BR9809137A - Métodos e composições para identificar suìnos geneticamente resistentes a doenças associadas a e. coli f18 - Google Patents
Métodos e composições para identificar suìnos geneticamente resistentes a doenças associadas a e. coli f18Info
- Publication number
- BR9809137A BR9809137A BR9809137-9A BR9809137A BR9809137A BR 9809137 A BR9809137 A BR 9809137A BR 9809137 A BR9809137 A BR 9809137A BR 9809137 A BR9809137 A BR 9809137A
- Authority
- BR
- Brazil
- Prior art keywords
- coli
- pigs
- resistant
- compositions
- diseases associated
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
Patente de Invenção: <B>"MéTODOS E COMPOSIçõES PARA IDENTIFICAR SUìNOS GENETICAMENTE RESISTENTES A DOENçAS ASSOCIADAS A E. COLI F18"<D>. A presente invenção fornece métodos não-invasivos e composições para diferenciar, com um alto nível de sensibilidade e especificidade, suínos que sejam geneticamente suscetíveis a doenças associadas com infecção por E. coli F18, de suínos resistentes. Foram usados polimorfismos de DNA no gene de suíno alfa (1,2) fucosiltransferase 1 (FUT1) para diferenciar suínos resistentes de suscetíveis. A invenção inclui um polipeptídeo com substituições de aminoácidos, codificado pelo polimorfismos de nucleotídeo, um teste de diagnóstico molecular, e um kit para a diferenciação de porcos resistentes à adesão de E. coli F18, heterozigotos (veículo) e homozigotos suscetíveis. O teste molecular identifica suscetibilidade à doença de edema e diarréia após o desmame com alta sensibilidade e especificidade, portanto, é útil para criadores de suínos em seu esforço para aumentar a resistência. Informação sobre os polímorfismos da presente invenção provê percepção da causa e do tratamento de distúrbios intestinais associados com E. coli.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4718197P | 1997-05-20 | 1997-05-20 | |
| PCT/US1998/010318 WO1998053102A1 (en) | 1997-05-20 | 1998-05-20 | Methods and compositions to identify swine genetically resistant to f18 e. coli associated diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9809137A true BR9809137A (pt) | 2000-08-08 |
Family
ID=21947500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9809137-9A BR9809137A (pt) | 1997-05-20 | 1998-05-20 | Métodos e composições para identificar suìnos geneticamente resistentes a doenças associadas a e. coli f18 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6596923B1 (pt) |
| EP (1) | EP0985052B1 (pt) |
| JP (2) | JP3637420B2 (pt) |
| CN (1) | CN1314953A (pt) |
| AT (2) | ATE309392T1 (pt) |
| AU (2) | AU737862B2 (pt) |
| BR (1) | BR9809137A (pt) |
| CA (1) | CA2290768C (pt) |
| CZ (1) | CZ298021B6 (pt) |
| DE (3) | DE69832306T2 (pt) |
| DK (2) | DK1310570T3 (pt) |
| ES (2) | ES2203958T3 (pt) |
| HK (1) | HK1040097A1 (pt) |
| HU (1) | HUP0103587A3 (pt) |
| MX (1) | MXPA99011988A (pt) |
| NO (1) | NO996373L (pt) |
| NZ (1) | NZ501886A (pt) |
| PL (1) | PL195890B1 (pt) |
| PT (1) | PT985052E (pt) |
| RU (1) | RU2204609C2 (pt) |
| WO (2) | WO1998053102A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6355859B1 (en) * | 1997-05-20 | 2002-03-12 | Biotechnology Research And Development Corporation | Interactions between genotype and diet in swine that prevent E. coli associated intestinal disease |
| JP3637420B2 (ja) * | 1997-05-20 | 2005-04-13 | バイオテクノロジー・リサーチ・アンド・ディベロップメント・コーポレイション | Ｆ１８イー・コリ関連疾患に対して遺伝学的に耐性のブタを同定する方法および組成物 |
| HU221664B1 (hu) * | 1999-03-31 | 2002-12-28 | MTA Állatorvostudományi Kutatóintézete | Élő, szájon át adható Escherichia coli vakcina készítésére alkalmas törzs a sertések választási hasmenésének megelőzésére és a törzs előállítására alkalmas eljárás |
| GB0118549D0 (en) * | 2001-07-30 | 2001-09-19 | Pig Improvement Uk Ltd | Methods |
| JP2006506991A (ja) | 2002-11-25 | 2006-03-02 | デン・コンゲリエ・ヴェテリネー−オ・ランボホイスコレ | ブタ多型およびその検出のための方法 |
| AU2003303599B8 (en) | 2002-12-31 | 2010-03-25 | Branhaven LLC | Compositions, methods and systems for inferring bovine traits |
| CN104982387B (zh) * | 2015-05-25 | 2018-01-23 | 广东温氏食品集团股份有限公司 | 一种muc13和fut1基因的分子标记辅助选择方法 |
| DK3344282T3 (da) * | 2015-09-02 | 2020-12-14 | Dupont Nutrition Biosci Aps | Glycosidhydrolaser og anvendelse heraf til forebyggelse og/eller behandling af en patogen infektion hos et dyr |
| CN106480174B (zh) * | 2016-09-14 | 2019-04-16 | 扬州大学 | 一种用于猪抗病育种的遗传分子标记方法和应用 |
