BRPI0000596B8 - composto piridona, processo de produção do composto, composição farmacêutica, e uso do dito composto - Google Patents

composto piridona, processo de produção do composto, composição farmacêutica, e uso do dito composto

Info

Publication number: BRPI0000596B8
Authority: BR; Brazil
Prior art keywords: compound; pharmaceutical composition; production process; pyridone; intermediates
Prior art date: 2000-06-12

Application number

BR0111596A

Other languages

English (en)

Other versions

BR0111596A (pt

BRPI0111596B1 (pt

BRPI0111596B8 (pt

Inventor

Satoshi Nagato

Kohshi Ueno

Koki Kawano

Yoshihiko Norimine

Koichi Ito

Takahisa Hanada

Masataka Ueno

Hiroyuki Amino

Makoto Ogo

Shinji Hatakeyama

Yoshio Urawa

Hiroyuki Naka

Anthony Groom

Leanne Rivers

Terence Smith

Original Assignee

Eisai R&D Man Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-12

Filing date

2001-06-08

Publication date

2021-05-25

2000-09-13 Priority claimed from GB0022483A external-priority patent/GB0022483D0/en

2001-06-08 Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd

2004-03-02 Publication of BR0111596A publication Critical patent/BR0111596A/pt

2018-10-02 Publication of BRPI0111596B1 publication Critical patent/BRPI0111596B1/pt

2021-05-25 Publication of BRPI0000596B8 publication Critical patent/BRPI0000596B8/pt

2022-07-26 Publication of BRPI0111596B8 publication Critical patent/BRPI0111596B8/pt

Classifications

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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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BRPI0111596A 2000-06-12 2001-06-08 Composto piridona, processo de produção do composto, composição farmacêutica, e uso do dito composto BRPI0111596B8 (pt)

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GB0022483A GB0022483D0 (en)	2000-09-13	2000-09-13	1 2 Dihydropyridine compounds manufacturing method thereof and use thereof
PCT/JP2001/004857 WO2001096308A1 (fr)	2000-06-12	2001-06-08	Composes 1,2-dihydropyridine, leur procede de preparation et leur utilisation

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Families Citing this family (144)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ522773A (en) *	2000-06-12	2005-06-24	Eisai Co Ltd	1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
AU2002237664A1 (en) *	2000-11-20	2002-05-27	Bristol-Myers Squibb Company	Pyridone derivatives as AP2 inhibitors
US20030105144A1 (en)	2001-04-17	2003-06-05	Ping Gao	Stabilized oral pharmaceutical composition
JP4119114B2 (ja) *	2001-11-28	2008-07-16	広栄化学工業株式会社	新規なジヒドロキシ（３−ピリジル）ボラン類
GB0129260D0 (en) *	2001-12-06	2002-01-23	Eisai London Res Lab Ltd	Pharmaceutical compositions and their uses
CA2469435A1 (en) *	2001-12-21	2003-07-24	X-Ceptor Therapeutics, Inc.	Modulators of lxr
US7482366B2 (en)	2001-12-21	2009-01-27	X-Ceptor Therapeutics, Inc.	Modulators of LXR
US7101883B2 (en)	2002-03-18	2006-09-05	Bristol-Myers Squibb Company	Uracil derivatives as inhibitors of TNF-α converting enzyme (TACE) and matrix metalloproteinases
EP1497265B1 (en) *	2002-04-19	2009-02-18	Glaxo Group Limited	Compounds having affinity at 5ht2c receptor and use thereof in therapy
JP4208512B2 (ja) *	2002-07-23	2009-01-14	株式会社クラレ	５−（２’−ピリジル）−２−ピリドン誘導体の製造方法
AU2003274022A1 (en) *	2002-10-17	2004-05-04	Syngenta Participations Ag	3-heterocyclylpyridine derivatives useful as herbicides
BR0316785A (pt) *	2002-12-16	2005-10-25	Mitsubishi Pharma Corp	Derivados de 4-pirimidona-3-substituìdos
WO2004063151A2 (en) *	2003-01-03	2004-07-29	Bristol-Myers Squibb Company	Novel tyrosine kinase inhibitors
GB0305024D0 (en) *	2003-03-05	2003-04-09	Glaxo Group Ltd	Compounds
SE0302323D0 (sv) *	2003-08-28	2003-08-28	Astrazeneca Ab	Novel compounds
SE0302324D0 (sv) *	2003-08-28	2003-08-28	Astrazeneca Ab	Novel compounds
SE0302486D0 (sv) *	2003-09-18	2003-09-18	Astrazeneca Ab	Novel compounds
CA2562244A1 (en) *	2004-04-07	2005-10-27	Takeda Pharmaceutical Company Limited	Cyclic compounds
MY148809A (en) *	2004-07-06	2013-05-31	Eisai R&D Man Co Ltd	Crystals of 1,2-dihydropyridine compound and their production process
JP2007099781A (ja) *	2004-07-06	2007-04-19	Eisai R & D Management Co Ltd	１，２−ジヒドロピリジン化合物の結晶の製造方法
GB0420722D0 (en)	2004-09-17	2004-10-20	Addex Pharmaceuticals Sa	Novel allosteric modulators
US20060069260A1 (en) *	2004-09-28	2006-03-30	Huiping Zhang	Preparation of N-aryl pyridones
CA2591413A1 (en)	2004-12-16	2006-06-22	Vertex Pharmaceuticals Incorporated	Pyrid-2-ones useful as inhibitors of tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases
EP1858325A4 (en) *	2005-01-07	2010-06-30	Roskamp Res Llc	COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS FOR IDENTIFYING THESE COMPOUNDS
TW200700392A (en) *	2005-03-16	2007-01-01	Astrazeneca Ab	Novel compounds
DK1871368T3 (da) *	2005-04-04	2011-09-19	Eisai R&D Man Co Ltd	Dihydropyridinforbindelser til neurodegenerative sygdomme og demens
BRPI0607913A2 (pt) *	2005-04-08	2010-03-23	Eisai R&D Man Co Ltd	agente terapÊutico para discinesia
JP2008544743A (ja)	2005-05-10	2008-12-11	インターミューンインコーポレイテッド	ストレス活性化蛋白質キナーゼ系をモジュレートするためのピリドン誘導体
GB0510141D0 (en) *	2005-05-18	2005-06-22	Addex Pharmaceuticals Sa	Novel compounds B3
CA2617413A1 (en) *	2005-08-02	2007-02-08	Lexicon Pharmaceuticals, Inc.	2-aminoaryl pyridines as protein kinases inhibitors
CA2620269A1 (en)	2005-08-29	2007-03-08	Vertex Pharmaceuticals Incorporated	3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
US7786130B2 (en)	2005-08-29	2010-08-31	Vertex Pharmaceuticals Incorporated	Pyridones useful as inhibitors of kinases
CN101291926A (zh)	2005-08-29	2008-10-22	沃泰克斯药物股份有限公司	可用作Tec家族非受体酪氨酸激酶抑制剂的3,5-二取代的吡啶-2-酮
JP5119924B2 (ja) *	2005-10-03	2013-01-16	小野薬品工業株式会社	含窒素複素環化合物およびその医薬用途
US7803818B2 (en)	2005-12-21	2010-09-28	Eisai R&D Management Co., Ltd.	Amorphous form of 1,2-dihydropyridine compound
