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BR0206289A - Processos de administração de anticorpos anti-tnf(alfa) - Google Patents

Processos de administração de anticorpos anti-tnf(alfa)

Info

Publication number
BR0206289A
BR0206289A BR0206289-5A BR0206289A BR0206289A BR 0206289 A BR0206289 A BR 0206289A BR 0206289 A BR0206289 A BR 0206289A BR 0206289 A BR0206289 A BR 0206289A
Authority
BR
Brazil
Prior art keywords
htnf
antibody
less
antibodies
tnf
Prior art date
Application number
BR0206289-5A
Other languages
English (en)
Inventor
Joachim Kempeni
Roberta Weiss
Steven A Fischkoff
Original Assignee
Abbott Lab Bermuda Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23144283&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0206289(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab Bermuda Ltd filed Critical Abbott Lab Bermuda Ltd
Publication of BR0206289A publication Critical patent/BR0206289A/pt

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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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Abstract

"PROCESSOS DE ADMINISTRAçãO DE ANTICORPOS ANTITNF<244>". Apresentam-se processos para o tratamento de distúrbios em que a atividade de TNF<244> seja prejudicial mediante administração subcutânea bissemanal de anticorpos humanos, de preferência anticorpos humanos recombinantes, que se liguem especificamente ao fator de necrose tumoral humano <244> (hTNF<244>) . O anticorpo pode ser administrado com ou sem metotrexate. Esses anticorpos têm alta afinidade por hTNF<244> (por exemplo, K~ d~ = 10^ -8^ M ou menos), uma lenta taxa de desligamento para dissociação de hTNF<244> (por exemplo, K~ off~ = 10^ -3^ S^ -1^ ou menos) e neutralizam a atividade de hTNF<244> in vitro e in vivo. Um anticorpo da invenção pode ser um anticorpo de comprimento total ou sua parte de ligação a antigeno. Kits contendo uma composição farmacêutica e instruções para a dosagem e seringas pré-carregadas contendo composições farmacêuticas também são englobados pela invenção.
BR0206289-5A 2001-06-08 2002-06-05 Processos de administração de anticorpos anti-tnf(alfa) BR0206289A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29696101P 2001-06-08 2001-06-08
PCT/US2002/017790 WO2002100330A2 (en) 2001-06-08 2002-06-05 METHODS OF ADMINISTERING ANTI-TNFα ANTIBODIES

Publications (1)

Publication Number Publication Date
BR0206289A true BR0206289A (pt) 2004-11-30

Family

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