AR070455A1 - Compuestos antibioticos azatriciclicos, composiciones farmaceuticas y su uso para infecciones bacterianas - Google Patents
Compuestos antibioticos azatriciclicos, composiciones farmaceuticas y su uso para infecciones bacterianasInfo
- Publication number
- AR070455A1 AR070455A1 ARP090100595A ARP090100595A AR070455A1 AR 070455 A1 AR070455 A1 AR 070455A1 AR P090100595 A ARP090100595 A AR P090100595A AR P090100595 A ARP090100595 A AR P090100595A AR 070455 A1 AR070455 A1 AR 070455A1
- Authority
- AR
- Argentina
- Prior art keywords
- azatriciclicos
- pharmaceutical compositions
- bacterial infections
- antibiotic compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente se relaciona con compuestos antibacteriales de formula 1 en la cual n es 0 o 1; R1 representa H o F; U representa CH2 o, cuando n es 1, O o NH;ö-ô es un enlace o está ausente; V representa CH o N cuando ö-ô es un enlace, o CH2 o NH cuando ö-ôestá ausente; W representa CH o N; A representa -(CH2)p-NH-(CH2)q- en /// /// donde p es 1 y q es 1 o 2 o, cuando U representa CH2 y n es 1, p también puede ser 0 y q entonces es 2; G representa uno de los grupos de formulas (2) en donde Z representa N o CH y Q representa O o S; y Z0, Z1 y Z2 cada uno representa CH, o Z0 y Z1 cada uno representa CH y Z2 representa N, o Z0 representa CH, Z1 representa N y Z2 representa CH o N, o Z0 representa N y Z1 y Z2 cada uno representa CH; y con sales de tales compuestos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2008050603 | 2008-02-20 | ||
| IB2008054065 | 2008-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070455A1 true AR070455A1 (es) | 2010-04-07 |
Family
ID=40986002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100595A AR070455A1 (es) | 2008-02-20 | 2009-02-20 | Compuestos antibioticos azatriciclicos, composiciones farmaceuticas y su uso para infecciones bacterianas |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8349828B2 (es) |
| EP (1) | EP2257551B1 (es) |
| JP (1) | JP5349500B2 (es) |
| KR (1) | KR101590202B1 (es) |
| CN (1) | CN102015710B (es) |
| AR (1) | AR070455A1 (es) |
| AU (1) | AU2009215327A1 (es) |
| BR (1) | BRPI0907892A2 (es) |
| CA (1) | CA2713182C (es) |
| ES (1) | ES2411930T3 (es) |
| MX (1) | MX2010008922A (es) |
| RU (1) | RU2010138648A (es) |
| TW (1) | TW200940551A (es) |
| WO (1) | WO2009104147A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0907892A2 (pt) | 2008-02-20 | 2015-07-28 | Actelion Pharmaceuticals Ltd | Composto antibiótico azatricíclico, medicamento, composição farmacêutica que o contém e uso do mesmo |
| CA2739373C (en) * | 2008-10-07 | 2017-01-24 | Christian Hubschwerlen | Tricyclic oxazolidinone antibiotic compounds |
| EP2346862B1 (en) * | 2008-10-10 | 2012-09-12 | Actelion Pharmaceuticals Ltd. | 2-benzothiophenyl-and 2-naphthyl-0xaz0lidin0nes and their azaisostere analogues as antibacterial agents |
| EP2674430A4 (en) | 2011-02-07 | 2014-07-02 | Daiichi Sankyo Co Ltd | AMINO-GROUP-PYRROLIDINONE DERIVATIVES |
| CN105949466A (zh) * | 2011-06-30 | 2016-09-21 | 帝斯曼知识产权资产管理有限公司 | 含硅酮单体 |
| CA2842885A1 (en) | 2011-08-11 | 2013-02-14 | Actelion Pharmaceuticals Ltd | Quinazoline-2,4-dione derivatives |
| TW201326180A (zh) | 2011-11-30 | 2013-07-01 | Actelion Pharmaceuticals Ltd | ３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素 |
| WO2014024056A1 (en) | 2012-08-06 | 2014-02-13 | Daiichi Sankyo Company, Limited | Pyrrolidine derivatives with antibacterial properties |
| JP6375365B2 (ja) | 2013-04-16 | 2018-08-15 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌活性を有する二芳香族誘導体 |
| ITMI20131782A1 (it) * | 2013-10-25 | 2015-04-26 | Dipharma Francis Srl | Procedimento per la preparazione di un agonista della trombopoietina |
