveto
Ning Xi
Aaron C Siegmund
Kevin Yang
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of CY1113324T1 publication Critical patent/CY1113324T1/el

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Abstract

Επιλεγμένες ενώσεις είναι αποτελεσματικές για την πρόληψη και τη θεραπεία ασθενειών, όπως ασθενειών που προκαλούνται μέσω HGF. Η εφεύρεση περιλαμβάνει νέες ενώσεις, ανάλογες ενώσεις, προφάρμακα και φαρμακευτικώς αποδεκτά άλατα αυτών, φαρμακευτικές συνθέσεις και μεθόδους για την πρόληψη και τη θεραπεία ασθενειών κι άλλων παθήσεων ή καταστάσεων που ενέχουν καρκίνο κλπ. Η παρούσα εφεύρεση επίσης σχετίζεται με μεθόδους παρασκευής τέτοιων ενώσεων όπως επίσης και με ενδιάμεσες ενώσεις χρήσιμες σε τέτοιες μεθόδους.
CY20121101137T 2005-04-27 2012-11-26 Υποκατεστημενα αμιδικα παραγωγα ως αναστολεις πρωτεϊνικων κινασων CY1113324T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67580505P 2005-04-27 2005-04-27
EP06751834A EP1881976B1 (en) 2005-04-27 2006-04-27 Substituted amide derivatives as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
CY1113324T1 true CY1113324T1 (el) 2016-06-22

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CY20121101137T CY1113324T1 (el) 2005-04-27 2012-11-26 Υποκατεστημενα αμιδικα παραγωγα ως αναστολεις πρωτεϊνικων κινασων

Country Status (34)

Country Link
US (3) US7858623B2 (el)
EP (1) EP1881976B1 (el)
JP (1) JP5463033B2 (el)
KR (1) KR20080004617A (el)
CN (1) CN101248059A (el)
AR (1) AR054262A1 (el)
AU (1) AU2006239216B2 (el)
BR (1) BRPI0608097A2 (el)
CA (1) CA2605680C (el)
CR (1) CR9475A (el)
CY (1) CY1113324T1 (el)
DK (1) DK1881976T3 (el)
EA (1) EA013231B1 (el)
ES (1) ES2396219T3 (el)
GT (1) GT200600181A (el)
HK (1) HK1116161A1 (el)
HN (1) HN2006016313A (el)
HR (1) HRP20121069T1 (el)
IL (1) IL186526A (el)
JO (1) JO2787B1 (el)
MX (1) MX2007013216A (el)
MY (1) MY177111A (el)
NO (1) NO20076093L (el)
NZ (1) NZ562595A (el)
PE (1) PE20061436A1 (el)
PL (1) PL1881976T3 (el)
PT (1) PT1881976E (el)
RS (1) RS52596B (el)
SI (1) SI1881976T1 (el)
TW (1) TWI378094B (el)
UA (1) UA93375C2 (el)
UY (1) UY29503A1 (el)
WO (1) WO2006116713A1 (el)
ZA (1) ZA200708775B (el)

Families Citing this family (164)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0302486D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
WO2005070891A2 (en) * 2004-01-23 2005-08-04 Amgen Inc Compounds and methods of use
ES2438017T3 (es) 2004-07-30 2014-01-15 Methylgene Inc. Inhibidores de la señalización del receptor del VEGF y del receptor del HGF
MX2007014114A (es) 2005-05-10 2008-03-14 Intermune Inc Derivados de piridona para modular el sistema de proteina cinasa activada por estres.
