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PT2235002E - Compostos de 4-piridinona e a sua utilização para o tratamento do cancro - Google Patents

Compostos de 4-piridinona e a sua utilização para o tratamento do cancro

Info

Publication number
PT2235002E
PT2235002E PT97044572T PT09704457T PT2235002E PT 2235002 E PT2235002 E PT 2235002E PT 97044572 T PT97044572 T PT 97044572T PT 09704457 T PT09704457 T PT 09704457T PT 2235002 E PT2235002 E PT 2235002E
Authority
PT
Portugal
Prior art keywords
cancer
pyridinone compounds
pyridinone
compounds
Prior art date
Application number
PT97044572T
Other languages
English (en)
Inventor
Robert M Borzilleri
Zhen-Wei Cai
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PT2235002E publication Critical patent/PT2235002E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT97044572T 2008-01-23 2009-01-22 Compostos de 4-piridinona e a sua utilização para o tratamento do cancro PT2235002E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2284808P 2008-01-23 2008-01-23

Publications (1)

Publication Number Publication Date
PT2235002E true PT2235002E (pt) 2013-01-30

Family

ID=40637826

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97044572T PT2235002E (pt) 2008-01-23 2009-01-22 Compostos de 4-piridinona e a sua utilização para o tratamento do cancro

Country Status (22)

Country Link
US (2) US8124768B2 (pt)
EP (1) EP2235002B1 (pt)
JP (1) JP5314050B2 (pt)
KR (1) KR101596527B1 (pt)
CN (1) CN101977906B (pt)
AU (1) AU2009206440B2 (pt)
BR (1) BRPI0906444B8 (pt)
CA (1) CA2713111C (pt)
CO (1) CO6230986A2 (pt)
CY (1) CY1114140T1 (pt)
DK (1) DK2235002T3 (pt)
EA (1) EA017736B1 (pt)
ES (1) ES2398335T3 (pt)
HK (1) HK1143157A1 (pt)
HR (1) HRP20130040T1 (pt)
IL (1) IL207212A (pt)
NZ (1) NZ586630A (pt)
PL (1) PL2235002T3 (pt)
PT (1) PT2235002E (pt)
SI (1) SI2235002T1 (pt)
WO (1) WO2009094417A1 (pt)
ZA (1) ZA201005248B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011004018A (es) 2008-10-14 2011-06-24 Ning Xi Compuestos y metodos de uso.
JP5583751B2 (ja) 2009-03-21 2014-09-03 クイ ニング アミノエステル誘導体、その塩、及び使用方法
EP2563773A1 (en) 2010-04-29 2013-03-06 Deciphera Pharmaceuticals, LLC Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activites
RU2477723C2 (ru) 2011-06-16 2013-03-20 Общество С Ограниченной Ответственностью "Фьюжн Фарма" Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
MY165215A (en) 2012-01-31 2018-03-09 Daiichi Sankyo Co Ltd Pyridone derivatives
US8975282B2 (en) 2012-07-28 2015-03-10 Sunshine Lake Pharma Co., Ltd. Substituted pyrazolone compounds and methods of use
JP6342393B2 (ja) 2012-07-28 2018-06-13 カリター・サイエンシーズ・エルエルシー 置換型ピラゾロン化合物及び使用方法
US9102624B2 (en) * 2012-08-23 2015-08-11 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057926A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057920A1 (en) * 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
TWI690525B (zh) 2014-07-07 2020-04-11 日商第一三共股份有限公司 具有四氫吡喃基甲基之吡啶酮衍生物及其用途
CN105153026B (zh) * 2015-08-21 2018-02-02 江西科技师范大学 含联芳基酰胺结构的索拉非尼衍生物及其制备方法和应用
TWI745824B (zh) * 2019-01-03 2021-11-11 美商亞雷生物製藥股份有限公司 作為tam及met激酶抑制劑之喹啉化合物
EP4332106A4 (en) * 2021-06-22 2024-10-30 LG Chem, Ltd. NOVEL COMPOUND AS PROTEIN KINASE INHIBITOR
TW202428285A (zh) * 2022-09-28 2024-07-16 大陸商上海濟煜醫藥科技有限公司 含磷類化合物及其製備方法和醫藥應用

Family Cites Families (22)

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EP0430885A3 (en) 1989-12-01 1991-11-06 Ciba-Geigy Ag Anthelmintical compounds
WO1997017329A1 (fr) 1995-11-07 1997-05-15 Kirin Beer Kabushiki Kaisha Derives de quinoline et derives de quinazoline inhibant l'autophosphorylation d'un recepteur de facteur de croissance originaire de plaquettes, et compositions pharmaceutiques les contenant
WO1999065867A1 (en) * 1998-06-17 1999-12-23 Du Pont Pharmaceuticals Company Cyclic hydroxamic acids as metalloproteinase inhibitors
US6355660B1 (en) * 1999-07-20 2002-03-12 Dow Agrosciences Llc Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
JP2003528806A (ja) * 1999-07-20 2003-09-30 ダウ・アグロサイエンス・エル・エル・シー 殺菌・殺カビ性複素環式芳香族アミドおよびそれらの組成物、使用および製造方法
HUP0300059A3 (en) 1999-09-21 2003-08-28 Astrazeneca Ab Quinazoline derivatives, process for their preparation, pharmaceutical compositions containing the compounds and use of the new and known quinazoline derivatives against proliferative disease
CA2401984A1 (en) * 2000-03-22 2001-09-27 Merck Frosst Canada Inc. Sulfur substituted aryldifluoromethylphosphonic acids as ptp-1b inhibitors
FR2812633A1 (fr) * 2000-08-04 2002-02-08 Aventis Cropscience Sa Derives de phenyl(thio)urees et phenyl(thio)carbamates fongicides
SE0102384D0 (sv) * 2001-07-03 2001-07-03 Pharmacia Ab New compounds
AU2002344567A1 (en) * 2001-11-28 2003-06-10 Daiso Co., Ltd. Heterocyclic amide compounds as apolipoprotein b inhibitors
SE0302487D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
JP4829506B2 (ja) * 2004-02-17 2011-12-07 石原産業株式会社 チオアミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
US7459562B2 (en) * 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
AU2005245386B2 (en) * 2004-05-07 2008-11-27 Amgen Inc. Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer
US7439246B2 (en) * 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US7432373B2 (en) * 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7173031B2 (en) * 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
US7732613B2 (en) * 2005-09-14 2010-06-08 Bristol-Myers Squibb Company Met kinase inhibitors
WO2007035428A1 (en) * 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Met kinase inhibitors
US7348325B2 (en) * 2005-11-30 2008-03-25 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
ES2531396T3 (es) 2008-01-23 2015-03-13 Bristol Myers Squibb Co Proceso para preparar compuestos de piridinona

Also Published As

Publication number Publication date
HRP20130040T1 (hr) 2013-02-28
AU2009206440A1 (en) 2009-07-30
CN101977906A (zh) 2011-02-16
CA2713111A1 (en) 2009-07-30
CO6230986A2 (es) 2010-12-20
CY1114140T1 (el) 2016-07-27
US20120114643A1 (en) 2012-05-10
ES2398335T3 (es) 2013-03-15
DK2235002T3 (da) 2013-03-11
US8124768B2 (en) 2012-02-28
CA2713111C (en) 2015-06-30
JP5314050B2 (ja) 2013-10-16
SI2235002T1 (sl) 2013-06-28
NZ586630A (en) 2011-12-22
EA017736B1 (ru) 2013-02-28
EA201001196A1 (ru) 2011-02-28
BRPI0906444B1 (pt) 2021-03-16
CN101977906B (zh) 2014-11-05
BRPI0906444B8 (pt) 2021-05-25
ZA201005248B (en) 2011-09-28
AU2009206440B2 (en) 2013-08-15
US20110034416A1 (en) 2011-02-10
IL207212A (en) 2015-01-29
BRPI0906444A2 (pt) 2015-07-14
BRPI0906444A8 (pt) 2020-02-27
KR101596527B1 (ko) 2016-02-22
KR20100103636A (ko) 2010-09-27
JP2011510087A (ja) 2011-03-31
IL207212A0 (en) 2010-12-30
EP2235002A1 (en) 2010-10-06
EP2235002B1 (en) 2012-11-21
HK1143157A1 (en) 2010-12-24
WO2009094417A1 (en) 2009-07-30
PL2235002T3 (pl) 2013-04-30
US8258118B2 (en) 2012-09-04

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