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DK0924210T3 - 2-(1-(1,3-thiazolin-2-yl)azetidin-3-yl)thio-carbapenem-derivater - Google Patents

2-(1-(1,3-thiazolin-2-yl)azetidin-3-yl)thio-carbapenem-derivater

Info

Publication number
DK0924210T3
DK0924210T3 DK99104079T DK99104079T DK0924210T3 DK 0924210 T3 DK0924210 T3 DK 0924210T3 DK 99104079 T DK99104079 T DK 99104079T DK 99104079 T DK99104079 T DK 99104079T DK 0924210 T3 DK0924210 T3 DK 0924210T3
Authority
DK
Denmark
Prior art keywords
thiazolin
group
azetidin
thio
hydrogen
Prior art date
Application number
DK99104079T
Other languages
Danish (da)
English (en)
Inventor
Takao Abe
Takeshi Isoda
Ado Mihira
Satoshi Tamai
Toshio Kumagai
Chisato Sato
Original Assignee
Wyeth K K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth K K filed Critical Wyeth K K
Application granted granted Critical
Publication of DK0924210T3 publication Critical patent/DK0924210T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DK99104079T 1993-07-01 1994-06-30 2-(1-(1,3-thiazolin-2-yl)azetidin-3-yl)thio-carbapenem-derivater DK0924210T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP21330693 1993-07-01
JP7932094 1994-03-28
JP12204694 1994-05-12
EP94110186A EP0632039B1 (en) 1993-07-01 1994-06-30 2-[1-(1,3-Thiazolin-2-yl)azetidin-3-yl]thio-carbapenem derivatives

Publications (1)

Publication Number Publication Date
DK0924210T3 true DK0924210T3 (da) 2004-12-13

Family

ID=27302982

Family Applications (2)

Application Number Title Priority Date Filing Date
DK99104079T DK0924210T3 (da) 1993-07-01 1994-06-30 2-(1-(1,3-thiazolin-2-yl)azetidin-3-yl)thio-carbapenem-derivater
DK94110186T DK0632039T3 (da) 1993-07-01 1994-06-30 2-(1-(1,3-Thiazolin-2-yl)azetidin-3-yl)-thio-carbapenemderivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK94110186T DK0632039T3 (da) 1993-07-01 1994-06-30 2-(1-(1,3-Thiazolin-2-yl)azetidin-3-yl)-thio-carbapenemderivater

Country Status (16)

Country Link
US (2) US5534510A (zh)
EP (2) EP0924210B1 (zh)
JP (1) JP2666118B2 (zh)
KR (1) KR100331293B1 (zh)
AT (2) ATE273975T1 (zh)
AU (1) AU682510B2 (zh)
CA (1) CA2127193C (zh)
DE (2) DE69429742T2 (zh)
DK (2) DK0924210T3 (zh)
ES (2) ES2222630T3 (zh)
FI (1) FI106962B (zh)
HU (1) HU220609B1 (zh)
IL (1) IL110161A (zh)
NO (2) NO306780B1 (zh)
PT (2) PT924210E (zh)
TW (1) TW254943B (zh)

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EP0717042B1 (en) * 1994-12-12 2001-05-23 Wyeth Lederle Japan LTD. Process for preparing 1-(4,5-Dihydro-2-thiazolyle)-3-azetidine thiol derivatives
TW420681B (en) * 1995-12-08 2001-02-01 Lederle Japan Ltd Carbapenem-3-carboxylic acid ester derivatives
KR20000005535A (ko) 1996-05-09 2000-01-25 가와무라 요시부미 1-메틸카르바페넴 유도체를 유효성분으로 함유하는 항 헬리코박터 피롤리 조성물
EP1113016A4 (en) 1998-09-10 2001-12-12 Wyeth Lederle Japan Ltd CARBAPEN DERIVATIVES
KR100325375B1 (ko) * 2000-01-31 2002-03-06 박호군 이미다졸린 고리가 치환된 카바페넴 유도체
ES2273902T3 (es) * 2000-11-16 2007-05-16 Sankyo Company, Limited Derivados de 1-metilcarbapenem.
KR100441406B1 (ko) * 2001-09-05 2004-07-23 한국과학기술연구원 티아졸리딘 고리 치환체를 갖는 1-β-메틸 카바페넴유도체 및 그 제조 방법
KR100451670B1 (ko) * 2001-09-14 2004-10-08 한국화학연구원 내성균에 대해 항생작용을 갖는 카바페넴 유도체 및 이의제조방법
KR100945706B1 (ko) * 2001-11-05 2010-03-05 다이닛본 스미토모 세이야꾸 가부시끼가이샤 신규 카르바페넴 화합물
TW200403244A (en) * 2002-05-14 2004-03-01 Sankyo Co 1β-Methylcarbapenem derivatives for oral use
WO2004035539A1 (ja) * 2002-10-18 2004-04-29 Meiji Seika Kaisha, Ltd. カルバペネム類の製造方法およびその製造に用いられる中間体
WO2004035540A1 (ja) 2002-10-18 2004-04-29 Meiji Seika Kaisha, Ltd. マロン酸モノエステルおよびその製造方法
US7524952B2 (en) 2002-11-13 2009-04-28 Kaneka Corporation Process for producing carbapenem compound for oral administration
WO2004089954A1 (ja) * 2003-04-08 2004-10-21 Sumitomo Pharmaceuticals Co., Ltd. 新規なカルバペネム化合物
WO2005065409A2 (en) * 2003-12-30 2005-07-21 Liposonix, Inc. Ultrasound therapy head with movement control
EP1627891A1 (en) * 2004-08-11 2006-02-22 Covion Organic Semiconductors GmbH Polymers for use in organic electroluminescent devices
KR100599876B1 (ko) 2004-08-31 2006-07-13 한국화학연구원 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법
EP1785426A4 (en) * 2004-09-03 2008-02-20 Dainippon Sumitomo Pharma Co NEW CARBAPENEM DERIVATIVE
JP2006176418A (ja) * 2004-12-21 2006-07-06 Kaneka Corp 経口投与用カルバペネム化合物の製造方法と新規β−ラクタム化合物
JPWO2006103999A1 (ja) * 2005-03-25 2008-09-04 大日本住友製薬株式会社 新規なカルバペネム化合物
KR100723889B1 (ko) 2006-06-30 2007-05-31 주식회사 하이닉스반도체 직렬 입/출력 인터페이스를 가진 멀티 포트 메모리 소자
JP5013795B2 (ja) * 2006-09-25 2012-08-29 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 経口投与用カルバペネム
WO2009038328A2 (en) * 2007-09-20 2009-03-26 Kukje Pharm. Ind. Co., Ltd. Acid addition salts of synthetic intermediates for carbapenem antibiotics and processes for preparing the same
CN101868460A (zh) * 2007-11-23 2010-10-20 国际药品工业株式会社 2-芳基甲基吖丁啶-碳青霉烯-3-羧酸酯衍生物或其盐、其制备方法以及包含上述的药物组合物
CN102558181B (zh) * 2010-12-15 2015-04-22 石药集团中奇制药技术（石家庄）有限公司 一种碳青霉烯抗生素的制备方法
CN102731507B (zh) * 2011-04-13 2015-04-01 石药集团中奇制药技术（石家庄）有限公司 泰比培南晶型、其制备方法及其在制备药物中的应用
CN103059026A (zh) * 2011-10-20 2013-04-24 北京康健源科技有限公司 一种替比培南匹夫酯的制备方法
CN102584812B (zh) * 2011-11-18 2014-03-12 深圳万乐药业有限公司 一种泰比培南酯杂质的制备方法
CN102503940B (zh) * 2011-11-22 2013-12-25 深圳万乐药业有限公司 制备泰比培南酯开环杂质的方法
CN103059027A (zh) * 2012-12-20 2013-04-24 安徽悦康凯悦制药有限公司 替比培南匹伏酯的制备方法
AU2017377062B2 (en) * 2016-12-15 2020-09-03 Spero Therapeutics, Inc. Novel tebipenem pivoxil immediate and modified release oral dosage forms
AU2018215687B2 (en) 2017-02-06 2020-09-03 Spero Therapeutics, Inc. Tebipenem pivoxil crystalline forms, compositions including the same, methods of manufacture, and methods of use
CN110698469A (zh) * 2019-10-28 2020-01-17 南京红杉生物科技有限公司 泰比培南酯中间体及其合成方法、应用
CA3201497A1 (en) 2020-11-11 2022-05-19 Spero Therapeutics, Inc. High dosage tebipenem pivoxil tablet formulation

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GB9210096D0 (en) * 1992-05-11 1992-06-24 Fujisawa Pharmaceutical Co 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives and their preparation

Also Published As

Publication number Publication date
AU682510B2 (en) 1997-10-09
DK0632039T3 (da) 2002-05-13
US5534510A (en) 1996-07-09
KR100331293B1 (ko) 2002-10-25
FI943164L (fi) 1995-01-02
EP0924210B1 (en) 2004-08-18
JP2666118B2 (ja) 1997-10-22
NO991019L (no) 1995-01-02
KR950003292A (ko) 1995-02-16
NO942483L (no) 1995-01-02
ES2170080T3 (es) 2002-08-01
ATE273975T1 (de) 2004-09-15
HU220609B1 (hu) 2002-03-28
NO307379B1 (no) 2000-03-27
NO991019D0 (no) 1999-03-02
EP0632039B1 (en) 2002-01-30
CA2127193A1 (en) 1995-01-02
DE69429742D1 (de) 2002-03-14
NO306780B1 (no) 1999-12-20
EP0632039A1 (en) 1995-01-04
IL110161A (en) 1998-09-24
AU6598794A (en) 1995-01-12
ES2222630T3 (es) 2005-02-01
DE69433955D1 (de) 2004-09-23
JPH0853453A (ja) 1996-02-27
CA2127193C (en) 2005-04-12
PT632039E (pt) 2002-06-28
TW254943B (zh) 1995-08-21
FI106962B (fi) 2001-05-15
IL110161A0 (en) 1994-10-07
US5679790A (en) 1997-10-21
DE69429742T2 (de) 2002-06-06
NO942483D0 (no) 1994-06-30
HUT68057A (en) 1995-05-29
DE69433955T2 (de) 2005-09-08
ATE212636T1 (de) 2002-02-15
HU9401957D0 (en) 1994-09-28
EP0924210A1 (en) 1999-06-23
PT924210E (pt) 2004-12-31
FI943164A0 (fi) 1994-07-01

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