EP1904504B1 (en) 2005-05-20 2014-03-19 MethylGene Inc. Inhibitors of vegf receptor and hgf receptor signaling
AU2006343808B2 (en) * 2005-05-20 2012-03-29 Mirati Therapeutics, Inc. Inhibitors of VEGF receptor and HGF receptor signaling
US7880004B2 (en) 2005-09-15 2011-02-01 Bristol-Myers Squibb Company Met kinase inhibitors
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
TWI333953B (en) * 2005-10-06 2010-12-01 Schering Corp Pyrazolopyrimidines as protein kinase inhibitors
JP2009526761A (ja) 2006-01-30 2009-07-23 アレイ バイオファーマ、インコーポレイテッド ヘテロ二環式チオフェン化合物および使用の方法
US7723330B2 (en) 2006-03-07 2010-05-25 Array Biopharma Inc. Heterobicyclic pyrazole compounds and methods of use
EP2004697A2 (en) 2006-04-07 2008-12-24 The Procter & Gamble Company Antibodies that bind human protein tyrosine phosphatase beta (hptpbeta) and uses thereof
TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
TW200808771A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
ATE528002T1 (de) * 2006-05-19 2011-10-15 Bayer Pharma AG Pyridoncarboxamidderivate zur behandlung hyperproliferativer und angiogenese-vermittelter leiden
WO2008035209A2 (en) * 2006-05-30 2008-03-27 Methylgene Inc. Inhibitors of protein tyrosine kinase activity
JP2009539878A (ja) * 2006-06-08 2009-11-19 アレイ バイオファーマ、インコーポレイテッド キノリン化合物および使用方法
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
EP2038272B8 (en) 2006-06-30 2013-10-23 Sunesis Pharmaceuticals, Inc. Pyridinonyl pdk1 inhibitors
ES2424851T3 (es) 2006-11-08 2013-10-09 Bristol-Myers Squibb Company Compuestos de piridona
AU2007338793B2 (en) 2006-12-20 2012-05-03 Amgen Inc. Heterocyclic compounds and their use in treating inflammation, angiogenesis and cancer
WO2008079294A1 (en) * 2006-12-20 2008-07-03 Amgen Inc. Substituted heterocycles and methods of use
US7687522B2 (en) 2006-12-20 2010-03-30 Amgen Inc. Substituted pyridines and pyrimidines and their use in treatment of cancer
US7737149B2 (en) 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
MX2009008531A (es) * 2007-02-16 2009-08-26 Amgen Inc Cetonas de heterociclilo que contienen nitrogeno y su uso como inhibidores de c-met.
PL2183254T3 (pl) * 2007-08-29 2017-10-31 Methylgene Inc Inhibitory aktywności białkowej kinazy tyrozynowej
ES2593279T3 (es) 2007-08-29 2016-12-07 Methylgene Inc. Procesos e intermedios para preparar inhibidores de cinasa heterocíclicos condensados
WO2009054544A1 (en) * 2007-10-26 2009-04-30 Eisai R & D Management Co., Ltd. Ampa receptor antagonists for parkinson's disease and movement disorders
JP5343082B2 (ja) * 2007-10-29 2013-11-13 アムジエン・インコーポレーテツド ベンゾモルホリン誘導体および使用方法
EP2217591A4 (en) 2007-11-06 2011-10-26 Astrazeneca Ab CERTAIN 2-PYRAZINONE DERIVATIVES AND THEIR USE AS NEUTROPHILES ELASTASE INHIBITORS
PT2235002E (pt) 2008-01-23 2013-01-30 Bristol Myers Squibb Co Compostos de 4-piridinona e a sua utilização para o tratamento do cancro
ES2531396T3 (es) 2008-01-23 2015-03-13 Bristol Myers Squibb Co Proceso para preparar compuestos de piridinona
RU2533827C2 (ru) * 2008-03-05 2014-11-20 Метилджин Инк. Ингибиторы активности протеинтирозинкиназы
WO2009140549A1 (en) * 2008-05-14 2009-11-19 Amgen Inc. Combinations vegf(r) inhibitors and hepatocyte growth factor (c-met) inhibitors for the treatment of cancer
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
TWI365185B (en) 2008-07-24 2012-06-01 Lilly Co Eli Amidophenoxyindazoles useful as inhibitors of c-met
MX2011001904A (es) 2008-08-20 2011-03-29 Pfizer Compuestos de pirrolo[2,3-d]pirimidina.
CA2738314C (en) 2008-09-23 2017-01-10 Georgetown University 1,2-benzisothiazolinone and isoindolinone derivatives
EP2349328A1 (en) * 2008-10-01 2011-08-03 Ludwig Institute For Cancer Research Methods for the treatment of cancer
EP2340244A4 (en) * 2008-10-14 2012-07-25 Ning Xi COMPOUNDS AND APPLICATION PROCEDURES
KR100961410B1 (ko) * 2008-10-14 2010-06-09 (주)네오팜 단백질 키나제 억제제로서 헤테로사이클릭 화합물
EP2373636A4 (en) * 2008-12-05 2012-10-17 Merck Sharp & Dohme INHIBITORS OF PHOSPHOINOSITID DEPENDENT KINASE 1 (PDK1)
US8691866B2 (en) * 2008-12-10 2014-04-08 The General Hospital Corporation HIF inhibitors and use thereof
EP2376491B1 (en) 2008-12-19 2015-03-04 Cephalon, Inc. Pyrrolotriazines as alk and jak2 inhibitors
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
JP5583751B2 (ja) 2009-03-21 2014-09-03 クイ ニング アミノエステル誘導体、その塩、及び使用方法
EP2424841A1 (en) * 2009-04-27 2012-03-07 Elan Pharmaceuticals Inc. Pyridinone antagonists of alpha-4 integrins
BRPI1006897A2 (pt) 2009-07-06 2015-09-08 Akebia Therapeutics Inc compostos, composições e métodos de prevenção da metástase de células cancerosas.
