YU41294B - Process for obtaining the crystalline alpha-from of 2-(4(2-furoy)-piperazione-1-yl)-4-amino-6,7-dimethoxy quinazoline hydroclorides - Google Patents

Process for obtaining the crystalline alpha-from of 2-(4(2-furoy)-piperazione-1-yl)-4-amino-6,7-dimethoxy quinazoline hydroclorides

Info

Publication number: YU41294B
Authority: YU; Yugoslavia
Prior art keywords: piperazione; hydroclorides; furoy; amino; obtaining
Prior art date: 1976-03-01

Application number

YU499/77A

Other languages

English (en)

Other versions

YU49977A (en

Inventor

E J Bianco

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-03-01

Filing date

1977-02-23

Publication date

1987-02-28

1977-02-23 Application filed by Pfizer filed Critical Pfizer

1983-12-31 Publication of YU49977A publication Critical patent/YU49977A/xx

1987-02-28 Publication of YU41294B publication Critical patent/YU41294B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

YU499/77A 1976-03-01 1977-02-23 Process for obtaining the crystalline alpha-from of 2-(4(2-furoy)-piperazione-1-yl)-4-amino-6,7-dimethoxy quinazoline hydroclorides YU41294B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/662,937 US4092315A (en)	1976-03-01	1976-03-01	Novel crystalline forms of prazosin hydrochloride

Publications (2)

Publication Number	Publication Date
YU49977A YU49977A (en)	1983-12-31
YU41294B true YU41294B (en)	1987-02-28

Family

ID=24659839

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
YU499/77A YU41294B (en)	1976-03-01	1977-02-23	Process for obtaining the crystalline alpha-from of 2-(4(2-furoy)-piperazione-1-yl)-4-amino-6,7-dimethoxy quinazoline hydroclorides

Country Status (32)

Country	Link
US (1)	US4092315A (xx)
JP (1)	JPS604188B2 (xx)
AR (1)	AR210937A1 (xx)
AU (1)	AU506937B2 (xx)
BE (1)	BE851878A (xx)
BG (1)	BG29724A3 (xx)
CA (1)	CA1068269A (xx)
CH (1)	CH618436A5 (xx)
CS (1)	CS191332B2 (xx)
DD (1)	DD129652A5 (xx)
DE (1)	DE2708192C3 (xx)
DK (1)	DK145858C (xx)
ES (1)	ES8707447A1 (xx)
FI (1)	FI62082C (xx)
FR (1)	FR2372828A1 (xx)
GB (1)	GB1538713A (xx)
HK (1)	HK30881A (xx)
HU (1)	HU173641B (xx)
IE (1)	IE44522B1 (xx)
IL (1)	IL51481A (xx)
LU (1)	LU76868A1 (xx)
MY (1)	MY8100271A (xx)
NL (1)	NL169591C (xx)
NO (1)	NO146499C (xx)
NZ (1)	NZ183450A (xx)
PL (1)	PL105559B1 (xx)
PT (1)	PT66227B (xx)
RO (1)	RO73095A (xx)
SE (1)	SE423234B (xx)
SU (1)	SU644387A3 (xx)
YU (1)	YU41294B (xx)
ZA (1)	ZA77918B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX5483E (es) *	1977-08-04	1983-08-23	Abbott Lab	Procedimiento para la preparacion del dihidrato clorhidrato de 1-(4-amino-6,7-dimetoxi-2-quinazolinil)-4-(2-tetrahidrofuroil)piperazina
GB1591490A (en) *	1977-08-04	1981-06-24	Abbott Lab	1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
US4197301A (en) *	1978-10-16	1980-04-08	Allergan Pharmaceuticals, Inc.	Topical ophthalmic use of Prazosin
FI67699C (fi) *	1979-01-31	1985-05-10	Orion Yhtymae Oy	Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan
US4440769A (en) *	1983-02-11	1984-04-03	Abbott Laboratories	2-(4-Phenylalkanoylpiperazin-1-yl) quinazoline compounds, pharmaceutical compositions and method of producing α1 antagonistic activity
FI79107C (fi) *	1984-06-25	1989-11-10	Orion Yhtymae Oy	Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.
US5322943A (en) *	1985-09-12	1994-06-21	The Upjohn Company	Piperazine compounds which are substituted
US4601897A (en) *	1985-11-06	1986-07-22	Pfizer Inc.	Prazosin-pirbuterol combination for bronchodilation
EP0237608B1 (de) *	1986-03-21	1992-01-29	HEUMANN PHARMA GMBH & CO	Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung
US5110927A (en) *	1987-12-31	1992-05-05	The United States Of America As Represented By The Department Of Health And Human Services	Prazosin analog with increased selectivity and duration of action
JP2652272B2 (ja) *	1990-12-31	1997-09-10	住化ファインケム株式会社	１−（４−アミノ−６，７−ジメトキシ−２−キナゾリニル）−４−（２−テトラヒドロフロイル）ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法
GB9417310D0 (en) *	1994-08-27	1994-10-19	Pfizer Ltd	Therapeutic agents
US5952003A (en) *	1996-08-01	1999-09-14	Novartis Corporation	Terazosin capsules
EP0849264A1 (de) *	1996-12-20	1998-06-24	HEUMANN PHARMA GmbH	Neue polymorphe Form von doxazosinmesylat (Form I)
EP0849266B8 (de) *	1996-12-20	2007-10-03	Heumann PCS GmbH	Neue polymorphe Form von Doxazosinmesylat (Form III)
EP0849265A1 (de) *	1996-12-20	1998-06-24	HEUMANN PHARMA GmbH	Neue polymorphe Form von Doxazosin-Mesylat (Form II)
WO2016014412A2 (en)	2014-07-21	2016-01-28	David Watkins	Aerodynamic flyer bow

