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HK1245350A1 - 用針對特定群體的抗原篩選t細胞的組合物和方法 - Google Patents

用針對特定群體的抗原篩選t細胞的組合物和方法

Info

Publication number
HK1245350A1
HK1245350A1 HK18104800.2A HK18104800A HK1245350A1 HK 1245350 A1 HK1245350 A1 HK 1245350A1 HK 18104800 A HK18104800 A HK 18104800A HK 1245350 A1 HK1245350 A1 HK 1245350A1
Authority
HK
Hong Kong
Prior art keywords
antigens
screening
compositions
cells
methods
Prior art date
Application number
HK18104800.2A
Other languages
English (en)
Inventor
James R Heath
Songming Peng
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Publication of HK1245350A1 publication Critical patent/HK1245350A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/131—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a member of a cognate binding pair, i.e. extends to antibodies, haptens, avidin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/143—Magnetism, e.g. magnetic label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/155—Particles of a defined size, e.g. nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50—Detection characterised by immobilisation to a surface
    • C12Q2565/514—Detection characterised by immobilisation to a surface characterised by the use of the arrayed oligonucleotides as identifier tags, e.g. universal addressable array, anti-tag or tag complement array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539—MHC-molecules, e.g. HLA-molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Nanotechnology (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK18104800.2A 2015-06-01 2018-04-12 用針對特定群體的抗原篩選t細胞的組合物和方法 HK1245350A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562169337P 2015-06-01 2015-06-01
PCT/US2016/035357 WO2016196691A2 (en) 2015-06-01 2016-06-01 Compositions and methods for screening t cells with antigens for specific populations

Publications (1)

Publication Number Publication Date
HK1245350A1 true HK1245350A1 (zh) 2018-08-24

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HK18104800.2A HK1245350A1 (zh) 2015-06-01 2018-04-12 用針對特定群體的抗原篩選t細胞的組合物和方法

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Country Link
US (1) US10481158B2 (zh)
EP (1) EP3303635B1 (zh)
JP (1) JP6752231B2 (zh)
KR (1) KR102489353B1 (zh)
CN (1) CN107636162B (zh)
AU (1) AU2016270823B2 (zh)
CA (1) CA2986072C (zh)
HK (1) HK1245350A1 (zh)
IL (1) IL255631B (zh)
WO (1) WO2016196691A2 (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11585806B2 (en) 2014-06-13 2023-02-21 Immudex Aps General detection and isolation of specific cells by binding of labeled molecules
US11384327B2 (en) 2016-11-01 2022-07-12 California Institute Of Technology Microfluidic devices and methods for purifying rare antigen-specific T cell populations
EP3592862A1 (en) 2017-03-08 2020-01-15 California Institute of Technology Pairing antigen specificity of a t cell with t cell receptor sequences
US12066430B2 (en) 2017-07-25 2024-08-20 California Institute Of Technology Trogocytosis mediated epitope discovery methods
KR20190050523A (ko) 2017-11-03 2019-05-13 광주과학기술원 면역세포 진단칩
CA3095741A1 (en) * 2018-04-02 2019-10-10 Pact Pharma, Inc. Peptide-mhc compacts
CN108865993A (zh) * 2018-06-11 2018-11-23 深圳市第二人民医院 肿瘤新抗原的筛选方法和试剂盒
WO2019238939A1 (en) * 2018-06-15 2019-12-19 F. Hoffmann-La Roche Ag A system for identification of antigens recognized by t cell receptors expressed on tumor infiltrating lymphocytes
CN110687298A (zh) * 2018-09-06 2020-01-14 天津美瑞特医疗科技有限公司 一种以Chitosan多糖为骨架制备MHC抗原肽多聚体检测试剂的新方法
WO2020056173A1 (en) * 2018-09-13 2020-03-19 Pact Pharma, Inc. Antigen specific tcr identification using single-cell sorting
EP3867353A4 (en) * 2018-10-18 2022-07-27 Berkeley Lights, Inc. PROTO-ANTIGEN PRESENTING SYNTHETIC SURFACES, ACTIVATED T-CELLS AND THEIR USES
CA3124432A1 (en) * 2018-12-18 2020-06-25 Mbl International Corp. Compositions of streptavidin-oligo conjugates of pmhc occupancy
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
KR20210126073A (ko) * 2019-02-12 2021-10-19 팩트 파마, 인크. 항원 특이적 t 세포의 식별을 위한 조성물 및 방법
AU2020232971A1 (en) * 2019-03-01 2021-09-23 Scott R. BURKHOLZ Design, manufacture, and use of personalized cancer vaccines
CN111696628A (zh) * 2019-03-15 2020-09-22 痕准生物科技有限公司 新生抗原的鉴定方法
CN110567861B (zh) * 2019-09-09 2021-12-21 浙江普罗亭健康科技有限公司 基于质谱流式检测技术筛查具有免疫原性抗原肽的试剂盒及检测方法
CN111234002A (zh) * 2020-01-15 2020-06-05 华东师范大学 肽-主要组织相容性复合物多聚体DNA-pMHC及其制备方法和应用
TW202144388A (zh) 2020-02-14 2021-12-01 美商健生生物科技公司 在卵巢癌中表現之新抗原及其用途
TW202144389A (zh) 2020-02-14 2021-12-01 美商健生生物科技公司 在多發性骨髓瘤中表現之新抗原及其用途
KR102376443B1 (ko) 2020-02-26 2022-03-17 포항공과대학교 산학협력단 나노구조체, 나노구조체를 포함하는 바이오센서, 및 스크리닝 방법

Family Cites Families (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818680A (en) * 1985-12-18 1989-04-04 Mary Collins Method and kit involving displacement and rehybridization of labeled polynucleotide
US5423778A (en) 1989-12-14 1995-06-13 Elof Eriksson System and method for transplantation of cells
GB9010138D0 (en) 1990-05-04 1990-06-27 Slater James H An ultrasensitive microtrace procedure for monitoring the origin,movement and fate of any liquid or solid material
JPH06506056A (ja) 1990-10-30 1994-07-07 イミュロジック　ファーマシューティカル　コーポレイション Ｍｈｃ抗原によるペプチド結合検定法
US5635602A (en) 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates
US6037167A (en) 1994-10-03 2000-03-14 Ericomp Magnetic polynucleotide separation and analysis
US5989813A (en) 1995-07-13 1999-11-23 Molecular Innovations, Inc. Detection of amplified nucleic acid sequences using bifunctional haptenization and dyed microparticles
US6153425A (en) 1995-07-13 2000-11-28 Xtrana, Inc. Self-contained device integrating nucleic acid extraction, amplification and detection
US20030219752A1 (en) 1995-12-07 2003-11-27 Diversa Corporation Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof
US6100079A (en) 1996-02-25 2000-08-08 Precision System Science Co., Ltd. Method for treating biopolymers, microorganisms or materials by using more than one type of magnetic particles
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US5994089A (en) 1997-05-16 1999-11-30 Coulter International Corp. Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry
AU734636B2 (en) 1997-07-11 2001-06-21 Xzillion Gmbh & Co. Kg Characterising nucleic acids
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US6261779B1 (en) 1998-11-10 2001-07-17 Bio-Pixels Ltd. Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
GB9828785D0 (en) 1998-12-30 1999-02-17 Amersham Pharm Biotech Ab Sequencing systems