| CN108384865A (zh) * | 2018-02-07 | 2018-08-10 | 扬州大学 | Alpha菌毛基因在仔猪腹泻致病性大肠杆菌监测、鉴别中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK41885A (da) | 1985-01-31 | 1986-11-13 | Slagteriernes Forskningsinst | 987p-fimbrie-producerende mikroorganisme, vaccine til immunisering af grise samt fremgangsmaade til fremstilling af vaccinen |
| IE67816B1 (en) | 1990-12-21 | 1996-05-01 | Univ Toronto | Diagnosis for porcine malignant hyperthermia |
| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5552144A (en) | 1992-01-22 | 1996-09-03 | Microcarb, Inc. | Immunogenic shiga-like toxin II variant mutants |
| WO1994013811A1 (en) | 1992-12-04 | 1994-06-23 | N.V. Innogenetics S.A. | New polypeptides, nucleic acid sequences encoding them, and their use to prevent the adhesion of f107-fimbriated bacteria |
| US5625124A (en) * | 1994-07-11 | 1997-04-29 | Washington University | Animal model for helicobacter pylori infection |
| WO1996028967A1 (fr) | 1995-03-17 | 1996-09-26 | Chihiro Koike | Mammiferes transgeniques autres que des primates, ou des serotypes de primates superieurs ont ete exprimes par un transfert de genes etrangers et procede pour creer ceux-ci |
| US6355859B1 (en) * | 1997-05-20 | 2002-03-12 | Biotechnology Research And Development Corporation | Interactions between genotype and diet in swine that prevent E. coli associated intestinal disease |
| JP3637420B2 (ja) * | 1997-05-20 | 2005-04-13 | バイオテクノロジー・リサーチ・アンド・ディベロップメント・コーポレイション | Ｆ１８イー・コリ関連疾患に対して遺伝学的に耐性のブタを同定する方法および組成物 |
| DE60034674T2 (de) * | 1999-03-19 | 2008-01-17 | Polycem LLC, Grand Haven | Polymer-zement-komposite und verfahren zur herstellung derselben |
-
1998
- 1998-05-20 JP JP55057998A patent/JP3637420B2/ja not_active Expired - Fee Related
- 1998-05-20 AU AU75832/98A patent/AU737862B2/en not_active Ceased
- 1998-05-20 EP EP98923570A patent/EP0985052B1/en not_active Expired - Lifetime
- 1998-05-20 MX MXPA99011988A patent/MXPA99011988A/es active IP Right Grant
- 1998-05-20 CN CN98807387A patent/CN1314953A/zh active Pending
- 1998-05-20 NZ NZ501886A patent/NZ501886A/en unknown
- 1998-05-20 DE DE69832306T patent/DE69832306T2/de not_active Expired - Fee Related
- 1998-05-20 RU RU99127287/13A patent/RU2204609C2/ru not_active IP Right Cessation
- 1998-05-20 PL PL98364701A patent/PL195890B1/pl unknown
- 1998-05-20 PT PT98923570T patent/PT985052E/pt unknown
- 1998-05-20 ES ES98923570T patent/ES2203958T3/es not_active Expired - Lifetime
- 1998-05-20 AT AT03001366T patent/ATE309392T1/de not_active IP Right Cessation
- 1998-05-20 ES ES03001366T patent/ES2248647T3/es not_active Expired - Lifetime
- 1998-05-20 BR BR9809137-9A patent/BR9809137A/pt not_active Application Discontinuation
- 1998-05-20 DE DE0985052T patent/DE985052T1/de active Pending
- 1998-05-20 AT AT98923570T patent/ATE246731T1/de not_active IP Right Cessation
- 1998-05-20 CZ CZ0460799A patent/CZ298021B6/cs not_active IP Right Cessation
- 1998-05-20 WO PCT/US1998/010318 patent/WO1998053102A1/en active IP Right Grant
- 1998-05-20 DK DK03001366T patent/DK1310570T3/da active
- 1998-05-20 AU AU75807/98A patent/AU7580798A/en not_active Withdrawn
- 1998-05-20 DE DE69816987T patent/DE69816987T2/de not_active Expired - Fee Related
- 1998-05-20 DK DK98923570T patent/DK0985052T3/da active
- 1998-05-20 WO PCT/US1998/010259 patent/WO1998053101A2/en active Application Filing
- 1998-05-20 HU HU0103587A patent/HUP0103587A3/hu unknown
- 1998-05-20 CA CA002290768A patent/CA2290768C/en not_active Expired - Lifetime
-
1999
- 1999-11-19 US US09/443,766 patent/US6596923B1/en not_active Expired - Lifetime
- 1999-12-21 NO NO996373A patent/NO996373L/no unknown
-
2001
- 2001-04-27 US US09/844,705 patent/US6965022B2/en not_active Expired - Lifetime
- 2001-07-25 US US09/844,268 patent/US7193072B2/en not_active Expired - Fee Related
-
2002
- 2002-03-05 HK HK02101688.3A patent/HK1040097A1/zh unknown
-
2004
- 2004-10-13 JP JP2004299458A patent/JP3941956B2/ja not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: O DEPOSITANTE DEIXOU DE APRESENTAR MANIFESTACAO SOBRE O PARECER NEGATIVO DE FOLHAS 128 A 132 PUBLICADO NA RPI N.O 1975, DE 11/11/2008. ASSIM, DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR. PORTANTO, INDEFIRO O PRESENTE PEDIDO. |
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| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |