SK3902001A3 - Alzheimer's disease secretase - Google Patents

Alzheimer's disease secretase Download PDF

Info

Publication number: SK3902001A3
Authority: SK; Slovakia
Prior art keywords: polypeptide; asp2; seq; cell; amino acid
Prior art date: 1998-09-24

Application number

SK390-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Mark E Gurney

Michael Jerome Bienkowski

Robert Leroy Heinrikson

Luis A Parodi

Riqiang Yan

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-24

Filing date

1999-09-23

Publication date

2001-12-03

1999-09-23 Application filed by Upjohn Co filed Critical Upjohn Co

2001-12-03 Publication of SK3902001A3 publication Critical patent/SK3902001A3/sk

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96472—Aspartic endopeptidases (3.4.23)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Neurosurgery (AREA)
Physics & Mathematics (AREA)
Public Health (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SK390-2001A 1998-09-24 1999-09-23 Alzheimer's disease secretase SK3902001A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10159498P	1998-09-24	1998-09-24
PCT/US1999/020881 WO2000017369A2 (en)	1998-09-24	1999-09-23	Alzheimer's disease secretase

Publications (1)

Publication Number	Publication Date
SK3902001A3 true SK3902001A3 (en)	2001-12-03

Family

ID=22285461

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK390-2001A SK3902001A3 (en)	1998-09-24	1999-09-23	Alzheimer's disease secretase

Country Status (28)

Country	Link
US (2)	US6835565B1 (zh)
EP (1)	EP1115874B1 (zh)
JP (3)	JP2002526081A (zh)
KR (8)	KR20060111905A (zh)
CN (4)	CN1300320C (zh)
AT (1)	ATE420185T1 (zh)
AU (2)	AU772812C (zh)
BR (1)	BR9913920A (zh)
CA (1)	CA2343004A1 (zh)
CY (1)	CY1111006T1 (zh)
CZ (1)	CZ2001966A3 (zh)
DE (1)	DE69940265D1 (zh)
DK (1)	DK1115874T3 (zh)
EA (1)	EA009216B1 (zh)
ES (1)	ES2318902T3 (zh)
HK (2)	HK1042730B (zh)
HU (1)	HUP0103838A3 (zh)
IL (2)	IL142207A (zh)
IS (1)	IS5905A (zh)
NO (1)	NO20011505L (zh)
NZ (2)	NZ527053A (zh)
PL (1)	PL205294B1 (zh)
PT (1)	PT1115874E (zh)
SG (1)	SG113454A1 (zh)
SK (1)	SK3902001A3 (zh)
TR (3)	TR200601231T2 (zh)
WO (1)	WO2000017369A2 (zh)
ZA (1)	ZA200102387B (zh)

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TR200601231T2 (tr)	2006-09-21
ATE420185T1 (de)	2009-01-15
NZ527053A (en)	2005-04-29
SG113454A1 (en)	2005-08-29
HK1042730B (zh)	2005-11-18
AU772812C (en)	2004-12-09
JP2002526081A (ja)	2002-08-20
AU772812B2 (en)	2004-05-06
PT1115874E (pt)	2009-04-09
KR20010085837A (ko)	2001-09-07
HUP0103838A2 (hu)	2002-03-28
WO2000017369B1 (en)	2000-12-28
JP2008113665A (ja)	2008-05-22
EP1115874A2 (en)	2001-07-18
AU2004203588B2 (en)	2007-11-22
TR200101484T2 (tr)	2002-06-21
PL205294B1 (pl)	2010-03-31
KR20060126626A (ko)	2006-12-07
CN1339066A (zh)	2002-03-06
NO20011505L (no)	2001-05-23
CY1111006T1 (el)	2015-06-11
EA009216B1 (ru)	2007-12-28
TR200200662T2 (tr)	2002-06-21
EA200100387A1 (ru)	2001-10-22
EP1115874B1 (en)	2009-01-07
WO2000017369A2 (en)	2000-03-30
PL348629A1 (en)	2002-06-03
ZA200102387B (en)	2002-09-23
KR100839284B1 (ko)	2008-06-17
CN1198936C (zh)	2005-04-27
ES2318902T3 (es)	2009-05-01
DE69940265D1 (de)	2009-02-26
AU2004203588A1 (en)	2004-09-02
WO2000017369A3 (en)	2000-11-23
KR20060111905A (ko)	2006-10-30
IL142207A (en)	2010-11-30
NZ510708A (en)	2003-12-19
US7812123B2 (en)	2010-10-12
CA2343004A1 (en)	2000-03-30
HUP0103838A3 (en)	2006-05-29
JP2009201517A (ja)	2009-09-10
US20050026256A1 (en)	2005-02-03
IL182070A0 (en)	2007-07-24
CZ2001966A3 (cs)	2001-10-17
AU6141899A (en)	2000-04-10
KR20040099362A (ko)	2004-11-26
NO20011505D0 (no)	2001-03-23
HK1062187A1 (en)	2004-10-21
KR100768381B1 (ko)	2007-10-18
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CN1502697A (zh)	2004-06-09
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IS5905A (is)	2001-03-22
KR20040097216A (ko)	2004-11-17
US6835565B1 (en)	2004-12-28
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HK1042730A1 (en)	2002-08-23
DK1115874T3 (da)	2009-04-20
BR9913920A (pt)	2001-11-06
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Publication	Publication Date	Title
SK3902001A3 (en)	2001-12-03	Alzheimer's disease secretase
US7368536B2 (en)	2008-05-06	Alzheimer's disease secretase, APP substrates therefor, and uses therefor
JP2002526081A5 (zh)	2007-01-18
EP1224297B1 (en)	2009-05-13	Alzheimer's disease secretase, app substrates therefor, and uses therefor
US20090075316A1 (en)	2009-03-19	Alzheimer's Disease Secretase, APP Substrates Therefor and Uses Therefor
US6844148B1 (en)	2005-01-18	Alzheimer's disease secretase, APP substrates therefor, and uses therefor
AU2005225037B2 (en)	2008-05-22	Alzheimer's disease secretase, APP substrates therefor, and uses therefor
EP1939297A1 (en)	2008-07-02	Alzheimer's disease secretase
US20090162883A1 (en)	2009-06-25	Alzheimer's Disease Secretase, APP Substrates Thereof, and Uses Thereof
NZ517297A (en)	2004-04-30	Aspartic proteases, termed aspartyl protease 1 and 2 (ASP1 and ASP2) and gene variants thereof and their role in Alzheimer's disease
MXPA01003038A (en)	2001-12-13	Alzheimer's disease secretase

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