[go: up one dir, main page]

GB9514265D0 - Hetrocyclic compounds - Google Patents

Hetrocyclic compounds

Info

Publication number
GB9514265D0
GB9514265D0 GBGB9514265.9A GB9514265A GB9514265D0 GB 9514265 D0 GB9514265 D0 GB 9514265D0 GB 9514265 A GB9514265 A GB 9514265A GB 9514265 D0 GB9514265 D0 GB 9514265D0
Authority
GB
United Kingdom
Prior art keywords
hetrocyclic compounds
hetrocyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB9514265.9A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GBGB9514265.9A priority Critical patent/GB9514265D0/en
Publication of GB9514265D0 publication Critical patent/GB9514265D0/en
Priority to HR9514265.9A priority patent/HRP960316A2/en
Priority to EP96925710A priority patent/EP0843671A1/en
Priority to AU66139/96A priority patent/AU6613996A/en
Priority to JP9505503A priority patent/JPH11508906A/en
Priority to PCT/EP1996/003026 priority patent/WO1997003069A1/en
Priority to ZA9605935A priority patent/ZA965935B/en
Priority to UY24313A priority patent/UY24313A1/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GBGB9514265.9A 1995-07-13 1995-07-13 Hetrocyclic compounds Pending GB9514265D0 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
GBGB9514265.9A GB9514265D0 (en) 1995-07-13 1995-07-13 Hetrocyclic compounds
HR9514265.9A HRP960316A2 (en) 1995-07-13 1996-07-04 Heterocyclic compounds
EP96925710A EP0843671A1 (en) 1995-07-13 1996-07-11 Heterocyclic compounds and pharmaceutical compositions containing them
AU66139/96A AU6613996A (en) 1995-07-13 1996-07-11 Heterocyclic compounds and pharmaceutical compositions containing them
JP9505503A JPH11508906A (en) 1995-07-13 1996-07-11 Heterocyclic compounds and pharmaceutical compositions containing them
PCT/EP1996/003026 WO1997003069A1 (en) 1995-07-13 1996-07-11 Heterocyclic compounds and pharmaceutical compositions containing them
ZA9605935A ZA965935B (en) 1995-07-13 1996-07-12 Heterocyclic compounds.
UY24313A UY24313A1 (en) 1995-07-13 1996-08-21 PROCEDURE FOR PREPARING HETEROCYCLIC COMPOUNDS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9514265.9A GB9514265D0 (en) 1995-07-13 1995-07-13 Hetrocyclic compounds

Publications (1)

Publication Number Publication Date
GB9514265D0 true GB9514265D0 (en) 1995-09-13

Family

ID=10777551

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9514265.9A Pending GB9514265D0 (en) 1995-07-13 1995-07-13 Hetrocyclic compounds

Country Status (7)

Country Link
EP (1) EP0843671A1 (en)
JP (1) JPH11508906A (en)
AU (1) AU6613996A (en)
GB (1) GB9514265D0 (en)
HR (1) HRP960316A2 (en)
WO (1) WO1997003069A1 (en)
ZA (1) ZA965935B (en)

