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DK3626825T3 - Anti-cdh6-antistof og anti-cdh6-antistof-lægemiddelkonjugat - Google Patents

Anti-cdh6-antistof og anti-cdh6-antistof-lægemiddelkonjugat Download PDF

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Publication number
DK3626825T3
DK3626825T3 DK18802536.5T DK18802536T DK3626825T3 DK 3626825 T3 DK3626825 T3 DK 3626825T3 DK 18802536 T DK18802536 T DK 18802536T DK 3626825 T3 DK3626825 T3 DK 3626825T3
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Prior art keywords
cdh6 antibody
drug conjugate
cdh6
antibody
conjugate
Prior art date
Application number
DK18802536.5T
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English (en)
Inventor
Atsuko Saito
Tsuyoshi Hirata
Kensuke Nakamura
Original Assignee
Daiichi Sankyo Co Ltd
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Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
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Publication of DK3626825T3 publication Critical patent/DK3626825T3/da

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    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI794230B (zh) * 2017-05-15 2023-03-01 日商第一三共股份有限公司 抗ｃｄｈ６抗體及抗ｃｄｈ６抗體-藥物結合物、以及其製造方法
CN116999572A (zh) 2017-09-29 2023-11-07 第一三共株式会社 抗体－药物偶联物、药物组合物及其在制备治疗肿瘤的药物中的应用
US20210283269A1 (en) 2018-07-25 2021-09-16 Daiichi Sankyo Company, Limited Effective method for manufacturing antibody-drug conjugate
JP7406488B2 (ja) 2018-07-27 2023-12-27 第一三共株式会社 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質
TWI822822B (zh) 2018-07-31 2023-11-21 日商第一三共股份有限公司 抗體-藥物結合物之用途
EP3834843A4 (en) 2018-08-06 2022-05-11 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and tubulin inhibitor
TW202016317A (zh) 2018-08-23 2020-05-01 日商第一三共股份有限公司 抗體藥物結合物之感受性標記
KR102567590B1 (ko) 2018-09-06 2023-08-17 다이이찌 산쿄 가부시키가이샤 신규 고리형 디뉴클레오티드 유도체 및 그 항체 약물 콘쥬게이트
JP7401456B2 (ja) * 2018-11-14 2023-12-19 第一三共株式会社 抗ｃｄｈ６抗体－ピロロベンゾジアゼピン誘導体コンジュゲート
BR112021011119A2 (pt) * 2018-12-11 2022-01-25 Daiichi Sankyo Co Ltd Composição farmacêutica
US20220040324A1 (en) * 2018-12-21 2022-02-10 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and kinase inhibitor
US20200306243A1 (en) 2019-03-29 2020-10-01 Medimmune Limited Compounds and conjugates thereof
WO2021260578A1 (en) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combination of antibody-drug conjugate and cdk9 inhibitor
WO2021260583A1 (en) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combination of antibody-drug conjugate and dna-pk inhibitor
WO2021260580A1 (en) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combination of antibody-drug conjugate and atm inhibitor
MX2022016375A (es) 2020-06-24 2023-04-04 Astrazeneca Uk Ltd Combinación de conjugado de anticuerpo-fármaco e inhibidor de la cinasa relacionada con ataxia telangiectasia y rad3 (atr).
