DE69429742D1 - 2-[1-(1,3-Thiazolin-2-yl)azetidin-3-yl]thio-carbapenem-Derivate - Google Patents
2-[1-(1,3-Thiazolin-2-yl)azetidin-3-yl]thio-carbapenem-DerivateInfo
- Publication number
- DE69429742D1 DE69429742D1 DE69429742T DE69429742T DE69429742D1 DE 69429742 D1 DE69429742 D1 DE 69429742D1 DE 69429742 T DE69429742 T DE 69429742T DE 69429742 T DE69429742 T DE 69429742T DE 69429742 D1 DE69429742 D1 DE 69429742D1
- Authority
- DE
- Germany
- Prior art keywords
- thiazolin
- group
- azetidin
- thio
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- WXLPEIBBDQOTFV-UHFFFAOYSA-N 1-(4,5-dihydro-1,3-thiazol-2-yl)azetidine-3-thiol Chemical class C1C(S)CN1C1=NCCS1 WXLPEIBBDQOTFV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21330693 | 1993-07-01 | ||
| JP7932094 | 1994-03-28 | ||
| JP12204694 | 1994-05-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69429742D1 true DE69429742D1 (de) | 2002-03-14 |
| DE69429742T2 DE69429742T2 (de) | 2002-06-06 |
Family
ID=27302982
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69433955T Expired - Lifetime DE69433955T2 (de) | 1993-07-01 | 1994-06-30 | 2-(1-(1,3-Thiazolin-2-yl)azetidin-3-yl) thio-carbapenem-Derivate |
| DE69429742T Expired - Lifetime DE69429742T2 (de) | 1993-07-01 | 1994-06-30 | 2-[1-(1,3-Thiazolin-2-yl)azetidin-3-yl]thio-carbapenem-Derivate |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69433955T Expired - Lifetime DE69433955T2 (de) | 1993-07-01 | 1994-06-30 | 2-(1-(1,3-Thiazolin-2-yl)azetidin-3-yl) thio-carbapenem-Derivate |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5534510A (de) |
| EP (2) | EP0632039B1 (de) |
| JP (1) | JP2666118B2 (de) |
| KR (1) | KR100331293B1 (de) |
| AT (2) | ATE273975T1 (de) |
| AU (1) | AU682510B2 (de) |
| CA (1) | CA2127193C (de) |
| DE (2) | DE69433955T2 (de) |
| DK (2) | DK0924210T3 (de) |
| ES (2) | ES2170080T3 (de) |
| FI (1) | FI106962B (de) |
| HU (1) | HU220609B1 (de) |
| IL (1) | IL110161A (de) |
| NO (2) | NO306780B1 (de) |
| PT (2) | PT632039E (de) |
| TW (1) | TW254943B (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5783703A (en) * | 1993-07-01 | 1998-07-21 | Lederle (Japan), Ltd. | Sulfur-containing compounds method for their use and prodction |
| TW432061B (en) * | 1994-08-09 | 2001-05-01 | Pfizer Res & Dev | Lactams |
| ATE201410T1 (de) * | 1994-12-12 | 2001-06-15 | Wyeth Lederle Japan Ltd | Verfahren zur herstellung von 1-(4,5-dihydro)2- thiazolyl-3-azetidinthiolderivaten |
| TW420681B (en) * | 1995-12-08 | 2001-02-01 | Lederle Japan Ltd | Carbapenem-3-carboxylic acid ester derivatives |
| NZ332687A (en) | 1996-05-09 | 2000-05-26 | Sankyo Co | use of 1-methyl-carbapenem derivatives as anti-helicobacter pylori agents |
| KR20010079713A (ko) * | 1998-09-10 | 2001-08-22 | 마쓰자와 도로, 하야시 지로 | 카르바페넴 화합물 |
| KR100325375B1 (ko) * | 2000-01-31 | 2002-03-06 | 박호군 | 이미다졸린 고리가 치환된 카바페넴 유도체 |
| CZ300137B6 (cs) * | 2000-11-16 | 2009-02-18 | Sankyo Company Limited | Deriváty 1-methylkarbapenemu |
| KR100441406B1 (ko) * | 2001-09-05 | 2004-07-23 | 한국과학기술연구원 | 티아졸리딘 고리 치환체를 갖는 1-β-메틸 카바페넴유도체 및 그 제조 방법 |
| KR100451670B1 (ko) * | 2001-09-14 | 2004-10-08 | 한국화학연구원 | 내성균에 대해 항생작용을 갖는 카바페넴 유도체 및 이의제조방법 |
| WO2003040146A1 (fr) | 2001-11-05 | 2003-05-15 | Sumitomo Pharmaceuticals Co., Ltd. | Nouveaux composes carbapenem |
| TW200403244A (en) * | 2002-05-14 | 2004-03-01 | Sankyo Co | 1β-Methylcarbapenem derivatives for oral use |
| JPWO2004035539A1 (ja) * | 2002-10-18 | 2006-02-16 | 明治製菓株式会社 | カルバペネム類の製造方法およびその製造に用いられる中間体 |
| JP4694370B2 (ja) | 2002-10-18 | 2011-06-08 | 明治製菓株式会社 | マロン酸モノエステルおよびその製造方法 |
| JPWO2004043961A1 (ja) * | 2002-11-13 | 2006-03-09 | 株式会社カネカ | 経口投与用カルバペネム化合物の製造方法 |
| WO2004089954A1 (ja) * | 2003-04-08 | 2004-10-21 | Sumitomo Pharmaceuticals Co., Ltd. | 新規なカルバペネム化合物 |
| AU2004311459B2 (en) * | 2003-12-30 | 2011-07-14 | Medicis Technologies Corporation | Ultrasound therapy head with movement control |
| EP1627891A1 (de) * | 2004-08-11 | 2006-02-22 | Covion Organic Semiconductors GmbH | Polymere zur Verwendung in elektrolumineszierenden Anordnungen |
| KR100599876B1 (ko) * | 2004-08-31 | 2006-07-13 | 한국화학연구원 | 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법 |
| WO2006025475A1 (ja) * | 2004-09-03 | 2006-03-09 | Dainippon Sumitomo Pharma Co., Ltd. | 新規なカルバペネム化合物 |
| JP2006176418A (ja) * | 2004-12-21 | 2006-07-06 | Kaneka Corp | 経口投与用カルバペネム化合物の製造方法と新規β−ラクタム化合物 |
| US20090029964A1 (en) * | 2005-03-25 | 2009-01-29 | Makoto Sunagawa | Novel carbapenem compound |
| KR100723889B1 (ko) | 2006-06-30 | 2007-05-31 | 주식회사 하이닉스반도체 | 직렬 입/출력 인터페이스를 가진 멀티 포트 메모리 소자 |
| JP5013795B2 (ja) * | 2006-09-25 | 2012-08-29 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 経口投与用カルバペネム |
| JP2010540433A (ja) * | 2007-09-20 | 2010-12-24 | クジェ ファーマシューティカル インダストリアル カンパニー リミテッド | カルバペネム系抗生物質の合成中間体の酸付加塩及びその製造方法 |
| JP2011504495A (ja) * | 2007-11-23 | 2011-02-10 | クジェ ファーマシューティカル インダストリアル カンパニー リミテッド | ２−アリールメチルアゼチジン−カルバペネム−３−カルボン酸エステル誘導体またはその塩、その製造方法及びそれを含む医薬組成物 |
| CN102558181B (zh) * | 2010-12-15 | 2015-04-22 | 石药集团中奇制药技术（石家庄）有限公司 | 一种碳青霉烯抗生素的制备方法 |
| CN102731507B (zh) * | 2011-04-13 | 2015-04-01 | 石药集团中奇制药技术（石家庄）有限公司 | 泰比培南晶型、其制备方法及其在制备药物中的应用 |
| CN103059026A (zh) * | 2011-10-20 | 2013-04-24 | 北京康健源科技有限公司 | 一种替比培南匹夫酯的制备方法 |
| CN102584812B (zh) * | 2011-11-18 | 2014-03-12 | 深圳万乐药业有限公司 | 一种泰比培南酯杂质的制备方法 |
| CN102503940B (zh) * | 2011-11-22 | 2013-12-25 | 深圳万乐药业有限公司 | 制备泰比培南酯开环杂质的方法 |
| CN103059027A (zh) * | 2012-12-20 | 2013-04-24 | 安徽悦康凯悦制药有限公司 | 替比培南匹伏酯的制备方法 |
| EP3554484A1 (de) * | 2016-12-15 | 2019-10-23 | Spero Therapeutics, Inc. | Neuartige orale darreichungsformen von tebipenem-pivoxil mit unmittelbarer und modifizierter freisetzung |
| CA3049690C (en) | 2017-02-06 | 2023-03-21 | Spero Therapeutics, Inc. | Tebipenem pivoxil crystalline forms, compositions including the same, methods of manufacture, and methods of use |
| CN110698469A (zh) * | 2019-10-28 | 2020-01-17 | 南京红杉生物科技有限公司 | 泰比培南酯中间体及其合成方法、应用 |
