SE457326B - Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa - Google Patents
Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosaInfo
- Publication number
- SE457326B SE457326B SE8600657A SE8600657A SE457326B SE 457326 B SE457326 B SE 457326B SE 8600657 A SE8600657 A SE 8600657A SE 8600657 A SE8600657 A SE 8600657A SE 457326 B SE457326 B SE 457326B
- Authority
- SE
- Sweden
- Prior art keywords
- preparing
- optionally
- microcristallin
- cellulosa
- substantial
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 239000008187 granular material Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002195 soluble material Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Mushroom Cultivation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8600657A SE457326B (sv) | 1986-02-14 | 1986-02-14 | Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa |
DE8787850052T DE3772072D1 (de) | 1986-02-14 | 1987-02-13 | Pharmazeutische zusammensetzung. |
AT87850052T ATE66141T1 (de) | 1986-02-14 | 1987-02-13 | Pharmazeutische zusammensetzung. |
EP87850052A EP0237506B1 (en) | 1986-02-14 | 1987-02-13 | Pharmaceutical composition |
CA000529687A CA1297018C (en) | 1986-02-14 | 1987-02-13 | Pharmaceutical composition |
ES198787850052T ES2029285T3 (es) | 1986-02-14 | 1987-02-13 | Un procedimiento para la preparacion de un nucleo granulado de rapida disgregacion. |
US07/015,011 US4840799A (en) | 1986-02-14 | 1987-02-17 | Process for preparing rapidly disintegrating granulates |
FI871380A FI90725C (sv) | 1986-02-14 | 1987-03-30 | Förfarande för framställning av ett snabbt sönderfallande kärngranulat innehållande en läkemedelsaktiv substans |
GR91401384T GR3002770T3 (en) | 1986-02-14 | 1991-09-20 | Pharmaceutical composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8600657A SE457326B (sv) | 1986-02-14 | 1986-02-14 | Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8600657D0 SE8600657D0 (sv) | 1986-02-14 |
SE8600657L SE8600657L (sv) | 1987-08-15 |
SE457326B true SE457326B (sv) | 1988-12-19 |
Family
ID=20363470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8600657A SE457326B (sv) | 1986-02-14 | 1986-02-14 | Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa |
Country Status (9)
Country | Link |
---|---|
US (1) | US4840799A (sv) |
EP (1) | EP0237506B1 (sv) |
AT (1) | ATE66141T1 (sv) |
CA (1) | CA1297018C (sv) |
DE (1) | DE3772072D1 (sv) |
ES (1) | ES2029285T3 (sv) |
FI (1) | FI90725C (sv) |
GR (1) | GR3002770T3 (sv) |
SE (1) | SE457326B (sv) |
Families Citing this family (80)
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US4983400A (en) * | 1986-06-16 | 1991-01-08 | Merck & Co., Inc. | Controlled release combination of carbidopa/levodopa |
US5651991A (en) * | 1987-10-28 | 1997-07-29 | Nippon Shinyaku Co. Ltd. | Drug carriers |
US5028433A (en) * | 1988-11-30 | 1991-07-02 | Banyu Pharmaceutical Co., Ltd. | Readily absorbable drug formulation of NB-818 |
US5055307A (en) * | 1988-12-29 | 1991-10-08 | Asahi Kagaku Kogyo Kabushiki Kaisha | Slow release drug delivery granules and process for production thereof |
GB8903328D0 (en) * | 1989-02-14 | 1989-04-05 | Ethical Pharma Ltd | Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
US4994458A (en) * | 1990-04-30 | 1991-02-19 | Basf Corporation | Process for rotary fluid bed granulation of riboflavin |
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FR2692146B1 (fr) * | 1992-06-16 | 1995-06-02 | Ethypharm Sa | Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention. |
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US6191105B1 (en) | 1993-05-10 | 2001-02-20 | Protein Delivery, Inc. | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
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ES2065313T5 (es) * | 1993-05-15 | 2004-01-01 | Roche Diagnostics Gmbh | Tableta con biodisponibilidad mejorada que contiene acido diclorometilendifosfonico como sustancia activa. |