US9340555B2 (en) 2009-09-03 2016-05-17 Allergan, Inc. Compounds as tyrosine kinase modulators
SG178965A1 (en) * 2009-09-03 2012-04-27 Allergan Inc Compounds as tyrosine kinase modulators
US8293925B2 (en) * 2009-09-21 2012-10-23 Chemocentryx, Inc. Pyrrolidinone carboxamide derivatives
EP2483244A1 (en) 2009-10-02 2012-08-08 AstraZeneca AB 2-pyridone compounds used as inhibitors of neutrophil elastase
WO2011051958A1 (en) 2009-10-30 2011-05-05 E.I. Du Pont De Nemours And Company Fungicidal pyrazolones
WO2011080341A1 (en) 2010-01-04 2011-07-07 Enantia, S.L. Process for the preparation of rivaroxaban and intermediates thereof
CN102212062B (zh) * 2010-04-02 2015-04-29 广东东阳光药业有限公司 氨基酯类衍生物及其盐和使用方法
JP2013525286A (ja) * 2010-04-16 2013-06-20 メチルジーン・インコーポレイテッド タンパク質チロシンキナーゼ活性の阻害剤
US8569319B2 (en) 2010-04-29 2013-10-29 Deciphera Pharmaceuticals, LLS Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities
ES2715611T3 (es) 2010-05-17 2019-06-05 Incozen Therapeutics Pvt Ltd Compuestos novedosos de 3H-imidazo[4,5-b]piridina-3,5-disustituida y 3H-[1,2,3]triazolo[4,5-b]piridina 3,5-disustituida como moduladores de proteína cinasas
WO2011161217A2 (en) 2010-06-23 2011-12-29 Palacký University in Olomouc Targeting of vegfr2
US20130102477A1 (en) 2010-06-23 2013-04-25 Ryan D. Morin Biomarkers for non-hodgkin lymphomas and uses thereof
US20130225581A1 (en) * 2010-07-16 2013-08-29 Kyowa Hakko Kirin Co., Ltd Nitrogen-containing aromatic heterocyclic derivative
EP2423208A1 (en) 2010-08-28 2012-02-29 Lead Discovery Center GmbH Pharmaceutically active compounds as Axl inhibitors
PL2614369T3 (pl) 2010-09-10 2016-08-31 Epizyme Inc Sposób określania przydatności inhibitorów ludzkiego ezh2 w leczeniu
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
CN103391773A (zh) 2010-09-27 2013-11-13 埃克塞里艾克西斯公司 用于治疗去势抵抗性前列腺癌和成骨性骨转移的met和vegf的双重抑制剂
SG190735A1 (en) * 2011-02-28 2013-07-31 Calitor Sciences Llc Substituted quinoline compounds and methods of use
KR101940340B1 (ko) 2011-03-04 2019-01-18 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 키나제 억제제로서의 아미노-퀴놀린
TWI598336B (zh) 2011-04-13 2017-09-11 雅酶股份有限公司 經取代之苯化合物
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
WO2013022519A1 (en) 2011-08-10 2013-02-14 Merck Patent Gmbh Pyrido-pyrimidine derivatives
US9428472B2 (en) 2011-08-16 2016-08-30 Georgetown University Methods of treating bacterial infections with 1,2-benzisothiazolinone and isoindolinone derivatives
TWI547494B (zh) 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
MY163296A (en) 2011-08-30 2017-09-15 Astex Pharmaceuticals Inc Drug formulations
MX363351B (es) 2011-10-13 2019-03-20 Aerpio Therapeutics Inc Un agente de unión a hptp?-ecd para usarse en el tratamiento de síndrome de fuga vascular.