JP2004501340A (ja) 2000-01-13 2004-01-15 ナノスフェアー　インコーポレイテッド オリゴヌクレオチドを付着させたナノ粒子とその使用方法
AU2010202492A1 (en) 2000-03-28 2010-07-08 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
AU2001268500A1 (en) 2000-06-14 2001-12-24 Board Of Regents, The University Of Texas System Dielectrically-engineered microparticles
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US20020127603A1 (en) 2000-10-12 2002-09-12 Amnis Corporation Methods for synthesizing reporter labeled beads
WO2002100325A2 (en) 2000-10-13 2002-12-19 Ligocyte Pharmaceuticals, Inc. Polyvalent nanoparticles
ATE291584T1 (de) 2000-10-20 2005-04-15 Hope City Immunoreaktive peptidische ctl-epitope aus dem menschlichen cytomegalovirus pp150
US20020168663A1 (en) 2001-02-27 2002-11-14 Phan Brigitte Chau Methods for DNA conjugation onto solid phase including related optical biodiscs and disc drive systems
US20060040286A1 (en) 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
CA2440474A1 (en) 2001-04-05 2002-10-17 Virginia Mason Research Center Methods of mhc class ii epitope mapping, detection of autoimmune t cells and antigens, and autoimmune treatment
DE10117858A1 (de) 2001-04-10 2002-10-24 Gsf Forschungszentrum Umwelt MHC-Tetramere
GB0109545D0 (en) 2001-04-18 2001-06-06 Scient Generics Ltd Chemical libraries based on coded particles
US7147687B2 (en) 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7902121B2 (en) * 2001-07-02 2011-03-08 The Board Of Trustees Of The Leland Stanford Junior University MHC-antigen arrays for detection and characterization of immune responses
US20030027234A1 (en) 2001-07-30 2003-02-06 Pandian Murugan R. Methods for detecting Down's syndrome
WO2003035829A2 (en) 2001-10-09 2003-05-01 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
WO2003081202A2 (en) 2001-11-09 2003-10-02 Nanosphere, Inc. Bioconjugate-nanoparticle probes
JP3897285B2 (ja) 2002-02-05 2007-03-22 日立ソフトウエアエンジニアリング株式会社 生体高分子検出用試薬及び生体高分子検出方法
CN1464070A (zh) 2002-06-20 2003-12-31 中国科学院化学研究所 提高dna检测灵敏度的方法
JP2006506987A (ja) 2002-06-28 2006-03-02 エクサイト セラピーズ インコーポレーティッド 自己免疫および臓器または造血幹細胞移植に関連する免疫学的欠損を有する患者における免疫レパートリー回復のための組成物および方法
US20050084967A1 (en) 2002-06-28 2005-04-21 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
AU2003268089A1 (en) 2002-08-13 2004-02-25 National Jewish Medical And Research Center Method for identifying mhc-presented peptide epitopes for t cells
US7361821B2 (en) 2002-09-20 2008-04-22 Intel Corporation Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
DE10247014A1 (de) 2002-10-09 2004-04-22 Erfle, Volker, Prof. Priv.-Doz. Dr. MHC-Multimere
US20040102369A1 (en) 2002-11-27 2004-05-27 The Regents Of The University Of California Transport of basic fibroblast growth factor across the blood brain barrier
JP2004187606A (ja) 2002-12-12 2004-07-08 Institute Of Physical & Chemical Research 核酸アイソフォームの同定、分析および／またはクローニング方法
JP4761202B2 (ja) 2003-01-31 2011-08-31 学校法人慶應義塾 切断可能な対応付け分子およびそれを用いるスクリーニング方法
JP2004354164A (ja) 2003-05-28 2004-12-16 Olympus Corp 微粒子を用いた検体の検査方法及びその検査システム
US20050250094A1 (en) 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
DE10324912A1 (de) 2003-05-30 2005-01-05 Siemens Ag Verfahren zur Detektion von DNA-Punktmutationen (SNP-Analyse) sowie zugehörige Anordnung
WO2005001113A2 (en) 2003-06-27 2005-01-06 Thomas Jefferson University Methods for detecting nucleic acid variations
JP2007531496A (ja) 2003-07-11 2007-11-08 サロメッド，インコーポレイテッド 病原体を検出するためのマルチプレックス分子ビーコンアッセイ
WO2005021800A2 (en) 2003-08-22 2005-03-10 Sirna Therapeutics, Inc. Detection and quantitation of nucleic acid molecules in biological samples
WO2005108612A2 (en) 2003-11-28 2005-11-17 Genorx, Inc. Nanoscale biosensor device, system and technique
US7381529B2 (en) 2003-12-31 2008-06-03 Intel Corporation Methods and compositions for detecting nucleic acids using scanning probe microscopy and nanocodes
EP1766393A4 (en) 2004-05-07 2008-06-18 Beckman Coulter Inc MHC-BRIDGE SYSTEM FOR DETECTION OF THE CTL-MEDIATED LYSE OF ANTIGEN-PRESENTING CELLS
WO2006078289A2 (en) 2004-05-12 2006-07-27 Nanosphere, Inc. Bio-barcode based detection of target analytes
WO2006031883A2 (en) 2004-09-13 2006-03-23 Xencor, Inc. Analysis of mhc-peptide binding interactions
JP2006158276A (ja) 2004-12-06 2006-06-22 Institute Of Physical & Chemical Research Ｄｎａコンジュゲート、ｄｎａコンジュゲートの作製方法、及びｄｎａ検出方法
WO2006076793A1 (en) 2005-01-19 2006-07-27 Grade Biosense Inc. Dna sequence recognition
JP2006328032A (ja) 2005-05-30 2006-12-07 Fujifilm Holdings Corp 核酸プローブ及び多重鎖核酸蛍光検出方法
CA2616404A1 (en) * 2005-07-26 2007-02-01 Oregon Health & Science University Nanoparticle probes for capture, sorting and placement of targets
US20090111094A1 (en) 2005-08-19 2009-04-30 Nanosphere, Inc. Methods for preparing hybrid substrates comprising DNA and antibodies and uses thereof
WO2007024840A2 (en) 2005-08-22 2007-03-01 Critical Therapeutics, Inc. Method of quantitating nucleic acids by flow cytometry microparticle-based array
ES2324435B1 (es) 2005-10-27 2010-05-31 Fundacion Para El Estudio De La Hematologia Y Hemoterapia De Aragon (Fehha) Procedimiento y dispositivo de analisis in vitro de mrna de genes implicados en neoplasias hematologicas.
US7625702B2 (en) 2005-12-20 2009-12-01 International Business Machines Corporation Helical wrapping of single-walled carbon nanotubes by genomic DNA
JP2007262114A (ja) 2006-03-27 2007-10-11 Jsr Corp 磁性粒子およびその製造方法、ならびに磁性粒子分散体
US20070264652A1 (en) 2006-05-10 2007-11-15 National Institute Of Immunology Method for detection of a sequence
CA2652280C (en) 2006-05-15 2014-01-28 Massachusetts Institute Of Technology Polymers for functional particles
WO2008001376A2 (en) 2006-06-28 2008-01-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Detection of analytes in a medium
WO2008091364A2 (en) 2006-06-30 2008-07-31 Intel Corporation Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance
JP2009545747A (ja) * 2006-08-02 2009-12-24 カリフォルニア インスティチュート オブ テクノロジー 標的を検出及び／又は選別する方法並びにシステム
CN101522915A (zh) * 2006-08-02 2009-09-02 加州理工学院 用于检测和/或分选靶标的方法和系统
US8394590B2 (en) * 2006-08-02 2013-03-12 California Institute Of Technology Capture agents and related methods and systems for detecting and/or sorting targets
GB2442001A (en) 2006-08-11 2008-03-26 Chembiotech Nanoparticle - i-motif nucleic acid bioconjugates
KR100904825B1 (ko) 2006-09-09 2009-06-25 재단법인서울대학교산학협력재단 산란 현상을 이용한 ｄｎａ혼성화 측정방법
KR100823684B1 (ko) 2006-12-06 2008-04-21 한국전자통신연구원 바코드 ｄｎａ를 이용한 생물학적 표적 물질의 검출 방법
US20100112569A1 (en) 2007-01-23 2010-05-06 Roy Bar-Ziv Microfluidic devices and methods of generating and using same
US20080188374A1 (en) 2007-01-30 2008-08-07 Academia Sinica In-Solution Microarray Assay
CN101678090B (zh) 2007-03-07 2012-04-11 乌第有限合伙公司 用于预防和治疗自身免疫病的组合物和方法
AU2016203838A1 (en) 2007-03-07 2016-06-30 The General Hospital Corporation Compositions and methods for the prevention and treatment of autoimmune conditions
US7807372B2 (en) 2007-06-04 2010-10-05 Northwestern University Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay
US20110059431A1 (en) 2007-06-18 2011-03-10 Northwestern University Non-enzymatic detection of bacterial genomic dna
EP2167537A2 (en) 2007-07-03 2010-03-31 Dako Denmark A/S Compiled methods for analysing and sorting samples
AU2008276027B2 (en) * 2007-07-16 2014-09-04 California Institute Of Technology Arrays, substrates, devices, methods and systems for detecting target molecules
JP2009068869A (ja) 2007-09-11 2009-04-02 Panasonic Corp 生体分子検出方法
AU2007100888A4 (en) 2007-09-13 2007-11-01 Shan, Jianguo Dr Design and synthesis of streptavidin-DNA conjugates
US8993714B2 (en) 2007-10-26 2015-03-31 Imiplex Llc Streptavidin macromolecular adaptor and complexes thereof
WO2009055068A1 (en) 2007-10-26 2009-04-30 Imiplex Llc Streptavidin macromolecular adaptor and complexes thereof
WO2009083856A2 (en) 2007-12-20 2009-07-09 Koninklijke Philips Electronics N.V. Concentrated unbound magnetic particle assay for biosensors
DE102008013715B4 (de) 2008-02-29 2011-12-08 Eberhard-Karls-Universität Tübingen Verfahren zur DNA-Analyse
US9738888B2 (en) 2008-03-24 2017-08-22 Universidade Federal de Pernambuco—UFPE Magnetic nanocomposite retrieval of nucleotide sequence
CA2719211C (en) 2008-04-04 2017-01-24 Allopartis Biotechnologies, Inc. Method of enhancing enzyme activity
JP2011518553A (ja) * 2008-04-09 2011-06-30 カリフォルニア インスティチュート オブ テクノロジー 標的を検出及び／又は分類する捕捉剤および関連する方法およびシステム
SG192445A1 (en) 2008-06-02 2013-08-30 Brookhaven Science Ass Llc Controllable assembly and disassembly of nanoparticle systems via protein and dna agents
CN101684503A (zh) 2008-09-23 2010-03-31 武汉哇哇噻纳技术开发有限公司 基于dna信号转换的磁颗粒/微电极检测方法
EP2337795A2 (en) 2008-10-01 2011-06-29 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
WO2010037397A1 (en) 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cmv immune monitoring
WO2010042823A1 (en) 2008-10-09 2010-04-15 Northeastern Universtiy Multifunctional self-assembling polymeric nanosystems
US20110171749A1 (en) 2009-03-02 2011-07-14 Board Of Trustees Of Michigan State University Nanoparticle tracer-based electrochemical dna sensor for detection of pathogens-amplification by a universal nano-tracer (aunt)
US8999263B2 (en) 2009-05-29 2015-04-07 Ondavia, Inc. Microfluidic separation device
WO2011050000A2 (en) 2009-10-20 2011-04-28 The Regents Of The University Of California Single molecule nucleic acid nanoparticles
EP2491056B1 (en) 2009-10-22 2021-09-15 Universiteit Twente Vhh for application in tissue repair, organ regeneration, organ replacement and tissue engineering
US9023650B2 (en) 2009-11-02 2015-05-05 Lawrence Livermore National Security, Llc DNA tagged microparticles
US20110237449A1 (en) 2010-01-07 2011-09-29 Affymetrix, Inc. Methods and Compositions for Nucleic Acid Purification
WO2011090445A1 (en) 2010-01-22 2011-07-28 Huseyin Avni Oktem Method for detection of non-labeled pcr products on sandwich hybridization based array platforms
WO2011100669A2 (en) 2010-02-15 2011-08-18 North Carolina State University Office Of Technology Transfer Lable-free multiplexing bioassays using fluorescent conjugated polymers and barcoded nanoparticles
GB201003088D0 (en) 2010-02-24 2010-04-14 Univ Exeter Method for the preparation of a novel nanoparticle conjugate
KR101100664B1 (ko) 2010-03-25 2012-01-03 충남대학교산학협력단 디지털 바코드 나노 와이어 및 이를 이용한 바이오 센싱 시스템
CN102234682B (zh) 2010-04-20 2012-11-28 中国科学院广州生物医药与健康研究院 基于生物条码的核酸纳米金生物传感器
CN101852808A (zh) 2010-05-18 2010-10-06 中国医学科学院生物医学工程研究所 应用生物条码与基因芯片检测蛋白浓度的方法
KR101171738B1 (ko) 2010-06-07 2012-08-07 터프츠 유니버시티 복제몰딩에 의한 ｄｎａ-컨쥬게이티드 하이드로겔 마이크로입자의 제조 방법 및 이를 이용한 핵산의 혼성화 분석 방법
US20150050747A1 (en) 2010-07-19 2015-02-19 Board Of Trustees Of Michigan State University DIRECTED DNA CO-POLYMER MASS AMPLIFICATION FOR ssDNA DETECTION
WO2012044999A2 (en) * 2010-10-01 2012-04-05 Ludwig Institute For Cancer Research Ltd. Reversible protein multimers, methods for their production and use
US9511151B2 (en) 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
CN102072931B (zh) 2010-12-09 2013-07-17 华东师范大学 一种基于硅纳米线的生物传感器制备方法及在dna检测中的应用
CN102147414B (zh) 2010-12-30 2013-07-03 中国科学院上海微系统与信息技术研究所 基于纳米探针的微流体芯片检测微量蛋白的方法
CN102168066A (zh) 2011-01-31 2011-08-31 浙江大学 体外诱导乙型肝炎病毒特异性细胞毒性t淋巴细胞的方法
JPWO2012111686A1 (ja) 2011-02-15 2014-07-07 協和メデックス株式会社 ストレプトアビジン結合磁性粒子の製造方法
WO2012111687A1 (ja) 2011-02-15 2012-08-23 協和メデックス株式会社 ストレプトアビジン結合磁性粒子の製造方法
KR20140007413A (ko) 2011-02-15 2014-01-17 교와 메덱스 가부시키가이샤 스트렙트아비딘 결합 자성 입자 및 이의 제조 방법
US9657336B2 (en) 2011-04-25 2017-05-23 University Of Notre Dame Du Lac Systems and methods for detecting and quantifying a sequence of nucleotides
WO2012149265A2 (en) 2011-04-29 2012-11-01 Selecta Biosciences, Inc. Tolerogenic synthetic nanocarriers to reduce cytotoxic t lymphocyte responses
US8709722B2 (en) 2011-08-24 2014-04-29 Agency For Science, Technology And Research Methods for detecting DNA-binding proteins
WO2013036826A2 (en) 2011-09-09 2013-03-14 The Trustees Of Columbia University In The City Of New York Streptavidin complexes and uses thereof
CN102321762B (zh) 2011-09-14 2014-07-30 上海德诺产品检测有限公司 一种高灵敏度快速检测单增李斯特菌的方法及其试剂盒
AU2012325791B2 (en) 2011-10-21 2018-04-05 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
JP2013092501A (ja) 2011-10-27 2013-05-16 Toyohashi Univ Of Technology バイオ物質の検出方法
WO2013071520A1 (zh) 2011-11-18 2013-05-23 深圳华大基因科技有限公司 用于病毒检测的方法和系统
KR101355994B1 (ko) 2011-11-22 2014-01-29 한국과학기술원 병원체 검출용 마이크로디바이스
US20150031571A1 (en) 2012-02-07 2015-01-29 University Of Kansas Chemiluminescent nanoparticles and uses thereof
US10988516B2 (en) 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
KR101360405B1 (ko) 2012-04-10 2014-02-11 서강대학교산학협력단 신경전달-관련 물질 검출용 센서
KR20130121550A (ko) 2012-04-27 2013-11-06 서강대학교산학협력단 티로신 수산화효소 검출용 센서
FR2998899B1 (fr) 2012-11-30 2015-07-17 Commissariat Energie Atomique Methode de criblage a haut-debit pour l'identification de biomarqueurs, cibles therapeutiques ou d'agents therapeutiques
US9486768B2 (en) 2012-10-29 2016-11-08 New York University Colloids with valence: fabrication, functionalization and directional bonding
KR101488436B1 (ko) 2013-01-28 2015-02-04 고려대학교 산학협력단 금 나노입자를 이용한 ｄｎａ 혼성화 반응의 단일 부정합 검출방법
US11473152B2 (en) 2013-02-15 2022-10-18 The Governing Council Of The University Of Toronto Metal nanoshell-coated barcodes
US9914960B2 (en) 2013-03-15 2018-03-13 Boise State University Enhanced DNA sensing via catalytic aggregation of gold nanoparticles by DNA hybridization chain reaction
KR102245908B1 (ko) 2013-03-15 2021-04-30 메사추세츠 인스티튜트 오브 테크놀로지 물체 및 티슈의 라벨링을 위한 희토류 공간/스펙트럼 미세 입자 바코드
CN103266170A (zh) 2013-05-13 2013-08-28 江南大学 一种基于pcr组装磁性纳米粒子进行dna检测的方法
KR101580360B1 (ko) 2013-05-22 2015-12-28 김성천 연자성미세구조물을 이용한 리간드의 스크리닝 시스템 및 그 용도
CN103276087B (zh) 2013-05-30 2015-03-18 杭州金溪生物技术有限公司 高灵敏度的蛋白检测方法
US9903861B2 (en) 2013-05-30 2018-02-27 Osaka Prefecture University Public Corporation Device and method for detecting an analyte
ES2828985T3 (es) 2013-06-07 2021-05-28 Massachusetts Inst Technology Detección basada en la afinidad de biomarcadores sintéticos codificados por ligando
CN103333967B (zh) 2013-07-12 2016-06-22 湖南工程学院 一种基于微流控微珠阵列芯片的核酸检测方法
CA2929042A1 (en) 2013-10-25 2015-04-30 The Foundation For The Promotion Of Industrial Science Dna detection method
KR101537165B1 (ko) 2013-10-30 2015-07-15 서울대학교산학협력단 바코드 dna를 이용한 겔 전기영동 기반 생물물질의 분석방법
US10168271B2 (en) 2013-11-01 2019-01-01 The General Hospital Corporation Microparticles having reference markers arranged in different concentrations
KR102475314B1 (ko) 2013-12-23 2022-12-06 일루미나, 인코포레이티드 광 방출의 검출을 개선시키기 위한 구조화 기판 및 이와 관련한 방법
GB201404552D0 (en) 2014-03-14 2014-04-30 Philochem Ag Purification of dna-conjugate products
JP2015173626A (ja) 2014-03-14 2015-10-05 ジェノダイブファーマ株式会社 次世代シークエンサーのためのｄｎａライブラリー調製方法
CN106460069B (zh) 2014-04-18 2021-02-12 威廉马歇莱思大学 用于富集含稀有等位基因的物质的核酸分子的竞争性组合物
WO2015174862A1 (en) 2014-05-15 2015-11-19 Victoria Link Limited Polynucleotide sequence
KR20150144644A (ko) 2014-06-17 2015-12-28 건국대학교 산학협력단 Dna 검출용 바이오센서 및 이의 제조방법
WO2015200384A1 (en) 2014-06-23 2015-12-30 Abreos Biosciences, Inc. Multiplex dna nanoparticle protein assay and quantitation
WO2016015027A1 (en) 2014-07-25 2016-01-28 SeLux Diagnostics, Inc. Assay methods involving dissociable nanoparticles
DE102014116567A1 (de) 2014-11-12 2016-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zum Sortieren von Mikropartikeln in einem Fluidstrom
WO2016090115A1 (en) 2014-12-04 2016-06-09 The Regents Of The University Of California Novel multivalent bioassay reagents
MX2017009272A (es) 2015-01-16 2018-04-11 Anticuerpos que penetran en células.
AU2016215058B2 (en) 2015-02-06 2021-06-24 Board Of Regents, The University Of Texas System Systems and methods for high-resolution imaging
US20160287152A1 (en) 2015-03-30 2016-10-06 Verily Life Sciences Llc Functionalized Nanoparticles, Methods and In Vivo Diagnostic System
US20160289769A1 (en) 2015-03-30 2016-10-06 Verily Life Sciences Llc Methods for Combining Single Cell Profiling with Combinatorial Nanoparticle Conjugate Library Screening and In Vivo Diagnostic System
CN104962570A (zh) 2015-06-03 2015-10-07 湖北文理学院 一种高均一性单价链霉亲和素四聚体的制备方法
CN105651992B (zh) 2016-02-16 2018-10-12 中国农业科学院农业质量标准与检测技术研究所 三唑磷生物条形码免疫分析测定试剂盒及其应用
CN105648069A (zh) 2016-02-25 2016-06-08 青岛科技大学 基于适体的靶向激活循环放大spr检测蛋白质的方法
CN105755118B (zh) 2016-03-10 2020-01-21 杭州市疾病预防控制中心 免疫磁珠环介导等温扩增法快速检测副溶血性弧菌的方法

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