[go: up one dir, main page]

NO20042905L - Farmasoytisk nanopartikkelpreparat av en takykinin reseptor antagonist - Google Patents

Farmasoytisk nanopartikkelpreparat av en takykinin reseptor antagonist

Info

Publication number
NO20042905L
NO20042905L NO20042905A NO20042905A NO20042905L NO 20042905 L NO20042905 L NO 20042905L NO 20042905 A NO20042905 A NO 20042905A NO 20042905 A NO20042905 A NO 20042905A NO 20042905 L NO20042905 L NO 20042905L
Authority
NO
Norway
Prior art keywords
receptor antagonist
tachykinin receptor
nanoparticle preparation
pharmaceutical nanoparticle
pharmaceutical
Prior art date
Application number
NO20042905A
Other languages
English (en)
Other versions
NO336943B1 (no
Inventor
William H Bosch
Elaine Liversidge
Suhas D Shelukar
Karen C Thompson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23331619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20042905(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20042905L publication Critical patent/NO20042905L/no
Publication of NO336943B1 publication Critical patent/NO336943B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20042905A 2001-12-10 2004-07-09 Farmasøytisk nanopartikkelpreparat av en takykininreseptorantagonist NO336943B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34004001P 2001-12-10 2001-12-10
PCT/US2002/041655 WO2003049718A1 (en) 2001-12-10 2002-12-09 Pharmaceutical nanoparticulate composition of a tachykinin receptor antagonist

Publications (2)

Publication Number Publication Date
NO20042905L true NO20042905L (no) 2004-09-10
NO336943B1 NO336943B1 (no) 2015-11-30

Family

ID=23331619

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20042905A NO336943B1 (no) 2001-12-10 2004-07-09 Farmasøytisk nanopartikkelpreparat av en takykininreseptorantagonist

Country Status (39)

Country Link
US (1) US8258132B2 (no)
EP (1) EP1455756B2 (no)
JP (1) JP4532114B2 (no)
KR (1) KR20040063991A (no)
CN (1) CN100352443C (no)
AR (1) AR037713A1 (no)
AT (1) ATE400254T1 (no)
AU (1) AU2002360824B8 (no)
BR (1) BRPI0214786B8 (no)
CA (1) CA2469315C (no)
CO (1) CO5590887A2 (no)
CY (1) CY1108354T1 (no)
DE (1) DE60227556D1 (no)
DK (1) DK1455756T4 (no)
DO (1) DOP2002000542A (no)
EA (1) EA007332B1 (no)
EC (1) ECSP045144A (no)
ES (1) ES2307820T5 (no)
GE (1) GEP20063875B (no)
HK (1) HK1078017A1 (no)
HR (1) HRP20040532B1 (no)
HU (1) HU230736B1 (no)
IL (3) IL162296A0 (no)
IS (1) IS2991B (no)
JO (1) JO3060B1 (no)
ME (1) ME00450B (no)
MX (1) MXPA04005563A (no)
MY (1) MY155911A (no)
NO (1) NO336943B1 (no)
NZ (1) NZ534009A (no)
PE (1) PE20030641A1 (no)
PL (1) PL211243B6 (no)
PT (1) PT1455756E (no)
RS (1) RS52280B (no)
SI (1) SI1455756T2 (no)
TW (1) TWI249403B (no)
UA (1) UA76810C2 (no)
WO (1) WO2003049718A1 (no)
ZA (1) ZA200404012B (no)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100356871C (zh) * 2002-02-22 2007-12-26 味之素株式会社 氨基酸粉末及其制备方法
AR045142A1 (es) * 2003-07-30 2005-10-19 Novartis Ag Composicion veterinaria masticable ductil de buen sabor
US20090004277A1 (en) * 2004-05-18 2009-01-01 Franchini Miriam K Nanoparticle dispersion containing lactam compound
EA013433B1 (ru) * 2005-02-15 2010-04-30 Элан Фарма Интернэшнл Лтд. Аэрозольные и впрыскиваемые рецептуры лекарственных препаратов бензодиазепина, состоящего из наночастиц
WO2007016582A2 (en) * 2005-07-29 2007-02-08 Dr. Reddy's Laboratories Ltd. Amorphous aprepitant coprecipitates
CA2631233C (en) 2005-11-28 2011-11-08 Marinus Pharmaceuticals Ganaxolone formulations and methods for the making and use thereof
US9227958B2 (en) * 2006-02-03 2016-01-05 Glenmark Pharmaceuticals Limited Amorphous and crystalline forms of aprepitant and processes for the preparation thereof
US20090209541A1 (en) * 2006-06-16 2009-08-20 Dr. Reddy's Laboratories Ltd. Aprepitant compositions
WO2008026216A2 (en) * 2006-08-28 2008-03-06 Hetero Drugs Limited Process for purification of aprepitant
CA2669815A1 (en) 2006-11-28 2008-06-05 Marinus Pharmaceuticals Nanoparticulate formulations and methods for the making and use thereof
EP2134327A1 (en) * 2007-03-13 2009-12-23 Sandoz AG Pharmaceutical compositions of poorly soluble drugs
EP1970057A1 (en) * 2007-03-13 2008-09-17 Sandoz AG Process for the preparation of stable pharmaceutical compositions of 2-(R) - (1-(R)-(3, 5- bis (trifluoromethyl) phenyl) ethoxy)-3-(S)-(4-fluoro) phenyl-4-(3-(5-oxo-1H, 4H-1, 2, 4-triazolo) methylmorpholine (aprepitant)
WO2009108828A2 (en) * 2008-02-27 2009-09-03 Dr. Reddy's Laboratories Ltd. Solubility-enhanced forms of aprepitant and pharmaceutical compositions thereof
WO2009116081A2 (en) * 2008-03-03 2009-09-24 Msn Laboratories Limited An improved process for the preparation of aprepitant
WO2010076596A1 (en) * 2008-12-30 2010-07-08 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Pharmaceutical formulations of olmesartan
JP5661748B2 (ja) * 2009-05-15 2015-01-28 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ 製造プロセスを制御するための熱画像の利用
HUP1000325A2 (en) 2010-06-18 2012-01-30 Druggability Technologies Ip Holdco Jersey Ltd Nanostructured aprepitant compositions and process for their preparation
US9040091B2 (en) * 2012-03-22 2015-05-26 Nanotherapeutics, Inc. Compositions and methods for oral delivery of encapsulated diethylenetriaminepentaacetate particles
SG10201610869TA (en) 2012-06-26 2017-02-27 Del Mar Pharmaceuticals Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalacti
JP2016522251A (ja) 2013-06-20 2016-07-28 グレンマーク ファーマシューティカルズ， エセ．アー． Ｔｒｐａ１アンタゴニストを含むナノ粒子製剤
WO2015013579A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
CN104367551B (zh) * 2013-08-15 2017-06-13 上海星泰医药科技有限公司 一种阿瑞匹坦复合物及其制备方法
ES2750246T3 (es) * 2013-10-08 2020-03-25 Innopharma Inc Formulaciones liquidas orales de aprepitant
EP2893919B1 (en) 2014-01-09 2017-07-12 Sanofi Formulation of aprepitant with enhanced solubility
DE102014004512A1 (de) * 2014-03-28 2015-10-01 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Bereich Universitätsmedizin Anorganisch-organische Hybridverbindung
SI3174535T1 (sl) 2014-08-01 2019-06-28 Glenmark Pharmaceuticals S.A. Formulacija nanodelcev, obsegajoča MPGES-1 inhibitor
KR101492572B1 (ko) * 2015-01-14 2015-02-11 주식회사 대웅제약 신규 약학 조성물
US10780099B2 (en) 2015-10-16 2020-09-22 Marinus Pharmaceuticals, Inc. Injectable neurosteroid formulations containing nanoparticles
GR1009002B (el) * 2016-03-22 2017-03-31 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Φαρμακευτικο σκευασμα περιεχον εναν αντιεμετικο παραγοντα και μεθοδος για την παρασκευη αυτου
CN119112906A (zh) 2016-08-11 2024-12-13 奥维德医疗公司 用于治疗癫痫性紊乱的方法和组合物
US10391105B2 (en) 2016-09-09 2019-08-27 Marinus Pharmaceuticals Inc. Methods of treating certain depressive disorders and delirium tremens
GR1009209B (el) * 2016-11-17 2018-02-05 Φαρματεν Αβεε Φαρμακευτικο σκευασμα περιεχον εναν αντιεμετικο παραγοντα και μεθοδος για την παρασκευη αυτου
CN106377517A (zh) * 2016-11-25 2017-02-08 遵义医学院 银杏内酯‑pvp纳米粒及其制备方法
CN107260705A (zh) * 2017-06-08 2017-10-20 武汉励合生物医药科技有限公司 一种阿瑞匹坦纳米胶囊的制备方法
EP3658123A4 (en) 2017-07-24 2021-04-28 Acryspharm LLC PHARMACEUTICAL COMPOSITIONS WITH HIGH ACTIVE INGREDIENT LOAD
JP2019073445A (ja) * 2017-10-12 2019-05-16 日本化薬株式会社 アプレピタントを有効成分とする医薬組成物
CN108066745A (zh) * 2017-12-26 2018-05-25 兆科药业（广州）有限公司 一种环孢素眼凝胶的处理工艺
EP3735222A1 (en) 2018-02-20 2020-11-11 FTF Pharma Private Limited Liquid compositions of aprepitant
WO2019191391A1 (en) * 2018-03-28 2019-10-03 The Regents Of The University Of Colorado, A Body Corporate Treatment and prevention of alpha herpes virus infection
US11266662B2 (en) 2018-12-07 2022-03-08 Marinus Pharmaceuticals, Inc. Ganaxolone for use in prophylaxis and treatment of postpartum depression
CN110478316A (zh) * 2019-02-27 2019-11-22 江西中医药大学 一种阿瑞吡坦纳米结晶混悬剂及其制备方法和应用
JP2022543837A (ja) 2019-08-05 2022-10-14 マリナス ファーマシューティカルズ， インコーポレイテッド てんかん重積状態の治療に使用するためのガナキソロン
WO2021113834A1 (en) 2019-12-06 2021-06-10 Marinus Pharmaceuticals, Inc. Ganaxolone for use in treating tuberous sclerosis complex
EP3915546A1 (de) 2020-05-25 2021-12-01 Leon-Nanodrugs GmbH Verwendung von säure als lösungsmittel für präzipitationen
CN116077462A (zh) * 2022-12-01 2023-05-09 北京诺康达医药科技股份有限公司 阿瑞匹坦微丸及其制备方法和包含它的制剂