ES2774972T3 (es) 2011-10-13 2020-07-23 Aerpio Therapeutics Inc Tratamiento de enfermedades oculares
CA2855980A1 (en) * 2011-11-22 2013-05-30 Deciphera Pharmaceuticals, Llc Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities
CN102643268B (zh) * 2011-12-30 2014-05-21 沈阳药科大学 喹啉类及噌啉类化合物及其应用
CN103319468B (zh) * 2012-03-21 2016-07-13 广东东阳光药业有限公司 取代的螺双环化合物及其使用方法和用途
EA026412B1 (ru) 2012-03-30 2017-04-28 Ризен Фармасьютикалз Са НОВЫЕ СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ c-MET ПРОТЕИНКИНАЗ
LT3184523T (lt) 2012-04-13 2020-02-10 Epizyme Inc N-((4,6-dimetil-2-okso-1,2-dihidropiridin-3-il)metil)-5-(etil (tetrahidro-2h-piran-4-il)amino)-4-metil-4'-(morfolinometil)-[1,1'-bifenil]-3-karboksamido hidrobromidas, skirtas naudoti hematologinės sistemos proliferacinio sutrikimo gydymui
CN103420986A (zh) * 2012-05-18 2013-12-04 广东东阳光药业有限公司 取代的喹啉化合物及其使用方法和用途
PL2864291T3 (pl) * 2012-06-26 2017-07-31 Bayer Pharma Aktiengesellschaft N-[4-(chinolin-4-yloksy)cykloheksylo(metylo)](hetero)arylokarboksyamidy jako antagoniści receptora androgenowego, ich wytwarzanie i zastosowanie jako produktów medycznych
TWI520962B (zh) * 2012-06-29 2016-02-11 As the c-Met tyrosine kinase inhibitors novel fused pyridine derivatives
CN104507930B (zh) * 2012-06-29 2017-10-10 贝达药业股份有限公司 作为c‑Met酪氨酸激酶抑制剂的新型稠合吡啶衍生物
CN103565653B (zh) * 2012-07-16 2017-01-25 广东东阳光药业有限公司 取代的吡唑酮化合物及其使用方法和用途
CA2876246C (en) 2012-07-28 2019-05-07 Calitor Sciences, Llc Substituted pyrazolone compounds and methods of use
US8975282B2 (en) 2012-07-28 2015-03-10 Sunshine Lake Pharma Co., Ltd. Substituted pyrazolone compounds and methods of use
TWI565702B (zh) * 2012-08-03 2017-01-11 習寧 取代的吡唑酮化合物及其使用方法
KR101350006B1 (ko) * 2012-09-06 2014-02-13 씨제이제일제당 (주) 피리돈 유도체를 포함하는 단백질 키나제 억제제
AR092530A1 (es) 2012-09-13 2015-04-22 Glaxosmithkline Llc Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
AR092529A1 (es) 2012-09-13 2015-04-22 Glaxosmithkline Llc Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
EP2906537B1 (en) 2012-10-15 2020-03-11 Epizyme, Inc. Substituted benzene compounds
US20140179712A1 (en) 2012-12-21 2014-06-26 Astrazeneca Ab Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide
US9353122B2 (en) 2013-02-15 2016-05-31 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
CN107915751A (zh) 2013-02-20 2018-04-17 卡拉制药公司 治疗性化合物和其用途
US9650364B2 (en) 2013-02-21 2017-05-16 GlaxoSmithKline Intellectual Property Development Limted Quinazolines as kinase inhibitors
US20150050277A1 (en) 2013-03-15 2015-02-19 Aerpio Therapeutics Inc. Compositions and methods for treating ocular diseases
JP6572201B2 (ja) 2013-03-15 2019-09-04 エアーピオ セラピューティクス インコーポレイテッド 眼疾患を処置するための組成物、製剤、および方法
NO3003315T3 (el) 2013-06-06 2018-06-16
TWI649308B (zh) 2013-07-24 2019-02-01 小野藥品工業股份有限公司 喹啉衍生物
FI3057962T3 (fi) 2013-10-16 2023-11-03 Epizyme Inc Hydrokloridisuolamuoto ezh2-estoon
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9458169B2 (en) 2013-11-01 2016-10-04 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3116503A4 (en) 2014-03-14 2017-08-23 Aerpio Therapeutics, Inc. Hptp-beta inhibitors
CN110452216B (zh) 2014-04-02 2022-08-26 英特穆恩公司 抗纤维化吡啶酮类
CN104974162B (zh) * 2014-04-09 2018-09-14 广东东阳光药业有限公司 双环吡唑酮化合物及其使用方法和用途
US20150299219A1 (en) * 2014-04-22 2015-10-22 Calitor Sciences, Llc Bicyclic pyrazolone compounds and methods of use
WO2016104617A1 (ja) * 2014-12-25 2016-06-30 小野薬品工業株式会社 キノリン誘導体
BR112017021929B1 (pt) 2015-04-14 2023-05-09 Qurient Co., Ltd. Derivados de quinolina como inibidores tam rtk, composição farmacêutica compreendendo os referidos derivados e uso destes
CN106279147A (zh) 2015-05-21 2017-01-04 中国科学院上海药物研究所 一种吡啶并氮杂环化合物及其制备方法和用途
MX2018000016A (es) 2015-07-02 2019-01-31 Otsuka Pharma Co Ltd Composiciones farmaceuticas liofilizadas.
JP6721617B2 (ja) 2015-07-20 2020-07-15 ベータ ファーマシューティカルズ カンパニー リミテッド 縮合ピリジン誘導体のマレエートの結晶形態およびその使用
CN106632253B (zh) * 2015-11-02 2019-03-22 广东东阳光药业有限公司 一种取代的喹啉化合物的晶型及其药物组合物和用途
CN106632254B (zh) * 2015-11-02 2019-03-01 广东东阳光药业有限公司 一种取代的喹啉化合物的晶型及其药物组合物和用途
EP3373934B1 (en) * 2015-11-14 2020-05-20 Sunshine Lake Pharma Co., Ltd. Crystalline form of a substituted quinoline compound and pharmaceutical compositions thereof
ES2911678T3 (es) * 2015-11-14 2022-05-20 Sunshine Lake Pharma Co Ltd Forma cristalina de un compuesto de quinolina sustituida y composiciones farmacéuticas de la misma
CA3012832A1 (en) 2016-02-05 2017-08-10 Denali Therapeutics Inc. N-azepinyl-carboxamide inhibitors of receptor-interacting protein kinase1
CN107286140A (zh) * 2016-04-12 2017-10-24 上海医药工业研究院 取代芳胺基芳杂环类化合物及其作为抗肿瘤药物的应用
WO2017198196A1 (zh) * 2016-05-18 2017-11-23 王子厚 具有抗肿瘤活性的喹啉衍生物
EP3509423A4 (en) 2016-09-08 2020-05-13 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
CA3036065A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN110099898B (zh) 2016-10-24 2023-07-25 优曼尼蒂治疗公司 化合物及其用途
PL3552017T3 (pl) 2016-12-09 2022-08-08 Denali Therapeutics Inc. Związki użyteczne jako inhibitory RIPK1
PT3575293T (pt) 2017-01-26 2021-05-25 Ono Pharmaceutical Co Sal de etanossulfonato de n-{5-[(6,7-dimetoxi-4-quinolinil)oxi]-2-piridinil}-2,5-dioxo-1-fenil-1,2,5,6,7,8-hexahidro-3-quinolinocarboxamida
ES2888298T3 (es) 2017-04-27 2022-01-03 Astrazeneca Ab Compuestos de C5-anilinoquinazolina y su uso en el tratamiento de cáncer
CA3070013A1 (en) 2017-07-18 2019-01-24 Bayer Pharma Aktiengesellschaft Substituted pyrrolopyridine-derivatives
JP2020529409A (ja) 2017-08-03 2020-10-08 大塚製薬株式会社 薬物化合物およびその精製方法
WO2019048988A1 (en) 2017-09-08 2019-03-14 Pi Industries Ltd. NOVEL FUNGICIDE HETEROCYCLIC COMPOUNDS
KR20200105652A (ko) 2017-09-08 2020-09-08 피아이 인더스트리스 엘티디. 새로운 살균성 헤테로시클릭 화합물
US11826363B2 (en) 2017-10-13 2023-11-28 Ono Pharmaceutical Co., Ltd. Therapeutic agent for solid cancers, which comprises Axl inhibitor as active ingredient
WO2019084157A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. COMPOUNDS AND USES THEREOF
WO2019141202A1 (zh) * 2018-01-17 2019-07-25 南京药捷安康生物科技有限公司 Tam家族激酶/和csf1r激酶抑制剂及其用途
CA3072169C (en) 2018-03-08 2022-04-19 Wellmarker Bio Co., Ltd. Thienopyridine derivatives and pharmaceutical composition comprising same