WO2007072868A1 (ja) *	2005-12-21	2007-06-28	Eisai R & D Management Co., Ltd.	１，２－ジヒドロピリジン化合物の結晶（ｉｖ型）
JP4865337B2 (ja) *	2006-01-24	2012-02-01	富士フイルムファインケミカルズ株式会社	２，３’−ビピリジル−６’−オンの製造方法
TWI417095B (zh)	2006-03-15	2013-12-01	Janssen Pharmaceuticals Inc	１，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
WO2007126060A1 (ja) *	2006-04-28	2007-11-08	Eisai R & D Management Co., Ltd	１，２－ジヒドロピリジン化合物の塩
TW200808763A (en)	2006-05-08	2008-02-16	Astrazeneca Ab	Novel compounds I
TW200808771A (en) *	2006-05-08	2008-02-16	Astrazeneca Ab	Novel compounds II
US20080108622A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
US20080108603A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
US20100099714A1 (en) *	2007-03-05	2010-04-22	Eisai R&D Management Co., Ltd.	AMPA and NMDA Receptor Antagonists for Neurodegenerative Diseases
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en)	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
JP2010524844A (ja) *	2007-04-26	2010-07-22	エーザイ・アール・アンド・ディー・マネジメント株式会社	認知症のためのシンナミド化合物
EP2164488A1 (en) *	2007-07-13	2010-03-24	Eisai R&D Management Co., Ltd.	Ampa receptor antagonists and aldose reductase inhibitors for neuropathic pain
CA2690110A1 (en) *	2007-07-13	2009-01-22	Eisai R&D Management Co., Ltd.	Ampa receptor antagonists for neuropathic pain
ATE516272T1 (de)	2007-09-14	2011-07-15	Ortho Mcneil Janssen Pharm	1,3-disubstituierte 4-(aryl-x-phenyl)-1h-pyridin- 2-one
US9114138B2 (en)	2007-09-14	2015-08-25	Janssen Pharmaceuticals, Inc.	1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones
EA016969B1 (ru)	2007-09-14	2012-08-30	Аддекс Фарма С.А.	1,3-двузамещенные-4-фенил-1н-пиридин-2-оны
WO2009054544A1 (en) *	2007-10-26	2009-04-30	Eisai R & D Management Co., Ltd.	Ampa receptor antagonists for parkinson's disease and movement disorders
PE20091565A1 (es) *	2007-11-06	2009-11-06	Astrazeneca Ab	Derivados de 2-pirazinona como inhibidores de la elastasa de los neutrofilos
JP5433582B2 (ja)	2007-11-14	2014-03-05	ジャンセンファーマシューティカルズ，インコーポレイテッド．	イミダゾ［１，２−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用
EP2223912A4 (en)	2007-12-21	2012-04-25	Kuraray Co	PROCESS FOR THE PREPARATION OF A 6-HALOGENO-3-ARYLPYRIDINE DERIVATIVE
JP2011507799A (ja) *	2007-12-26	2011-03-10	エーザイ・アール・アンド・ディー・マネジメント株式会社	癲癇のためのａｍｐａ受容体アンタゴニストおよびゾニサミド
JP2011507800A (ja) *	2007-12-26	2011-03-10	エーザイ・アール・アンド・ディー・マネジメント株式会社	癲癇、精神障害、または感覚器官の障害のためのａｍｐａ受容体アンタゴニスト
AU2009244504A1 (en) *	2008-05-05	2009-11-12	Amgen Inc.	Urea compounds as gamma secretase modulators
CA3034994A1 (en) *	2008-06-03	2009-12-10	Intermune, Inc.	Substituted aryl-2 pyridone compounds and use thereof for treating inflammatory and fibrotic disorders
US8859760B2 (en)	2008-07-29	2014-10-14	Frontier Scientific, Inc.	Compositions for killing or preventing the growth of microbes
CN102143955B (zh)	2008-09-02	2013-08-14	Omj制药公司	作为代谢型谷氨酸受体调节剂的3-氮杂二环[3.1.0]己烷衍生物
AU2009304293B2 (en)	2008-10-16	2012-04-26	Addex Pharma S.A.	Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
US8598209B2 (en) *	2008-10-31	2013-12-03	Merck Sharp & Dohme Corp.	P2X3, receptor antagonists for treatment of pain
CA2744138C (en)	2008-11-28	2015-08-11	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
AU2009331659B2 (en)	2008-12-23	2015-09-03	F. Hoffmann-La Roche Ag	Dihydropyridone amides as P2X7 modulators
EP2391604A1 (en)	2008-12-23	2011-12-07	F. Hoffmann-La Roche AG	Dihydropyridone amides as p2x7 modulators
WO2010072599A1 (en)	2008-12-23	2010-07-01	F. Hoffmann-La Roche Ag	Dihydropyridone ureas as p2x7 modulators
CA2745952A1 (en)	2008-12-23	2010-07-01	F.Hoffmann-La Roche Ag	Dihydropyridone amides as p2x7 modulators
US8153808B2 (en)	2008-12-23	2012-04-10	Roche Palo Alto Llc	Dihydropyridone amides as P2X7 modulators
TW201036957A (en) *	2009-02-20	2010-10-16	Astrazeneca Ab	Novel salt 628