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3635979A (en) *	1969-09-29	1972-01-18	Pfizer	Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines

1976
- 1976-03-01 US US05/662,937 patent/US4092315A/en not_active Expired - Lifetime
1977
- 1977-02-11 GB GB5756/77A patent/GB1538713A/en not_active Expired
- 1977-02-14 SE SE7701624A patent/SE423234B/xx not_active IP Right Cessation
- 1977-02-16 ZA ZA770918A patent/ZA77918B/xx unknown
- 1977-02-17 IL IL51481A patent/IL51481A/xx unknown
- 1977-02-18 AU AU22443/77A patent/AU506937B2/en not_active Expired
- 1977-02-18 CA CA272,080A patent/CA1068269A/en not_active Expired
- 1977-02-23 YU YU499/77A patent/YU41294B/xx unknown
- 1977-02-24 PT PT66227A patent/PT66227B/pt unknown
- 1977-02-24 IE IE399/77A patent/IE44522B1/en not_active IP Right Cessation
- 1977-02-25 DE DE2708192A patent/DE2708192C3/de not_active Expired
- 1977-02-28 BE BE1007976A patent/BE851878A/xx not_active IP Right Cessation
- 1977-02-28 NZ NZ183450A patent/NZ183450A/xx unknown
- 1977-02-28 DK DK86877A patent/DK145858C/da not_active IP Right Cessation
- 1977-02-28 NL NLAANVRAGE7702123,A patent/NL169591C/xx not_active IP Right Cessation
- 1977-02-28 FI FI770634A patent/FI62082C/fi not_active IP Right Cessation
- 1977-02-28 NO NO770674A patent/NO146499C/no unknown
- 1977-02-28 HU HU76UO128A patent/HU173641B/hu unknown
- 1977-02-28 JP JP52021433A patent/JPS604188B2/ja not_active Expired
- 1977-02-28 FR FR7705819A patent/FR2372828A1/fr active Granted
- 1977-02-28 ES ES545368A patent/ES8707447A1/es not_active Expired
- 1977-02-28 SU SU772457100A patent/SU644387A3/ru active
- 1977-03-01 DD DD7700197618A patent/DD129652A5/xx unknown
- 1977-03-01 CS CS771358A patent/CS191332B2/cs unknown
- 1977-03-01 CH CH255577A patent/CH618436A5/fr not_active IP Right Cessation
- 1977-03-01 BG BG035558A patent/BG29724A3/xx unknown
- 1977-03-01 AR AR266724A patent/AR210937A1/es active
- 1977-03-01 PL PL1977196354A patent/PL105559B1/pl not_active IP Right Cessation
- 1977-03-01 RO RO7789566A patent/RO73095A/ro unknown
- 1977-03-01 LU LU76868A patent/LU76868A1/xx unknown
1981
- 1981-07-02 HK HK308/81A patent/HK30881A/xx unknown
- 1981-12-30 MY MY271/81A patent/MY8100271A/xx unknown