WO2021260582A1 (en) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combination of antibody-drug conjugate and aurora b inhibitor
CN116348115A (zh) 2020-10-09 2023-06-27 阿斯利康(英国)有限公司 抗体-药物缀合物和parp1选择性抑制剂的组合
IL302812A (en) 2020-11-11 2023-07-01 Daiichi Sankyo Co Ltd Combinations of an antibody-drug conjugate with anti-sirp alpha antibody
TW202241454A (zh) 2021-02-01 2022-11-01 日商第一三共股份有限公司 抗體－免疫賦活化劑共軛物之新穎製造方法
KR20230157983A (ko) 2021-03-12 2023-11-17 다이이찌 산쿄 가부시키가이샤 당사슬 및 당사슬을 포함하는 의약품의 제조 방법
WO2022228495A1 (zh) 2021-04-29 2022-11-03 上海汇连生物医药有限公司 抗体偶联药物的制备方法及应用
WO2023009891A2 (en) * 2021-07-30 2023-02-02 Janssen Biotech, Inc. Materials and methods of making or using il-23r binding proteins
EP4401791A1 (en) * 2021-09-15 2024-07-24 Daiichi Sankyo Company, Limited Antibody-drug conjugate for use in methods of treating chemotherapy-resistant cancer
AU2022406708A1 (en) * 2021-12-10 2024-06-27 Multitude Therapeutics Inc. Anti-cdh6 antibodies and antibody-drug conjugates thereof
WO2023102875A1 (en) * 2021-12-10 2023-06-15 Multitude Therapeutics Inc. Anti-cdh6 antibody drug conjugate
WO2023126822A1 (en) 2021-12-28 2023-07-06 Astrazeneca Uk Limited Combination of antibody-drug conjugate and rasg12c inhibitor
WO2023143387A1 (en) * 2022-01-26 2023-08-03 Beigene , Ltd. ANTI-DXd ANTIBODIES AND METHODS OF USE
IL315341A (en) 2022-03-02 2024-10-01 Daiichi Sankyo Co Ltd METHOD FOR PRODUCING Fc-CONTAINING MOLECULE
CN119095624A (zh) 2022-04-27 2024-12-06 第一三共株式会社 抗体-药物缀合物与ezh1和/或ezh2抑制剂的组合
WO2023218378A1 (en) 2022-05-11 2023-11-16 Daiichi Sankyo Company, Limited Combination of an antibody specific for a tumor antigen and a cd47 inhibitor
CN119136840A (zh) 2022-05-12 2024-12-13 海南先声再明医药股份有限公司 喜树碱类衍生物及配体-药物偶联物
KR20250012631A (ko) 2022-05-24 2025-01-24 다이이찌 산쿄 가부시키가이샤 항-cdh6 항체-약물 접합체의 투약
TW202412859A (zh) 2022-07-28 2024-04-01 英商阿斯特捷利康英國股份有限公司 抗體-藥物結合物及雙特異性檢查點抑制劑之組合
WO2024165049A1 (zh) * 2023-02-10 2024-08-15 山东先声生物制药有限公司 抗cdh6的抗体及其用途
TW202444423A (zh) * 2023-03-14 2024-11-16 日商第一三共股份有限公司 抗cdh6抗體-藥物結合物與vegf抑制劑之組合
WO2024199337A1 (en) * 2023-03-28 2024-10-03 Hansoh Bio Llc Ligand-cytotoxicity drug conjugates and pharmaceutical uses thereof
TW202444760A (zh) * 2023-03-29 2024-11-16 日商第一三共股份有限公司 抗ｃｄ２５抗體及抗ｃｄ２５抗體－藥物複合體
WO2024204679A1 (ja) * 2023-03-31 2024-10-03 第一三共株式会社 抗ＣＤＨ６抗体－薬物コンジュゲートとＨＩＦ－２α阻害剤の組み合わせ

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
AU665190B2 (en) 1990-07-10 1995-12-21 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
JP3008226B2 (ja) 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
US5658920A (en) 1991-01-16 1997-08-19 Daiichi Pharmaceutical Co., Ltd. Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
DE69233254T2 (de) 1991-06-14 2004-09-16 Genentech, Inc., South San Francisco Humanisierter Heregulin Antikörper
CA2119930C (en) 1991-09-23 2002-10-01 Hendricus R. J. M. Hoogenboom Production of chimeric antibodies - a combinatorial approach
WO1993011236A1 (en) 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
CA2131151A1 (en) 1992-03-24 1994-09-30 Kevin S. Johnson Methods for producing members of specific binding pairs
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
JPH09506508A (ja) 1993-12-03 1997-06-30 メディカル リサーチ カウンシル 組換え結合タンパク質およびペプチド
JPH08337584A (ja) 1995-04-10 1996-12-24 Dai Ichi Seiyaku Co Ltd 縮合六環式アミノ化合物、これを含有する医薬及びその製法
US6504029B1 (en) 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
SG50747A1 (en) 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
CA2192725C (en) 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
JPH1095802A (ja) 1995-12-28 1998-04-14 Tanabe Seiyaku Co Ltd カンプトテシン誘導体
US5968511A (en) 1996-03-27 1999-10-19 Genentech, Inc. ErbB3 antibodies
TW409058B (en) 1996-06-06 2000-10-21 Daiichi Seiyaku Co Method for preparation of a drug complex
TW527183B (en) 1996-06-06 2003-04-11 Daiichi Seiyaku Co Drug complex
JPH1171280A (ja) 1997-06-26 1999-03-16 Tanabe Seiyaku Co Ltd 医薬組成物
JPH1192405A (ja) 1997-09-19 1999-04-06 Dai Ichi Seiyaku Co Ltd 薬物複合体
AU3657899A (en) 1998-04-20 1999-11-08 James E. Bailey Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
CA2333321A1 (en) 1998-05-22 1999-12-02 Daiichi Pharmaceutical Co., Ltd. Drug complex
BR9915198A (pt) 1998-10-30 2001-08-14 Daiichi Seiyaku Co Composto dds e método para medição do mesmo
EP1914244B1 (en) 1999-04-09 2013-05-29 Kyowa Hakko Kirin Co., Ltd. Method of modulating the activity of functional immune molecules
EP2803367B1 (en) 1999-06-25 2018-01-31 ImmunoGen, Inc. Methods of treatment using anti-ERBB antibody-maytansinoid conjugates
JP2002060351A (ja) 2000-03-22 2002-02-26 Dai Ichi Seiyaku Co Ltd 水酸基を有する薬物を含むｄｄｓ化合物
WO2002000734A1 (fr) 2000-06-29 2002-01-03 Daiichi Pharmaceutical Co., Ltd. Compose dds et son procede de preparation
US6815435B2 (en) 2000-07-13 2004-11-09 Daiichi Pharmaceutical Co., Ltd. Pharmaceutical compositions containing DDS compounds
EA013224B1 (ru) 2000-10-06 2010-04-30 Киова Хакко Кирин Ко., Лтд. Клетки, продуцирующие композиции антител
EP1283053A1 (en) 2001-08-09 2003-02-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibitors of HER3 activity
TWI313609B (en) 2001-08-21 2009-08-21 Mitsubishi Tanabe Pharma Corp Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor
AU2002363939A1 (en) 2001-11-20 2003-06-10 Seattle Genetics, Inc. Treatment of immunological disorders using anti-cd30 antibodies
US8877901B2 (en) 2002-12-13 2014-11-04 Immunomedics, Inc. Camptothecin-binding moiety conjugates
US9745380B2 (en) 2002-03-01 2017-08-29 Immunomedics, Inc. RS7 antibodies
CA2508831C (en) 2002-12-13 2012-05-01 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
US20040202666A1 (en) 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
BRPI0508233A (pt) 2004-02-26 2007-07-17 Inotek Pharmaceuticals Corp derivados de isoquinolina e métodos para emprego destes
CA2558399C (en) 2004-03-02 2015-05-19 Seattle Genetics, Inc. Partially loaded antibodies and methods of their conjugation
MXPA06013413A (es) 2004-05-19 2007-01-23 Medarex Inc Enlazadores quimicos y conjugados de los mismos.
EP2286844A3 (en) 2004-06-01 2012-08-22 Genentech, Inc. Antibody-drug conjugates and methods
KR20180091967A (ko) 2004-07-22 2018-08-16 제넨테크, 인크. Ｈｅｒ２ 항체 조성물
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
CA2587589A1 (en) 2004-11-29 2006-06-22 Seattle Genetics, Inc. Engineered antibodies and immunoconjugates
KR20150083139A (ko) 2005-01-21 2015-07-16 제넨테크, 인크. Ｈｅｒ 항체의 고정 용량 투여법
DE102005009099A1 (de) 2005-02-28 2006-08-31 Ktb Tumorforschungsgesellschaft Mbh Proteinbindende Camptothecin-Peptid-Derivate und diese enthaltende Arzneimittel
DE102005009084A1 (de) 2005-02-28 2006-08-31 Ktb Tumorforschungsgesellschaft Mbh Proteinbindende Anthrazyklin-Peptid-Derivate und diese enthaltende Arzneimittel
US7833979B2 (en) 2005-04-22 2010-11-16 Amgen Inc. Toxin peptide therapeutic agents
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
US20080131428A1 (en) 2006-02-24 2008-06-05 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of TROP-2
CN103030696B (zh) 2006-05-30 2016-09-28 健泰科生物技术公司 抗体和免疫偶联物及其用途
SI2032606T1 (sl) 2006-05-30 2014-02-28 Genentech, Inc. Protitelesa in imunokonjugati in njihove uporabe
ITMI20061473A1 (it) 2006-07-26 2008-01-27 Indena Spa Derivati della camptotecina ad attivita antitumorale
CN101687838A (zh) 2006-12-21 2010-03-31 先灵公司 抑制ksp驱动蛋白活性的吡咯并[3,2-a]吡啶衍生物
AU2008216600B2 (en) 2007-02-16 2013-09-05 Merrimack Pharmaceuticals, Inc. Antibodies against ErbB3 and uses thereof
KR20100014527A (ko) 2007-03-22 2010-02-10 슬로안-케테링인스티튜트퍼캔서리서치 단일클론항체 8ｈ9의 용도
MX347442B (es) 2008-04-30 2017-04-25 Immunogen Inc Entrelazadores y sus usos.
US8541178B2 (en) 2008-05-13 2013-09-24 Genentech, Inc. Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry
CN102282168A (zh) 2008-11-18 2011-12-14 梅里麦克制药股份有限公司 人血清白蛋白接头以及其结合物
HUE060624T2 (hu) 2009-02-13 2023-04-28 Immunomedics Inc Sejten belüli hasítható kötést tartalmazó immunkonjugátumok
KR20120104158A (ko) 2009-07-22 2012-09-20 엔즌 파마슈티칼스, 인코포레이티드 7-에틸-10-히드록시캠토테신의 다분지형 중합 컨쥬게이트와 ｈｅｒ２ 수용체 길항제를 병용하여 ｈｅｒ２ 양성 암을 치료하는 방법
WO2011021397A1 (ja) 2009-08-20 2011-02-24 国立大学法人千葉大学 コルヒチン誘導体
US20110070248A1 (en) 2009-09-24 2011-03-24 Seattle Genetics, Inc. Dr5 ligand drug conjugates
AU2010319483B2 (en) 2009-11-13 2015-03-12 Amgen Inc. Material and methods for treating or preventing HER-3 associated diseases
WO2011068845A1 (en) 2009-12-02 2011-06-09 Immunomedics, Inc. Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy
JP6121323B2 (ja) 2010-05-13 2017-05-10 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ 核内ホルモン受容体の活性を示すグルカゴンスーパーファミリーのペプチド
PH12012502231A1 (en) 2010-05-17 2013-02-04 Livtech Inc Anti-human trop-2 antibody having antitumor activity in vivo
WO2011146638A1 (en) 2010-05-18 2011-11-24 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
WO2011155579A1 (ja) 2010-06-10 2011-12-15 北海道公立大学法人札幌医科大学 抗Ｔｒｏｐ－２抗体
ES2704223T3 (es) 2010-07-12 2019-03-15 Pfizer Healthcare Ireland Conjugados de anticuerpos multifuncionales
WO2012019024A2 (en) 2010-08-04 2012-02-09 Immunogen, Inc. Her3-binding molecules and immunoconjugates thereof
WO2012018404A2 (en) 2010-08-06 2012-02-09 U3 Pharma Gmbh Use of her3 binding agents in prostate treatment
US20130330350A1 (en) 2010-11-09 2013-12-12 Medimmune, Llc Antibody Scaffold For Homogenous Conjugation
ES2544608T3 (es) 2010-11-17 2015-09-02 Genentech, Inc. Conjugados de anticuerpo y de alaninil-maitansinol
MX2014005728A (es) 2011-11-11 2014-05-30 Rinat Neuroscience Corp Anticuerpos especificos para antigeno de la superficie celular de trofoblasto-2 y sus usos.
