[go: up one dir, main page]

TW254943B - - Google Patents

Info

Publication number
TW254943B
TW254943B TW083106001A TW83106001A TW254943B TW 254943 B TW254943 B TW 254943B TW 083106001 A TW083106001 A TW 083106001A TW 83106001 A TW83106001 A TW 83106001A TW 254943 B TW254943 B TW 254943B
Authority
TW
Taiwan
Prior art keywords
group
hydrogen
alkoxy
alkyl
alkyl group
Prior art date
Application number
TW083106001A
Other languages
English (en)
Original Assignee
Nippon Redaly Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Redaly Kk filed Critical Nippon Redaly Kk
Application granted granted Critical
Publication of TW254943B publication Critical patent/TW254943B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
TW083106001A 1993-07-01 1994-07-01 TW254943B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21330693 1993-07-01
JP7932094 1994-03-28
JP12204694 1994-05-12

Publications (1)

Publication Number Publication Date
TW254943B true TW254943B (zh) 1995-08-21

Family

ID=27302982

Family Applications (1)

Application Number Title Priority Date Filing Date
TW083106001A TW254943B (zh) 1993-07-01 1994-07-01

Country Status (16)

Country Link
US (2) US5534510A (zh)
EP (2) EP0924210B1 (zh)
JP (1) JP2666118B2 (zh)
KR (1) KR100331293B1 (zh)
AT (2) ATE273975T1 (zh)
AU (1) AU682510B2 (zh)
CA (1) CA2127193C (zh)
DE (2) DE69433955T2 (zh)
DK (2) DK0632039T3 (zh)
ES (2) ES2222630T3 (zh)
FI (1) FI106962B (zh)
HU (1) HU220609B1 (zh)
IL (1) IL110161A (zh)
NO (2) NO306780B1 (zh)
PT (2) PT924210E (zh)
TW (1) TW254943B (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8031552B2 (en) 2006-06-30 2011-10-04 Hynix Semiconductor Inc. Multi-port memory device with serial input/output interface

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5783703A (en) * 1993-07-01 1998-07-21 Lederle (Japan), Ltd. Sulfur-containing compounds method for their use and prodction
TW432061B (en) * 1994-08-09 2001-05-01 Pfizer Res & Dev Lactams
PT717042E (pt) * 1994-12-12 2001-08-30 Wyeth Lederle Japan Ltd Processo para a preparacao de derivados de 1-(4,5-di-hidro-2-tiazolil)-3-azetidina-tiol
TW420681B (en) * 1995-12-08 2001-02-01 Lederle Japan Ltd Carbapenem-3-carboxylic acid ester derivatives
CA2253860A1 (en) 1996-05-09 1997-11-13 Sankyo Company, Limited Anti-helicobacter pylori compositions containing 1-methylcarbapenem derivatives as the active ingredient
AU5450199A (en) * 1998-09-10 2000-04-03 Wyeth Lederle Japan, Ltd. Carbapenem compounds
KR100325375B1 (ko) * 2000-01-31 2002-03-06 박호군 이미다졸린 고리가 치환된 카바페넴 유도체
CN1289498C (zh) * 2000-11-16 2006-12-13 三共株式会社 1－甲基碳青霉素烯衍生物
KR100441406B1 (ko) * 2001-09-05 2004-07-23 한국과학기술연구원 티아졸리딘 고리 치환체를 갖는 1-β-메틸 카바페넴유도체 및 그 제조 방법
KR100451670B1 (ko) * 2001-09-14 2004-10-08 한국화학연구원 내성균에 대해 항생작용을 갖는 카바페넴 유도체 및 이의제조방법
JP4377231B2 (ja) 2001-11-05 2009-12-02 大日本住友製薬株式会社 新規なカルバペネム化合物
TW200403244A (en) * 2002-05-14 2004-03-01 Sankyo Co 1β-Methylcarbapenem derivatives for oral use
WO2004035539A1 (ja) * 2002-10-18 2004-04-29 Meiji Seika Kaisha, Ltd. カルバペネム類の製造方法およびその製造に用いられる中間体
US7553989B2 (en) 2002-10-18 2009-06-30 Meiji Seika Kaisha, Ltd. Malonic acid monoesters and process for producing the same
US7524952B2 (en) 2002-11-13 2009-04-28 Kaneka Corporation Process for producing carbapenem compound for oral administration
JPWO2004089954A1 (ja) * 2003-04-08 2006-07-06 大日本住友製薬株式会社 新規なカルバペネム化合物
KR101188930B1 (ko) * 2003-12-30 2012-10-08 메디시스 테크놀로지스 코포레이션 가동 제어가 있는 초음파 치료 헤드
EP1627891A1 (en) * 2004-08-11 2006-02-22 Covion Organic Semiconductors GmbH Polymers for use in organic electroluminescent devices
KR100599876B1 (ko) * 2004-08-31 2006-07-13 한국화학연구원 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법
US20070265242A1 (en) * 2004-09-03 2007-11-15 Makoto Sunagawa Novel Carbapenem Compound
JP2006176418A (ja) * 2004-12-21 2006-07-06 Kaneka Corp 経口投与用カルバペネム化合物の製造方法と新規β−ラクタム化合物
WO2006103999A1 (ja) * 2005-03-25 2006-10-05 Dainippon Sumitomo Pharma Co., Ltd. 新規なカルバペネム化合物
JP5013795B2 (ja) * 2006-09-25 2012-08-29 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 経口投与用カルバペネム
JP2010540433A (ja) * 2007-09-20 2010-12-24 クジェ ファーマシューティカル インダストリアル カンパニー リミテッド カルバペネム系抗生物質の合成中間体の酸付加塩及びその製造方法
US20110118229A1 (en) * 2007-11-23 2011-05-19 Kukje Pharm. Ind. Co., Ltd. 2-arylmethylazetidine-carbapenem-3-carboxylic acid ester derivative or its salt, process for the preparation thereof and pharmaceutical composition comprising the same
CN102558181B (zh) * 2010-12-15 2015-04-22 石药集团中奇制药技术（石家庄）有限公司 一种碳青霉烯抗生素的制备方法
CN102731507B (zh) * 2011-04-13 2015-04-01 石药集团中奇制药技术（石家庄）有限公司 泰比培南晶型、其制备方法及其在制备药物中的应用
CN103059026A (zh) * 2011-10-20 2013-04-24 北京康健源科技有限公司 一种替比培南匹夫酯的制备方法
CN102584812B (zh) * 2011-11-18 2014-03-12 深圳万乐药业有限公司 一种泰比培南酯杂质的制备方法
CN102503940B (zh) * 2011-11-22 2013-12-25 深圳万乐药业有限公司 制备泰比培南酯开环杂质的方法
CN103059027A (zh) * 2012-12-20 2013-04-24 安徽悦康凯悦制药有限公司 替比培南匹伏酯的制备方法
JP7083828B2 (ja) * 2016-12-15 2022-06-13 スペロ セラピューティックス，インコーポレイテッド 新規テビペネムピボキシルの即放性および調節放出性経口剤形
EP3577119A1 (en) 2017-02-06 2019-12-11 Spero Therapeutics, Inc. Tebipenem pivoxil crystalline forms, compositions including the same, methods of manufacture, and methods of use
CN110698469A (zh) * 2019-10-28 2020-01-17 南京红杉生物科技有限公司 泰比培南酯中间体及其合成方法、应用
CA3201497A1 (en) 2020-11-11 2022-05-19 Spero Therapeutics, Inc. High dosage tebipenem pivoxil tablet formulation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3665001A (en) * 1970-06-11 1972-05-23 Exxon Research Engineering Co Azinyl organophosphorus compounds
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
US4696923A (en) * 1984-04-23 1987-09-29 Merck & Co., Inc. 6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids
JPS63255280A (ja) * 1987-04-11 1988-10-21 Nippon Redarii Kk （１ｒ，５ｓ，６ｓ）−２−置換−６−〔（ｒ）−１−ヒドロキシエチル〕−１−メチル−カルバペネム−３−カルボン酸誘導体
GB9210096D0 (en) * 1992-05-11 1992-06-24 Fujisawa Pharmaceutical Co 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives and their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8031552B2 (en) 2006-06-30 2011-10-04 Hynix Semiconductor Inc. Multi-port memory device with serial input/output interface

