AR102256A1 - Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi - Google Patents
Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxiInfo
- Publication number
- AR102256A1 AR102256A1 ARP150103308A ARP150103308A AR102256A1 AR 102256 A1 AR102256 A1 AR 102256A1 AR P150103308 A ARP150103308 A AR P150103308A AR P150103308 A ARP150103308 A AR P150103308A AR 102256 A1 AR102256 A1 AR 102256A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- represent
- atoms
- heterocycloalkyl ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Un compuesto de la fórmula (1) donde: n representa 0, 1, 2 ó 3; R¹ᵃ representa H o C₁₋₃ alquilo; R²ᵃ y R²ᵇ de manera independiente entre sí representan H o C₁₋₃ alquilo; R³ᵃ y R³ᵇ de manera independiente entre sí representan H o C₁₋₃ alquilo; R⁴ representa H, C₁₋₃ alquilo, o C₂₋₃ alquilo-NR⁴ᵃR⁴ᵇ, donde R⁴ᵃ y R⁴ᵇ son de manera independiente entre sí H o C₁₋₃ alquilo; R⁵ representa H, C₁₋₃ alquilo, o C₂₋₃ alquilo-NR⁵ᵃR⁵ᵇ, donde R⁵ᵃ y R⁵ᵇ son de manera independiente entre sí H o C₁₋₃ alquilo; o R²ᵃ y R²ᵇ junto con el átomo de carbono que los porta forman un anillo cicloalquilo de 3 a 6 miembros; o R⁴ y R⁵ junto con el átomo de nitrógeno que los porta forman un anillo heterocicloalquilo de 4 a 6 miembros; o R⁴ y R⁵ junto con el átomo de nitrógeno que los porta forman un anillo heterocicloalquilo bicíclico de 6 a 8 miembros, donde dicho anillo heterocicloalquilo bicíclico puede estar opcionalmente sustituido con un grupo NR⁶R⁷, donde R⁶ y R⁷ son de manera independiente entre sí H o C₁₋₃ alquilo; o R⁴ y R⁵ junto con el átomo de nitrógeno que los porta y el adyacente CR²ᵃR²ᵇ o CR³ᵃR³ᵇ juntos forman un grupo amidina; o R¹ᵃ y R³ᵃ, junto con los átomos de carbono que los portan y el átomo de carbono que conecta estos dos últimos átomos, forman un anillo cicloalquilo de 4 a 6 miembros, donde R²ᵃ, R²ᵇ y R³ᵇ representan independientemente H, y n representa 1; o R¹ᵃ y R⁴, junto con los átomos de carbono y nitrógeno que los portan y los átomos de carbono que conectan los últimos dos átomos, forman un anillo heterocicloalquilo de 4 a 6 miembros, donde R²ᵃ, R²ᵇ, opcional R³ᵃ y opcional R³ᵇ representan independientemente H, n representa 0 ó 1, y dicho anillo heterocicloalquilo de 4 a 6 miembros opcionalmente contiene un sustituyente seleccionados de OCH₃ y CH₃; o R²ᵃ y R⁴ junto con los átomos de carbono y nitrógeno que los portan y los átomos de carbono opcionales que conectan los dos últimos átomos, forman un anillo heterocicloalquilo de 4 a 6 miembros, donde R¹ᵃ, opcional R³ᵃ y opcional R³ᵇ representan independientemente H, R²ᵇ representa H, NH₂ u OH, y n representa 0, 1 ó 2; U¹ representa N o CH, U² representa N, CH, C-O-C₁₋₃ alquilo, o C-CN, U³ representa N o CH y U⁴ representa N o CH, donde se entiende que como máximo tres de U¹, U², U³ y U⁴ pueden representar N al mismo tiempo; V¹ representa N o CH, V² representa N o CH, V³ representa N o CH y V⁴ representa N o CH, donde se entiende que como máximo tres de V¹, V², V³ y V⁴ pueden representar N al mismo tiempo; X representa CH o N; Q representa O ó S; o una sal de este compuesto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14189026 | 2014-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR102256A1 true AR102256A1 (es) | 2017-02-15 |
Family
ID=51743312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150103308A AR102256A1 (es) | 2014-10-15 | 2015-10-13 | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9850256B2 (es) |
| EP (1) | EP3207042B1 (es) |
| JP (1) | JP2017531008A (es) |
| KR (1) | KR20170066644A (es) |
| CN (1) | CN106795171A (es) |
| AR (1) | AR102256A1 (es) |
| AU (1) | AU2015332747A1 (es) |
| BR (1) | BR112017007438A2 (es) |
| CA (1) | CA2963699A1 (es) |
| ES (1) | ES2702214T3 (es) |
| MX (1) | MX2017004891A (es) |
| RU (1) | RU2017116617A (es) |
| TW (1) | TW201613907A (es) |
| WO (1) | WO2016059097A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA030067B1 (ru) | 2013-07-22 | 2018-06-29 | Идорсиа Фармасьютиклз Лтд | Производные 1-(пиперазин-1-ил)-2-([1,2,4]триазол-1-ил)этанона |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| AU2016207988B2 (en) * | 2015-01-15 | 2019-08-15 | Idorsia Pharmaceuticals Ltd | Hydroxyalkyl-piperazine derivatives as CXCR3 receptor modulators |
