ATE355269T1 - Phenylalaninderivate - Google Patents
PhenylalaninderivateInfo
- Publication number
- ATE355269T1 ATE355269T1 AT00976347T AT00976347T ATE355269T1 AT E355269 T1 ATE355269 T1 AT E355269T1 AT 00976347 T AT00976347 T AT 00976347T AT 00976347 T AT00976347 T AT 00976347T AT E355269 T1 ATE355269 T1 AT E355269T1
- Authority
- AT
- Austria
- Prior art keywords
- phenylalanine derivatives
- integrin
- alpha
- analogues
- specified
- Prior art date
Links
- 150000002993 phenylalanine derivatives Chemical class 0.000 title abstract 2
- 108010041012 Integrin alpha4 Proteins 0.000 abstract 2
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32846899 | 1999-11-18 | ||
| JP2000197139 | 2000-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE355269T1 true ATE355269T1 (de) | 2006-03-15 |
Family
ID=26572884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00976347T ATE355269T1 (de) | 1999-11-18 | 2000-11-20 | Phenylalaninderivate |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6855706B2 (de) |
| EP (1) | EP1233013B1 (de) |
| JP (1) | JP4788939B2 (de) |
| AT (1) | ATE355269T1 (de) |
| AU (1) | AU1416501A (de) |
| DE (1) | DE60033684T2 (de) |
| WO (1) | WO2001036376A1 (de) |
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| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| CA2420040C (en) | 2000-08-18 | 2009-02-03 | Ajinomoto Co., Inc. | New phenylalanine derivatives |
| EP1323711B1 (de) * | 2000-09-29 | 2006-11-15 | Ajinomoto Co., Inc. | Neue phenylalanin-derivate |
| WO2003010135A1 (en) * | 2001-07-26 | 2003-02-06 | Ajinomoto Co., Inc. | Novel phenylpropionic acid derivatives |
| JP4452899B2 (ja) | 2001-12-13 | 2010-04-21 | 味の素株式会社 | 新規フェニルアラニン誘導体 |
| AU2003208105C1 (en) * | 2002-02-07 | 2009-08-13 | J-Pharma Co., Ltd. | Aromatic amino acid derivatives and medicinal compositions |
| ATE464299T1 (de) * | 2002-02-20 | 2010-04-15 | Ajinomoto Kk | Neues phenylalaninderivat |
| WO2003074478A1 (en) | 2002-03-05 | 2003-09-12 | Sumitomo Chemical Company, Limited | Process for the preparation of biaryl compounds |
| US7091373B2 (en) | 2002-03-18 | 2006-08-15 | Sumitomo Chemical Company, Limited | Production method for biarylalanine |
| AU2003235256A1 (en) * | 2002-04-19 | 2003-11-03 | Kyowa Hakko Kogyo Co., Ltd. | Phenylalanine derivative |
| AU2003265398A1 (en) * | 2002-08-09 | 2004-02-25 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
| CN101386600B (zh) | 2003-02-20 | 2011-07-06 | 味之素株式会社 | 具有喹唑二酮骨架的苯丙氨酸衍生物的制造方法及制造中间体 |
| RU2342365C2 (ru) | 2003-05-01 | 2008-12-27 | Бристол-Маерс Сквибб Компани | Арилзамещенные пиразоламиды в качестве ингибиторов киназ |
| US7501538B2 (en) | 2003-08-08 | 2009-03-10 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
| US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| CA2531796A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| GB0324269D0 (en) * | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| US7160902B2 (en) * | 2003-11-14 | 2007-01-09 | Adolor Corporation | Amide derivatives and methods of their use |
| ZA200605587B (en) | 2003-12-22 | 2008-02-27 | Ajinomoto Kk | Novel phenylalanine derivative |
| EP1725542A1 (de) * | 2004-03-10 | 2006-11-29 | Merck & Co., Inc. | Vla-4-antagonisten |
| KR20070044054A (ko) * | 2004-08-16 | 2007-04-26 | 머크 앤드 캄파니 인코포레이티드 | Vla-4 길항제 |
| WO2006022442A1 (ja) * | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| EP1804786A4 (de) * | 2004-09-29 | 2008-01-02 | Cytovia Inc | Substituierte n-aryl-9-oxo-9h-fluorene-1-carboxamide und analoga als aktivatoren von caspasen und apoptose-auslösern |
| WO2007060409A1 (en) * | 2005-11-23 | 2007-05-31 | Astrazeneca Ab | L-alanine derivatives |
| US7691902B2 (en) * | 2005-12-28 | 2010-04-06 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US7671221B2 (en) * | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| CA2635531C (en) | 2005-12-29 | 2014-06-17 | Lexicon Pharmaceutical Inc. | Multicyclic amino acid derivatives and methods of their use |
| WO2007087441A2 (en) * | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Substituted aromatic compounds for inflammation and immune-related uses |
| AR059224A1 (es) * | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
| US20080045521A1 (en) * | 2006-06-09 | 2008-02-21 | Astrazeneca Ab | Phenylalanine derivatives |
| WO2008093065A1 (en) * | 2007-01-29 | 2008-08-07 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS |
| US20080182842A1 (en) * | 2007-01-29 | 2008-07-31 | Astrazeneca Ab | L-alanine derivatives as a5beta1 antagonists |
| WO2008103378A2 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
| WO2008125811A1 (en) * | 2007-04-11 | 2008-10-23 | Astrazeneca Ab | N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS |
| NZ589086A (en) | 2008-04-11 | 2012-09-28 | Merrimack Pharmaceuticals Inc | Human serum albumin (HSA) linkers and conjugates thereof |
| US8927694B2 (en) | 2008-11-18 | 2015-01-06 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| WO2011094890A1 (en) * | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
| WO2013057092A1 (en) | 2011-10-17 | 2013-04-25 | Westfaelische Wilhelms-Universitaet Muenster | Methods of risk assessment of pml and related apparatus |
| WO2014036520A1 (en) | 2012-08-30 | 2014-03-06 | Merrimack Pharmaceuticals, Inc. | Combination therapies comprising anti-erbb3 agents |
| WO2014201172A1 (en) * | 2013-06-11 | 2014-12-18 | Receptos, Inc. | Novel glp-1 receptor modulators |
| JP6447557B2 (ja) * | 2016-03-24 | 2019-01-09 | 日亜化学工業株式会社 | 発光装置の製造方法 |
| SG11201909570PA (en) * | 2017-04-20 | 2019-11-28 | Univ California | K-ras modulators |
| EP3873897B1 (de) | 2018-10-30 | 2024-08-14 | Gilead Sciences, Inc. | N-benzoyl-phenylalanin-derivate als alpha4beta7 integrin-inhibitoren zur behandlung von entzündlichen erkrankungen |
| LT3873884T (lt) | 2018-10-30 | 2025-03-10 | Gilead Sciences, Inc. | 3-(chinolin-8-il)-1,4-dihidropirido[3,4-d]pirimidin-2,4-diono dariniai kaip alfa4beta7 integrino inhibitoriai, skirti uždegiminių ligų gydymui |
| PL3873900T3 (pl) | 2018-10-30 | 2025-06-02 | Gilead Sciences, Inc. | Imidazo[1,2-a]pirydynowe pochodne jako inhibitory integryny alpha4beta7 do leczenia chorób zapalnych |
| KR102659859B1 (ko) | 2018-10-30 | 2024-04-25 | 길리애드 사이언시즈, 인코포레이티드 | 알파4β7 인테그린의 억제를 위한 화합물 |
| EP4013499A1 (de) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Verbindungen zur inhibierung von alpha-4-beta-7-integrin |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US130320A (en) * | 1872-08-06 | Improvement in copying-press beds | ||
| GB8820844D0 (en) * | 1988-09-05 | 1988-10-05 | Pfizer Ltd | Therapeutic agents |
| GB9004260D0 (en) * | 1990-02-26 | 1990-04-18 | Pfizer Ltd | Therapeutic agents |
| BR9811730B1 (pt) | 1997-08-22 | 2014-04-08 | Hoffmann La Roche | Derivados de n-aroilfenilalanina, uso dos mesmos, medicamentos contendo os mesmos. |
| CN1276785A (zh) * | 1997-08-22 | 2000-12-13 | 霍夫曼-拉罗奇有限公司 | N-烷酰基苯丙氨酸衍生物 |
| MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| US6420418B1 (en) * | 1999-08-16 | 2002-07-16 | Merck & Co., Inc. | Heterocycle amides as cell adhesion inhibitors |
| AU2224901A (en) * | 1999-12-28 | 2001-07-09 | Ajinomoto Co., Inc. | Novel phenylalanine derivatives |
| AU2001242743A1 (en) * | 2000-03-23 | 2001-10-03 | Ajinomoto Co. Inc. | Novel phenylalanine derivative |
| US6403584B1 (en) * | 2000-06-22 | 2002-06-11 | Merck & Co., Inc. | Substituted nipecotyl derivatives as inhibitors of cell adhesion |
| US6579889B2 (en) * | 2000-06-22 | 2003-06-17 | Merck & Co., Inc. | Substituted isonipecotyl derivatives as inhibitors of cell adhesion |
-
2000
- 2000-11-20 AT AT00976347T patent/ATE355269T1/de not_active IP Right Cessation
- 2000-11-20 WO PCT/JP2000/008152 patent/WO2001036376A1/ja not_active Ceased
- 2000-11-20 JP JP2001538868A patent/JP4788939B2/ja not_active Expired - Fee Related
- 2000-11-20 DE DE60033684T patent/DE60033684T2/de not_active Expired - Lifetime
- 2000-11-20 EP EP00976347A patent/EP1233013B1/de not_active Expired - Lifetime
- 2000-11-20 AU AU14165/01A patent/AU1416501A/en not_active Abandoned
-
2002
- 2002-05-20 US US10/150,067 patent/US6855706B2/en not_active Expired - Fee Related
-
2004
- 2004-11-15 US US10/986,829 patent/US7160874B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1233013A4 (de) | 2004-05-12 |
| EP1233013B1 (de) | 2007-02-28 |
| US7160874B2 (en) | 2007-01-09 |
| DE60033684T2 (de) | 2007-12-06 |
| US20050070485A1 (en) | 2005-03-31 |
| US6855706B2 (en) | 2005-02-15 |
| AU1416501A (en) | 2001-05-30 |
| US20030149083A1 (en) | 2003-08-07 |
| DE60033684D1 (de) | 2007-04-12 |
| EP1233013A1 (de) | 2002-08-21 |
| WO2001036376A1 (en) | 2001-05-25 |
| JP4788939B2 (ja) | 2011-10-05 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |