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ES2151541T3 - Microesferas que contienen hormona del crecimiento de liberacion prolongada. - Google Patents

Microesferas que contienen hormona del crecimiento de liberacion prolongada.

Info

Publication number
ES2151541T3
ES2151541T3 ES94902475T ES94902475T ES2151541T3 ES 2151541 T3 ES2151541 T3 ES 2151541T3 ES 94902475 T ES94902475 T ES 94902475T ES 94902475 T ES94902475 T ES 94902475T ES 2151541 T3 ES2151541 T3 ES 2151541T3
Authority
ES
Spain
Prior art keywords
growth hormone
microspheres
biological activity
growth
polymeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94902475T
Other languages
English (en)
Inventor
Henry Auer
M Amin Khan
Howard Bernstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Original Assignee
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25530460&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2151541(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alkermes Inc, Alkermes Controlled Therapeutics Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of ES2151541T3 publication Critical patent/ES2151541T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE DESCRIBEN LOS SISTEMAS DE LIBERACION CONTROLADA DE HORMONA POLIMERICA DEL CRECIMIENTO EN LOS QUE LA HORMONA DEL CRECIMIENTO CONSERVA UNA ACTIVIDAD BIOLOGICAMENTE BUENA Y SE LIBERA DURANTE UN PERIODO DE TIEMPO PROLONGADO A PARTIR DE SU ADMINISTRACION INYECTADA. EN SU MATERIALIZACION PREFERENTE, LAS MICROESFERAS POLIMERICAS DE LA HORMONA DEL CRECIMIENTO HUMANO, SE ELABORAN UTILIZANDO TEMPERATURAS MUY BAJAS PARA CONGELAR LAS MEZCLAS HORMONALES POLIMERICAS DE CRECIMENTO Y CONVERTIRLAS EN MICROESFERAS POLIMERICAS CON UNA ALTA CONSERVACION DE ACTIVIDAD Y MATERIAL BIOLOGICO. LA LIBERACION SOSTENIDA DE HORMONA DEL CRECIMIENTO BIOLOGICAMENTE ACTIVA SE CONSIGUE CUANDO SE TESTAN LAS HORMONAS IN VITRO, DURANTE UN PERIODO SUPERIOR A UN DIA QUE PUEDE PROLONGARSE HASTA VARIOS MESES. UNA LIBERACION MODIFICADA SE PUEDE OBTENER MEDIANTE LA INCLUSION DE MODIFICADORES DE DEGRADACION, AGENTES DE FORMACION DE POROS Y ESTABILIZADORES DE LA HORMONA DEL CRECIMIENTO.
ES94902475T 1992-12-02 1993-12-02 Microesferas que contienen hormona del crecimiento de liberacion prolongada. Expired - Lifetime ES2151541T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98432392A 1992-12-02 1992-12-02
PCT/US1993/011621 WO1994012158A1 (en) 1992-12-02 1993-12-02 Controlled release growth hormone containing microspheres

Publications (1)

Publication Number Publication Date
ES2151541T3 true ES2151541T3 (es) 2001-01-01

Family

ID=25530460

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94902475T Expired - Lifetime ES2151541T3 (es) 1992-12-02 1993-12-02 Microesferas que contienen hormona del crecimiento de liberacion prolongada.

Country Status (13)

Country Link
US (6) US5667808A (es)
EP (2) EP1013270A3 (es)
JP (1) JPH08503950A (es)
KR (1) KR19990022038A (es)
AT (1) ATE195652T1 (es)
AU (2) AU670168B2 (es)
CA (1) CA2150803C (es)
DE (1) DE69329295T2 (es)
DK (1) DK0674506T3 (es)
ES (1) ES2151541T3 (es)
GR (1) GR3034873T3 (es)
PT (1) PT674506E (es)
WO (1) WO1994012158A1 (es)

Families Citing this family (278)

* Cited by examiner, † Cited by third party
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EP1013270A3 (en) 2001-03-28
ATE195652T1 (de) 2000-09-15
US20030211153A1 (en) 2003-11-13
US5667808A (en) 1997-09-16
DK0674506T3 (da) 2001-01-08
PT674506E (pt) 2001-01-31
CA2150803A1 (en) 1994-06-09
US6051259A (en) 2000-04-18
AU5683594A (en) 1994-06-22
AU694378B2 (en) 1998-07-16
WO1994012158A1 (en) 1994-06-09
US5891478A (en) 1999-04-06
CA2150803C (en) 2006-01-31
US5654010A (en) 1997-08-05
US6500448B1 (en) 2002-12-31
DE69329295T2 (de) 2001-03-15
EP0674506A1 (en) 1995-10-04
EP1013270A2 (en) 2000-06-28
DE69329295D1 (de) 2000-09-28
JPH08503950A (ja) 1996-04-30
AU670168B2 (en) 1996-07-04
EP0674506B1 (en) 2000-08-23
GR3034873T3 (en) 2001-02-28
KR19990022038A (ko) 1999-03-25
AU6802996A (en) 1996-12-19

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