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EA201600373A1 - ПИРРОЛО[2,3-d]ПИРИМИДИНИЛ-, ПИРРОЛО[2,3-b]ПИРАЗИНИЛ- И ПИРРОЛО[2,3-d]ПИРИДИНИЛАКРИЛАМИДЫ - Google Patents

ПИРРОЛО[2,3-d]ПИРИМИДИНИЛ-, ПИРРОЛО[2,3-b]ПИРАЗИНИЛ- И ПИРРОЛО[2,3-d]ПИРИДИНИЛАКРИЛАМИДЫ

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Publication number
EA201600373A1
EA201600373A1 EA201600373A EA201600373A EA201600373A1 EA 201600373 A1 EA201600373 A1 EA 201600373A1 EA 201600373 A EA201600373 A EA 201600373A EA 201600373 A EA201600373 A EA 201600373A EA 201600373 A1 EA201600373 A1 EA 201600373A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolo
pyrimidinyl
pyrazinyl
acrylamide
pyridine
Prior art date
Application number
EA201600373A
Other languages
English (en)
Other versions
EA030472B1 (ru
Inventor
Мэтью Франк Браун
Агустин Казимиро-Гарсиа
Е Че
Джосам Уодсворт Коэ
Марк Эдвард Фланаган
Адам Мэтью Гилберт
Мэтью Меррил Хэйвард
Джонатан Дэвид Лангилли
Джастин Иэн Монтгомери
Жан Батист Теллиез
Атли Тораренсен
Раймонд Джал Унвалла
Джон I Трухильо
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52144776&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201600373(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA201600373A1 publication Critical patent/EA201600373A1/ru
Publication of EA030472B1 publication Critical patent/EA030472B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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Abstract

Настоящее изобретение предусматривает фармацевтически активные пирроло[2,3-d]пиримидинил и пирроло[2,3-d]пиридинилакриламиды и их аналоги. Такие соединения являются полезными для ингибирования Янус-киназы (JAK). Изобретение также касается композиций, включающих данные соединения, способов получения таких соединений и способов лечения и предупреждения состояний, опосредованных JAK.
EA201600373A 2013-12-05 2014-11-20 ПИРРОЛО[2,3-d]ПИРИМИДИНИЛ-, ПИРРОЛО[2,3-b]ПИРАЗИНИЛ- И ПИРРОЛО[2,3-d]ПИРИДИНИЛАКРИЛАМИДЫ EA030472B1 (ru)

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