TW201100398A (en)	2009-03-31	2011-01-01	Arqule Inc	Substituted indolo-pyridinone compounds
NZ596053A (en)	2009-05-12	2013-05-31	Janssen Pharmaceuticals Inc	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN102439008B (zh)	2009-05-12	2015-04-29	杨森制药有限公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2483244A1 (en)	2009-10-02	2012-08-08	AstraZeneca AB	2-pyridone compounds used as inhibitors of neutrophil elastase
JP2013234123A (ja) *	2010-09-03	2013-11-21	Taisho Pharmaceutical Co Ltd	３−ピラゾリル−２−ピリドン誘導体
EP2661435B1 (en)	2010-11-08	2015-08-19	Janssen Pharmaceuticals, Inc.	1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
US9012448B2 (en)	2010-11-08	2015-04-21	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
US9271967B2 (en)	2010-11-08	2016-03-01	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
HUE040101T2 (hu) *	2010-12-06	2019-02-28	Aclaris Therapeutics Inc	Szubsztituált piridinon-piridinil-származékok
US10059672B2 (en)	2011-03-04	2018-08-28	Yale University	(−)-Huperzine A processes and related compositions and methods of treatment
ITMI20111952A1 (it)	2011-10-27	2013-04-28	Italiana Sint Spa	Procedimento per la prepazione di 2-metossi-5-(piridin-2-il)piridina, un intermedio del perampanel
US9096574B2 (en)	2012-01-03	2015-08-04	Mapi Pharma Ltd.	Polymorphs of perampanel
WO2013148174A1 (en) *	2012-03-31	2013-10-03	University Of Georgia Research Foundation, Inc.	New anti-mycobacterial drugs against tuberculosis
KR102057877B1 (ko) *	2012-07-18	2019-12-20	노스 앤드 사우스 브라더 파마시 인베스트먼트 컴파니 리미티드	질소함유 헤테로고리 유도체 및 그의 약물에서의 용도
ITMI20121390A1 (it)	2012-08-06	2014-02-07	F I S Fabbrica Italiana Sint P A	Procedimento per la preparazione di acido 2-cianofenilboronico e suoi esteri, intermedi del perampanel o di e2040
AR092742A1 (es)	2012-10-02	2015-04-29	Intermune Inc	Piridinonas antifibroticas
JO3225B1 (ar) *	2012-11-27	2018-03-08	Lilly Co Eli	6-((s)-1-{1-[5-(2-هيدروكسي-إيثوكسي)-بيريدين-2-يل]-1h-بيرازول-3-يل}إيثيل)-3h-1 ، 3-بنزو ثيازول-2- أون باعتباره مضاد مستقبل ampa يعتمد على tarp- جاما 8
TW201441193A (zh)	2012-12-06	2014-11-01	Kyowa Hakko Kirin Co Ltd	吡啶酮化合物
US9242969B2 (en)	2013-03-14	2016-01-26	Novartis Ag	Biaryl amide compounds as kinase inhibitors
EP2981531A1 (en)	2013-04-04	2016-02-10	Eisai R&D Management Co., Ltd.	[11 c]and [18f]labeled 1,3-diphenyl-5-(pyrimidin-2-yl)-pyridin-2(1 h)-one derivatives and their use for pet imaging of the ampa receptor
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
CN103274993A (zh) *	2013-06-13	2013-09-04	南京工业大学	二氢吡啶和吡咯类杂环的新合成方法
EA031384B1 (ru) *	2013-07-25	2018-12-28	Тева Фармасьютикалз Интернэшнл Гмбх	Улучшенные способы получения перампанеля
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
SMT201900101T1 (it)	2013-10-29	2019-02-28	Takeda Pharmaceuticals Co	Composto eterociclico
CN103664756A (zh) *	2013-11-26	2014-03-26	苏州晶云药物科技有限公司	吡仑帕奈新晶型a及其制备方法
CN104706604A (zh) *	2013-12-12	2015-06-17	北京星昊医药股份有限公司	一种吡仑帕奈冻干口崩片及其制备方法
CN104725301A (zh) *	2013-12-20	2015-06-24	北京蓝贝望生物医药科技股份有限公司	一种1,2-二氢吡啶-2-酮衍生物的制备方法
KR102461134B1 (ko)	2014-01-21	2022-10-28	얀센 파마슈티카 엔.브이.	대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
LT3431106T (lt)	2014-01-21	2021-02-10	Janssen Pharmaceutica Nv	Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas
WO2015153683A1 (en)	2014-04-02	2015-10-08	Intermune, Inc.	Anti-fibrotic pyridinones
CN105085382B (zh) *	2014-05-14	2019-10-18	江苏豪森药业集团有限公司	吡仑帕奈异构体晶型及其制备方法和用途
TW201609719A (zh)	2014-05-28	2016-03-16	美國禮來大藥廠	作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物
CN103980188B (zh) *	2014-05-30	2016-01-27	浙江永宁药业股份有限公司	一种吡仑帕奈的合成方法及其中间体和中间体的合成方法
UY36294A (es)	2014-09-12	2016-04-29	Novartis Ag	Compuestos y composiciones como inhibidores de quinasa
CN107250130B (zh)	2015-02-04	2019-11-08	Beyondbio株式会社	杂环化合物及包含其的药物组合物
EP3259262A4 (en) *	2015-02-17	2018-08-01	Mapi Pharma Limited	Process and intermediates for the preparation of perampanel