US6210714B1 (en) | 1993-11-23 | 2001-04-03 | Euro-Celtique S.A. | Immediate release tablet cores of acetaminophen having sustained-release coating |
US5500227A (en) * | 1993-11-23 | 1996-03-19 | Euro-Celtique, S.A. | Immediate release tablet cores of insoluble drugs having sustained-release coating |
ZA939565B (en) † | 1993-12-21 | 1994-08-11 | Applied Analytical Ind Inc | Method for preparing low dose pharmaceutical products. |
ES2087823B1 (es) * | 1994-07-13 | 1997-02-16 | Estudes Et Richerches Pharma E | Formulacion de microgranulos gastroresistentes de omeprazol y su procedimiento de fabricacion. |
MX9706449A (es) * | 1995-02-28 | 1997-11-29 | Hoechst Marion Roussel Inc | Composicion farmaceutica para compuestos de piperidinalcanol. |
US5789014A (en) * | 1995-12-25 | 1998-08-04 | Shin-Etsu Chemical Co., Ltd. | Method of manufacturing a solid preparation coated with non-solvent coating |
US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
CZ295461B6 (cs) * | 1997-08-26 | 2005-08-17 | Aventis Pharmaceuticals Inc. | Farmaceutický prostředek ve formě dvouvrstvé tablety |
US6129932A (en) * | 1997-09-05 | 2000-10-10 | Merck & Co., Inc. | Compositions for inhibiting platelet aggregation |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6174548B1 (en) | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
FR2781793B1 (fr) | 1998-08-03 | 2001-07-20 | Prographarm Lab | Procede de fabrication de granules de gabapentine enrobes |
US6703381B1 (en) * | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
US6733778B1 (en) * | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6440394B2 (en) * | 1999-06-01 | 2002-08-27 | Church & Dwight, Co., Inc. | Remineralizing-mineralizing oral products containing discrete cationic and anionic agglomerate components and method of use |
US7169889B1 (en) | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
US6309633B1 (en) | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
FR2795962B1 (fr) | 1999-07-08 | 2003-05-09 | Prographarm Laboratoires | Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif |
US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6627223B2 (en) * | 2000-02-11 | 2003-09-30 | Eurand Pharmaceuticals Ltd. | Timed pulsatile drug delivery systems |
EP1604663A1 (en) | 2000-04-24 | 2005-12-14 | Teva Pharmaceutical Industries Ltd | Zolpidem Hemitartrate Form H Solvate |
AU2001257213B2 (en) * | 2000-04-24 | 2005-09-29 | Teva Pharmaceutical Industries Ltd. | Zolpidem hemitartrate |
US6344215B1 (en) | 2000-10-27 | 2002-02-05 | Eurand America, Inc. | Methylphenidate modified release formulations |
US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6867183B2 (en) * | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828305B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6835802B2 (en) * | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7713932B2 (en) * | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6913903B2 (en) | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US9358214B2 (en) * | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
US7601688B2 (en) * | 2002-06-13 | 2009-10-13 | Biocon Limited | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
JP2003146878A (ja) * | 2002-11-22 | 2003-05-21 | Sawai Pharmaceutical Co Ltd | ニルバジピン含有易溶性固形製剤およびその製造法 |
US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
US20040166162A1 (en) * | 2003-01-24 | 2004-08-26 | Robert Niecestro | Novel pharmaceutical formulation containing a proton pump inhibitor and an antacid |
US20050065172A1 (en) * | 2003-09-23 | 2005-03-24 | Shah Indukumar G. | Solid dosage form comprising caffeine |
PT1685126E (pt) * | 2003-10-16 | 2007-04-30 | Teva Pharma | Preparação de candesartan cilexetil |