CA3094527A1 (en) * 2018-03-23 2019-09-26 Yumanity Therapeutics, Inc. Compounds and uses thereof
CN110372666B (zh) * 2018-04-13 2022-11-08 华东理工大学 喹唑啉类化合物作为egfr三突变抑制剂及其应用
CN110511218A (zh) * 2018-05-21 2019-11-29 中国科学院上海药物研究所 一类并环吡唑啉酮甲酰胺类化合物及其制备方法、药物组合物和用途
CN111484442B (zh) * 2018-06-01 2021-11-09 杭州阿诺生物医药科技有限公司 一种具有抗肿瘤活性的csf1r抑制剂中间体的制备方法
CN108727386A (zh) * 2018-07-16 2018-11-02 广州医科大学 一种吡唑并嘧啶类化合物及其制备方法和用途
PL3842425T3 (pl) * 2018-08-24 2024-08-19 Transthera Sciences (Nanjing), Inc. Nowy inhibitor będący pochodną chinoliny
EP3894406A1 (en) 2018-12-11 2021-10-20 Bayer Aktiengesellschaft Substituted pyrrolopyridine-derivatives
CN111303024B (zh) * 2018-12-12 2023-03-28 安徽中科拓苒药物科学研究有限公司 一种喹啉结构的pan-KIT激酶抑制剂及其用途
SG11202108079RA (en) 2019-01-24 2021-08-30 Yumanity Therapeutics Inc Compounds and uses thereof
NL2022471B1 (en) 2019-01-29 2020-08-18 Vationpharma B V Solid state forms of oclacitinib
EP4005637A4 (en) * 2019-07-29 2023-07-19 Takeda Pharmaceutical Company Limited Heterocyclic compound
EP4007638A1 (en) * 2019-08-02 2022-06-08 Amgen Inc. Pyridine derivatives as kif18a inhibitors
WO2021023888A1 (en) * 2019-08-08 2021-02-11 B.C.I. Pharma Isoquinoline derivatives as protein kinase inhibitors
WO2021045279A1 (ko) 2019-09-06 2021-03-11 웰마커바이오 주식회사 바이오마커 기반 치료용 조성물
CN112625026B (zh) * 2019-09-24 2022-09-09 药捷安康(南京)科技股份有限公司 Tam家族激酶抑制剂的喹啉衍生物
WO2021062245A1 (en) * 2019-09-26 2021-04-01 Exelixis, Inc. Pyridone compounds and methods of use in the modulation of a protein kinase
CN113121429B (zh) * 2020-01-15 2024-04-26 鲁南制药集团股份有限公司 一种c-Met激酶抑制剂及其制备方法和应用
WO2021173591A1 (en) * 2020-02-24 2021-09-02 Exelixis, Inc. Compounds and methods of use
CN111440174B (zh) * 2020-04-02 2021-07-09 广州医科大学 一种吡啶酰胺类化合物及其制备方法与应用
WO2021249913A1 (en) 2020-06-09 2021-12-16 Bayer Aktiengesellschaft 2'-(quinolin-3-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxylate derivatives and related compounds as map4k1 (hpk1) inhibitors for the treatment of cancer
US20240174683A1 (en) 2021-02-05 2024-05-30 Bayer Aktiengesellschaft Map4k1 inhibitors
KR20230170039A (ko) 2021-04-13 2023-12-18 뉴베일런트, 아이엔씨. Egfr 돌연변이를 지니는 암을 치료하기 위한 아미노-치환된 헤테로사이클
MX2023014754A (es) 2021-06-18 2024-02-12 Aligos Therapeutics Inc Métodos y composiciones dirigidos a pd-l1.