AR104259A1 (es) *	2015-04-15	2017-07-05	Celgene Quanticel Res Inc	Inhibidores de bromodominio
WO2016172333A1 (en)	2015-04-21	2016-10-27	Teva Pharmaceuticals International Gmbh	A solid state form of perampanel
MX386015B (es)	2015-07-06	2025-03-18	Public Univ Corp Yokohama City Univ	Compuesto novedoso que se une específicamente a receptor de ácido alfa-amino-3-hidroxi-5-metil-4-isoxazol-propiónico (ampa).
CN105085383B (zh) *	2015-08-19	2017-09-01	四川大学	5‑甲基‑2(1h)吡啶酮衍生物及其制备方法和用途
SG11201803433TA (en) *	2015-11-13	2018-05-30	Eisai R&D Man Co Ltd	Pyranodipyridine compound
KR101652750B1 (ko) *	2015-12-03	2016-08-31	김종선	피리딘 및 그 유도체의 정제방법
AU2017329090B9 (en)	2016-09-19	2019-09-05	Novartis Ag	Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor
US11970486B2 (en)	2016-10-24	2024-04-30	Janssen Pharmaceutica Nv	Compounds and uses thereof
CN109982996A (zh) *	2016-11-18	2019-07-05	美国陶氏益农公司	4-((6-溴吡啶-3-基)氧基)苄腈及制备方法
EP3558407B1 (en) *	2016-12-22	2023-03-15	Biotronik AG	Drug releasing coatings for medical devices and methods of making same
JP6241974B1 (ja)	2017-01-11	2017-12-06	公立大学法人横浜市立大学	霊長類生体の脳内ａｍｐａ受容体のイメージング方法、プログラム、及びスクリーニング方法
GB201702221D0 (en)	2017-02-10	2017-03-29	Univ Of Sussex	Compounds
TWI798218B (zh)	2017-05-02	2023-04-11	瑞士商諾華公司	組合療法
JP7360171B2 (ja) *	2017-07-31	2023-10-12	ワシントン・ユニバーシティ	Ｂリンパ球活性の調節及び臓器保護のためのピルフェニドン誘導体
US11873298B2 (en)	2017-10-24	2024-01-16	Janssen Pharmaceutica Nv	Compounds and uses thereof
CN110028442B (zh) *	2018-01-11	2020-07-17	新发药业有限公司	一种吡仑帕奈的简便制备方法
GB201803340D0 (en) *	2018-03-01	2018-04-18	Univ Of Sussex	Compounds
MX2020009942A (es)	2018-03-23	2021-01-08	Yumanity Therapeutics Inc	Compuestos y usos de los mismos.
EP3560934A1 (en)	2018-04-26	2019-10-30	F.I.S.- Fabbrica Italiana Sintetici S.p.A.	Process for the preparation of pure 2-cyanophenylboronic acid and esters thereof, intermediates of perampanel or of e2040
WO2020124090A1 (en)	2018-12-14	2020-06-18	Eisai R&D Management Co., Ltd.	Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds
WO2020154571A1 (en)	2019-01-24	2020-07-30	Yumanity Therapeutics, Inc.	Compounds and uses thereof
CA3138123A1 (en)	2019-05-13	2020-11-19	Novartis Ag	New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2 (trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
CN110483563B (zh) *	2019-09-06	2021-12-28	山西医科大学	一种新型离子型β-萘酚醛席夫碱锆配合物的制备方法及应用
EP4037770A1 (en) *	2019-10-04	2022-08-10	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Novel pyridin-2(1h)one derivatives, their preparation and their use for the treatment of pain
EA202192047A1 (ru)	2019-11-13	2021-12-08	Юманити Терапьютикс, Инк.	Соединения и их применение
KR102392825B1 (ko)	2020-02-18	2022-04-29	명인제약주식회사	2-(2-옥소-1-페닐-5-피리딘-2-일피리딘-3-일)벤조니트릴과 ｌ-말릭산의 공결정 화합물 및 이의 제조 방법
CN111362930B (zh) *	2020-04-15	2023-02-03	安徽医科大学	一种1，2，4-噁二唑-吡啶类化合物及其应用
US20240398775A1 (en)	2021-09-15	2024-12-05	University Of The Ryukyus	Pharmaceutical composition for use in treating cognitive decline or for use in treating overweight or obesity
EP4403185A1 (en)	2021-09-15	2024-07-24	University of The Ryukyus	Pharmaceutical composition for treating cognitive decline or for treating overweightness or obesity
CN116265440B (zh) *	2021-12-16	2024-09-27	贵州大学	一种水杨酮拼接吡啶酮类化合物及其制备方法及应用
CN114057630B (zh) *	2021-12-23	2023-06-02	郑州大学	吡非尼酮衍生物及其合成方法和应用
WO2023230205A1 (en)	2022-05-25	2023-11-30	Ikena Oncology, Inc.	Mek inhibitors and uses thereof
WO2024010585A1 (en) *	2022-07-07	2024-01-11	Yale University	Non-covalent inhibitors of the main protease of sars-cov-2 and methods of use
KR102768044B1 (ko) *	2022-07-12	2025-02-17	이화여자대학교 산학협력단	연속 흐름 공정을 포함하는 페람파넬 유도체의 제조 방법
US11958832B1 (en)	2023-10-12	2024-04-16	King Faisal University	2-alkoxy[4,3:6,3-terpyridine]-3-carbonitriles as antimicrobial compounds

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5283761A (en) *	1976-01-01	1977-07-12	Yamanouchi Pharmaceut Co Ltd	Novel pyridone derivative
JPS5531072A (en) *	1979-07-30	1980-03-05	Rikagaku Kenkyusho	Preparation of 2-pyridone compound
DE4003541C1 (pt) *	1990-02-06	1991-08-08	Alter S.A., Madrid, Es
US5356902A (en)	1992-11-06	1994-10-18	Eli Lilly And Company	Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists
IL109397A0 (en)	1993-04-28	1994-07-31	Schering Ag	Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HU219777B (hu)	1993-07-02	2001-07-30	Gyógyszerkutató Intézet Kft.	Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására
DE69524246T2 (de)	1994-09-27	2002-06-27	Yamanouchi Pharmaceutical Co., Ltd.	1,2,3,4-Tetrahydroquinoxalindion Derivate und ihre Verwendung als Glutamat Rezeptor Antagonisten
CN1188401C (zh) *	1995-04-27	2005-02-09	三菱制药株式会社	杂环类酰胺化合物及其医药用途
WO1997018163A1 (en)	1995-11-15	1997-05-22	California Institute Of Technology	Synthesis of zeolites by hydrothermal reaction of zeolite p1
DE19604920A1 (de)	1996-02-01	1997-08-07	Schering Ag	Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
US5891871A (en)	1996-03-21	1999-04-06	Cocensys, Inc.	Substituted 2,3-benzodiazepin-4-ones and the use thereof
HU9600871D0 (en)	1996-04-04	1996-05-28	Gyogyszerkutato Intezet	New 2,3-benzodiazepine derivatives
AU730503B2 (en)	1996-05-15	2001-03-08	Pfizer Inc.	Novel 2,3 disubstituted-4(3H)-quinazolinones
DE19643037A1 (de)	1996-10-18	1998-04-23	Boehringer Ingelheim Kg	Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
HUP0001140A3 (en)	1996-12-05	2002-05-28	Amgen Inc Thousand Oaks	Substituted pyrimidinone and pyridone compounds and methods of use
ATE267817T1 (de)	1997-02-28	2004-06-15	Pfizer Prod Inc	Atropisomere von 3-aryl-4(3h)-chinazolinonen und ihre verwendung als ampa-rezeptor
GB9708945D0 (en)	1997-05-01	1997-06-25	Merck Sharp & Dohme	Therapeutic agents
GB9711753D0 (en)	1997-06-06	1997-08-06	Merck Sharp & Dohme	Therapeutic agents
JP4321737B2 (ja) *	1997-12-17	2009-08-26	塩野義製薬株式会社	新規ピリジン化合物
WO2000001376A2 (en)	1998-07-02	2000-01-13	Eisai Co., Ltd	Pharmaceutical compositions and their uses for treatment of demyelinating disorders
DE19835918A1 (de)	1998-08-07	2000-02-10	Dresden Arzneimittel	Neue antikonvulsiv wirkende 4-Amino-1-aryl-pyridin-2-one und Verfahren zu deren Herstellung
NZ522773A (en)	2000-06-12	2005-06-24	Eisai Co Ltd	1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
GB0129260D0 (en)	2001-12-06	2002-01-23	Eisai London Res Lab Ltd	Pharmaceutical compositions and their uses