| JP6112724B2 (ja) * | 2013-10-31 | 2017-04-12 | 日本化薬株式会社 | １，５−ナフチリジン誘導体およびそれを有効成分として含んでなる殺虫剤 |
| AR102256A1 (es) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| JP7390728B2 (ja) * | 2017-11-29 | 2023-12-04 | バグワークス・リサーチ・インコーポレイテッド | 抗菌複素環式化合物及びそれらの合成 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5746987A (en) * | 1980-09-05 | 1982-03-17 | Mitsubishi Chem Ind Ltd | 3,4-dihydrocarbostyril derivative and agricultural and horticultural germicide containing the same as active constituent |
| IT1212552B (it) | 1982-10-20 | 1989-11-30 | Italo Britannica L Manet Ti H | Alcanolaminossi derivati di 3,4-diidro-2h-1.4-benzotiazin-3-one, loro procedimento di produzione e loro utilizzazione farmaceutica |
| US5298518A (en) * | 1989-09-29 | 1994-03-29 | Eisai Co., Ltd. | Biphenylmethane derivative and pharmacological use |
| US5254682A (en) | 1989-12-08 | 1993-10-19 | Merck & Co., Inc. | Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs |
| NZ334891A (en) | 1996-10-24 | 2001-04-27 | Novartis Ag | Substituted aminoalkane phosphonic acids for treating block excitatory amino acid receptors related diseases |
| AU1026901A (en) | 1999-10-29 | 2001-05-08 | Syngenta Participations Ag | Novel herbicides |
| AR040336A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
| WO2005016883A2 (en) | 2003-08-14 | 2005-02-24 | Icos Corporation | Acrylamide derivatives as vla-1 integrin antagonists and uses thereof |
| FR2873695A1 (fr) * | 2004-07-30 | 2006-02-03 | Palumed Sa | Molecules hybrides qa ou q est une aminoquinoleine et a est un antibiotique ou un inhibiteur de resistance), leur synthese et leurs utilisations en tant qu'agent antibacterien |
| CA2572442A1 (fr) * | 2004-07-30 | 2006-03-09 | Palumed S.A. | Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien |
| DE102004041163A1 (de) | 2004-08-25 | 2006-03-02 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| WO2006032466A2 (en) | 2004-09-24 | 2006-03-30 | Actelion Pharmaceuticals Ltd | New bicyclic antibiotics |
| WO2006046552A1 (ja) | 2004-10-27 | 2006-05-04 | Toyama Chemical Co., Ltd. | 新規な含窒素複素環化合物およびその塩 |
| CN101258157A (zh) | 2005-05-24 | 2008-09-03 | 阿斯利康(瑞典)有限公司 | 具有抗菌活性的氨基哌啶喹啉及其氮杂等构类似物 |
| WO2007016610A2 (en) | 2005-08-02 | 2007-02-08 | Glaxo Group Limited | Antibacterial agents |
| PT1954697E (pt) | 2005-10-21 | 2010-05-17 | Glaxo Group Ltd | Compostos tricíclicos peri-condensados úteis como agentes antibacterianos |
| ES2344523T3 (es) | 2005-12-22 | 2010-08-30 | Glaxo Group Limited | Compuestos heterociclicos, su preparacion y su uso como agentes antibacterianos. |
| JP2009526832A (ja) * | 2006-02-14 | 2009-07-23 | ファイザー・プロダクツ・インク | 抗菌剤としてのベンゾオキサジノンおよびベンゾオキサゼピノンオキサゾリジノン |
| ATE469649T1 (de) | 2006-03-23 | 2010-06-15 | Actelion Pharmaceuticals Ltd | Antibiotische cyclohexyl- oder piperidinylcarboxamid-derivate |
| DE602007009205D1 (de) | 2006-04-06 | 2010-10-28 | Glaxo Group Ltd | Pyrrolochinoxalinonderivate als antibakterielle mittel |
| GB0608263D0 (en) | 2006-04-26 | 2006-06-07 | Glaxo Group Ltd | Compounds |
| ATE522514T1 (de) | 2006-06-16 | 2011-09-15 | Pharma Mar Sa | Dihydropyran-2-onverbindungen mit antitumorwirkung |
| GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
| TW200819457A (en) | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
| US7977352B2 (en) | 2006-12-01 | 2011-07-12 | Galapagos Nv | Triazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases |
| CL2007003693A1 (es) | 2006-12-22 | 2008-06-27 | Actelion Pharmaceuticals Ltd | Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas. |
| GB0705672D0 (en) | 2007-03-23 | 2007-05-02 | Glaxo Group Ltd | Compounds |
