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WO2012040184A3 - Novel low molecular weight cationic lipids for oligonucleotide delivery - Google Patents

Novel low molecular weight cationic lipids for oligonucleotide delivery Download PDF

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Publication number
WO2012040184A3
WO2012040184A3 PCT/US2011/052328 US2011052328W WO2012040184A3 WO 2012040184 A3 WO2012040184 A3 WO 2012040184A3 US 2011052328 W US2011052328 W US 2011052328W WO 2012040184 A3 WO2012040184 A3 WO 2012040184A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipid
molecular weight
low molecular
lipids
cationic lipids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/052328
Other languages
French (fr)
Other versions
WO2012040184A2 (en
Inventor
Matthew G. Stanton
Brian W. Budzik
Gregory L. Beutner
Hongbiao Liao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2013529412A priority Critical patent/JP5961170B2/en
Priority to BR112013004585-0A priority patent/BR112013004585B1/en
Priority to CN201180045234.2A priority patent/CN103167866B/en
Priority to MX2017009025A priority patent/MX384381B/en
Priority to EP11827342.4A priority patent/EP2618847A4/en
Priority to RU2013118224A priority patent/RU2617641C2/en
Priority to MX2013003084A priority patent/MX349088B/en
Priority to KR1020187019563A priority patent/KR102038241B1/en
Priority to CA2809858A priority patent/CA2809858C/en
Priority to KR1020137006919A priority patent/KR101878361B1/en
Priority to EP21171748.3A priority patent/EP3943114B1/en
Priority to AU2011305617A priority patent/AU2011305617A1/en
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Priority to US13/823,830 priority patent/US9669097B2/en
Priority to EP16001229.0A priority patent/EP3144015B1/en
Publication of WO2012040184A2 publication Critical patent/WO2012040184A2/en
Publication of WO2012040184A3 publication Critical patent/WO2012040184A3/en
Anticipated expiration legal-status Critical
Priority to AU2016202433A priority patent/AU2016202433B2/en
Priority to US15/591,818 priority patent/US10576155B2/en
Priority to AU2018202688A priority patent/AU2018202688B2/en
Priority to US16/741,100 priority patent/US11413348B2/en
Priority to US17/848,967 priority patent/US11911475B2/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
    • C07C209/40—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of hydroxylamino or oxyimino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/04—Mono-, di- or tri-methylamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/08—Monoamines containing alkyl groups having a different number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/16—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings
    • C07C211/17—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/21—Monoamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/16—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/25—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The instant invention provides for novel catiomc lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
PCT/US2011/052328 2010-09-20 2011-09-20 Novel low molecular weight cationic lipids for oligonucleotide delivery Ceased WO2012040184A2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
EP21171748.3A EP3943114B1 (en) 2010-09-20 2011-09-20 Novel low molecular weight cationic lipids for oligonucleotide delivery
CN201180045234.2A CN103167866B (en) 2010-09-20 2011-09-20 For the novel low molecular weight amount cation lipid of oligonucleotide delivery
MX2017009025A MX384381B (en) 2010-09-20 2011-09-20 NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY.
EP11827342.4A EP2618847A4 (en) 2010-09-20 2011-09-20 NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR THE ADMINISTRATION OF OLIGONUCLEOTIDES
RU2013118224A RU2617641C2 (en) 2010-09-20 2011-09-20 Novel low-molecular cationic lipids for delivery of oligonucleotides
BR112013004585-0A BR112013004585B1 (en) 2010-09-20 2011-09-20 CATIONIC LIPIDIUM, LNP COMPOSITION, E, USE OF A CATIONIC LIPIDE
KR1020187019563A KR102038241B1 (en) 2010-09-20 2011-09-20 Novel low molecular weight cationic lipids for oligonucleotide delivery
CA2809858A CA2809858C (en) 2010-09-20 2011-09-20 Novel low molecular weight cationic lipids for oligonucleotide delivery
KR1020137006919A KR101878361B1 (en) 2010-09-20 2011-09-20 Novel low molecular weight cationic lipids for oligonucleotide delivery
AU2011305617A AU2011305617A1 (en) 2010-09-20 2011-09-20 Novel low molecular weight cationic lipids for oligonucleotide delivery
MX2013003084A MX349088B (en) 2010-09-20 2011-09-20 Novel low molecular weight cationic lipids for oligonucleotide delivery.
JP2013529412A JP5961170B2 (en) 2010-09-20 2011-09-20 Novel low molecular weight cationic lipids for oligonucleotide delivery
US13/823,830 US9669097B2 (en) 2010-09-20 2011-09-20 Low molecular weight cationic lipids for oligonucleotide delivery
EP16001229.0A EP3144015B1 (en) 2010-09-20 2011-09-20 Low molecular weight cationic lipids for oligonucleotide delivery
AU2016202433A AU2016202433B2 (en) 2010-09-20 2016-04-18 Novel low molecular weight cationic lipids for oligonucleotide delivery
US15/591,818 US10576155B2 (en) 2010-09-20 2017-05-10 Low molecular weight cationic lipids for oligonucleotide delivery
AU2018202688A AU2018202688B2 (en) 2010-09-20 2018-04-18 Novel low molecular weight cationic lipids for oligonucleotide delivery
US16/741,100 US11413348B2 (en) 2010-09-20 2020-01-13 Low molecular weight cationic lipids for oligonucleotide delivery
US17/848,967 US11911475B2 (en) 2010-09-20 2022-06-24 Low molecular weight cationic lipids for oligonucleotide delivery

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38448610P 2010-09-20 2010-09-20
US61/384,486 2010-09-20
US201161514270P 2011-08-02 2011-08-02
US61/514,270 2011-08-02

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/823,830 A-371-Of-International US9669097B2 (en) 2010-09-20 2011-09-20 Low molecular weight cationic lipids for oligonucleotide delivery
US15/591,818 Continuation US10576155B2 (en) 2010-09-20 2017-05-10 Low molecular weight cationic lipids for oligonucleotide delivery

Publications (2)

Publication Number Publication Date
WO2012040184A2 WO2012040184A2 (en) 2012-03-29
WO2012040184A3 true WO2012040184A3 (en) 2012-08-16

Family

ID=45874319

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/052328 Ceased WO2012040184A2 (en) 2010-09-20 2011-09-20 Novel low molecular weight cationic lipids for oligonucleotide delivery

Country Status (12)

Country Link
US (4) US9669097B2 (en)
EP (3) EP3943114B1 (en)
JP (3) JP5961170B2 (en)
KR (2) KR102038241B1 (en)
CN (1) CN103167866B (en)
AU (3) AU2011305617A1 (en)
BR (1) BR112013004585B1 (en)
CA (1) CA2809858C (en)
ES (2) ES2888231T3 (en)
MX (2) MX384381B (en)
RU (1) RU2617641C2 (en)
WO (1) WO2012040184A2 (en)

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