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CY2012032I2 (el)	2015-08-05
US7939549B2 (en)	2011-05-10
FR12C0074I1 (pt)	2013-01-18
KR20030012882A (ko)	2003-02-12
JPWO2001096308A1 (ja)	2004-01-08
IL192605A0 (en)	2009-02-11
DK1300396T3 (da)	2009-04-06
CY1108969T1 (el)	2014-07-02
AU2001262723C1 (en)	2006-05-11
TWI292757B (pt)	2008-01-21
LU92113I2 (fr)	2013-02-12
CN1245386C (zh)	2006-03-15
HUP0303398A3 (en)	2010-03-29
AU6272301A (en)	2001-12-24
FR12C0074I2 (fr)	2013-08-16
KR20070094994A (ko)	2007-09-27
BR0111596A (pt)	2004-03-02
JP2012207021A (ja)	2012-10-25
US20090275751A1 (en)	2009-11-05
BE2013C003I2 (pt)	2020-08-20
HK1056871A1 (en)	2004-03-05
CA2412172A1 (en)	2002-12-06
IL184687A (en)	2010-06-30
NO325160B1 (no)	2008-02-11
NL300565I2 (pt)	2016-01-18
KR100869271B1 (ko)	2008-11-18
US6949571B2 (en)	2005-09-27
MXPA02012314A (es)	2004-09-06
EP1300396A1 (en)	2003-04-09
KR100904011B1 (ko)	2009-06-22
ZA200209270B (en)	2005-08-31
NO2012021I2 (no)	2013-09-09
CY2012032I1 (el)	2014-07-02
IL184686A (en)	2010-05-17
IL152848A0 (en)	2003-06-24
WO2001096308A1 (fr)	2001-12-20
DE60137426D1 (de)	2009-03-05
US20050245581A1 (en)	2005-11-03
CN1436172A (zh)	2003-08-13
ES2320973T3 (es)	2009-06-01
PT1300396E (pt)	2009-04-20
KR100850728B1 (ko)	2008-08-06
HU1300187D0 (hu)	2004-03-01
TW200815402A (en)	2008-04-01
JP5068069B2 (ja)	2012-11-07
HU229553B1 (en)	2014-01-28
BRPI0111596B1 (pt)	2018-10-02
NZ522773A (en)	2005-06-24
KR20070094995A (ko)	2007-09-27
EP2053041A2 (en)	2009-04-29
EP1300396B1 (en)	2009-01-14
US20040023973A1 (en)	2004-02-05
US7563811B2 (en)	2009-07-21
NO2012021I1 (no)	2013-01-07
BRPI0111596B8 (pt)	2022-07-26
ATE420862T1 (de)	2009-01-15
IL184686A0 (en)	2007-12-03
EP2053041A3 (en)	2009-07-29
IL184687A0 (en)	2007-12-03
TWI321565B (pt)	2010-03-11
CA2412172C (en)	2012-07-24
IL192605A (en)	2012-06-28
NL300565I1 (pt)	2016-01-18
JP2007119486A (ja)	2007-05-17
EP2177520A1 (en)	2010-04-21
JP3922368B2 (ja)	2007-05-30
EP1300396A4 (en)	2005-06-15
IL152848A (en)	2007-09-20
AU2001262723B2 (en)	2005-05-12
NO20025955D0 (no)	2002-12-11
NO20025955L (no)	2003-02-12
HUP0303398A2 (hu)	2004-03-01

