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CS191332B2 - Method of producing crystalline alpha-form of 2-/4-/2-furoyl/piperazine-1-yl/-4-amino-6,7-dimethoxy quinazoline hydrochloride - Google Patents

Method of producing crystalline alpha-form of 2-/4-/2-furoyl/piperazine-1-yl/-4-amino-6,7-dimethoxy quinazoline hydrochloride

Info

Publication number
CS191332B2
CS191332B2 CS771358A CS135877A CS191332B2 CS 191332 B2 CS191332 B2 CS 191332B2 CS 771358 A CS771358 A CS 771358A CS 135877 A CS135877 A CS 135877A CS 191332 B2 CS191332 B2 CS 191332B2
Authority
CS
Czechoslovakia
Prior art keywords
furoyl
piperazine
amino
producing crystalline
quinazoline hydrochloride
Prior art date
Application number
CS771358A
Other languages
English (en)
Inventor
Ernest J Bianco
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS191332B2 publication Critical patent/CS191332B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CS771358A 1976-03-01 1977-03-01 Method of producing crystalline alpha-form of 2-/4-/2-furoyl/piperazine-1-yl/-4-amino-6,7-dimethoxy quinazoline hydrochloride CS191332B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/662,937 US4092315A (en) 1976-03-01 1976-03-01 Novel crystalline forms of prazosin hydrochloride

Publications (1)

Publication Number Publication Date
CS191332B2 true CS191332B2 (en) 1979-06-29

Family

ID=24659839

Family Applications (1)

Application Number Title Priority Date Filing Date
CS771358A CS191332B2 (en) 1976-03-01 1977-03-01 Method of producing crystalline alpha-form of 2-/4-/2-furoyl/piperazine-1-yl/-4-amino-6,7-dimethoxy quinazoline hydrochloride

Country Status (32)

Country Link
US (1) US4092315A (cs)
JP (1) JPS604188B2 (cs)
AR (1) AR210937A1 (cs)
AU (1) AU506937B2 (cs)
BE (1) BE851878A (cs)
BG (1) BG29724A3 (cs)
CA (1) CA1068269A (cs)
CH (1) CH618436A5 (cs)
CS (1) CS191332B2 (cs)
DD (1) DD129652A5 (cs)
DE (1) DE2708192C3 (cs)
DK (1) DK145858C (cs)
ES (1) ES8707447A1 (cs)
FI (1) FI62082C (cs)
FR (1) FR2372828A1 (cs)
GB (1) GB1538713A (cs)
HK (1) HK30881A (cs)
HU (1) HU173641B (cs)
IE (1) IE44522B1 (cs)
IL (1) IL51481A (cs)
LU (1) LU76868A1 (cs)
MY (1) MY8100271A (cs)
NL (1) NL169591C (cs)
NO (1) NO146499C (cs)
NZ (1) NZ183450A (cs)
PL (1) PL105559B1 (cs)
PT (1) PT66227B (cs)
RO (1) RO73095A (cs)
SE (1) SE423234B (cs)
SU (1) SU644387A3 (cs)
YU (1) YU41294B (cs)
ZA (1) ZA77918B (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX5483E (es) * 1977-08-04 1983-08-23 Abbott Lab Procedimiento para la preparacion del dihidrato clorhidrato de 1-(4-amino-6,7-dimetoxi-2-quinazolinil)-4-(2-tetrahidrofuroil)piperazina
GB1591490A (en) * 1977-08-04 1981-06-24 Abbott Lab 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
US4197301A (en) * 1978-10-16 1980-04-08 Allergan Pharmaceuticals, Inc. Topical ophthalmic use of Prazosin
FI67699C (fi) * 1979-01-31 1985-05-10 Orion Yhtymae Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan
US4440769A (en) * 1983-02-11 1984-04-03 Abbott Laboratories 2-(4-Phenylalkanoylpiperazin-1-yl) quinazoline compounds, pharmaceutical compositions and method of producing α1 antagonistic activity
FI79107C (fi) * 1984-06-25 1989-11-10 Orion Yhtymae Oy Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.
US5322943A (en) * 1985-09-12 1994-06-21 The Upjohn Company Piperazine compounds which are substituted
US4601897A (en) * 1985-11-06 1986-07-22 Pfizer Inc. Prazosin-pirbuterol combination for bronchodilation
DE3683760D1 (de) * 1986-03-21 1992-03-12 Heumann Pharma Gmbh & Co Kristalline, wasserfreie sigma -form von 2-(4-(2-furoyl-(2-piperazin)-1-yl)-4-amino-6,7-dimethoxychinazolinhydrochlorid und verfahren zu ihrer herstellung.
US5110927A (en) * 1987-12-31 1992-05-05 The United States Of America As Represented By The Department Of Health And Human Services Prazosin analog with increased selectivity and duration of action
JP2652272B2 (ja) * 1990-12-31 1997-09-10 住化ファインケム株式会社 １−（４−アミノ−６，７−ジメトキシ−２−キナゾリニル）−４−（２−テトラヒドロフロイル）ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
US5952003A (en) * 1996-08-01 1999-09-14 Novartis Corporation Terazosin capsules
EP0849264A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von doxazosinmesylat (Form I)
EP0849266B8 (de) * 1996-12-20 2007-10-03 Heumann PCS GmbH Neue polymorphe Form von Doxazosinmesylat (Form III)
EP0849265A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von Doxazosin-Mesylat (Form II)
EP3172377B1 (en) 2014-07-21 2018-09-12 KEIR Manufacturing, Inc. Aerodynamic flyer bow

