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TWI800691B - 抑制α4β7整合素的化合物 - Google Patents

抑制α4β7整合素的化合物 Download PDF

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Publication number
TWI800691B
TWI800691B TW108139359A TW108139359A TWI800691B TW I800691 B TWI800691 B TW I800691B TW 108139359 A TW108139359 A TW 108139359A TW 108139359 A TW108139359 A TW 108139359A TW I800691 B TWI800691 B TW I800691B
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Taiwan
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integrin
inhibition
compounds
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TW108139359A
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TW202033493A (zh
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彼得 A 布洛葛恩
塔琳 康貝爾
亞拉曼 錢德拉塞卡
克里斯多幅 Ｔ 克萊克
朱利安 Ａ 克得利
凱文 Ｓ 可利
傑弗瑞 E 克洛普夫
優思明 莫亞瑞迷
尼可 納瓦
莉娜 帕堤爾
史帝芬 裴洛特
傑生 Ｋ 派利
坎薩卓 Ｆ 聖迪羅
娜塔莉 塞格
克爾柯 Ｌ 史蒂芬斯
珍妮佛 安 崔柏
雪松 楊
仲冬 趙
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美商基利科學股份有限公司
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/415—1,2-Diazoles
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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