Publication	Publication Date	Title
BRPI0000596B8 (pt)	2021-05-25	composto piridona, processo de produção do composto, composição farmacêutica, e uso do dito composto
NO20033385D0 (no)	2003-07-29	Fuserte heterocykliske forbindelser
CY1111876T1 (el)	2015-11-04	Νεες πυρρολες με υπολiπiδaiμiκες και υποχοληστερολαιμικες δραστικοτητες, μεθοδος για την παρασκευη αυτων και φαρμακευτικες συνθεσεις που τις περιεχουν και η χρηση αυτων στην ιατρικη
EP1423111A4 (en)	2007-04-18	FXR NR1H4 NUCLEAR RECEPTOR BINDING COMPOUNDS
BR0314688A (pt)	2005-08-02	Novos derivados de piperidina para utilização no tratamento de estados de doença mediados pela quimiocina
CY1107403T1 (el)	2012-12-19	Μια μεθοδος δια την παρασκευη υπερινδοπριλης,των αναλογων ενωσεων αυτης και των αλατων αυτων με χρησιμοποιηση ενδιαμεσων ενωσεων 2,5-διοξο-οξαζολιδινης
MX2009010790A (es)	2009-10-29	Derivados de heteroarilo biciclico fusionados.
MA27991A1 (fr)	2006-07-03	Derives d'aminoquinoline et leur utilisation comme ligands d'adenosine a3
ATE377602T1 (de)	2007-11-15	Morphinanderivate und ihre medizinische anwendung
PT1101755E (pt)	2005-02-28	Derivados do acido antranilico
ID24846A (id)	2000-08-24	Turunan-turunan bifenilamidina
ATE453389T1 (de)	2010-01-15	Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen
DK0902018T3 (da)	2008-10-20	2-(arylpheny)amino-imidazolinderivater
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