Families Citing this family (195)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW321649B (en) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5932574A (en) * 1995-04-27 1999-08-03 Zeneca Limited Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
AU719434B2 (en) 1996-02-13 2000-05-11 Astrazeneca Ab Quinazoline derivatives as VEGF inhibitors
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
ES2169355T3 (en) 1996-03-05 2002-07-01 Astrazeneca Ab DERIVATIVES OF 4-ANILINOQUINAZOLINA.
DE69710712T3 (en) 1996-04-12 2010-12-23 Warner-Lambert Co. Llc REVERSIBLE INHIBITORS OF TYROSINE KINASEN
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9707800D0 (en) 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
EP0912559B1 (en) 1996-07-13 2002-11-06 Glaxo Group Limited Fused heterocyclic compounds as protein tyrosine kinase inhibitors
JP2002505660A (en) 1996-09-10 2002-02-19 ファルマシア・アンド・アップジョン・カンパニー 8-Hydroxy-7-substituted quinolines as antiviral agents
CN1252054C (en) 1996-09-25 2006-04-19 曾尼卡有限公司 Qinoline derivatives inhibiting effect of growth factors such as VEGF
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
US7863444B2 (en) 1997-03-19 2011-01-04 Abbott Laboratories 4-aminopyrrolopyrimidines as kinase inhibitors
WO1998056376A1 (en) * 1997-06-13 1998-12-17 Sugen, Inc. Novel heteroaryl compounds for the modulation of protein tyrosine enzyme related cellular signal transduction
US6294532B1 (en) 1997-08-22 2001-09-25 Zeneca Limited Oxindolylquinazoline derivatives as angiogenesis inhibitors
RS49779B (en) 1998-01-12 2008-06-05 Glaxo Group Limited, BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS
GB9800575D0 (en) * 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
US6706721B1 (en) 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
KR20010089171A (en) * 1998-08-21 2001-09-29 추후제출 Quinazoline derivatives
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
HK1039126B (en) * 1998-10-08 2005-09-30 阿斯特拉曾尼卡有限公司 Quinazoline derivatives
GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
JP2002534468A (en) 1999-01-13 2002-10-15 バイエル コーポレイション ω-Carboxyaryl-substituted diphenylureas as p38 kinase inhibitors
WO2000043383A1 (en) * 1999-01-20 2000-07-27 Smithkline Beecham P.L.C. Piperidinylquinolines as protein tyrosine kinase inhibitors
MXPA01008182A (en) 1999-02-10 2003-08-20 Astrazeneca Ab Quinazoline derivatives as angiogenesis inhibitors.
GB9904103D0 (en) 1999-02-24 1999-04-14 Zeneca Ltd Quinoline derivatives
GB9910580D0 (en) 1999-05-08 1999-07-07 Zeneca Ltd Chemical compounds
GB9910579D0 (en) 1999-05-08 1999-07-07 Zeneca Ltd Chemical compounds
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
TWI262914B (en) * 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
AU6578900A (en) 1999-07-07 2001-01-30 Astrazeneca Uk Limited Quinazoline derivatives
JP2003504363A (en) 1999-07-09 2003-02-04 グラクソ グループ リミテッド Anilinoquinazolines as protein tyrosine kinase inhibitors
US6933299B1 (en) 1999-07-09 2005-08-23 Smithkline Beecham Corporation Anilinoquinazolines as protein tyrosine kinase inhibitors
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
US7071199B1 (en) 1999-09-17 2006-07-04 Abbott Gmbh & Cco. Kg Kinase inhibitors as therapeutic agents
CN1390219A (en) 1999-09-17 2003-01-08 艾博特股份有限两合公司 Pyrazolopyrimidines as therapeutic agents
EP1676845B1 (en) 1999-11-05 2008-06-11 AstraZeneca AB New quinazoline derivatives
UA74803C2 (en) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. A stable polymorph of n-(3-ethynylphenyl)-6,7-bis(2-methoxyetoxy)-4-quinazolinamine hydrochloride, a method for producing thereof (variants) and pharmaceutical use
US7087613B2 (en) 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
WO2001066099A2 (en) 2000-03-06 2001-09-13 Astrazeneca Ab Use of quinazoline derivatives as angiogenesis inhibitors
WO2001076630A1 (en) * 2000-04-06 2001-10-18 Kyowa Hakko Kogyo Co., Ltd. Diagnostics and remedies for rheumatoid arthritis
DK1274692T3 (en) 2000-04-07 2006-10-30 Astrazeneca Ab quinazoline
UA73993C2 (en) 2000-06-06 2005-10-17 Астразенека Аб Quinazoline derivatives for the treatment of tumours and a pharmaceutical composition
AU7425801A (en) 2000-06-24 2002-01-08 Astrazeneca Ab Guanidine derivatives of quinazoline and quinoline for use in the treatment of autoimmune diseases
RU2283311C2 (en) 2000-06-28 2006-09-10 Астразенека Аб Quinazoline substituted derivatives and their using as inhibitors
NZ523749A (en) 2000-07-26 2005-03-24 Smithkline Beecham P Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
WO2002012226A1 (en) 2000-08-09 2002-02-14 Astrazeneca Ab Quinoline derivatives having vegf inhibiting activity
CA2419301C (en) 2000-08-21 2009-12-08 Astrazeneca Ab Quinazoline derivatives
ATE448226T1 (en) 2000-09-01 2009-11-15 Novartis Vaccines & Diagnostic AZA HETEROCYCLIC DERIVATIVES AND THEIR THERAPEUTIC USE
AP1666A (en) 2000-09-11 2006-09-29 Chiron Corp Quinolinone derivatives as tyrosine kinase inhibitors.
HUP0302221A3 (en) 2000-09-20 2004-01-28 Merck Patent Gmbh 4-amino-quinazolines
AU2001292138A1 (en) 2000-10-13 2002-04-22 Astrazeneca Ab Quinazoline derivatives with anti-tumour activity
DE60134679D1 (en) 2000-10-20 2008-08-14 Eisai R&D Man Co Ltd Nitrogen-containing aromatic heterocycles
US20040063733A1 (en) * 2000-10-25 2004-04-01 Lambert Christine Marie Paul Quinazoline derivatives
JP4564713B2 (en) 2000-11-01 2010-10-20 ミレニアム・ファーマシューティカルズ・インコーポレイテッド Nitrogen heterocyclic compounds, and methods for making nitrogen heterocyclic compounds and intermediates thereof
JP2004514718A (en) 2000-11-02 2004-05-20 アストラゼネカ アクチボラグ Substituted quinolines as anticancer agents
WO2002036570A1 (en) 2000-11-02 2002-05-10 Astrazeneca Ab 4-substituted quinolines as antitumor agents
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
DK1370553T3 (en) * 2001-03-23 2006-09-11 Bayer Corp Rho kinase inhibitors
AR035792A1 (en) * 2001-03-23 2004-07-14 Bayer Corp COMPOUNDS OF N- (4-QUINAZOLINIL) -N- (1H-INDAZOL-5-IL) AMINA, INHIBITOR OF RHO-KINASE, ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND METHOD TO PREPARE IT
CA2440842A1 (en) 2001-04-16 2002-10-24 Eisai Co., Ltd. Novel 1h-indazole compounds
WO2002085895A1 (en) 2001-04-19 2002-10-31 Astrazeneca Ab Quinazoline derivatives
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US7829566B2 (en) 2001-09-17 2010-11-09 Werner Mederski 4-amino-quinazolines
KR100810468B1 (en) * 2001-10-10 2008-03-07 씨제이제일제당 (주) 1H-indole derivative having excellent selectivity as an inhibitor of cyclooxygenase-2
ATE423104T1 (en) * 2001-11-03 2009-03-15 Astrazeneca Ab QUINAZOLINE DERIVATIVES AS ANTI-TUMOR AGENT
GB0126433D0 (en) * 2001-11-03 2002-01-02 Astrazeneca Ab Compounds
WO2003055866A1 (en) * 2001-12-21 2003-07-10 Bayer Pharmaceuticals Corporation Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
RU2323215C2 (en) 2001-12-24 2008-04-27 Астразенека Аб Substituted derivatives of quinazoline as aurorakinase inhibitors
AU2003202263A1 (en) 2002-01-10 2003-07-30 Bayer Healthcare Ag Roh-kinase inhibitors
ES2298497T3 (en) 2002-01-23 2008-05-16 Bayer Pharmaceuticals Corporation QUINASA RHO INHIBITORS.
WO2003062225A1 (en) 2002-01-23 2003-07-31 Bayer Pharmaceuticals Corporation Pyrimidine derivatives as rho-kinase inhibitors
EP1470125A1 (en) 2002-01-29 2004-10-27 Glaxo Group Limited Aminopiperidine derivatives
JP4508650B2 (en) 2002-01-29 2010-07-21 グラクソ グループ リミテッド Aminopiperidine compound, process for producing the compound and pharmaceutical composition containing the compound
US7268230B2 (en) * 2002-02-01 2007-09-11 Astrazeneca Ab Quinazoline compounds
PT1478358E (en) 2002-02-11 2013-09-11 Bayer Healthcare Llc Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis
TW200302722A (en) * 2002-02-13 2003-08-16 Astrazeneca Ab Therapeutic agents
US7645878B2 (en) * 2002-03-22 2010-01-12 Bayer Healthcare Llc Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
GB0215823D0 (en) 2002-07-09 2002-08-14 Astrazeneca Ab Quinazoline derivatives
JP2005536486A (en) 2002-07-09 2005-12-02 アストラゼネカ アクチボラグ Quinazoline derivatives for use in the treatment of cancer