US9427464B2 (en) 2011-11-22 2016-08-30 Chiome Bioscience Inc. Anti-human TROP-2 antibody having an antitumor activity in vivo
JP2015505850A (ja) 2011-12-14 2015-02-26 シアトル ジェネティックス， インコーポレイテッド 新規な抗体薬物コンジュゲート（ａｄｃ）およびそれらの使用
US20130280282A1 (en) 2012-04-24 2013-10-24 Daiichi Sankyo Co., Ltd. Dr5 ligand drug conjugates
CN104619350A (zh) 2012-06-14 2015-05-13 Ambrx公司 结合到核受体配体多肽的抗psma抗体
BR122021014396B1 (pt) 2012-10-11 2022-07-05 Daiichi Sankyo Company, Limited Compostos intermediários ligantes de fármacos, e ligante
US9872924B2 (en) 2012-10-19 2018-01-23 Daiichi Sankyo Company, Limited Antibody-drug conjugate produced by binding through linker having hydrophilic structure
US9814784B2 (en) 2013-01-03 2017-11-14 Celltrion, Inc. Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same
KR102535900B1 (ko) 2013-12-25 2023-05-26 다이이찌 산쿄 가부시키가이샤 항 trop2 항체-약물 컨쥬게이트
KR102445502B1 (ko) 2014-04-10 2022-09-21 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
BR112017001588A2 (pt) 2014-08-12 2017-11-21 Novartis Ag conjugados de anticorpo/fármaco anti-cdh6
WO2018185618A1 (en) 2017-04-03 2018-10-11 Novartis Ag Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment
TWI794230B (zh) 2017-05-15 2023-03-01 日商第一三共股份有限公司 抗ｃｄｈ６抗體及抗ｃｄｈ６抗體-藥物結合物、以及其製造方法

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EP3626825A1 (en) 2020-03-25
EP3626825B1 (en) 2024-09-18
RU2019141268A (ru) 2021-06-16
JP2022090057A (ja) 2022-06-16
CO2019013020A2 (es) 2020-01-17
EP3626825A4 (en) 2021-02-17
RU2019141268A3 (da) 2021-09-23
EP4374852A3 (en) 2024-09-25
TW201900683A (zh) 2019-01-01
RS66163B1 (sr) 2024-12-31
US20200390900A1 (en) 2020-12-17
JP2024045758A (ja) 2024-04-02
BR112019023832A2 (pt) 2020-07-28
AU2018270961A1 (en) 2019-12-19
JPWO2018212136A1 (ja) 2020-02-27
US11077202B2 (en) 2021-08-03
JP7064629B2 (ja) 2022-05-10
KR20200006061A (ko) 2020-01-17
US20230226205A1 (en) 2023-07-20
US11446386B2 (en) 2022-09-20
US20200171163A1 (en) 2020-06-04
FI3626825T3 (fi) 2024-11-29
JP7445699B2 (ja) 2024-03-07
JP6827534B2 (ja) 2021-02-10

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