TW202315628A (zh) * 2021-06-24 2023-04-16 南韓商Lg化學股份有限公司 作為ron抑制劑之新穎吡啶衍生物化合物
CN113999205B (zh) * 2021-12-13 2023-09-15 辽宁大学 含三氮唑酮酰胺和咪唑酰胺结构的吡啶类化合物及其应用
AU2023206890A1 (en) 2022-01-12 2024-08-22 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide
CN117362275A (zh) * 2022-06-29 2024-01-09 广州百霆医药科技有限公司 一种酪氨酸蛋白激酶抑制剂及其用途
CN116283920B (zh) * 2023-03-31 2024-04-16 贵州医科大学 2,4-二取代吡啶类化合物及其应用

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3755332A (en) 1971-07-01 1973-08-28 Ciba Geigy Corp Substituted 4 indazolaminoquinolines
DE2948434A1 (de) * 1979-12-01 1981-06-11 Hoechst Ag, 6000 Frankfurt 1-piperidinsulfonylharnstoffe und verfahren zu ihrer herstellung
JPS63145272A (ja) 1986-12-09 1988-06-17 Morishita Seiyaku Kk 4,5−ジヒドロ−6−(4−置換フエニル)−3(2h)−ピリダジノン誘導体
US4916135A (en) 1989-05-08 1990-04-10 Hoechst Roussel Pharmaceuticals Inc. N-heteroaryl-4-quinolinamines
GB9323290D0 (en) 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
JPH08193070A (ja) * 1995-01-11 1996-07-30 Mitsubishi Chem Corp 2−イミダゾリジノン誘導体及びそれを有効成分とする除草剤、並びにその製造中間体
AU4547396A (en) 1995-01-31 1996-08-21 Zenyaku Kogyo Kabushiki Kaisha Thioquinoline derivatives
GB9505702D0 (en) 1995-03-21 1995-05-10 Agrevo Uk Ltd Fungicidal compounds
GB9505651D0 (en) 1995-03-21 1995-05-10 Agrevo Uk Ltd AgrEvo UK Limited
GB9514265D0 (en) 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
DE69622183D1 (de) 1995-11-07 2002-08-08 Kirin Brewery Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen
ATE201873T1 (de) 1995-11-14 2001-06-15 Pharmacia & Upjohn Spa Aryl- und heteroaryl- purin- und pyridopyrimidin- derivate
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
DE19614718A1 (de) 1996-04-15 1997-10-16 Hoechst Schering Agrevo Gmbh Substituierte Pyridine/Pyrimidine, Verfahren zu ihrer Herstellung, und ihre Verwendung als Schädlingsbekämpfungsmittel
KR20000075615A (ko) 1997-02-19 2000-12-26 벌렉스 래보라토리즈, 인크. Nos 억제제로서의 n-헤테로시클릭 유도체
JP4194678B2 (ja) 1997-11-28 2008-12-10 キリンファーマ株式会社 キノリン誘導体およびそれを含む医薬組成物
GB9800575D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
AU3534699A (en) 1998-04-23 1999-11-08 Takeda Chemical Industries Ltd. Naphthalene derivatives, their production and use
CA2333392A1 (en) 1998-05-28 1999-12-02 Parker Hughes Institute Quinazolines for treating brain tumor
EP1105378B1 (en) 1998-08-21 2005-03-30 Parker Hughes Institute Quinazoline derivatives
IL144461A0 (en) 1999-01-22 2002-05-23 Kirin Brewery Quinoline and quinazoline derivatives and pharmaceutical compositions containing them
CA2362715C (en) 1999-02-10 2010-10-19 Astrazeneca Ab Quinazoline derivatives as angiogenesis inhibitors
GB9904103D0 (en) 1999-02-24 1999-04-14 Zeneca Ltd Quinoline derivatives
US6258820B1 (en) 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
EP1183254B1 (en) 1999-04-12 2005-01-12 Aventis Pharma Limited Substituted bicyclic heteroaryl compounds as integrin antagonists
EE200200149A (et) 1999-09-21 2003-04-15 Astrazeneca Ab Kinasoliinühendid ja neid sisaldavad ravimkoostised
WO2001070734A2 (en) 2000-03-17 2001-09-27 Bristol-Myers Squibb Pharma Company Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha
WO2001070673A2 (en) 2000-03-17 2001-09-27 Bristol-Myers Squibb Pharma Company CYCLIC β-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-$g(a)
WO2002000005A1 (en) 2000-06-21 2002-01-03 Alexion Pharmaceuticals, Inc. Libraries displaying human antibody fragments with hybrid complementarity determining regions
KR100896664B1 (ko) 2000-09-15 2009-05-14 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제로서 유용한 피라졸 화합물
EP1326859A1 (en) 2000-10-13 2003-07-16 AstraZeneca AB Quinazoline derivatives with anti-tumour activity
KR100589032B1 (ko) 2000-10-20 2006-06-14 에자이 가부시키가이샤 질소 함유 방향환 유도체
