EE03221B1 - Inhaleeritavad ravimpreparaadid, nende valmistamise protsess ja inhalaator nende kasutamiseks - Google Patents

Inhaleeritavad ravimpreparaadid, nende valmistamise protsess ja inhalaator nende kasutamiseks

Info

Publication number: EE03221B1
Authority: EE; Estonia
Prior art keywords: inhalation; preparation; inhaler; pharmaceutical formulations; insulin
Prior art date: 1993-06-24

Application number

EE9400429A

Other languages

English (en)

Estonian (et)

Inventor

G�ran Erik B�ckstr�m Kjell

Magnus Olof Dahlb�ck Carl

Charlotte Birgit Johansson Ann

Edman Peter

Original Assignee

Astra Aktiebolag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-24

Filing date

1994-11-23

Publication date

1999-10-15

1993-06-24 Priority claimed from SE9302198A external-priority patent/SE9302198D0/xx

1994-02-04 Priority claimed from SE9400370A external-priority patent/SE9400370L/xx

1994-11-23 Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag

1999-10-15 Publication of EE03221B1 publication Critical patent/EE03221B1/xx

Links

238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
238000010521 absorption reaction Methods 0.000 abstract 1
239000000843 powder Substances 0.000 abstract 1
210000002345 respiratory system Anatomy 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Zoology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

EE9400429A 1993-06-24 1994-11-23 Inhaleeritavad ravimpreparaadid, nende valmistamise protsess ja inhalaator nende kasutamiseks EE03221B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9302198A SE9302198D0 (sv)	1993-06-24	1993-06-24	Powder preparation for inhalation
SE9400370A SE9400370L (sv)	1994-02-04	1994-02-04	Terapeutisk komposition för inhalation

Publications (1)

Publication Number	Publication Date
EE03221B1 true EE03221B1 (et)	1999-10-15

Family

ID=26661778

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9400429A EE03221B1 (et)	1993-06-24	1994-11-23	Inhaleeritavad ravimpreparaadid, nende valmistamise protsess ja inhalaator nende kasutamiseks

Country Status (32)

Country	Link
US (3)	US5518998C1 (zh)
EP (1)	EP0706382B1 (zh)
JP (2)	JP3874789B2 (zh)
KR (1)	KR100372673B1 (zh)
CN (1)	CN1110301C (zh)
AT (1)	ATE183920T1 (zh)
AU (1)	AU692780B2 (zh)
BR (1)	BR9406907A (zh)
CA (1)	CA2166108C (zh)
CZ (1)	CZ287314B6 (zh)
DE (1)	DE69420412T2 (zh)
DK (1)	DK0706382T3 (zh)
EE (1)	EE03221B1 (zh)
EG (1)	EG20599A (zh)
ES (1)	ES2138087T3 (zh)
FI (1)	FI111688B (zh)
GR (1)	GR3031974T3 (zh)
HK (1)	HK1009584A1 (zh)
HU (1)	HU228129B1 (zh)
IL (1)	IL110084A (zh)
IS (1)	IS1768B (zh)
MX (1)	MX9404761A (zh)
MY (1)	MY112098A (zh)
NO (1)	NO313657B1 (zh)
NZ (1)	NZ268137A (zh)
PL (1)	PL178403B1 (zh)
RU (1)	RU2148398C1 (zh)
SA (1)	SA94150030B1 (zh)
SK (1)	SK283145B6 (zh)
TW (1)	TW402506B (zh)
UA (1)	UA49794C2 (zh)
WO (1)	WO1995000127A1 (zh)

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US5506203C1 (en) *	1993-06-24	2001-02-06	Astra Ab	Systemic administration of a therapeutic preparation
US5661130A (en)	1993-06-24	1997-08-26	The Uab Research Foundation	Absorption enhancers for drug administration
GB9314614D0 (en)	1993-07-14	1993-08-25	Minnesota Mining & Mfg	Dry powder inhalers
US5514670A (en)	1993-08-13	1996-05-07	Pharmos Corporation	Submicron emulsions for delivery of peptides
US6051256A (en)	1994-03-07	2000-04-18	Inhale Therapeutic Systems	Dispersible macromolecule compositions and methods for their preparation and use
CZ295827B6 (cs) *	1994-03-07	2005-11-16	Nektar Therapeutics	Způsob aerosolizace dávky inzulinu, inzulinový přípravek a jeho použití
US5451569A (en)	1994-04-19	1995-09-19	Hong Kong University Of Science And Technology R & D Corporation Limited	Pulmonary drug delivery system
SE9404468D0 (sv) *	1994-12-22	1994-12-22	Astra Ab	Powder formulations

1994
- 1994-06-20 TW TW083105540A patent/TW402506B/zh not_active IP Right Cessation
- 1994-06-21 IS IS4178A patent/IS1768B/is unknown
- 1994-06-22 IL IL11008494A patent/IL110084A/xx not_active IP Right Cessation
- 1994-06-22 EG EG36694A patent/EG20599A/xx active
- 1994-06-23 PL PL94312205A patent/PL178403B1/pl not_active IP Right Cessation
- 1994-06-23 KR KR1019950705904A patent/KR100372673B1/ko not_active Expired - Fee Related
- 1994-06-23 ES ES94919960T patent/ES2138087T3/es not_active Expired - Lifetime
- 1994-06-23 BR BR9406907A patent/BR9406907A/pt not_active Application Discontinuation
- 1994-06-23 RU RU96103636A patent/RU2148398C1/ru not_active IP Right Cessation
- 1994-06-23 SK SK1601-95A patent/SK283145B6/sk not_active IP Right Cessation
- 1994-06-23 NZ NZ268137A patent/NZ268137A/en not_active IP Right Cessation
- 1994-06-23 DE DE69420412T patent/DE69420412T2/de not_active Expired - Lifetime
- 1994-06-23 DK DK94919960T patent/DK0706382T3/da active
- 1994-06-23 MX MX9404761A patent/MX9404761A/es unknown
- 1994-06-23 UA UA95125417A patent/UA49794C2/uk unknown
- 1994-06-23 AU AU70901/94A patent/AU692780B2/en not_active Ceased
- 1994-06-23 MY MYPI94001630A patent/MY112098A/en unknown
- 1994-06-23 CN CN94193190A patent/CN1110301C/zh not_active Expired - Fee Related
- 1994-06-23 US US08265372 patent/US5518998C1/en not_active Expired - Lifetime
- 1994-06-23 JP JP50273695A patent/JP3874789B2/ja not_active Expired - Fee Related
- 1994-06-23 AT AT94919960T patent/ATE183920T1/de active
- 1994-06-23 CA CA002166108A patent/CA2166108C/en not_active Expired - Fee Related
- 1994-06-23 HU HU9503659A patent/HU228129B1/hu not_active IP Right Cessation
- 1994-06-23 EP EP94919960A patent/EP0706382B1/en not_active Expired - Lifetime
- 1994-06-23 CZ CZ19953428A patent/CZ287314B6/cs not_active IP Right Cessation
- 1994-06-23 WO PCT/SE1994/000633 patent/WO1995000127A1/en active IP Right Grant
- 1994-06-27 SA SA94150030A patent/SA94150030B1/ar unknown
- 1994-11-23 EE EE9400429A patent/EE03221B1/xx not_active IP Right Cessation
1995
- 1995-06-06 US US08/471,488 patent/US5658878A/en not_active Expired - Lifetime
- 1995-12-21 NO NO19955226A patent/NO313657B1/no not_active IP Right Cessation
- 1995-12-22 FI FI956227A patent/FI111688B/fi not_active IP Right Cessation
1997
- 1997-08-06 US US08/906,825 patent/US6306440B1/en not_active Expired - Fee Related
1998
- 1998-08-29 HK HK98110295A patent/HK1009584A1/xx not_active IP Right Cessation
1999
- 1999-11-29 GR GR990403067T patent/GR3031974T3/el unknown
2005
- 2005-11-09 JP JP2005325056A patent/JP4294635B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL110084A (en)	1999-07-14
CA2166108A1 (en)	1995-01-05
GR3031974T3 (en)	2000-03-31
MY112098A (en)	2001-04-30
EP0706382B1 (en)	1999-09-01
SA94150030B1 (ar)	2006-04-04
UA49794C2 (uk)	2002-10-15
HK1009584A1 (en)	1999-06-04
AU692780B2 (en)	1998-06-18
CZ342895A3 (en)	1996-05-15
JP2006089496A (ja)	2006-04-06
BR9406907A (pt)	1996-04-02
SK160195A3 (en)	1997-02-05
CN1110301C (zh)	2003-06-04
HUT75065A (en)	1997-03-28
NO313657B1 (no)	2002-11-11
WO1995000127A1 (en)	1995-01-05
US5518998C1 (en)	2001-02-13
TW402506B (en)	2000-08-21
EP0706382A1 (en)	1996-04-17
CN1129904A (zh)	1996-08-28
US6306440B1 (en)	2001-10-23
ES2138087T3 (es)	2000-01-01
NO955226L (no)	1996-02-15
JP3874789B2 (ja)	2007-01-31
HU228129B1 (en)	2012-12-28
NO955226D0 (no)	1995-12-21
NZ268137A (en)	1997-10-24
DE69420412D1 (de)	1999-10-07
JPH08512027A (ja)	1996-12-17
DK0706382T3 (da)	2000-03-13
AU7090194A (en)	1995-01-17
PL312205A1 (en)	1996-04-01
IS1768B (is)	2001-05-02
FI956227A0 (fi)	1995-12-22
JP4294635B2 (ja)	2009-07-15
US5658878A (en)	1997-08-19
PL178403B1 (pl)	2000-04-28
MX9404761A (es)	1995-01-31
IS4178A (is)	1994-12-25
EG20599A (en)	1999-09-30
KR100372673B1 (ko)	2003-05-12
HU9503659D0 (en)	1996-02-28
US5518998A (en)	1996-05-21
FI111688B (fi)	2003-09-15
CA2166108C (en)	2008-10-21
FI956227L (fi)	1995-12-22
CZ287314B6 (en)	2000-10-11
IL110084A0 (en)	1994-10-07
SK283145B6 (sk)	2003-03-04
RU2148398C1 (ru)	2000-05-10
ATE183920T1 (de)	1999-09-15
DE69420412T2 (de)	2000-04-13

Publication	Publication Date	Title
EE03221B1 (et)	1999-10-15	Inhaleeritavad ravimpreparaadid, nende valmistamise protsess ja inhalaator nende kasutamiseks
ES2162927T3 (es)	2002-01-16	Formulacion para la aplicacion por inhalacion.
HUP0102468A2 (hu)	2002-03-28	Nyomás alatti dózisadagoló inhaláló berendezés és aeroszol formájú gyógyászati készítmények
PH27594A (en)	1993-08-31	Medicaments for the treatment of asthma and other respiratory disorders
CA2146954A1 (en)	1996-10-13	Breath activated nicotine inhalers
AR002261A1 (es)	1998-03-11	Composicion en polvo para la administracion por inhalacion de polipeptidos utiles en medicina, metodos para la manufactura de dicha composicion, y uso de la composicion para la manufactura de un medicamento para el tratamietno de enfermedades a traves del tracto respiratorio
FI101858B1 (fi)	1998-09-15	Kertakäyttöinen lääkkeen sisäänhengityslaite
ATE271852T1 (de)	2004-08-15	Verbesserte inhalationspräparate
DK0533896T3 (zh)	1997-02-17
RU94040242A (ru)	1996-09-20	Способ лечения туберкулеза
IT9030691V0 (it)	1990-07-27	Inalatore per aerosolterapia basato sul sistema "usa e getta" dei due componenti "mascheria per inalazione " e "contenitore portafarmaco"
IT9041667A1 (it)	1992-01-28	Inalatore per aerosolterapia basato sul sistema "usa e getta" dei due componenti "mascherina per inalazione" e "contenitore portafarmaco".
MY111155A (en)	1999-09-30	Medicaments

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