Also Published As

Publication number Publication date
IL110161A0 (en) 1994-10-07
HUT68057A (en) 1995-05-29
ES2170080T3 (es) 2002-08-01
EP0924210B1 (en) 2004-08-18
FI943164A (fi) 1995-01-02
EP0924210A1 (en) 1999-06-23
HU9401957D0 (en) 1994-09-28
ATE273975T1 (de) 2004-09-15
HU220609B1 (hu) 2002-03-28
EP0632039A1 (en) 1995-01-04
DE69433955T2 (de) 2005-09-08
NO991019L (no) 1995-01-02
PT632039E (pt) 2002-06-28
AU6598794A (en) 1995-01-12
DK0632039T3 (da) 2002-05-13
AU682510B2 (en) 1997-10-09
IL110161A (en) 1998-09-24
DE69433955D1 (de) 2004-09-23
ES2222630T3 (es) 2005-02-01
JP2666118B2 (ja) 1997-10-22
KR100331293B1 (ko) 2002-10-25
DK0924210T3 (da) 2004-12-13
FI106962B (fi) 2001-05-15
NO942483L (no) 1995-01-02
NO942483D0 (no) 1994-06-30
NO991019D0 (no) 1999-03-02
ATE212636T1 (de) 2002-02-15
DE69429742D1 (de) 2002-03-14
FI943164A0 (fi) 1994-07-01
US5679790A (en) 1997-10-21
DE69429742T2 (de) 2002-06-06
EP0632039B1 (en) 2002-01-30
NO307379B1 (no) 2000-03-27
US5534510A (en) 1996-07-09
CA2127193A1 (en) 1995-01-02
KR950003292A (ko) 1995-02-16
PT924210E (pt) 2004-12-31
NO306780B1 (no) 1999-12-20
CA2127193C (en) 2005-04-12
JPH0853453A (ja) 1996-02-27

Similar Documents

Publication Publication Date Title
TW254943B (zh)
ES2195510T3 (es) Derivados de imidazopiridina y procedimiento para prepararlos.
EP0807630A4 (en) HETEROCYCLIC CONNECTIONS
ZA956327B (en) Novel pyrrolocarbazoles
HU9101983D0 (en) Process for the production of hexahydroazepine derivatives
AU3354095A (en) Process for producing alkoxyiminoacetamide derivative
HU0203891D0 (en) Novel intermediates for the production of thioles
EP0555479A4 (zh)
EP0854135A3 (en) Process for preparing 2-cyanobiphenyl compound
HU9601701D0 (en) Aromatic hydroxamic acid compounds, process for producing them and their use
EP0590681A3 (en) A process for the preparation of aminothiadiazolylacetyl halide derivatives
AU669507B2 (en) Process for producing 4-substituted azetidinone derivatives
KR0137673B1 (en) Process for preparing sulfonamide derivative of norbornane
EP0844236A4 (en) METHOD FOR PRODUCING CARBAMOYL METHYL URINE DERIVATIVES

Legal Events

Date Code Title Description
MK4A Expiration of patent term of an invention patent