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DK2357226T3 - Rationelt udformede meganukleaser med ændret sekvensspecificitet og DNA-bindingsaffinitet - Google Patents

Rationelt udformede meganukleaser med ændret sekvensspecificitet og DNA-bindingsaffinitet

Info

Publication number
DK2357226T3
DK2357226T3 DK10191888.6T DK10191888T DK2357226T3 DK 2357226 T3 DK2357226 T3 DK 2357226T3 DK 10191888 T DK10191888 T DK 10191888T DK 2357226 T3 DK2357226 T3 DK 2357226T3
Authority
DK
Denmark
Prior art keywords
mechanucleases
binding affinity
dna binding
sequence specificity
rationally designed
Prior art date
Application number
DK10191888.6T
Other languages
English (en)
Inventor
Homme W Hellinga
James Jefferson Smith
Derek Jantz
Original Assignee
Prec Biosciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37963286&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2357226(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Prec Biosciences filed Critical Prec Biosciences
Application granted granted Critical
Publication of DK2357226T3 publication Critical patent/DK2357226T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/905—Stable introduction of foreign DNA into chromosome using homologous recombination in yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Enzymes And Modification Thereof (AREA)
DK10191888.6T 2005-10-18 2006-10-18 Rationelt udformede meganukleaser med ændret sekvensspecificitet og DNA-bindingsaffinitet DK2357226T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72751205P 2005-10-18 2005-10-18
EP06826293.0A EP1945762B1 (en) 2005-10-18 2006-10-18 Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity

Publications (1)

Publication Number Publication Date
DK2357226T3 true DK2357226T3 (da) 2012-06-25

Family

ID=37963286

Family Applications (9)

Application Number Title Priority Date Filing Date
DK17161899.4T DK3246403T3 (da) 2005-10-18 2006-10-18 Rationelt designede meganucleaser med ændret sekvens-specificitet og dna-bindende affinitet
DK13164564.0T DK2650365T3 (da) 2005-10-18 2006-10-18 Rationelt konstruerede meganukleaser med ændret sekvensspecificitet og dna-bindingsaffinitet
DK13164585.5T DK2650366T3 (da) 2005-10-18 2006-10-18 Rationelt konstruerede meganucleaser med ændret sekvensspecificitet og DNA-bindingsaffinitet
DK12162075.1T DK2484758T3 (da) 2005-10-18 2006-10-18 Rationelt konstruerede meganucleaser med ændret sekvensspecificitet og DNA-bindingsaffinitet
DK10191888.6T DK2357226T3 (da) 2005-10-18 2006-10-18 Rationelt udformede meganukleaser med ændret sekvensspecificitet og DNA-bindingsaffinitet
DK13164623.4T DK2662442T3 (da) 2005-10-18 2006-10-18 Rationelt designet meganuklease med ændret dimerdannelsesaffinitet
DK06826293.0T DK1945762T3 (da) 2005-10-18 2006-10-18 Rationelt konstruerede meganucleaser med ændret sekvensspecificitet og DNA-bindingsaffinitet
DK10191904T DK2360244T3 (da) 2005-10-18 2006-10-18 Rationelt konstruerede meganukleaser med ændret specificitet og DNA-bindingsaffinitet
DK13164628.3T DK2628794T3 (da) 2005-10-18 2006-10-18 Rationelt konstruerede meganukleaser med ændret sekvensspecificitet og dna-bindingsaffinitet

Family Applications Before (4)

Application Number Title Priority Date Filing Date
DK17161899.4T DK3246403T3 (da) 2005-10-18 2006-10-18 Rationelt designede meganucleaser med ændret sekvens-specificitet og dna-bindende affinitet
DK13164564.0T DK2650365T3 (da) 2005-10-18 2006-10-18 Rationelt konstruerede meganukleaser med ændret sekvensspecificitet og dna-bindingsaffinitet
DK13164585.5T DK2650366T3 (da) 2005-10-18 2006-10-18 Rationelt konstruerede meganucleaser med ændret sekvensspecificitet og DNA-bindingsaffinitet
DK12162075.1T DK2484758T3 (da) 2005-10-18 2006-10-18 Rationelt konstruerede meganucleaser med ændret sekvensspecificitet og DNA-bindingsaffinitet

Family Applications After (4)

Application Number Title Priority Date Filing Date
DK13164623.4T DK2662442T3 (da) 2005-10-18 2006-10-18 Rationelt designet meganuklease med ændret dimerdannelsesaffinitet
DK06826293.0T DK1945762T3 (da) 2005-10-18 2006-10-18 Rationelt konstruerede meganucleaser med ændret sekvensspecificitet og DNA-bindingsaffinitet
DK10191904T DK2360244T3 (da) 2005-10-18 2006-10-18 Rationelt konstruerede meganukleaser med ændret specificitet og DNA-bindingsaffinitet
DK13164628.3T DK2628794T3 (da) 2005-10-18 2006-10-18 Rationelt konstruerede meganukleaser med ændret sekvensspecificitet og dna-bindingsaffinitet

Country Status (9)

Country Link
US (21) US8021867B2 (da)
EP (13) EP2484758B1 (da)
JP (10) JP5937292B2 (da)
AT (1) ATE549401T1 (da)
AU (1) AU2006304668B2 (da)
CA (3) CA2626262C (da)
DK (9) DK3246403T3 (da)
ES (9) ES2626025T3 (da)
WO (1) WO2007047859A2 (da)

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