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HUP0104495A2 - N-szubsztituált 2-ciano-pirrolidinek és ezeket tartalmazó gyógyászati készítmények - Google Patents

N-szubsztituált 2-ciano-pirrolidinek és ezeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP0104495A2
HUP0104495A2 HU0104495A HUP0104495A HUP0104495A2 HU P0104495 A2 HUP0104495 A2 HU P0104495A2 HU 0104495 A HU0104495 A HU 0104495A HU P0104495 A HUP0104495 A HU P0104495A HU P0104495 A2 HUP0104495 A2 HU P0104495A2
Authority
HU
Hungary
Prior art keywords
dpp
substituted
compounds
formula
cyanopyrrolidines
Prior art date
Application number
HU0104495A
Other languages
English (en)
Inventor
Edwin Bernard Villhauer
Original Assignee
Novartis Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22777194&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0104495(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag. filed Critical Novartis Ag.
Publication of HUP0104495A2 publication Critical patent/HUP0104495A2/hu
Publication of HUP0104495A3 publication Critical patent/HUP0104495A3/hu
Publication of HU226769B1 publication Critical patent/HU226769B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A tal lm ny (I) ltal nos képletű, szabad form ban vagy savaddíciós sókform j ban lévő N-(szubsztitu lt glicil)-2-ciano-pirrolidinekrevonatkozik, amelyek képletében R jelentése szubsztitu ltadamantilcsoport; és n értéke 0, 1, 2 vagy 3. Az (I) ltal nos képletűvegyületek g tolj k a DPP-IV (dipeptidil-peptid z-IV) aktivit st. ═gya vegyületek gyógyszerhatóanyagokként felhaszn lhatók a DPP-IV g tl sra és a DPP-IV ltal medi lt llapotok, péld ul nem inzulinfüggődiabetes mellitus, arthritis, obesitas, osteoporosis és a k rosodottglükóztolerancia egyéb llapotainak a kezelésére. A tal lm ny kiterjeda vegyületeket tartalmazó gyógy szati készítményekre is. Ó
HU0104495A 1998-12-10 1999-12-09 N-substituted 2-cyanopyrrolidines and pharmaceutical compositions containing them HU226769B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20906898A 1998-12-10 1998-12-10
PCT/EP1999/009708 WO2000034241A1 (en) 1998-12-10 1999-12-09 N-substituted 2-cyanopyrrolidines

Publications (3)

Publication Number Publication Date
HUP0104495A2 true HUP0104495A2 (hu) 2002-04-29
HUP0104495A3 HUP0104495A3 (en) 2002-11-28
HU226769B1 HU226769B1 (en) 2009-09-28

Family

ID=22777194

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104495A HU226769B1 (en) 1998-12-10 1999-12-09 N-substituted 2-cyanopyrrolidines and pharmaceutical compositions containing them

Country Status (34)

Country Link
US (1) US6166063A (hu)
EP (1) EP1137635B1 (hu)
JP (2) JP3681110B2 (hu)
KR (2) KR100509311B1 (hu)
CN (1) CN1160330C (hu)
AR (1) AR023719A1 (hu)
AT (1) ATE307112T1 (hu)
BR (1) BRPI9915985B8 (hu)
CA (1) CA2350609C (hu)
CO (1) CO5150173A1 (hu)
CY (3) CY1105355T1 (hu)
CZ (1) CZ299151B6 (hu)
DE (3) DE69927844T2 (hu)
DK (1) DK1137635T3 (hu)
ES (1) ES2251847T3 (hu)
FR (1) FR08C0005I2 (hu)
HK (1) HK1040394B (hu)
HU (1) HU226769B1 (hu)
ID (1) ID28796A (hu)
IL (2) IL143091A0 (hu)
LU (2) LU91409I2 (hu)
MY (1) MY123244A (hu)
NL (2) NL300333I2 (hu)
NO (3) NO318741B1 (hu)
NZ (1) NZ511935A (hu)
PE (1) PE20001317A1 (hu)
PL (1) PL199443B1 (hu)
RU (1) RU2251544C2 (hu)
SK (1) SK286635B6 (hu)
TR (1) TR200101478T2 (hu)
TW (1) TW509674B (hu)
UY (1) UY25843A1 (hu)
WO (1) WO2000034241A1 (hu)
ZA (1) ZA200104581B (hu)

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