| AR108108A1 (es) * | 2016-04-14 | 2018-07-18 | Idorsia Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos con sustitución de oxetan-3-iloxi |
| GB2550437B (en) * | 2016-05-20 | 2021-06-23 | Bugworks Res Inc | Heterocyclic compounds useful as anti-bacterial agents and method for production |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| CN119285538A (zh) | 2017-05-04 | 2025-01-10 | 发现号收购集团 | 作为例如用于保护植物的害虫防治剂的2-{[2-(苯氧基甲基)吡啶-5-基]氧基}乙胺衍生物及相关化合物 |
| JP2019019124A (ja) * | 2017-07-19 | 2019-02-07 | 日本化薬株式会社 | ピラジン化合物 |
| WO2023041757A1 (en) * | 2021-09-20 | 2023-03-23 | F. Hoffmann-La Roche Ag | New compounds and their use in the treatment of bacterial infection |
| WO2023041756A1 (en) * | 2021-09-20 | 2023-03-23 | F. Hoffmann-La Roche Ag | New compounds and their use in the treatment of bacterial infection |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19802239A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
| TW200406413A (en) | 2002-06-26 | 2004-05-01 | Glaxo Group Ltd | Compounds |
| CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| WO2009005794A2 (en) | 2007-06-29 | 2009-01-08 | Acucela, Inc. | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders |
| JP5323088B2 (ja) | 2007-12-18 | 2013-10-23 | アクテリオン ファーマシューティカルズ リミテッド | ５−アミノシクリルメチル−オキサゾリジン−２−オン誘導体 |
| MX2010008922A (es) * | 2008-02-20 | 2010-09-07 | Actelion Pharmaceuticals Ltd | Compuestos antibioticos azatriciclicos. |
| MX2010008921A (es) | 2008-02-22 | 2010-09-07 | Actelion Pharmaceuticals Ltd | Derivados de oxazolidinona. |
| WO2010015985A1 (en) * | 2008-08-04 | 2010-02-11 | Actelion Pharmaceuticals Ltd | Tricyclic alkylaminomethyloxazolidinone derivatives |
| TWI415853B (zh) | 2008-10-07 | 2013-11-21 | Actelion Pharmaceuticals Ltd | 三環唑啶酮抗生素化合物 |
| JP5490809B2 (ja) | 2008-10-10 | 2014-05-14 | アクテリオン ファーマシューティカルズ リミテッド | オキサゾリジニル抗生物質 |
| US20110195949A1 (en) | 2008-10-10 | 2011-08-11 | Actelion Pharmaceuticals Ltd. | 2-benzothiophenyl- and 2-naphthyl-oxazolidinones and their azaisostere analogues as antibacterial agents |
| US8575364B2 (en) | 2008-10-30 | 2013-11-05 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
| MX2014001680A (es) * | 2011-08-11 | 2014-05-27 | Actelion Pharmaceuticals Ltd | Derivados de quinazolina-2, 4-diona. |
| AR088691A1 (es) | 2011-11-08 | 2014-06-25 | Actelion Pharmaceuticals Ltd | Derivados antibioticos de 2-oxo-oxazolidin-3,5-diilo |
| BR112015026261A8 (pt) | 2013-04-16 | 2017-12-26 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos |
-
2015
- 2015-10-13 AR ARP150103308A patent/AR102256A1/es unknown
- 2015-10-14 MX MX2017004891A patent/MX2017004891A/es unknown
- 2015-10-14 BR BR112017007438A patent/BR112017007438A2/pt not_active Application Discontinuation
- 2015-10-14 ES ES15778983T patent/ES2702214T3/es active Active
- 2015-10-14 KR KR1020177012871A patent/KR20170066644A/ko unknown
- 2015-10-14 JP JP2017520323A patent/JP2017531008A/ja not_active Ceased
- 2015-10-14 RU RU2017116617A patent/RU2017116617A/ru unknown
- 2015-10-14 AU AU2015332747A patent/AU2015332747A1/en not_active Abandoned
- 2015-10-14 CN CN201580055488.0A patent/CN106795171A/zh active Pending
- 2015-10-14 CA CA2963699A patent/CA2963699A1/en not_active Abandoned
- 2015-10-14 EP EP15778983.5A patent/EP3207042B1/en not_active Not-in-force
- 2015-10-14 TW TW104133759A patent/TW201613907A/zh unknown
- 2015-10-14 WO PCT/EP2015/073751 patent/WO2016059097A1/en active Application Filing
- 2015-10-14 US US15/516,290 patent/US9850256B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9850256B2 (en) | 2017-12-26 |
| TW201613907A (en) | 2016-04-16 |
| EP3207042B1 (en) | 2018-10-03 |
| JP2017531008A (ja) | 2017-10-19 |
| EP3207042A1 (en) | 2017-08-23 |
| AU2015332747A1 (en) | 2017-06-01 |
| CA2963699A1 (en) | 2016-04-21 |
| US20170305927A1 (en) | 2017-10-26 |
| BR112017007438A2 (pt) | 2018-01-16 |
| WO2016059097A1 (en) | 2016-04-21 |
| MX2017004891A (es) | 2017-12-07 |
| ES2702214T3 (es) | 2019-02-27 |
| KR20170066644A (ko) | 2017-06-14 |
| RU2017116617A (ru) | 2018-11-15 |
| CN106795171A (zh) | 2017-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |