EE03902B1 - Osakesed, nende valmistamismeetod ja kasutamine, farmatseutiline doseerimisvorm ja selle valmistamismeetod, tahke dispersioon ning farmatseutiline pakend - Google Patents

Osakesed, nende valmistamismeetod ja kasutamine, farmatseutiline doseerimisvorm ja selle valmistamismeetod, tahke dispersioon ning farmatseutiline pakend

Info

Publication number: EE03902B1
Authority: EE; Estonia
Prior art keywords: preparation; pharmaceutical; particles; dosage form; solid dispersion
Prior art date: 1996-05-20

Application number

EE9800304A

Other languages

English (en)

Estonian (et)

Other versions

EE9800304A (et

Inventor

Elvire Colette Baert Lieven

Verreck Geert

Thon Dany

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-20

Filing date

1997-05-12

Publication date

2002-12-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26142825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03902(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-05-12 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

1999-02-15 Publication of EE9800304A publication Critical patent/EE9800304A/xx

2002-12-16 Publication of EE03902B1 publication Critical patent/EE03902B1/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EE9800304A 1996-05-20 1997-05-12 Osakesed, nende valmistamismeetod ja kasutamine, farmatseutiline doseerimisvorm ja selle valmistamismeetod, tahke dispersioon ning farmatseutiline pakend EE03902B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP96201430		1996-05-20
EP97200698		1997-03-07
PCT/EP1997/002507 WO1997044014A1 (en)	1996-05-20	1997-05-12	Antifungal compositions with improved bioavailability

Publications (2)

Publication Number	Publication Date
EE9800304A EE9800304A (et)	1999-02-15
EE03902B1 true EE03902B1 (et)	2002-12-16

Family

ID=26142825

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800304A EE03902B1 (et)	1996-05-20	1997-05-12	Osakesed, nende valmistamismeetod ja kasutamine, farmatseutiline doseerimisvorm ja selle valmistamismeetod, tahke dispersioon ning farmatseutiline pakend

Country Status (34)

Country	Link
US (4)	US6509038B2 (sk)
EP (1)	EP0904060B1 (sk)
JP (1)	JP3391801B2 (sk)
KR (1)	KR19990044257A (sk)
CN (1)	CN1165291C (sk)
AR (1)	AR007195A1 (sk)
AT (1)	ATE255883T1 (sk)
AU (1)	AU722101B2 (sk)
BG (1)	BG64368B1 (sk)
BR (1)	BR9706897B1 (sk)
CA (1)	CA2240161C (sk)
CY (1)	CY2434B1 (sk)
CZ (1)	CZ293841B6 (sk)
DE (1)	DE69726729T2 (sk)
DK (1)	DK0904060T3 (sk)
EA (1)	EA001219B1 (sk)
EE (1)	EE03902B1 (sk)
ES (1)	ES2212810T3 (sk)
HK (1)	HK1018002A1 (sk)
HR (1)	HRP970270B1 (sk)
HU (1)	HU227745B1 (sk)
ID (1)	ID16926A (sk)
IL (1)	IL124935A (sk)
MX (1)	MX9805418A (sk)
MY (1)	MY123827A (sk)
NO (1)	NO320495B1 (sk)
NZ (1)	NZ330739A (sk)
PL (1)	PL188566B1 (sk)
PT (1)	PT904060E (sk)
SI (1)	SI0904060T1 (sk)
SK (1)	SK284145B6 (sk)
TR (1)	TR199801225T2 (sk)
TW (1)	TW460282B (sk)
WO (1)	WO1997044014A1 (sk)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR19990001564A (ko) *	1997-06-16	1999-01-15	유충식	용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
KR100288890B1 (ko) *	1997-12-31	2001-05-02	최현식	이트라코나졸 경구용 제제 및 그의 제조방법
CA2317106C (en)	1997-12-31	2004-11-23	Choongwae Pharma Corporation	Method and composition of an oral preparation of itraconazole
KR100514330B1 (ko) *	1997-12-31	2006-02-17	주식회사 중외제약	난용성 약물을 함유하는 코팅정
ES2157731B1 (es) *	1998-07-21	2002-05-01	Liconsa Liberacion Controlada	Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
IL145140A0 (en) *	1999-03-24	2002-06-30	Fmc Corp	Improved aqueous solubility pharmaceutical formulations
KR100331529B1 (ko) *	1999-06-16	2002-04-06	민경윤	난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법
EP1175205B1 (en)	1999-11-12	2006-06-14	Abbott Laboratories	Solid dispersion comprising ritonavir, fenofibrate or griseofulvin
AU2331801A (en) *	1999-12-23	2001-07-09	F.H. Faulding & Co. Limited	Improved pharmaceutical compositions for poorly soluble drugs
FR2803748A1 (fr) *	2000-01-14	2001-07-20	Ethypharm Lab Prod Ethiques	Composition d'itraconazole et procede de preparation
DE10026698A1 (de)	2000-05-30	2001-12-06	Basf Ag	Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
NZ522953A (en) *	2000-06-22	2005-10-28	Novartis Ag	Tablet containing valsartan, microcrystalline cellulose, crospovidone, colloidal anhydrous silica/colloidal silicon dioxide and magnesium stearate
DE10038571A1 (de) *	2000-08-03	2002-02-14	Knoll Ag	Zusammensetzungen und Dosierungsformen zur Anwendung in der Mundhöhle bei der Bhandlung von Mykosen
US20050048126A1 (en) *	2000-12-22	2005-03-03	Barrett Rabinow	Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US6977085B2 (en)	2000-12-22	2005-12-20	Baxter International Inc.	Method for preparing submicron suspensions with polymorph control
US6951656B2 (en)	2000-12-22	2005-10-04	Baxter International Inc.	Microprecipitation method for preparing submicron suspensions
US6607784B2 (en)	2000-12-22	2003-08-19	Baxter International Inc.	Microprecipitation method for preparing submicron suspensions
US6884436B2 (en)	2000-12-22	2005-04-26	Baxter International Inc.	Method for preparing submicron particle suspensions
US9700866B2 (en)	2000-12-22	2017-07-11	Baxter International Inc.	Surfactant systems for delivery of organic compounds
US8067032B2 (en)	2000-12-22	2011-11-29	Baxter International Inc.	Method for preparing submicron particles of antineoplastic agents
US7193084B2 (en)	2000-12-22	2007-03-20	Baxter International Inc.	Polymorphic form of itraconazole
KR100870184B1 (ko)	2001-02-14	2008-11-24	티보텍 파마슈티칼즈 리미티드	광범위 2-(치환된-아미노)-벤조티아졸 설폰아미드 ｈｉｖ프로티아제 억제제
CZ303139B6 (cs)	2001-04-09	2012-04-25	Tibotec Pharmaceuticals Ltd.	2-(substituovaný amino)-benzoxazolsulfonamidový derivát, farmaceutická kompozice s jeho obsahem a zpusob in vitro inhibice retrovirové replikace
CA2444895C (en)	2001-05-11	2011-02-15	Tibotec Pharmaceuticals Ltd.	Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors
WO2002100407A1 (en) *	2001-06-12	2002-12-19	Smartrix Technologies Inc.	Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