EP1521747B1 (en) 2002-07-15 2018-09-05 Symphony Evolution, Inc. Receptor-type kinase modulators and methods of use
CA2494061C (en) 2002-07-31 2011-06-14 Wayne R. Danter Protein tyrosine kinase inhibitors
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
CA2496164C (en) 2002-08-23 2010-11-09 Chiron Corporation Benzimidazole quinolinones and uses thereof
AU2003273675A1 (en) 2002-10-09 2004-05-04 Wayne R. Danter Protein tyrosine kinase inhibitors
WO2004041277A1 (en) * 2002-11-01 2004-05-21 Merck & Co., Inc. Carbonylamino-benzimidazole derivatives as androgen receptor modulators
GB0225579D0 (en) 2002-11-02 2002-12-11 Astrazeneca Ab Chemical compounds
CN100354278C (en) * 2002-11-04 2007-12-12 阿斯利康(瑞典)有限公司 Quinazoline derivatives as SRC tyrosine kinase inhibitors
ES2300619T3 (en) * 2002-11-04 2008-06-16 Astrazeneca Ab QUINOLINE DERIVATIVES AS INHIBITORS OF SRC THYROSINE QUINASE.
MXPA05004754A (en) 2002-11-13 2005-08-02 Chiron Corp Methods of treating cancer and related methods.
DE10260730A1 (en) 2002-12-23 2004-07-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel substituted nitrogen-containing heterobicyclene, their preparation and their use as pharmaceuticals
US7429597B2 (en) 2002-12-23 2008-09-30 Boehringer Ingelheim Pharma Gmbh & Co., Kg Substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions
PL221490B1 (en) 2002-12-24 2016-04-29 Astrazeneca Ab Phosphonooxy quinazoline derivatives and their pharmaceutical use
GB0307333D0 (en) * 2003-03-29 2003-05-07 Astrazeneca Ab Therapeutic agent
GB0309009D0 (en) * 2003-04-22 2003-05-28 Astrazeneca Ab Quinazoline derivatives
GB0309850D0 (en) 2003-04-30 2003-06-04 Astrazeneca Ab Quinazoline derivatives
DK1636585T3 (en) 2003-05-20 2008-05-26 Bayer Pharmaceuticals Corp Diarylurines with kinase inhibitory activity
GB0317665D0 (en) 2003-07-29 2003-09-03 Astrazeneca Ab Qinazoline derivatives
GB0318422D0 (en) * 2003-08-06 2003-09-10 Astrazeneca Ab Chemical compounds
MXPA06002964A (en) 2003-09-16 2006-06-14 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors.
GB0322409D0 (en) 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
ES2925655T3 (en) 2003-09-26 2022-10-19 Exelixis Inc c-Met modulators and methods of use
JP4303726B2 (en) 2003-11-11 2009-07-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 Urea derivative and method for producing the same
GB0326459D0 (en) 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
JP4503022B2 (en) 2003-12-23 2010-07-14 ファイザー・インク New quinoline derivatives
GB0330042D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
GB0330043D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
GB0330002D0 (en) 2003-12-24 2004-01-28 Astrazeneca Ab Quinazoline derivatives
US7626030B2 (en) 2004-01-23 2009-12-01 Amgen Inc. Compounds and methods of use
KR20070026390A (en) 2004-01-23 2007-03-08 암젠 인코포레이션 Compound and how to use
EP1713781B1 (en) 2004-02-03 2008-11-05 AstraZeneca AB Quinazoline derivatives
CN1960731B (en) 2004-02-20 2011-12-07 诺华疫苗和诊断公司 Method for regulating inflammatory and metastatic processes
AP2204A (en) 2004-05-06 2011-02-07 Warner Lambert Co 4-phenylamino-quinazolin-6-yl-amides.
CA2569404A1 (en) 2004-06-04 2005-12-22 Amphora Discovery Corporation Quinoline- and isoquinoline-based compounds exhibiting atp-utilizing enzyme inhibitory activity, and compositions, and uses thereof
CN1993349A (en) * 2004-06-04 2007-07-04 阿斯利康(瑞典)有限公司 Quinazoline derivatives as ERBB receptor tyrosine kinases
ES2322175T3 (en) 2004-09-17 2009-06-17 EISAI R&D MANAGEMENT CO., LTD. MEDICINAL COMPOSITION WITH IMPROVED STABILITY AND REDUCED GELIFICATION.
BRPI0516093A (en) 2004-10-12 2008-08-19 Astrazeneca Ab quinazoline derivative, process for preparing it, pharmaceutical composition, use of a quinazoline derivative, and method for treating cell proliferative disorders in a warm-blooded animal
JP2008521900A (en) 2004-11-30 2008-06-26 アムジエン・インコーポレーテツド Quinolines and quinazoline analogues and their use as medicaments for the treatment of cancer