PT1633364E (pt) * | 2004-01-05 | 2008-05-29 | Teva Pharma | Métodos para a produção de sildenafil base e sal citrato de sildenafil |
WO2005077941A2 (en) * | 2004-02-11 | 2005-08-25 | Teva Pharmaceutical Industries Ltd. | Candesartan cilexetil polymorphs |
KR101309770B1 (ko) | 2004-07-19 | 2013-09-30 | 바이오콘 리미티드 | 인슐린―올리고머 접합체,제형 및 이들의 용도 |
US8747895B2 (en) * | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
US9884014B2 (en) * | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
US20060105039A1 (en) | 2004-10-21 | 2006-05-18 | Jin-Wang Lai | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
US20060105038A1 (en) * | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
AU2007266574A1 (en) * | 2006-06-01 | 2007-12-06 | Dexcel Pharma Technologies Ltd. | Multiple unit pharmaceutical formulation |
EP2063861B1 (en) * | 2006-09-15 | 2015-02-25 | Echo Pharmaceuticals B.V. | Dosage unit for sublingual, buccal or oral administration of water-insoluble pharmaceutically active substances |
CN101594848B (zh) * | 2006-09-15 | 2014-10-29 | 艾可制药有限公司 | 包含药物活性物质和乳化剂的颗粒及其制备方法 |
KR101234540B1 (ko) | 2007-10-16 | 2013-02-19 | 바이오콘 리미티드 | 경구 투여가능한 고형 약제학적 조성물 및 그 제조방법 |
NZ600256A (en) | 2009-12-02 | 2014-05-30 | Aptalis Pharma Ltd | Fexofenadine microcapsules and compositions containing them |
CN102908337B (zh) * | 2012-10-12 | 2014-03-05 | 大连医诺生物有限公司 | 微囊化氨基酸组合物及其制备方法 |
US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE621147A (sv) * | ||||
DE2301664C3 (de) * | 1973-01-13 | 1979-07-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Oral verabreichbares, Nitroglycerin enthaltendes Arzneimittel |
CA1146866A (en) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
CA1163559A (en) * | 1980-07-09 | 1984-03-13 | Alec D. Keith | Polymeric diffusion matrix for administration of drugs |
US4456628A (en) * | 1981-01-07 | 1984-06-26 | Bauer Kurt H | Process for film-coating a particulate solid, and emulsions for conducting the process |
JPS57171428A (en) * | 1981-04-13 | 1982-10-22 | Sankyo Co Ltd | Preparation of coated solid preparation |
JPS5846019A (ja) * | 1981-09-14 | 1983-03-17 | Kanebo Ltd | 持続性ニフエジピン製剤 |
JPS5877811A (ja) * | 1981-11-04 | 1983-05-11 | Kanebo Ltd | 安定な易吸収性ニフエジピン製剤の製法 |
US4525339A (en) * | 1982-10-15 | 1985-06-25 | Hoffmann-La Roche Inc. | Enteric coated oral dosage form |
DE3419129A1 (de) * | 1984-05-23 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | Nifedipinpraeparate und verfahren zu ihrer herstellung |
FR2581541B1 (fr) * | 1985-05-09 | 1988-05-20 | Rhone Poulenc Sante | Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation |
-
1986
- 1986-02-14 SE SE8600657A patent/SE457326B/sv unknown
-
1987
- 1987-02-13 ES ES198787850052T patent/ES2029285T3/es not_active Expired - Lifetime
- 1987-02-13 DE DE8787850052T patent/DE3772072D1/de not_active Expired - Fee Related
- 1987-02-13 CA CA000529687A patent/CA1297018C/en not_active Expired - Fee Related
- 1987-02-13 AT AT87850052T patent/ATE66141T1/de not_active IP Right Cessation
- 1987-02-13 EP EP87850052A patent/EP0237506B1/en not_active Expired
- 1987-02-17 US US07/015,011 patent/US4840799A/en not_active Expired - Fee Related
- 1987-03-30 FI FI871380A patent/FI90725C/sv not_active IP Right Cessation
-
1991
- 1991-09-20 GR GR91401384T patent/GR3002770T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI90725C (sv) | 1994-03-25 |
CA1297018C (en) | 1992-03-10 |
FI871380A0 (sv) | 1987-03-30 |
FI871380L (sv) | 1988-10-01 |
US4840799A (en) | 1989-06-20 |
EP0237506B1 (en) | 1991-08-14 |
SE8600657L (sv) | 1987-08-15 |
ES2029285T3 (es) | 1992-08-01 |
SE8600657D0 (sv) | 1986-02-14 |
DE3772072D1 (de) | 1991-09-19 |
ATE66141T1 (de) | 1991-08-15 |
EP0237506A1 (en) | 1987-09-16 |
GR3002770T3 (en) | 1993-01-25 |
FI90725B (sv) | 1993-12-15 |
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