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663706A (en) * 1969-09-29 1972-05-16 Pfizer Use of 2,4-diaminoquinazolines as hypotensive agents

Also Published As

Publication number Publication date
HU173641B (en) 1979-07-28
CH618436A5 (cs) 1980-07-31
BE851878A (fr) 1977-08-29
IL51481A0 (en) 1977-04-29
DE2708192B2 (de) 1979-08-02
FI62082B (fi) 1982-07-30
NL169591B (nl) 1982-03-01
FI770634A (cs) 1977-09-02
YU41294B (en) 1987-02-28
DE2708192A1 (de) 1977-09-08
FR2372828A1 (fr) 1978-06-30
DK145858C (da) 1983-09-12
NZ183450A (en) 1979-03-16
JPS604188B2 (ja) 1985-02-01
NO770674L (no) 1977-09-02
CA1068269A (en) 1979-12-18
PL196354A1 (pl) 1978-02-27
FI62082C (fi) 1982-11-10
ES8707447A1 (es) 1987-08-16
SE7701624L (sv) 1977-09-02
DK145858B (da) 1983-03-21
PL105559B1 (pl) 1979-10-31
SU644387A3 (ru) 1979-01-25
NO146499C (no) 1982-10-13
GB1538713A (en) 1979-01-24
NL169591C (nl) 1982-08-02
DK86877A (da) 1977-09-02
HK30881A (en) 1981-07-10
PT66227B (en) 1978-07-14
FR2372828B1 (cs) 1980-02-01
ZA77918B (en) 1977-12-28
ES545368A0 (es) 1978-06-01
DE2708192C3 (de) 1980-05-08
DD129652A5 (de) 1978-02-01
JPS52105206A (en) 1977-09-03
BG29724A3 (en) 1981-01-15
AU2244377A (en) 1978-11-23
NL7702123A (nl) 1977-09-05
RO73095A (ro) 1981-06-26
LU76868A1 (cs) 1977-09-21
US4092315A (en) 1978-05-30
IE44522B1 (en) 1981-12-30
AR210937A1 (es) 1977-09-30
MY8100271A (en) 1981-12-31
PT66227A (en) 1977-03-01
YU49977A (en) 1983-12-31
IL51481A (en) 1980-09-16
IE44522L (en) 1977-09-01
SE423234B (sv) 1982-04-26
NO146499B (no) 1982-07-05
AU506937B2 (en) 1980-01-31

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