DE60239097D1 (de) 2001-03-02 2011-03-17 Gpc Biotech Ag Drei-hybrid-assaysystem
PT1370553E (pt) 2001-03-23 2006-09-29 Bayer Corp Inibidores de rhoquinase
WO2002098426A1 (en) 2001-06-06 2002-12-12 Aventis Pharma Limtied Substituted tetrahydroisoquinolines for use in the treatment of inflammatory diseases
EP1411046B1 (en) 2001-06-22 2009-09-16 Kirin Pharma Kabushiki Kaisha Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus proliferator receptor, and medicinal composition containing the same
SE0102439D0 (sv) 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
AU2001271166A1 (en) 2001-07-05 2002-01-08 Telefonaktiebolaget Lm Ericsson (Publ) Detrimental latch-up avoidance
GB0126433D0 (en) 2001-11-03 2002-01-02 Astrazeneca Ab Compounds
BR0213842A (pt) 2001-11-03 2004-08-31 Astrazeneca Ab Derivado de quinazolina ou um sal deste farmaceuticamente aceitável, processo para a preparação do mesmo, composição farmacêutica, e, uso do derivado de quinazolina ou de um sal deste farmaceuticamente aceitável
UA81619C2 (ru) 2002-02-01 2008-01-25 Астразенека Аб Хиназолиновые соединения, способ их получения (варианты), фармацевтическая композиция на их основе
US6818772B2 (en) * 2002-02-22 2004-11-16 Abbott Laboratories Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
US7645878B2 (en) 2002-03-22 2010-01-12 Bayer Healthcare Llc Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
KR101071123B1 (ko) 2002-03-29 2011-10-07 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 치환된 벤자졸 및 raf 키나아제 저해제로서의 그들의이용
AU2003257666A1 (en) 2002-08-23 2004-03-11 Kirin Beer Kabushiki Kaisha COMPOUND HAVING TGFss INHIBITORY ACTIVITY AND MEDICINAL COMPOSITION CONTAINING THE SAME
WO2004030672A1 (en) 2002-10-02 2004-04-15 Merck Patent Gmbh Use of 4 amino-quinazolines as anti cancer agents
US7495016B2 (en) 2002-10-21 2009-02-24 Irm Llc Pyrrolidones with anti-HIV activity
TW200418466A (en) 2002-11-06 2004-10-01 Smithkline Beecham Corp Chemical compounds
TW200500341A (en) * 2002-11-12 2005-01-01 Astrazeneca Ab Novel compounds
GB0226724D0 (en) 2002-11-15 2002-12-24 Merck Sharp & Dohme Therapeutic agents
CA2517166A1 (en) 2003-02-28 2004-09-16 Encysive Pharmaceuticals Inc. Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-ii receptor antagonists
CA2517291C (en) 2003-03-19 2012-05-08 Exelixis, Inc. Ortho-substituted aryl and heteroaryl tie-2 modulators and methods of use
US7531553B2 (en) 2003-03-21 2009-05-12 Amgen Inc. Heterocyclic compounds and methods of use
GB0310401D0 (en) 2003-05-07 2003-06-11 Astrazeneca Ab Therapeutic agent
CA2531485C (en) 2003-07-07 2013-03-26 Merck Patent Gmbh Malonamide derivatives
CA2536788A1 (en) 2003-08-29 2005-03-10 Pfizer Inc. Naphthalene carboxamides and their derivatives useful as new anti-angiogenic agents
WO2005030140A2 (en) 2003-09-26 2005-04-07 Exelixis, Inc. C-met modulators and methods of use
AU2004281154A1 (en) 2003-10-16 2005-04-28 Novartis Vaccines And Diagnostics, Inc. 2,6-disubstituted quinazolines, quinoxalines, quinolines and isoquinolines as inhibitors of Raf kinase for treatment of cancer
EP1711495A2 (en) 2004-01-23 2006-10-18 Amgen Inc. Quinoline, quinazoline, pyridine and pyrimidine counds and their use in the treatment of inflammation, angiogenesis and cancer
WO2005070891A2 (en) 2004-01-23 2005-08-04 Amgen Inc Compounds and methods of use
TW200538120A (en) 2004-02-20 2005-12-01 Kirin Brewery Compound having TGF-beta inhibitory activity and pharmaceutical composition containing same
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
US7523317B2 (en) 2004-04-29 2009-04-21 International Business Machines Corporation Computer grid access management system
US7173031B2 (en) * 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors

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