| EP4243783A1 (de) | 2020-11-11 | 2023-09-20 | Spero Therapeutics, Inc. | Hochdosierte tebipenem-pivoxil-tablettenformulierung |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3665001A (en) * | 1970-06-11 | 1972-05-23 | Exxon Research Engineering Co | Azinyl organophosphorus compounds |
| JPS60202886A (ja) * | 1984-03-27 | 1985-10-14 | Sankyo Co Ltd | １―置換カルバペネム―３―カルボン酸誘導体 |
| US4696923A (en) * | 1984-04-23 | 1987-09-29 | Merck & Co., Inc. | 6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids |
| JPS63255280A (ja) * | 1987-04-11 | 1988-10-21 | Nippon Redarii Kk | （１ｒ，５ｓ，６ｓ）−２−置換−６−〔（ｒ）−１−ヒドロキシエチル〕−１−メチル−カルバペネム−３−カルボン酸誘導体 |
| GB9210096D0 (en) * | 1992-05-11 | 1992-06-24 | Fujisawa Pharmaceutical Co | 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives and their preparation |
-
1994
- 1994-06-28 AU AU65987/94A patent/AU682510B2/en not_active Expired
- 1994-06-29 IL IL11016194A patent/IL110161A/en not_active IP Right Cessation
- 1994-06-29 US US08/267,397 patent/US5534510A/en not_active Expired - Lifetime
- 1994-06-30 EP EP94110186A patent/EP0632039B1/de not_active Expired - Lifetime
- 1994-06-30 HU HU9401957A patent/HU220609B1/hu unknown
- 1994-06-30 PT PT94110186T patent/PT632039E/pt unknown
- 1994-06-30 ES ES94110186T patent/ES2170080T3/es not_active Expired - Lifetime
- 1994-06-30 AT AT99104079T patent/ATE273975T1/de active
- 1994-06-30 DK DK99104079T patent/DK0924210T3/da active
- 1994-06-30 NO NO942483A patent/NO306780B1/no not_active IP Right Cessation
- 1994-06-30 CA CA002127193A patent/CA2127193C/en not_active Expired - Lifetime
- 1994-06-30 DE DE69433955T patent/DE69433955T2/de not_active Expired - Lifetime
- 1994-06-30 EP EP99104079A patent/EP0924210B1/de not_active Expired - Lifetime
- 1994-06-30 AT AT94110186T patent/ATE212636T1/de active
- 1994-06-30 ES ES99104079T patent/ES2222630T3/es not_active Expired - Lifetime
- 1994-06-30 DE DE69429742T patent/DE69429742T2/de not_active Expired - Lifetime
- 1994-06-30 JP JP6170496A patent/JP2666118B2/ja not_active Expired - Lifetime
- 1994-06-30 DK DK94110186T patent/DK0632039T3/da active
- 1994-06-30 PT PT99104079T patent/PT924210E/pt unknown
- 1994-07-01 KR KR1019940015809A patent/KR100331293B1/ko not_active Expired - Lifetime
- 1994-07-01 TW TW083106001A patent/TW254943B/zh not_active IP Right Cessation
- 1994-07-01 FI FI943164A patent/FI106962B/fi not_active IP Right Cessation
-
1996
- 1996-04-12 US US08/631,224 patent/US5679790A/en not_active Expired - Lifetime
-
1999
- 1999-03-02 NO NO991019A patent/NO307379B1/no not_active IP Right Cessation
Also Published As
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| DE69429742D1 (de) | 2-[1-(1,3-Thiazolin-2-yl)azetidin-3-yl]thio-carbapenem-Derivate | |
| FI973207A (fi) | Heterosyklisiä yhdisteitä | |
| ES2195510T3 (es) | Derivados de imidazopiridina y procedimiento para prepararlos. | |
| ATE271045T1 (de) | Sauerstoffhaltige heterocyclische verbindungen | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: WYETH K.K., TOKIO/TOKYO, JP |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: PFIZER JAPAN INC., TOKIO/TOKYO, JP |