Also Published As

Publication number	Publication date
DE2708192C3 (de)	1980-05-08
NZ183450A (en)	1979-03-16
PT66227A (en)	1977-03-01
DK145858B (da)	1983-03-21
NO146499C (no)	1982-10-13
DE2708192B2 (de)	1979-08-02
RO73095A (ro)	1981-06-26
IE44522B1 (en)	1981-12-30
AU506937B2 (en)	1980-01-31
DK86877A (da)	1977-09-02
YU49977A (en)	1983-12-31
HU173641B (en)	1979-07-28
DE2708192A1 (de)	1977-09-08
ES8707447A1 (es)	1987-08-16
PL196354A1 (pl)	1978-02-27
FI62082C (fi)	1982-11-10
HK30881A (en)	1981-07-10
NO146499B (no)	1982-07-05
CH618436A5 (xx)	1980-07-31
FR2372828B1 (xx)	1980-02-01
PT66227B (en)	1978-07-14
LU76868A1 (xx)	1977-09-21
NO770674L (no)	1977-09-02
AR210937A1 (es)	1977-09-30
ES545368A0 (es)	1978-06-01
IL51481A0 (en)	1977-04-29
IE44522L (en)	1977-09-01
GB1538713A (en)	1979-01-24
NL169591C (nl)	1982-08-02
NL169591B (nl)	1982-03-01
FI770634A (xx)	1977-09-02
IL51481A (en)	1980-09-16
MY8100271A (en)	1981-12-31
FR2372828A1 (fr)	1978-06-30
JPS52105206A (en)	1977-09-03
FI62082B (fi)	1982-07-30
NL7702123A (nl)	1977-09-05
SE7701624L (sv)	1977-09-02
JPS604188B2 (ja)	1985-02-01
SE423234B (sv)	1982-04-26
CA1068269A (en)	1979-12-18
BE851878A (fr)	1977-08-29
BG29724A3 (en)	1981-01-15
DK145858C (da)	1983-09-12
US4092315A (en)	1978-05-30
ZA77918B (en)	1977-12-28
SU644387A3 (ru)	1979-01-25
DD129652A5 (de)	1978-02-01
CS191332B2 (en)	1979-06-29
AU2244377A (en)	1978-11-23
PL105559B1 (pl)	1979-10-31

Publication	Publication Date	Title
YU198282A (en)	1983-01-21	Process for obtaining quinazoline compounds
YU165282A (en)	1982-10-31	Process for producing 2-piperazinyl-6,7-dimethoxy-quinazoline
YU41294B (en)	1987-02-28	Process for obtaining the crystalline alpha-from of 2-(4(2-furoy)-piperazione-1-yl)-4-amino-6,7-dimethoxy quinazoline hydroclorides
GB1549447A (en)	1979-08-08	Process for the production of 4,4'-isopropylidene-bis-(2,6-dibromophenol)
YU160678A (en)	1983-01-21	Process for the manufacture of 1,2,4-triazine-5-one derivatives
YU146577A (en)	1982-06-30	Process for the manufacture of new gona-4,9(10)-dines
ZA773308B (en)	1978-07-26	Process for the preparation of 10,19-dihydro-vitamin d compounds
YU115279A (en)	1983-04-30	Process for obtaining new 4-amino-2-piperidino quinazoline derivatives
IT1101612B (it)	1985-10-07	Procedimento per la produzione di 2,6-diamminonebularine
YU39155B (en)	1984-06-30	Process for obtaining 2-(4-aroylpiperazine-1-yl)-4-amino-6,7-dimethoxy quinazolines
YU255378A (en)	1983-06-30	Process for obtaining antihypertensive quinazolines
IT1102597B (it)	1985-10-07	Procedimento per la produzione di 2,3-dimetil-pentanale
IT1145435B (it)	1986-11-05	Procedimento per la produzione di 2,3-dimetilbutene-2
LU78874A1 (fr)	1979-09-06	Procede de preparation de nouvelles sulfonylhydrazones de 1,4-dioxo-et 4-oxoquinoxaline-2-carboxaldehyde
GB1554493A (en)	1979-10-24	Process for the production of 2,4-diamino-5-(3',4',5'-trimethoxybenzyl)-pyramidine
GB2041932B (en)	1982-10-27	Method for producing 6,7-dimethoxy-4-amino-2-(4-(2-furoyl)-1-piper-azinyl) quinazoline hydrochloride
TR19681A (tr)	1979-10-05	2,1,3-tiadizain-4-on-2,2 sioksit tuerevlerinin ueretilmesini mahsus usul
YU40698B (en)	1986-04-30	Process for preparing 2-(2,2,2-trihaloethy)-4-halocyclobutane-l-ones
ZA774753B (en)	1978-06-28	Process for the manufacture of 2,9-dioxatricyclo(4,3,1,3 3'7)decanen
IT1105154B (it)	1985-10-28	Procedimento per la produzione di 2,4-diosso-ossazolidine
YU40849B (en)	1986-06-30	Process for obtaining 1,3-benzoxazine-2,4-dione derivatives
YU22980A (en)	1983-02-28	Process for obtaining quinazolines
ZA777223B (en)	1978-09-27	Method for the production of 6,7-dimethoxy-4-amino-2-(4-(2-furoyl)-1-piperazinyl)quinazoline having an antihypertensive effect
DE2860223D1 (en)	1980-12-04	Process for the preparation of 2,4,5-trichloropyrimidine
YU65979A (en)	1983-01-21	Process for obtaining quinazoline