US7947676B2 (en) 2004-12-14 2011-05-24 Astrazeneca Ab Pyrazolo[3,4-d]pyrimidine compounds as antitumor agents
ES2319462T3 (en) 2005-03-28 2009-05-07 Bristol-Myers Squibb Company COMPETITIVE INHIBITORS OF ATP CINASAS.
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Substituted Amid derivatives & methods of use
GB0508715D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
EP1885187B1 (en) 2005-05-13 2013-09-25 Novartis AG Methods for treating drug resistant cancer
EP1888556B1 (en) 2005-05-17 2011-10-26 Novartis AG Methods for synthesizing heterocyclic compounds
EP1904480A2 (en) 2005-05-23 2008-04-02 Novartis Pharma AG Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts
JP2009501235A (en) * 2005-07-15 2009-01-15 シェーリング コーポレイション Quinazoline derivatives useful in cancer treatment
US9006240B2 (en) 2005-08-02 2015-04-14 Eisai R&D Management Co., Ltd. Method for assay on the effect of vascularization inhibitor
PE20070427A1 (en) 2005-08-30 2007-04-21 Novartis Ag BENZIMIDAZOLES DERIVED COMPOUNDS SUBSTITUTED AS TYROSINE KINASE INHIBITORS
WO2007034144A1 (en) 2005-09-20 2007-03-29 Astrazeneca Ab 4- (ih-indazol-s-yl-amino)-quinazoline compounds as erbb receptor tyrosine kinase inhibitors for the treatment of cancer
CN101379060B (en) 2006-02-10 2012-05-23 转化技术制药公司 Benzoxazole Derivatives, Compositions and Methods of Use as Aurora Kinase Inhibitors
UY30183A1 (en) 2006-03-02 2007-10-31 Astrazeneca Ab QUINOLINE DERIVATIVES
CA2652442C (en) 2006-05-18 2014-12-09 Eisai R & D Management Co., Ltd. Antitumor agent for thyroid cancer
EP2065372B1 (en) 2006-08-28 2012-11-28 Eisai R&D Management Co., Ltd. Antitumor agent for undifferentiated gastric cancer
EP1921070A1 (en) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclic heterocycles, medicaments comprising them, their use and process for their preparation
JP5319306B2 (en) 2007-01-29 2013-10-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 Composition for treatment of undifferentiated gastric cancer
EP2118075A1 (en) 2007-02-06 2009-11-18 Boehringer Ingelheim International GmbH Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
US8288377B2 (en) * 2007-09-21 2012-10-16 Janssen Pharmaceutica N.V. Inhibitors of the interaction between MDM2 and p53
CA2703257C (en) 2007-10-29 2013-02-19 Amgen Inc. Benzomorpholine derivatives and methods of use
EP2220054A2 (en) 2007-10-29 2010-08-25 Natco Pharma Limited Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents
CN101848895B (en) 2007-11-09 2013-10-23 卫材R&D管理有限公司 Combined use of angiogenesis inhibitory substance and antitumor platinum complex
US8466151B2 (en) 2007-12-26 2013-06-18 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
CN101939316B (en) 2008-02-07 2013-10-02 贝林格尔.英格海姆国际有限公司 Spirocyclic heterocyclic compound, medicine containing said compound, use thereof and preparation method thereof
BRPI0912170A2 (en) 2008-05-13 2015-10-13 Astrazeneca Ab compound, form, process for preparation thereof, pharmaceutical composition, use of a compound, and method for treating cancer in a warm-blooded animal
CA2730890C (en) 2008-07-17 2018-05-15 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
US8648191B2 (en) 2008-08-08 2014-02-11 Boehringer Ingelheim International Gmbh Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
KR20250123237A (en) 2009-01-16 2025-08-14 엑셀리시스, 인코포레이티드 Malate salt of n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer
UA108618C2 (en) 2009-08-07 2015-05-25 APPLICATION OF C-MET-MODULATORS IN COMBINATION WITH THEMOSOLOMID AND / OR RADIATION THERAPY FOR CANCER TREATMENT
AU2010285740C1 (en) 2009-08-19 2016-03-17 Eisai R&D Management Co., Ltd. Quinoline derivative-containing pharmaceutical composition
SG178592A1 (en) 2009-09-03 2012-04-27 Bristol Myers Squibb Co Quinazolines as potassium ion channel inhibitors
EP2552915B1 (en) 2010-04-01 2017-07-19 Critical Outcome Technologies Inc. Compounds for the treatment of hiv
ES2573515T3 (en) 2010-06-25 2016-06-08 Eisai R&D Management Co., Ltd. Anti-tumor agent that uses compounds with combined kinase inhibitory effect
JP6014034B2 (en) * 2010-07-29 2016-10-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung Cyclic amine azaheterocyclic carboxamide
SG10201913982WA (en) 2011-03-04 2020-03-30 Newgen Therapeutics Inc Alkyne Substituted Quinazoline Compound And Methods Of Use
JP6021805B2 (en) 2011-04-18 2016-11-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 Tumor treatment
EP3444363B1 (en) 2011-06-03 2020-11-25 Eisai R&D Management Co., Ltd. Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
CN102942561A (en) * 2012-11-06 2013-02-27 深圳海王药业有限公司 4-amino quinazoline heterocyclic compound and purpose of 4-amino quinazoline heterocyclic compound
BR112015009004A8 (en) 2012-12-21 2021-07-20 Eisai R&D Man Co Ltd amorphous form of quinoline derivative and method of production thereof
JP6669499B2 (en) 2013-02-15 2020-03-18 カラ ファーマシューティカルズ インコーポレイテッド Therapeutic compounds
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
CA2900680C (en) 2013-02-20 2021-08-10 Kala Pharmaceuticals, Inc. Quinoline and quinazoline compounds and uses thereof for treating and/or preventing diseases
KR102274755B1 (en) 2013-04-04 2021-07-08 얀센 파마슈티카 엔.브이. NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-b]PYRIDIN-5-YL)-4-QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4-QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS
US10517861B2 (en) 2013-05-14 2019-12-31 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
TW201534597A (en) 2013-06-20 2015-09-16 Ab Science Benzimidazole derivatives as selective proteine kinase inhibitors
DK3046584T3 (en) 2013-09-16 2017-10-02 Astrazeneca Ab THERAPEUTIC POLYMER NANOPARTICLES AND PROCEDURES FOR PREPARING AND USING THEREOF
AU2014342042B2 (en) 2013-11-01 2017-08-17 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
RS58597B1 (en) * 2014-04-04 2019-05-31 Pfizer Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors
JP6659554B2 (en) 2014-08-28 2020-03-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 High purity quinoline derivative and method for producing the same
LT3263106T (en) 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. METHOD OF REDUCING BITTERNESS OF QUINOLINE DERIVATIVES
AU2015384801B2 (en) 2015-03-04 2022-01-06 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
CN104725364B (en) * 2015-03-12 2017-09-15 江苏省中国科学院植物研究所 The amine derivative of 6,7 dimethoxyquinazoline 4, its preparation method and medical usage
AU2016279474B2 (en) 2015-06-16 2021-09-09 Eisai R&D Management Co., Ltd. Anticancer agent
SG11201801083UA (en) 2015-08-20 2018-03-28 Eisai R&D Man Co Ltd Tumor therapeutic agent
AU2016333987A1 (en) 2015-10-05 2018-05-10 Ny State Psychiatric Institute Activators of autophagic flux and phospholipase D and clearance of protein aggregates including tau and treatment of proteinopathies
CN106045980B (en) * 2016-06-03 2017-11-03 江苏开放大学 A kind of quinazoline derivant and preparation method thereof
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
CA3036065A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CA3036340A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN110072528B (en) 2017-02-08 2022-04-26 卫材R&D管理有限公司 Pharmaceutical composition for treating tumor
EP3615526B1 (en) * 2017-04-27 2021-08-04 Astrazeneca AB Phenoxyquinazoline compounds and their use in treating cancer
TWI774758B (en) 2017-04-27 2022-08-21 瑞典商阿斯特捷利康公司 C5-anilinoquinazoline compounds and their use in treating cancer
KR20200013644A (en) 2017-05-16 2020-02-07 에자이 알앤드디 매니지먼트 가부시키가이샤 Treatment of Hepatocellular Carcinoma
KR20240017986A (en) * 2017-09-26 2024-02-08 더 리전트 오브 더 유니버시티 오브 캘리포니아 Compositions and methods for treating cancer
FR3080620B1 (en) * 2018-04-27 2021-11-12 Univ Paris Sud COMPOUNDS WITH TUBULIN POLYMERIZATION INHIBITOR ACTIVITY AND IMMUNOMODULATORY PROPERTIES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
GB9323290D0 (en) * 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
TW321649B (en) * 1994-11-12 1997-12-01 Zeneca Ltd

Also Published As

Publication number Publication date
EP0843671A1 (en) 1998-05-27
WO1997003069A1 (en) 1997-01-30
AU6613996A (en) 1997-02-10
ZA965935B (en) 1998-02-12
JPH11508906A (en) 1999-08-03
HRP960316A2 (en) 1998-02-28

Similar Documents

Publication Publication Date Title
GB9514265D0 (en) Hetrocyclic compounds
ZA9610022B (en) Cycloaza compounds
GB9508810D0 (en) Compounds
GB9500691D0 (en) Compounds
GB9504910D0 (en) Compounds
GB9504948D0 (en) Compounds
GB9502540D0 (en) Compounds
GB9321270D0 (en) Hetrocyclic compounds
GB9321272D0 (en) Hetrocyclic compounds
GB9522045D0 (en) Compounds
GB9507290D0 (en) Compounds
GB9504907D0 (en) Compounds
GB9504990D0 (en) Compounds
GB9506168D0 (en) Compounds
GB9507693D0 (en) Compounds
GB9508009D0 (en) Compounds
GB9509434D0 (en) Compounds
GB9509816D0 (en) Compounds
GB9510462D0 (en) Compounds
GB9512720D0 (en) Compounds
GB9518573D0 (en) Compounds
GB9520360D0 (en) Compounds
GB9520361D0 (en) Compounds
GB9520362D0 (en) Compounds
GB9504803D0 (en) Compounds