| EP2141154A4 (en) * | 2007-03-30 | 2011-06-01 | Inst Med Molecular Design Inc | OXAZOLIDINONE DERIVATIVITY WITH HEMMETIC EFFECT ON TYPE I 11-HYDROXYSTEROIDDEHYDROGENASE |
| WO2008120003A1 (en) | 2007-04-03 | 2008-10-09 | Astrazeneca Ab | Substituted piperidines for use in the treatment of bacterial infections |
| CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| EP1980251A1 (en) | 2007-04-13 | 2008-10-15 | Glaxo Group Limited | Pyrrolo[3,2,1-ij]quinoline-4-one derivatives for treating tuberculosis |
| SI2137196T1 (sl) | 2007-04-20 | 2011-01-31 | Glaxo Group Ltd Glaxo Welcome House | Tricikliäśne spojine, ki vsebujejo duĺ ik, uporabne kot antibakterijska sredstva |
| GB0707706D0 (en) | 2007-04-20 | 2007-05-30 | Glaxo Group Ltd | Compounds |
| GB0707708D0 (en) | 2007-04-20 | 2007-05-30 | Glaxo Group Ltd | Compounds |
| WO2008150827A1 (en) | 2007-05-29 | 2008-12-11 | Smithkline Beecham Corporation | Naphthyridine, derivatives as p13 kinase inhibitors |
| AR066879A1 (es) | 2007-06-08 | 2009-09-16 | Novartis Ag | Derivados de quinoxalina como inhibidores de la actividad de cinasa de tirosina de las cinasas janus |
| BRPI0812942B1 (pt) | 2007-06-15 | 2018-11-21 | Actelion Pharmaceuticals Ltd | composto derivado de 3-amino-6 - (1-amino-etil) - tetra-hidropirano, composição farmacêutica e uso de referido composto. |
| EP2005995A1 (en) | 2007-06-22 | 2008-12-24 | Glaxo Group Limited | Heterocyclic compounds for the treatment of tuberculosis |
| KR101578234B1 (ko) | 2007-12-18 | 2015-12-16 | 액테리온 파마슈티칼 리미티드 | 5-아미노시클릴메틸-옥사졸리딘-2-온 유도체 |
| GB0800367D0 (en) | 2008-01-09 | 2008-02-20 | Glaxo Group Ltd | Compounds |
| BRPI0907892A2 (pt) | 2008-02-20 | 2015-07-28 | Actelion Pharmaceuticals Ltd | Composto antibiótico azatricíclico, medicamento, composição farmacêutica que o contém e uso do mesmo |
| JP5404652B2 (ja) | 2008-02-22 | 2014-02-05 | アクテリオン ファーマシューティカルズ リミテッド | オキサゾリジノン誘導体 |
-
2009
- 2009-02-19 BR BRPI0907892-4A patent/BRPI0907892A2/pt not_active IP Right Cessation
- 2009-02-19 MX MX2010008922A patent/MX2010008922A/es not_active Application Discontinuation
- 2009-02-19 KR KR1020107019907A patent/KR101590202B1/ko active IP Right Grant
- 2009-02-19 EP EP09712156.0A patent/EP2257551B1/en not_active Not-in-force
- 2009-02-19 RU RU2010138648/04A patent/RU2010138648A/ru unknown
- 2009-02-19 ES ES09712156T patent/ES2411930T3/es active Active
- 2009-02-19 US US12/918,749 patent/US8349828B2/en not_active Expired - Fee Related
- 2009-02-19 AU AU2009215327A patent/AU2009215327A1/en not_active Abandoned
- 2009-02-19 CN CN2009801060558A patent/CN102015710B/zh not_active Expired - Fee Related
- 2009-02-19 WO PCT/IB2009/050675 patent/WO2009104147A2/en active Application Filing
- 2009-02-19 CA CA2713182A patent/CA2713182C/en not_active Expired - Fee Related
- 2009-02-19 TW TW098105338A patent/TW200940551A/zh unknown
- 2009-02-19 JP JP2010547289A patent/JP5349500B2/ja not_active Expired - Fee Related
- 2009-02-20 AR ARP090100595A patent/AR070455A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102015710A (zh) | 2011-04-13 |
| BRPI0907892A2 (pt) | 2015-07-28 |
| JP2011512398A (ja) | 2011-04-21 |
| TW200940551A (en) | 2009-10-01 |
| KR20100124273A (ko) | 2010-11-26 |
| MX2010008922A (es) | 2010-09-07 |
| JP5349500B2 (ja) | 2013-11-20 |
| EP2257551A2 (en) | 2010-12-08 |
| WO2009104147A3 (en) | 2009-11-05 |
| RU2010138648A (ru) | 2012-03-27 |
| US20100331318A1 (en) | 2010-12-30 |
| CA2713182A1 (en) | 2009-08-27 |
| EP2257551B1 (en) | 2013-04-10 |
| ES2411930T3 (es) | 2013-07-09 |
| WO2009104147A2 (en) | 2009-08-27 |
| KR101590202B1 (ko) | 2016-01-29 |
| AU2009215327A1 (en) | 2009-08-27 |
| CN102015710B (zh) | 2013-04-24 |
| CA2713182C (en) | 2016-09-13 |
| US8349828B2 (en) | 2013-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |