[go: up one dir, main page]

HK1042730B - 阿爾茨海默氏疾病分泌酶 - Google Patents

阿爾茨海默氏疾病分泌酶

Info

Publication number
HK1042730B
HK1042730B HK02104092.7A HK02104092A HK1042730B HK 1042730 B HK1042730 B HK 1042730B HK 02104092 A HK02104092 A HK 02104092A HK 1042730 B HK1042730 B HK 1042730B
Authority
HK
Hong Kong
Prior art keywords
alzheimer
secretase
disease secretase
disease
cleaving
Prior art date
Application number
HK02104092.7A
Other languages
English (en)
Other versions
HK1042730A1 (en
Inventor
M‧E‧格尼
M‧J‧比安科沃斯基
R‧L‧希裡克森
L‧A‧帕羅迪
R‧嚴
Original Assignee
法瑪西雅厄普約翰美國公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 法瑪西雅厄普約翰美國公司 filed Critical 法瑪西雅厄普約翰美國公司
Publication of HK1042730A1 publication Critical patent/HK1042730A1/xx
Publication of HK1042730B publication Critical patent/HK1042730B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96472—Aspartic endopeptidases (3.4.23)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK02104092.7A 1998-09-24 2002-05-31 阿爾茨海默氏疾病分泌酶 HK1042730B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10159498P 1998-09-24 1998-09-24
PCT/US1999/020881 WO2000017369A2 (en) 1998-09-24 1999-09-23 Alzheimer's disease secretase

Publications (2)

Publication Number Publication Date
HK1042730A1 HK1042730A1 (en) 2002-08-23
HK1042730B true HK1042730B (zh) 2005-11-18

Family

ID=22285461

Family Applications (2)

Application Number Title Priority Date Filing Date
HK02104092.7A HK1042730B (zh) 1998-09-24 2002-05-31 阿爾茨海默氏疾病分泌酶
HK04105123A HK1062187A1 (en) 1998-09-24 2004-07-14 Alzheimer's disease secretase

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK04105123A HK1062187A1 (en) 1998-09-24 2004-07-14 Alzheimer's disease secretase

Country Status (28)

Country Link
US (2) US6835565B1 (zh)
EP (1) EP1115874B1 (zh)
JP (3) JP2002526081A (zh)
KR (8) KR100866676B1 (zh)
CN (4) CN1198936C (zh)
AT (1) ATE420185T1 (zh)
AU (2) AU772812C (zh)
BR (1) BR9913920A (zh)
CA (1) CA2343004A1 (zh)
CY (1) CY1111006T1 (zh)
CZ (1) CZ2001966A3 (zh)
DE (1) DE69940265D1 (zh)
DK (1) DK1115874T3 (zh)
EA (1) EA009216B1 (zh)
ES (1) ES2318902T3 (zh)
HK (2) HK1042730B (zh)
HU (1) HUP0103838A3 (zh)
IL (2) IL142207A (zh)
IS (1) IS5905A (zh)
NO (1) NO20011505L (zh)
NZ (2) NZ527053A (zh)
PL (1) PL205294B1 (zh)
PT (1) PT1115874E (zh)
SG (1) SG113454A1 (zh)
SK (1) SK3902001A3 (zh)
TR (3) TR200101484T2 (zh)
WO (1) WO2000017369A2 (zh)
ZA (1) ZA200102387B (zh)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9701684D0 (en) 1997-01-28 1997-03-19 Smithkline Beecham Plc Novel compounds
AU1726199A (en) 1997-12-31 1999-07-19 Chiron Corporation Metastatic cancer regulated gene
US6699671B1 (en) * 1998-09-24 2004-03-02 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
CA2343004A1 (en) 1998-09-24 2000-03-30 Pharmacia & Upjohn Company Alzheimer's disease secretase
US20040234976A1 (en) * 1998-09-24 2004-11-25 Gurney Mark E. Alzheimer's disease secretase, app substrates therefor, and uses therefor
US7456007B1 (en) 1998-12-31 2008-11-25 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7115410B1 (en) 1999-02-10 2006-10-03 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
GB2364059B (en) 1999-02-10 2004-01-14 Elan Pharm Inc Beta-Secretase enzyme compositions and methods
AU3770800A (en) 1999-03-26 2000-10-16 Amgen, Inc. Beta secretase genes and polypeptides
JP4484410B2 (ja) 1999-06-28 2010-06-16 オクラホマ メディカル リサーチ ファウンデーション メマプシン２のインヒビターおよびその使用
EP1496124A1 (en) * 1999-06-28 2005-01-12 Oklahoma Medical Research Foundation Catalytically active recombinant memapsin and methods of use thereof
AR025754A1 (es) * 1999-09-23 2002-12-11 Pharmacia & Upjohn Co Llc Secretasa en la enfermedad de alzheimer, sustratos de la app y sus usos
US7514408B1 (en) 1999-12-02 2009-04-07 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US8273866B2 (en) 2002-02-20 2012-09-25 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US8202979B2 (en) 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
ATE343562T1 (de) 2000-03-23 2006-11-15 Elan Pharm Inc Verbindungen und verfahren zur behandlung der alzheimerschen krankheit
US6846813B2 (en) 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
EP1299352B1 (en) 2000-06-30 2005-12-28 Elan Pharmaceuticals, Inc. Compounds to treat alzheimer's disease
EP1666452A2 (en) 2000-06-30 2006-06-07 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
US6686449B2 (en) 2000-06-30 2004-02-03 Pharmacia & Upjohn Company Mutant presenilin 1 polypeptides
JP2004504018A (ja) 2000-07-19 2004-02-12 ファルマシア・アンド・アップジョン・カンパニー β−セレクターゼ活性の基質およびアッセイ
US20030190635A1 (en) * 2002-02-20 2003-10-09 Mcswiggen James A. RNA interference mediated treatment of Alzheimer's disease using short interfering RNA
US7806980B2 (en) 2000-12-23 2010-10-05 Elan Pharmaceuticals, Inc. Method for crystallizing human beta secretase in complex with an inhibitor
CA2438832A1 (en) 2001-02-23 2002-09-06 Elan Pharmaceuticals, Inc. Transgenic knockouts of bace-1
US7524668B1 (en) 2001-05-10 2009-04-28 Elan Pharmaceuticals, Inc. Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US7517864B2 (en) 2001-05-18 2009-04-14 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
CA2448253A1 (en) 2001-05-25 2002-11-28 Genset S.A. Human cdnas and proteins and uses thereof
EP1395551B1 (en) 2001-06-01 2008-05-21 Elan Pharmaceuticals, Inc. Hydroxy alkyl amine derivatives as beta-secretase inhibitors and their use for the treatment of alzheimer's disease and similar diseases
WO2002100410A1 (en) * 2001-06-08 2002-12-19 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease
JP2004532894A (ja) 2001-06-13 2004-10-28 イーラン　ファーマスーティカルズ、インコーポレイテッド アルツハイマー病を治療するためのアミンジオール
BR0210721A (pt) 2001-06-27 2004-07-20 Elan Pharm Inc Composto, sal ou éster farmaceuticamente aceitável, método para fabricar um composto, e, método para tratar um paciente que tem, ou para evitar que o paciente adquira uma doença ou condição
EP1404664A1 (en) 2001-07-10 2004-04-07 Elan Pharmaceuticals, Inc. Aminediols for the treatment of alzheimer's disease
JP2005504022A (ja) 2001-07-10 2005-02-10 イーラン ファーマスーティカルズ、インコーポレイテッド アルツハイマー病治療のためのジアミンジオール
BR0211122A (pt) 2001-07-10 2004-10-26 Elan Pharm Inc Composto, métodos para o tratamento ou prevenção de doenças e para fabricar um composto, intermediário, e, uso de um composto ou sal
US7186539B1 (en) 2001-08-31 2007-03-06 Pharmacia & Upjohn Company Method for refolding enzymes
BR0213139A (pt) 2001-10-04 2004-08-10 Elan Pharm Inc Composto, método de tratamento ou prevenção de doenças e de preparação de um composto, uso de um composto e composição farmacêutica
EP1448218A4 (en) 2001-10-23 2009-01-14 Oklahoma Med Res Found BETA SECRETASE INHIBITORS AND METHODS OF USE
BR0214035A (pt) 2001-11-08 2005-04-26 Elan Pharm Inc Composto
MXPA04004903A (es) * 2001-11-21 2005-06-06 Elan Pharm Inc Derivados de aminoacido utiles para el tratamiento de la enfermedad de alzheimer.
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
WO2003072733A2 (en) 2002-02-21 2003-09-04 Pharmacia & Upjohn Company Modified bace
AU2003303141A1 (en) 2002-04-30 2004-07-22 Elan Pharmaceuticals, Inc. Hydroxypropyl amides for the treatment of alzheimer's disease
US7442537B1 (en) 2002-05-10 2008-10-28 Elan Pharmaceuticals, Inc. Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
US7956176B2 (en) 2002-09-05 2011-06-07 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
UY27967A1 (es) 2002-09-10 2004-05-31 Pfizer Acetil 2-hindroxi-1,3-diaminoalcanos
PE20040762A1 (es) 2002-11-27 2004-11-06 Elan Pharm Inc Ureas substituidas y carbamatos utiles para el tratamiento de la enfermedad de alzheimer
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
AR044044A1 (es) 2003-04-21 2005-08-24 Elan Pharm Inc 2-hidroxi-3-diaminoalcanos de benzamida
US7482136B2 (en) 2003-05-02 2009-01-27 Elan Pharmaceuticals, Inc. Glycosylation variants of BACE
CA2558034A1 (en) 2004-03-09 2005-09-22 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamine aspartyl protease inhibitors
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
WO2006010094A1 (en) 2004-07-09 2006-01-26 Elan Pharmaceuticals, Inc. Oxime derivative hydroxyethylamine aspartyl-protease inhibitors
WO2006010095A2 (en) 2004-07-09 2006-01-26 Elan Pharmaceuticals Inc. Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors
CA2589860A1 (en) 2005-01-24 2006-08-03 Amgen Inc. Humanized anti-amyloid antibody
WO2006099379A2 (en) * 2005-03-14 2006-09-21 Transtech Pharma, Inc. Benzazole derivatives, compositions, and methods of use as b-secretase inhibitors
EP1746092A1 (en) 2005-07-22 2007-01-24 Exonhit Therapeutics SA Compounds and methods for treatment of amyloid-B-peptide related disorders
WO2007047305A1 (en) 2005-10-12 2007-04-26 Elan Pharmaceuticals, Inc. Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors
US7745484B2 (en) 2005-11-21 2010-06-29 Amgen Inc. Beta-secretase modulators and methods of use
US7872009B2 (en) 2005-11-21 2011-01-18 Amgen Inc. Beta-Secretase modulators and methods of use
US7838676B2 (en) 2005-11-21 2010-11-23 Amgen Inc. Beta-secretase modulators and methods of use
US20070292895A1 (en) * 2006-05-19 2007-12-20 Xiao-Ping Shi Assays and methods to detect beta-secretase and its activity in body fluids and tissue extracts
ATE523788T1 (de) * 2006-06-08 2011-09-15 Fu Berlin ASSAY ZUR DIAGNOSE VON ALZHEIMER BASIEREND AUF DER BESTIMMUNG DES VERHÄLTNISSES VON SEKRETASE-Aß-SPALTPRODUKTEN
TW200815349A (en) 2006-06-22 2008-04-01 Astrazeneca Ab New compounds
US8163909B2 (en) 2007-05-25 2012-04-24 Amgen Inc. Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
AU2008257145B2 (en) 2007-05-25 2011-11-10 Amgen Inc. Substituted hydroxyethyl amine compounds as Beta-secretase modulators and methods of use
US8222264B2 (en) 2007-07-06 2012-07-17 Boehringer Ingelheim International Gmbh Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture
US7803809B2 (en) 2008-11-12 2010-09-28 Amgen Inc. Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use
ES2459195T3 (es) * 2008-09-11 2014-05-08 Amgen Inc. Compuestos de anillo espiro-tetracíclico como moduladores de beta-secretasa y métodos de uso
TW201020244A (en) 2008-11-14 2010-06-01 Astrazeneca Ab New compounds
EP2281824A1 (en) 2009-08-07 2011-02-09 Noscira, S.A. Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders
WO2011063233A1 (en) 2009-11-23 2011-05-26 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
US8822485B2 (en) 2009-11-23 2014-09-02 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
WO2011090911A1 (en) 2010-01-19 2011-07-28 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
CA2791281A1 (en) 2010-03-15 2011-09-22 Amgen Inc. Spiro-tetracyclic ring compounds as beta-secretase modulators
MX2012010657A (es) 2010-03-15 2013-02-07 Amgen Inc Compuestos de espiro amino-dihidrooxazina y amino-dihidrotiazina como moduladores de beta-secretasa y su uso medico.
EP2601197B1 (en) 2010-08-05 2014-06-25 Amgen Inc. Amino-iso-indole, amino-aza-iso-indole, amino-dihydroisoquinoline and amino-benzoxazine compounds as beta-secretase modulators and methods of use
US10449177B2 (en) 2010-08-19 2019-10-22 Buck Institute For Research On Aging Methods of treating mild cognitive impairment (MCI) and related disorders
DK2632472T3 (en) 2010-10-29 2018-03-19 Sirna Therapeutics Inc RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
EP2643299B1 (en) 2010-11-22 2016-06-22 Noscira, S.A. Bipyridine sulfonamide derivatives for the treatment of neurodegenerative diseases or conditions
US8957083B2 (en) 2010-11-23 2015-02-17 Amgen Inc. Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use
EP2673279A1 (en) 2011-02-07 2013-12-18 Amgen Inc. 5-amino-oxazepine and 5-amino-thiazepane compounds as beta-secretase antagonists and methods of use
EP2675810A1 (en) 2011-02-15 2013-12-25 Amgen Inc. Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use
JP2014526560A (ja) 2011-09-21 2014-10-06 アムジエン・インコーポレーテツド β‐セクレターゼ調節因子としてのアミノオキサジン化合物およびアミノジヒドロチアジン化合物および使用方法
KR102160388B1 (ko) 2012-03-19 2020-09-28 버크 인스티튜트 포 리서치 온 에이징 App 특이적 bace 억제제(asbi) 및 이의 용도
WO2014059185A1 (en) 2012-10-12 2014-04-17 Amgen Inc. Amino - dihydrothiazine and amino - dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use
WO2014078314A1 (en) 2012-11-15 2014-05-22 Amgen Inc. Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
WO2014120658A1 (en) 2013-01-29 2014-08-07 Amgen Inc. Fused multicyclic 3-amino-5,6-dihydro-2h-1,4-thiazine derivatives and their use as beta-secretase inhibitors
DK2956443T3 (da) 2013-02-12 2020-01-20 Buck Inst Res Aging Hydantoiner som modulatorer af BACE-medieret APP-forarbejdning
US9296734B2 (en) 2013-03-01 2016-03-29 Amgen Inc. Perfluorinated 5,6-dihydro-4H-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
EA201591614A1 (ru) 2013-03-08 2015-12-30 Эмджен Инк. Соединения 1,3-оксазин-2-амина, конденсированные с перфторированным циклопропилом, в качестве ингибиторов бета-секретазы и способы их применения
US9096615B2 (en) 2013-07-30 2015-08-04 Amgen Inc. Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta-secretase and methods of use thereof
KR101791296B1 (ko) * 2014-04-17 2017-10-27 제주대학교 산학협력단 알츠하이머병 관련 돌연변이 유전자를 포함하는 발현 카세트, 벡터, 및 이를 이용하여 형질전환된 세포주
CA2957544C (en) 2014-08-08 2023-01-24 Amgen Inc. Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
DK3290525T3 (da) * 2015-04-30 2022-03-14 Jiangsu Nuo Beta Pharmaceutical Tech Co Ltd Fremgangsmåde til screening af lægemiddel og terapeutisk mål der anvendes til behandling af alzheimers sygdom
WO2017024180A1 (en) 2015-08-06 2017-02-09 Amgen Inc. Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
CA3096896A1 (en) 2015-08-27 2017-03-02 Nantneuro, Llc 5,5'-disubstituted aminohydantoin compounds and compositions useful for inhibition of bace and the treatment of associated diseases
JP7027341B2 (ja) 2016-05-12 2022-03-01 バック・インスティテュート・フォー・リサーチ・オン・エイジング Ａｐｐの正常なプロセシングを促進する化合物
US10889581B2 (en) 2016-12-15 2021-01-12 Amgen Inc. Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
AU2017376446B2 (en) 2016-12-15 2021-10-14 Amgen Inc. 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
CA3047285A1 (en) 2016-12-15 2018-06-21 Amgen Inc. Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
WO2018112081A1 (en) 2016-12-15 2018-06-21 Amgen Inc. Oxazine derivatives as beta-secretase inhibitors and methods of use
CA3047288A1 (en) 2016-12-15 2018-06-21 Amgen Inc. Thiazine derivatives as beta-secretase inhibitors and methods of use
CN107576785A (zh) * 2017-08-25 2018-01-12 广州市雷德生物科技有限公司 一种样本处理液及其应用
GB201803010D0 (en) * 2018-02-26 2018-04-11 Royal Holloway & Bedford New College Neurodegenerative disorders
CN111518793A (zh) * 2020-05-20 2020-08-11 谭骏 年轻人血源APPα-分泌酶在阿尔茨海默病中的应用
CN114480494B (zh) * 2022-02-10 2024-07-05 中国科学技术大学 蛋白探针以及其在检测bace1活性中的应用
CN116829956A (zh) * 2023-02-28 2023-09-29 湖南乾康科技有限公司 用于检测蛋白生物标志物组的抗体在制备诊断ad、mci和其它类型老年痴呆的试剂盒中的用途
CN118831181B (zh) * 2024-09-20 2025-02-11 江苏集萃药康生物科技股份有限公司 一种三突变阿尔兹海默症小鼠模型的构建方法及其应用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200339A (en) 1990-08-17 1993-04-06 Abraham Carmela R Proteases causing abnormal degradation of amyloid β-protein precursor
US5292652A (en) 1990-10-05 1994-03-08 Athena Neurosciences, Inc. Amyloidin protease and uses thereof
DE69233468T3 (de) 1991-01-21 2011-05-05 Elan Pharmaceuticals, Inc., San Francisco Prüfung und modell für alzheimers-krankheit
US5604131A (en) * 1992-01-07 1997-02-18 Athena Neurosciences, Inc. cDNA-genomic DNA hybrid sequence encoding APP770 containing a genomic DNA insert of the KI and OX-2 regions
TW327194B (en) * 1992-05-01 1998-02-21 American Cyanamid Co Novel amyloid precursor proteins and methods of using same
IL105793A0 (en) 1992-05-28 1993-09-22 Lilly Co Eli Protease and related dna compounds
US5455169A (en) * 1992-06-04 1995-10-03 Alzheimer's Institute Of America, Inc. Nucleic acids for diagnosing and modeling Alzheimer's disease
US5837672A (en) 1992-07-10 1998-11-17 Athena Neurosciences, Inc. Methods and compositions for the detection of soluble β-amyloid peptide
US5766846A (en) 1992-07-10 1998-06-16 Athena Neurosciences Methods of screening for compounds which inhibit soluble β-amyloid peptide production
US5605811A (en) * 1992-10-26 1997-02-25 Athena Neurosciences, Inc. Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein
CA2151927A1 (en) * 1992-12-16 1994-06-23 Paul Perry Tamburini Cathepsin d is an amyloidogenic protease in alzheimer's disease
EP0608546A3 (en) * 1992-12-22 1995-09-27 Takeda Chemical Industries Ltd Glia activating factor (gaf), antibodies against it and their uses.
DE69432629T3 (de) 1993-01-25 2008-01-17 Takeda Pharmaceutical Co. Ltd. Antikörper gegen beta-amyloid oder derivative davon und seine verwendung
JPH09507746A (ja) 1993-10-27 1997-08-12 アテナ ニューロサイエンシズ，インコーポレイティド Ｓｗｅｄｉｓｈ変異を有するＡＰＰ対立遺伝子を含有するトランスジェニック動物
WO1996006927A1 (en) 1994-09-01 1996-03-07 Merck & Co., Inc. Transgenic animal expressing a familial form of human amyloid precursor protein
AU5435496A (en) 1995-04-04 1996-10-23 Eli Lilly And Company Amyloid precursor protein protease
WO1996040885A2 (en) 1995-06-07 1996-12-19 Athena Neurosciences, Inc. β-SECRETASE, ANTIBODIES TO β-SECRETASE, AND ASSAYS FOR DETECTING β-SECRETASE INHIBITION
US5744346A (en) 1995-06-07 1998-04-28 Athena Neurosciences, Inc. β-secretase
US6221645B1 (en) 1995-06-07 2001-04-24 Elan Pharmaceuticals, Inc. β-secretase antibody
DE19641180A1 (de) 1996-09-24 1998-03-26 Schering Ag Verfahren zur Darstellung von APP-Sekretase Modulation und deren Verwendung als Mittel zur Behandlung der Alzheimer'schen Erkrankung
WO1998021589A1 (en) 1996-11-15 1998-05-22 The Trustees Of The University Of Pennsylvania Screening for modulators of amyloid processing
WO1998026059A1 (en) 1996-12-11 1998-06-18 Athena Neurosciences, Inc. Beta-secretase isolated from human 293 cells
GB9626022D0 (en) 1996-12-14 1997-01-29 Smithkline Beecham Plc Novel compounds
EP0848062A3 (en) 1996-12-14 2000-07-05 Smithkline Beecham Corporation Aspartic protease ASP1
GB9701684D0 (en) 1997-01-28 1997-03-19 Smithkline Beecham Plc Novel compounds
GB9721094D0 (en) * 1997-10-03 1997-12-03 Unilever Plc Autophobic hairspray compositions
ES2330903T3 (es) 1997-12-17 2009-12-16 Serono Genetics Institute S.A. Adncs extendidos para proteinas secretadas.
AU1726199A (en) 1997-12-31 1999-07-19 Chiron Corporation Metastatic cancer regulated gene
EP1490386B1 (en) * 1998-03-10 2008-08-13 Genentech, Inc. Novel polypeptide and nucleic acids encoding the same
AU4045599A (en) 1998-06-05 1999-12-30 Aventis Pharma S.A. Polypeptides with beta-secretase type activity
US6844148B1 (en) 1998-09-24 2005-01-18 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
CA2343004A1 (en) 1998-09-24 2000-03-30 Pharmacia & Upjohn Company Alzheimer's disease secretase
US6699671B1 (en) 1998-09-24 2004-03-02 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
US6245884B1 (en) 1998-10-16 2001-06-12 Vivian Y. H. Hook Secretases related to alzheimer's dementia
US6313268B1 (en) 1998-10-16 2001-11-06 Vivian Y. H. Hook Secretases related to Alzheimer's dementia
GB2364059B (en) * 1999-02-10 2004-01-14 Elan Pharm Inc Beta-Secretase enzyme compositions and methods
DE19910108C2 (de) 1999-03-08 2001-02-22 Falk Fahrenholz Zellen, die ein Amyloidvorläuferprotein und eine alpha-Sekretase coexprimieren, ein Testverfahren zur Identifikation alpha-Sekretase-aktiver Substanzen sowie eines zur Identifikation weiterer Sekretasen, ein Testverfahren zur Bestimmung der Anfälligkeit gegenüber Morbus Alzheimer und Verwendung von Nukleinsäuren, die für eine alpha-Sekretase codieren, für die Gentherapie
AU3770800A (en) 1999-03-26 2000-10-16 Amgen, Inc. Beta secretase genes and polypeptides
AU4640600A (en) 1999-05-11 2000-11-21 Eli Lilly And Company Amyloid precursor protein protease and related nucleic acid compounds
US7087399B1 (en) 1999-05-13 2006-08-08 Scios, Inc. β-secretase and modulation of β-secretase activity
JP4484410B2 (ja) 1999-06-28 2010-06-16 オクラホマ メディカル リサーチ ファウンデーション メマプシン２のインヒビターおよびその使用
GB9924957D0 (en) 1999-10-21 1999-12-22 Smithkline Beecham Plc Novel treatment
GB9925136D0 (en) 1999-10-22 1999-12-22 Smithkline Beecham Plc Novel treatment
US6361975B1 (en) 1999-11-16 2002-03-26 Smithkline Beecham Corporation Mouse aspartic secretase-2(mASP-2)
US6291223B1 (en) 1999-11-23 2001-09-18 Smithkline Beecham Corporation Mouse aspartic secretase-1 (mASP1)

Also Published As

Publication number Publication date
KR20070004143A (ko) 2007-01-05
AU772812B2 (en) 2004-05-06
US7812123B2 (en) 2010-10-12
US20050026256A1 (en) 2005-02-03
WO2000017369B1 (en) 2000-12-28
KR100691601B1 (ko) 2007-03-09
KR20010085837A (ko) 2001-09-07
AU2004203588A1 (en) 2004-09-02
CA2343004A1 (en) 2000-03-30
AU6141899A (en) 2000-04-10
CN1502697A (zh) 2004-06-09
IL142207A (en) 2010-11-30
KR100768381B1 (ko) 2007-10-18
CY1111006T1 (el) 2015-06-11
JP2009201517A (ja) 2009-09-10
EP1115874B1 (en) 2009-01-07
ES2318902T3 (es) 2009-05-01
TR200200662T2 (tr) 2002-06-21
CN1502696A (zh) 2004-06-09
CN1339066A (zh) 2002-03-06
KR20060126626A (ko) 2006-12-07
DE69940265D1 (de) 2009-02-26
EA009216B1 (ru) 2007-12-28
HUP0103838A2 (hu) 2002-03-28
HUP0103838A3 (en) 2006-05-29
WO2000017369A3 (en) 2000-11-23
CN1198936C (zh) 2005-04-27
TR200601231T2 (tr) 2006-09-21
AU772812C (en) 2004-12-09
ZA200102387B (en) 2002-09-23
ATE420185T1 (de) 2009-01-15
WO2000017369A2 (en) 2000-03-30
TR200101484T2 (tr) 2002-06-21
EP1115874A2 (en) 2001-07-18
CN1502692A (zh) 2004-06-09
NO20011505D0 (no) 2001-03-23
KR20070013361A (ko) 2007-01-30
DK1115874T3 (da) 2009-04-20
PT1115874E (pt) 2009-04-09
PL205294B1 (pl) 2010-03-31
SK3902001A3 (en) 2001-12-03
JP2008113665A (ja) 2008-05-22
NZ527053A (en) 2005-04-29
SG113454A1 (en) 2005-08-29
KR100839284B1 (ko) 2008-06-17
KR20040097216A (ko) 2004-11-17
KR20060111905A (ko) 2006-10-30
KR100866676B1 (ko) 2008-11-11
CN1300320C (zh) 2007-02-14
US6835565B1 (en) 2004-12-28
KR20040099362A (ko) 2004-11-26
KR20040093193A (ko) 2004-11-04
HK1062187A1 (en) 2004-10-21
JP2002526081A (ja) 2002-08-20
NO20011505L (no) 2001-05-23
AU2004203588B2 (en) 2007-11-22
CZ2001966A3 (cs) 2001-10-17
IL182070A0 (en) 2007-07-24
IS5905A (is) 2001-03-22
EA200100387A1 (ru) 2001-10-22
NZ510708A (en) 2003-12-19
BR9913920A (pt) 2001-11-06
HK1042730A1 (en) 2002-08-23
PL348629A1 (en) 2002-06-03

Similar Documents

Publication Publication Date Title
AU772812C (en) Alzheimer's disease secretase
WO2001049097A3 (en) Alzheimer's disease secretase, app substrates therefor, and uses therefor
WO2001023533A3 (en) Alzheimer's disease secretase, app substrates therefor, and uses therefor
WO1997033996A3 (en) Human bikunin
WO2002006457A3 (en) Novel lipase genes
GB9722320D0 (en) Human cell cycle checkpoint proteins
WO1999021976A3 (en) Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins
WO2000009677A3 (en) Sterol-regulated site-1 protease and assays of modulators thereof
AU2001238064A1 (en) 18477, a human protein kinase and uses therefor
AU2676801A (en) Xylosyltransferase and isoforms thereof
WO2001064912A3 (en) Triazine degrading enzymes
WO1999047673A3 (en) Isolated mammalian membrane protein genes and related reagents
WO1999022005A3 (en) Heparan sulfate d-glucosaminyl 3-o-sulfotransferases, an uses therefor
CA2337088A1 (en) Methods and constructs for protein expression
WO2002074921A3 (en) Methods for isolating proteins expressed by dendritic cells
CY1110496T1 (el) Σεκρεταση νοσου alzheimer, υποστρωματα app αυτης, και χρησεις αυτης
WO1998023775A3 (de) Dna zur abschätzung des progressionspotentials von zervixläsionen
GB2289125A (en) Methods of assaying data-repairing enzymes and their alkylated derivatives
AU3354199A (en) Prostate derived serine protease (pdsp) protein and nucleic acid molecules and uses therefor
ECSP003672A (es) Secretasa en la enfermedad de alzheimer, substratos de la app y sus usos
AU6471899A (en) Parvovirus vectors and their use
WO2003031579A3 (en) Human tyrosine-dna phosphodiesterase variant polypeptides and methods of use therefor

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100923