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BR9812001A - Composição farmacêutica para combinação de descongestionante piperidinoalcanol - Google Patents

Composição farmacêutica para combinação de descongestionante piperidinoalcanol

Info

Publication number
BR9812001A
BR9812001A BR9812001-8A BR9812001A BR9812001A BR 9812001 A BR9812001 A BR 9812001A BR 9812001 A BR9812001 A BR 9812001A BR 9812001 A BR9812001 A BR 9812001A
Authority
BR
Brazil
Prior art keywords
formulation
amount
weight
carrier material
basic carrier
Prior art date
Application number
BR9812001-8A
Other languages
English (en)
Inventor
David Douglas Maclaren
John Robert Lefler
Sharon Kay Minish
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25443270&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9812001(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of BR9812001A publication Critical patent/BR9812001A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: <B>"COMPOSIçãO FARMACêUTICA PARA COMBINAçãO DE DESCONGESTIONANTE PIPERIDINOALCANOL"<D>. A presente invenção provê uma composição farmacêutica na forma de um comprimido de dupla camada compreendendo: (a) uma primeira zona distinta feita com a Formulação A, que compreende uma quantidade terapeuticamente eficaz como descongestionante de um medicamento simpatomimético, ou de um sal farmaceuticamente aceitável do mesmo, em uma quantidade de cerca de 18% a cerca de 39% em peso da formulação (A), e um primeiro material básico carreador, o primeiro material básico carreador compreendendo uma mistura de: (i) cera de carnaúba em uma quantidade de cerca de 59% a cerca de 81% em peso da formulação (A); e (ii) um antiaderente adequado em uma quantidade de cerca de 0,25% a cerca de 2,00% em peso da formulação (A); em que o referido primeiro material básico carreador provê uma liberação sustentada do medicamento simpatomimético; e (b) uma segunda zona distinta feita com a formulação (B) que compreende uma quantidade terapeuticamente eficaz como anti-histamínico de um piperidinoalcanol, ou de um sal farmaceuticamente aceitável do mesmo, em uma quantidade de cerca de 15% a cerca de 30% em peso da Formulação (B) e de um segundo material básico carreador, o segundo material básico carreador compreendendo uma mistura de: (i) um diluente celulósico em uma quantidade de cerca de 27% a cerca de 73% em peso da Formulação (B); (ii) amido pré-gelatinizado em uma quantidade de cerca de 15% a cerca de 30% em peso da Formulação (B); (iii) um desintegrante adequado em uma quantidade de cerca de 0,25% a cerca de 6,0% em peso da Formulação (B); e (iv) um lubrificante adequado em uma quantidade de cerca de 0,25% a cerca de 2,00% em peso da Formulação (B); em que o segundo material básico carreador provê uma liberação imediata do piperidinoalcanol ou de seu sal farmaceuticamente aceitável.
BR9812001-8A 1997-08-26 1998-07-21 Composição farmacêutica para combinação de descongestionante piperidinoalcanol BR9812001A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92015897A 1997-08-26 1997-08-26
PCT/US1998/015237 WO1999009957A1 (en) 1997-08-26 1998-07-21 Pharmaceutical composition for combination of piperidinoalkanol-decongestant

Publications (1)

Publication Number Publication Date
BR9812001A true BR9812001A (pt) 2000-09-26

Family

ID=25443270

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812001-8A BR9812001A (pt) 1997-08-26 1998-07-21 Composição farmacêutica para combinação de descongestionante piperidinoalcanol

Country Status (31)

Country Link
US (1) US6039974A (pt)
EP (1) EP0998272B1 (pt)
JP (1) JP4344405B2 (pt)
KR (1) KR100514264B1 (pt)
CN (1) CN1159012C (pt)
AR (1) AR013947A1 (pt)
AT (1) ATE238773T1 (pt)
AU (1) AU725811B2 (pt)
BR (1) BR9812001A (pt)
CZ (1) CZ295461B6 (pt)
DE (1) DE69814086T2 (pt)
DK (1) DK0998272T3 (pt)
EE (1) EE04294B1 (pt)
ES (1) ES2192781T3 (pt)
HK (1) HK1025904A1 (pt)
HU (1) HU224921B1 (pt)
ID (1) ID22891A (pt)
IL (1) IL133420A (pt)
NO (1) NO318246B1 (pt)
NZ (1) NZ501248A (pt)
OA (1) OA11285A (pt)
PL (1) PL192079B1 (pt)
PT (1) PT998272E (pt)
RU (1) RU2207879C2 (pt)
SI (1) SI0998272T1 (pt)
SK (1) SK283803B6 (pt)
TR (1) TR200000517T2 (pt)
TW (1) TW570812B (pt)
UA (1) UA60335C2 (pt)
WO (1) WO1999009957A1 (pt)
ZA (1) ZA987552B (pt)

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NZ501248A (en) 2001-06-29
WO1999009957A1 (en) 1999-03-04
PT998272E (pt) 2003-09-30
US6039974A (en) 2000-03-21
IL133420A (en) 2004-07-25
CZ458199A3 (cs) 2000-05-17
ATE238773T1 (de) 2003-05-15
KR20010013543A (ko) 2001-02-26
AR013947A1 (es) 2001-01-31
OA11285A (en) 2003-07-29
AU8582098A (en) 1999-03-16
PL337348A1 (en) 2000-08-14
KR100514264B1 (ko) 2005-09-15
DE69814086D1 (de) 2003-06-05
NO20000932D0 (no) 2000-02-25
DE69814086T2 (de) 2004-04-08
NO318246B1 (no) 2005-02-21
DK0998272T3 (da) 2003-08-25
PL192079B1 (pl) 2006-08-31
ZA987552B (en) 1999-02-26
TW570812B (en) 2004-01-11
CN1268050A (zh) 2000-09-27
HUP0002183A3 (en) 2000-12-28
SK177799A3 (en) 2000-07-11
HUP0002183A2 (hu) 2000-11-28
CZ295461B6 (cs) 2005-08-17
EE04294B1 (et) 2004-06-15
EP0998272A1 (en) 2000-05-10
UA60335C2 (uk) 2003-10-15
EE200000098A (et) 2000-12-15
JP4344405B2 (ja) 2009-10-14
ES2192781T3 (es) 2003-10-16
SI0998272T1 (en) 2003-12-31
SK283803B6 (sk) 2004-02-03
HU224921B1 (hu) 2006-04-28
IL133420A0 (en) 2001-04-30
HK1025904A1 (en) 2000-12-01
NO20000932L (no) 2000-04-18
RU2207879C2 (ru) 2003-07-10
JP2002511102A (ja) 2002-04-09
AU725811B2 (en) 2000-10-19
EP0998272B1 (en) 2003-05-02
TR200000517T2 (tr) 2000-08-21
CN1159012C (zh) 2004-07-28

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