MXPA03011784A (es)	2001-06-22	2004-04-02	Pfizer Prod Inc	Composiciones farmaceuticas de dispersiones de farmacos y polimeros neutros.
KR100455216B1 (ko) *	2001-06-27	2004-11-09	한미약품 주식회사	난용성 항진균제의 경구투여용 조성물 및 이의 제조 방법
US7163700B2 (en) *	2001-07-31	2007-01-16	Capricorn Pharma, Inc.	Amorphous drug beads
KR100438485B1 (ko) *	2001-08-13	2004-07-09	한국디디에스제약 주식회사	아졸류 항진균제의 약제학적 조성물
US20060003012A9 (en)	2001-09-26	2006-01-05	Sean Brynjelsen	Preparation of submicron solid particle suspensions by sonication of multiphase systems
JP2005504090A (ja)	2001-09-26	2005-02-10	バクスター・インターナショナル・インコーポレイテッド	分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US7112340B2 (en)	2001-10-19	2006-09-26	Baxter International Inc.	Compositions of and method for preparing stable particles in a frozen aqueous matrix
UA79248C2 (en)	2001-11-09	2007-06-11	Janssen Pharmaceutica Nv	Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
CA2363376A1 (en) *	2001-11-16	2003-05-16	Bernard Charles Sherman	Solid pharmaceutical compositions for oral administration comprising itraconazole
US20040220240A1 (en) *	2001-11-28	2004-11-04	Pellegrini Cara A.	Method of increasing the extent of absorption of tizanidine
US6455557B1 (en) *	2001-11-28	2002-09-24	Elan Pharmaceuticals, Inc.	Method of reducing somnolence in patients treated with tizanidine
MY138657A (en)	2001-12-21	2009-07-31	Tibotec Pharm Ltd	broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
HRP20020124A2 (en) *	2002-02-11	2003-10-31	Pliva D D	Sustained/controlled release solid formulation as a novel drug delivery system with reduced risk of dose dumping
IL161134A0 (en) *	2002-02-28	2004-08-31	Japan Tobacco Inc	Ester compound and medical use thereof
MY142238A (en)	2002-03-12	2010-11-15	Tibotec Pharm Ltd	Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
EA010908B1 (ru)	2002-05-17	2008-12-30	Тиботек Фармасьютикалз Лтд.	Ингибиторы вич-протеазы на основе замещённых бензизоксазолсульфонамидов широкого спектра действия
US7407670B2 (en)	2002-07-04	2008-08-05	Janssen Pharmaceutica, N.V.	Solid dispersions comprising two different polymer matrixes
NZ538714A (en)	2002-08-14	2007-03-30	Tibotec Pharm Ltd	Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors
PT1551372T (pt)	2002-09-20	2018-07-23	Alpharma Pharmaceuticals Llc	Subunidade de sequestração e composições e métodos relacionados
US20040086567A1 (en) *	2002-10-30	2004-05-06	Pawan Seth	Bioequivalent composition of itraconazole and a hydrophilic polymer
ES2283725T5 (es) *	2003-01-14	2014-11-28	Acino Pharma Ag	Composición bioequivalente de itraconazol dispersada en un polímero hidrófilo
CN101091695B (zh) *	2003-02-03	2011-01-19	诺瓦提斯公司	药物制剂
ES2667668T3 (es) *	2003-07-17	2018-05-14	Janssen Sciences Ireland Uc	Procedimiento para preparar partículas que contienen un antiviral
FR2857591B1 (fr) *	2003-07-17	2007-11-02	Ethypharm Sa	Particules comprenant un principe actif sous forme de co-precipite
US8025899B2 (en)	2003-08-28	2011-09-27	Abbott Laboratories	Solid pharmaceutical dosage form
WO2005021486A1 (ja) *	2003-08-29	2005-03-10	Japan Tobacco Inc.	エステル誘導体及びその医薬用途
US20050058670A1 (en) *	2003-09-09	2005-03-17	Jong-Soo Woo	Oral itraconazole composition which is not affected by ingested food and process for preparing same
WO2005023242A1 (en)	2003-09-11	2005-03-17	Tibotec Pharmaceuticals Ltd.	Entry inhibitors of the hiv virus
US20050118265A1 (en) *	2003-11-28	2005-06-02	Anandi Krishnan	Antifungal oral dosage forms and the methods for preparation
TWI350762B (en) *	2004-02-12	2011-10-21	Euro Celtique Sa	Particulates
GB0403098D0 (en) *	2004-02-12	2004-03-17	Euro Celtique Sa	Extrusion
EP1729741A2 (en) *	2004-03-03	2006-12-13	Spherics, Inc.	Polymeric drug delivery system for hydrophobic drugs
AR048650A1 (es)	2004-05-04	2006-05-10	Tibotec Pharm Ltd	Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
EP2422780A1 (en)	2004-05-07	2012-02-29	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
JP2007538050A (ja)	2004-05-17	2007-12-27	テイボテク・フアーマシユーチカルズ・リミテツド	抗感染薬剤として有用な６，７，８，９−置換１−フェニル−１，５−ジヒドロ−ピリド［３，２−ｂ］インドール−２−オン
AU2005243439B2 (en)	2004-05-17	2011-09-29	Tibotec Pharmaceuticals Ltd.	1-heterocyclyl-1,5-dihydro-pyrido(3,2-b)indol-2-ones
MXPA06013315A (es)	2004-05-17	2007-02-02	Tibotec Pharm Ltd	1,5-dihidro-pirido[3,2-b]indol-2-onas 4-sustituidas.
WO2005117834A1 (en) *	2004-05-27	2005-12-15	Janssen Pharmaceutica N.V.	Solid dispersions of a basic drug compound and a polymer containing acidic groups
KR20050119397A (ko) *	2004-06-16	2005-12-21	보람제약주식회사	고상용해를 이용한 난용성 약물의 가용화 방법과 이를이용한 가용화 조성물
US20060030623A1 (en) *	2004-07-16	2006-02-09	Noboru Furukawa	Agent for the treatment or prevention of diabetes, obesity or arteriosclerosis
KR100708974B1 (ko) *	2004-07-19	2007-04-18	주식회사종근당	수용성 수지를 이용한 이트라코나졸 고체분산체
US20070281007A1 (en) *	2004-08-27	2007-12-06	Jacob Jules S	Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs
US20060045865A1 (en) *	2004-08-27	2006-03-02	Spherics, Inc.	Controlled regional oral delivery
US8101774B2 (en)	2004-10-18	2012-01-24	Japan Tobacco Inc.	Ester derivatives and medicinal use thereof
CA2582767C (en) *	2004-10-25	2011-05-24	Japan Tobacco Inc.	Solid formulation with improved solubility and stability and method for producing said formulation
US9504658B2 (en)	2004-11-09	2016-11-29	Board Of Regents, The University Of Texas System	Stabilized HME composition with small drug particles
DK1848430T3 (da) *	2004-12-31	2017-11-06	Dr Reddys Laboratories Ltd	Nye benzylamin-derivativer som cetp-inhibitors
US8604055B2 (en)	2004-12-31	2013-12-10	Dr. Reddy's Laboratories Ltd.	Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
AR056652A1 (es)	2005-04-11	2007-10-17	Tibotec Pharm Ltd	Derivados de (1,10-b dihidro-2-(aminoalquil-fenil) -5h-pirazolo (1,5-c) (1,3)benzoxazin-5-il) fenilmetanona y su uso en la fabricacion de un medicamento
DE102005026755A1 (de) *	2005-06-09	2006-12-14	Basf Ag	Herstellung von festen Lösungen schwerlöslicher Wirkstoffe durch Kurzzeitüberhitzung und schnelle Trocknung
ES2571032T3 (es) *	2005-08-08	2016-05-23	Abbvie Deutschland	Composiciones de itraconazol con biodisponibilidad mejorada
JP2009504590A (ja) *	2005-08-08	2009-02-05	アボットゲーエムベーハーウントコンパニーカーゲー	改善された生物学的利用能をもつ剤型
WO2007024971A2 (en)	2005-08-22	2007-03-01	The Johns Hopkins University	Hedgehog pathway antagonists to treat disease
JP2009527504A (ja) *	2006-02-23	2009-07-30	イオメディックススリープインターナショナルエスアールエル	良質な睡眠の誘導および維持のための組成物および方法
CN101415708A (zh)	2006-04-03	2009-04-22	泰博特克药品有限公司	抑制HIV的3,4-二氢-咪唑并[4,5-b]吡啶-5-酮
GB0607105D0 (en) *	2006-04-10	2006-05-17	Leuven K U Res & Dev	Enhancing solubility and dissolution rate of poorly soluble drugs
PL2034975T3 (pl)	2006-06-19	2012-09-28	Alpharma Pharmaceuticals Llc	Kompozycje farmaceutyczne
KR20090027734A (ko) *	2006-07-27	2009-03-17	(주)아모레퍼시픽	난용성 약물의 나노입자를 포함하는 분말의 제조방법
JP2010506833A (ja) *	2006-10-11	2010-03-04	アルファーマ，インコーポレイテッド	医薬組成物
CN101702878B (zh) *	2007-05-11	2012-11-28	弗·哈夫曼-拉罗切有限公司	可溶性差的药物的药物组合物
US8722736B2 (en)	2007-05-22	2014-05-13	Baxter International Inc.	Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en)	2007-05-22	2013-04-23	Baxter International Inc.	Colored esmolol concentrate
CN101835492B (zh) *	2007-08-21	2012-11-21	德克萨斯州立大学董事会	用于制药应用的热动力学混合
WO2009034558A2 (en)	2007-09-14	2009-03-19	Wockhardt Research Centre	Rhein or diacerein compositions
EP2520284A1 (en)	2007-09-27	2012-11-07	Wockhardt Limited	Pharmaceutical compositions of rhein or diacerein
US20090130160A1 (en) *	2007-11-21	2009-05-21	Fiber Innovation Technology, Inc.	Fiber for wound dressing
CA2707161C (en)	2007-11-28	2016-08-16	Sequoia Pharmaceuticals, Inc.	Compositions and methods for inhibiting cytochrome p450 2d6
US20090196890A1 (en) *	2007-12-17	2009-08-06	Alpharma Pharmaceuticals, Llc	Pharmaceutical compositions
US8623418B2 (en)	2007-12-17	2014-01-07	Alpharma Pharmaceuticals Llc	Pharmaceutical composition
CN101951891A (zh) *	2008-01-11	2011-01-19	希普拉有限公司	固态药物剂型
US8906647B2 (en)	2008-02-21	2014-12-09	Sequoia Pharmaceuticals, Inc.	Diamide inhibitors of cytochrome P450
US8372432B2 (en)	2008-03-11	2013-02-12	Depomed, Inc.	Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
CN102105136B (zh)	2008-03-11	2014-11-26	蒂宝制药公司	包含非-阿片类止痛剂和阿片类止痛剂的组合的胃滞留型缓释剂型
US20110123627A1 (en) *	2008-04-15	2011-05-26	Larry Yun Fang	High density compositions containing posaconazole and formulations comprising the same
EA200900145A1 (ru) *	2008-12-31	2010-02-26	Открытое Акционерное Общество "Верофарм"	Противогрибковое средство для вагинального применения
CN101780046B (zh) *	2009-01-16	2011-09-21	北京化工大学	一种伊曲康唑复合粉体及其制备方法
EP2512455B8 (en)	2009-12-18	2014-07-23	FrieslandCampina Nederland Holding B.V.	Co-processed tablet excipient composition its preparation and use
US8597681B2 (en)	2009-12-22	2013-12-03	Mallinckrodt Llc	Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US9198861B2 (en)	2009-12-22	2015-12-01	Mallinckrodt Llc	Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
CA2813510A1 (en) *	2010-10-14	2012-04-19	Abbott Gmbh & Co. Kg	Curcuminoid solid dispersion formulation
CN102068416A (zh) *	2010-12-30	2011-05-25	安徽先求药业有限公司	一种含有伊曲康唑的口服固体制剂及其制备方法
EP2675434A1 (en)	2011-02-17	2013-12-25	F.Hoffmann-La Roche Ag	A process for controlled crystallization of an active pharmaceutical ingredient from supercooled liquid state by hot melt extrusion
US8858963B1 (en)	2011-05-17	2014-10-14	Mallinckrodt Llc	Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
US8658631B1 (en)	2011-05-17	2014-02-25	Mallinckrodt Llc	Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia
US8741885B1 (en)	2011-05-17	2014-06-03	Mallinckrodt Llc	Gastric retentive extended release pharmaceutical compositions
CN103732216A (zh) *	2011-08-16	2014-04-16	默沙东公司	无机基质和有机聚合物组合用于制备稳定的无定形分散体的用途
EP2744803A2 (en)	2011-08-18	2014-06-25	Dr. Reddy's Laboratories Ltd.	Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors
WO2013037396A1 (en) *	2011-09-12	2013-03-21	Bioneer A/S	Solution of polymer in api for a solid dosage form
CN103958511A (zh)	2011-09-27	2014-07-30	雷迪博士实验室有限公司	作为胆固醇酯转移蛋白(CETP)抑制剂用于治疗动脉粥样硬化的5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物
US20140128431A1 (en)	2012-04-03	2014-05-08	Hoffmann-Laroche Inc.	Pharmaceutical composition with improved bioavailability, safety and tolerability
EP2649989B1 (en)	2012-04-13	2017-10-18	King Saud University	Method for preparing a solid dispersion, solid dispersion obtained thereby and use thereof
MX366829B (es)	2012-06-21	2019-07-25	Mayne Pharma Int Pty Ltd	Composiciones y formas de dosificacion de itraconazol y metodos de uso de las mismas.
WO2014014752A1 (en) *	2012-07-17	2014-01-23	Dow Global Technologies Llc	Solid dispersion comprising a highly substituted hydroxyalkyl methylcellulose
BR112015011515A2 (pt)	2012-11-19	2017-08-22	Dr Reddy´S Laboratories Ltd	Composições farmacêuticas de inibidores de cetp
EA028009B1 (ru)	2013-01-22	2017-09-29	Ф.Хоффманн-Ля Рош Аг	Фармацевтическая композиция с улучшенной биодоступностью
CN104721827A (zh) *	2013-12-18	2015-06-24	博瑞生物医药技术(苏州)有限公司	一种难溶性抗真菌药物固体分散体及其制备方法
JP6546179B2 (ja) *	2014-01-16	2019-07-17	ダウグローバルテクノロジーズエルエルシー	３ｄ印刷用支持材料
CN107690458B (zh) *	2015-06-09	2020-07-24	陶氏环球技术有限责任公司	用于三维印刷的支撑材料
AU2017262586B2 (en) *	2016-05-09	2023-04-13	AustinPx, LLC	Improved drug formulations
EP3675832A1 (en)	2017-09-01	2020-07-08	Jordan Sweden Medical and Sterilization Company	Fast self dispersible dosage forms of deferasirox
EP3581697B1 (en)	2018-06-11	2023-02-22	The Procter & Gamble Company	Photoactivating device for washing machine
CN109172532A (zh) *	2018-10-24	2019-01-11	北京哈三联科技有限责任公司	一种伊曲康唑分散片及其制备方法和应用
JP2022546411A (ja) *	2019-08-28	2022-11-04	ルブリゾルアドバンスドマテリアルズ，インコーポレイテッド	直鎖ポリ（アクリル酸）ポリマーを使用した薬物－ポリマーアモルファス固体分散体
KR102266145B1 (ko) *	2019-09-26	2021-06-17	대봉엘에스 주식회사	비정질 에피나코나졸 고체 분산체
US20240350414A1 (en)	2021-08-25	2024-10-24	Basf Se	Direct tableting auxiliary composition

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4218458A (en) *	1978-06-23	1980-08-19	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
ATE5852T1 (de) *	1978-11-20	1984-02-15	American Home Products Corporation	Therapeutische zusammensetzungen mit gesteigerter bioverfuegbarkeit und verfahren zu deren herstellung.
JPS5879915A (ja) *	1981-11-09	1983-05-13	Nippon Soda Co Ltd	棒状薬剤の製造方法
US4916134A (en) *	1987-03-25	1990-04-10	Janssen Pharmacuetica N.V.	4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones
JPH0667840B2 (ja) *	1988-11-30	1994-08-31	萬有製薬株式会社	Ｎｂ―８１８の易吸収性製剤
US5028433A (en)	1988-11-30	1991-07-02	Banyu Pharmaceutical Co., Ltd.	Readily absorbable drug formulation of NB-818
DK469989D0 (da) *	1989-09-22	1989-09-22	Bukh Meditec	Farmaceutisk praeparat
ATE159426T1 (de) *	1991-04-16	1997-11-15	Nippon Shinyaku Co Ltd	Verfahren zur herstellung einer festen dispersion
US5340591A (en)	1992-01-24	1994-08-23	Fujisawa Pharmaceutical Co., Ltd.	Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
HU221189B1 (en) *	1992-03-18	2002-08-28	Janssen Pharmaceutica Nv	Itraconazole and saperconazole stereoisomers, their cyclodextrin complexes and pharmaceutical compositions containing them and process for producing them
DE4226753A1 (de)	1992-08-13	1994-02-17	Basf Ag	Wirkstoffe enthaltende Zubereitungen in Form fester Teilchen
PH30929A (en) *	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
JP3413238B2 (ja) *	1993-03-31	2003-06-03	オリンパス光学工業株式会社	位相制御膜構造体
JPH07112928A (ja) *	1993-10-15	1995-05-02	Freunt Ind Co Ltd	難溶性薬物の溶解性改善方法およびそれにより得られた粒状薬剤
FR2722984B1 (fr) *	1994-07-26	1996-10-18	Effik Lab	Procede de preparation de formes pharmaceutiques seches et les compositions pharmaceutiques ainsi realisees
JP2948111B2 (ja)	1994-09-16	1999-09-13	塩野義製薬株式会社	経口投与用油性組成物

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CZ293841B6 (cs)	2004-08-18
NO320495B1 (no)	2005-12-12
EA001219B1 (ru)	2000-12-25
US7081255B2 (en)	2006-07-25
CZ188598A3 (cs)	1998-11-11
CY2434B1 (en)	2004-11-12
BR9706897B1 (pt)	2010-09-21
EA199800571A1 (ru)	1998-12-24
BG64368B1 (bg)	2004-12-30
HU227745B1 (en)	2012-02-28
DK0904060T3 (da)	2004-04-13
SK84898A3 (en)	1999-03-12
TR199801225T2 (xx)	1998-11-23
NZ330739A (en)	1999-06-29
JP3391801B2 (ja)	2003-03-31
WO1997044014A1 (en)	1997-11-27
CN1209740A (zh)	1999-03-03
SI0904060T1 (en)	2004-04-30
TW460282B (en)	2001-10-21
EP0904060B1 (en)	2003-12-10
EP0904060A1 (en)	1999-03-31
MY123827A (en)	2006-06-30
US20010007678A1 (en)	2001-07-12
US6509038B2 (en)	2003-01-21
US20030082239A1 (en)	2003-05-01
MX9805418A (es)	1998-10-31
DE69726729T2 (de)	2004-12-02
AU722101B2 (en)	2000-07-20
NO982599D0 (no)	1998-06-05
BR9706897A (pt)	1999-08-31
US9642806B2 (en)	2017-05-09
SK284145B6 (sk)	2004-10-05
AU2956297A (en)	1997-12-09
CN1165291C (zh)	2004-09-08
PL188566B1 (pl)	2005-02-28
PT904060E (pt)	2004-04-30
US20060263436A1 (en)	2006-11-23
JPH11509238A (ja)	1999-08-17
CA2240161C (en)	2005-05-24
PL330931A1 (en)	1999-06-07
HRP970270A2 (en)	1998-04-30
ATE255883T1 (de)	2003-12-15
NO982599L (no)	1998-11-19
ID16926A (id)	1997-11-20
HK1018002A1 (en)	1999-12-10
ES2212810T3 (es)	2004-08-01
DE69726729D1 (de)	2004-01-22
HRP970270B1 (en)	2005-02-28
HUP9901620A3 (en)	2000-03-28
IL124935A (en)	2001-06-14
HUP9901620A2 (hu)	1999-10-28
KR19990044257A (ko)	1999-06-25
CA2240161A1 (en)	1997-11-27
BG102532A (en)	1999-02-26
US8591948B2 (en)	2013-11-26
IL124935A0 (en)	1999-01-26
EE9800304A (et)	1999-02-15
US20140134244A1 (en)	2014-05-15
AR007195A1 (es)	1999-10-13

Publication	Publication Date	Title
EE03902B1 (et)	2002-12-16	Osakesed, nende valmistamismeetod ja kasutamine, farmatseutiline doseerimisvorm ja selle valmistamismeetod, tahke dispersioon ning farmatseutiline pakend
EE04996B1 (et)	2008-04-15	Reguleeritud vabanemisega galantamiinipreparaat, meetod selle valmistamiseks, seda sisaldav doseerimisvorm ning farmatseutiline pakend
EE04991B1 (et)	2008-04-15	Osake, ravimvorm, nende valmistamismeetodid, osakeste kasutamine ning farmatseutiline pakend
EE9800383A (et)	1999-04-15	Meetod bioloogiliselt sobivate biodegradeeruvate mikroosakeste valmistamiseks, mikroosakesed ja nendest koosnev materjal, farmatseutiline kompositsioon ning mikroosakeste kasutamine
EE05086B1 (et)	2008-10-15	Primidiini derivaadid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod, kombinatsioon ning saadus
EE9700061A (et)	1997-08-15	Farmatseutiline aerosoolpreparaat ja selle valmistamismeetod
EE9700328A (et)	1998-06-15	Tahke oraalne preparaat, mis sisaldab toimeainena olansapiini, selle valmistamismeetod ja kasutamine
EE04417B1 (et)	2005-02-15	Peroraalne farmatseutiline pulseeriva vabanemisega annusvorm, selle valmistamise meetod ja kasutamine
FI954143L (fi)	1995-10-19	Kiinteitä lipidihiukkasia, bioaktiivisten aineiden hiukkasia, menetelmiä niiden valmistamiseksi ja niiden käyttö
FI962901L (fi)	1996-07-19	Uudelleendispergoitava dispersiojauheseos, sen valmistusmenetelmä ja sen käyttö
EE9700145A (et)	1998-02-16	Tsükloalkaanpüridiinid, nende valmistamismeetod, kasutamine ravimite tootmiseks ja nimetatud ühendeid sisaldavad ravimid
EE9500064A (et)	1996-06-17	Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid
EE200000186A (et)	2001-04-16	Osake, selliste osakeste valmistamismeetod ja kasutamine, farmatseutiline doosivorm ja selle valmistamismeetod, tahke dispersioon ja farmatseutiline pakend
FI953898L (fi)	1996-02-20	Glysiiniamidijohdannaisia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä lääkeaineita
FR2742751B1 (fr)	1998-01-30	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
EE9800302A (et)	1999-02-15	Arüülglütsiinamiidi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline preparaat
GB2343117B (en)	2001-07-25	Benzimidazole pharmaceutical composition and process of preparation
EE200000226A (et)	2001-06-15	3,6-poolketaalid 9a-asaliidide klassist, nende valmistamismeetod ja farmatseutiline kompositsioon
FR2732968B1 (fr)	1997-05-16	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
EE04119B1 (et)	2003-08-15	Külmkuivatamiseks sobiv ravimkoostis ja selle valmistamise meetod
FR2757166B1 (fr)	1999-01-29	Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2745814B1 (fr)	1998-04-03	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
EE200000099A (et)	2000-12-15	Antimükootiline kompositsioon, selle kasutamine ja valmistamismeetod ning antimükootiline toode
EE03996B1 (et)	2003-04-15	Farmatseutilised kompositsioonid, nende valmistamismeetod ja kasutamine
FR2732342B1 (fr)	1997-04-30	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

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