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096742A (en) 1990-01-09 1992-03-17 Hoechst Celanese Corporation High temperature, high humidity stabilization process for optical information storage media containing polycarbonate substrates
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5552160A (en) * 1991-01-25 1996-09-03 Nanosystems L.L.C. Surface modified NSAID nanoparticles
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US6048859A (en) * 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
US5591456A (en) † 1995-02-10 1997-01-07 Nanosystems L.L.C. Milled naproxen with hydroxypropyl cellulose as a dispersion stabilizer
US5573783A (en) * 1995-02-13 1996-11-12 Nano Systems L.L.C. Redispersible nanoparticulate film matrices with protective overcoats
US5718919A (en) * 1995-02-24 1998-02-17 Nanosystems L.L.C. Nanoparticles containing the R(-)enantiomer of ibuprofen
NZ333062A (en) * 1996-06-26 2000-06-23 Warner Lambert Co Use of [R,S]-[2-(1H-indol-3-yl)-1-methyl-1-(1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2yl methyl ester in the treatment of emesis
WO1998035666A1 (en) * 1997-02-13 1998-08-20 Nanosystems Llc Formulations of nanoparticle naproxen tablets
US6045829A (en) * 1997-02-13 2000-04-04 Elan Pharma International Limited Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers
ZA985765B (en) * 1997-07-02 1999-08-04 Merck & Co Inc Polymorphic form of a tachykinin receptor antagonist.
GB9813025D0 (en) 1998-06-16 1998-08-12 Merck Sharp & Dohme Chemical synthesis
WO2000010545A2 (en) † 1998-08-25 2000-03-02 Novartis Ag Use of substance p antagonists for the treatment of chronic fatigue syndrome and/or fibromyalgia and use of nk-1 receptor antagonists for the treatment of chronic fatigue syndrome
US6165506A (en) * 1998-09-04 2000-12-26 Elan Pharma International Ltd. Solid dose form of nanoparticulate naproxen
US5997905A (en) 1998-09-04 1999-12-07 Mcneil-Ppc Preparation of pharmaceutically active particles
US6375986B1 (en) * 2000-09-21 2002-04-23 Elan Pharma International Ltd. Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate
US6267989B1 (en) † 1999-03-08 2001-07-31 Klan Pharma International Ltd. Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions
US6255545B1 (en) 1999-06-11 2001-07-03 Merck & Co., Inc. Process for the synthesis of 3,5-bis(trifluoromethyl)-bromobenzene
US6350915B1 (en) 1999-06-11 2002-02-26 Merck & Co., Inc. Process for the synthesis of 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one
US20070179367A1 (en) * 2000-05-02 2007-08-02 Ruchti Timothy L Method and Apparatus for Noninvasively Estimating a Property of an Animal Body Analyte from Spectral Data
US7801591B1 (en) * 2000-05-30 2010-09-21 Vladimir Shusterman Digital healthcare information management
EP1292583A4 (en) 2000-06-08 2004-02-25 Merck & Co Inc METHOD FOR PRODUCING (2R, 2-ALPHA-R) -4-BENZYL-2- 1- (3,5-BIS (TRIFLUOROMETHYL) PHENYL) ETHOXY] -1,4-OXAZIN-3-ON
US7778680B2 (en) * 2003-08-01 2010-08-17 Dexcom, Inc. System and methods for processing analyte sensor data

Also Published As

Publication number Publication date
DE60227556D1 (de) 2008-08-21
AU2002360824A1 (en) 2003-06-23
IS2991B (is) 2017-12-15
JO3060B1 (ar) 2017-03-15
RS52280B (en) 2012-10-31
CN100352443C (zh) 2007-12-05
EA200400794A1 (ru) 2004-10-28
EP1455756B1 (en) 2008-07-09
US8258132B2 (en) 2012-09-04
HRP20040532A2 (en) 2004-10-31
DK1455756T3 (da) 2008-11-17
HU230736B1 (hu) 2018-01-29
NO336943B1 (no) 2015-11-30
PL369887A1 (en) 2005-05-02
TWI249403B (en) 2006-02-21
IL201658A0 (en) 2011-08-01
CA2469315C (en) 2008-12-02
RS50404A (en) 2007-04-10
BRPI0214786B1 (pt) 2018-11-27
BR0214786A (pt) 2004-11-09
BRPI0214786B8 (pt) 2021-05-25
MXPA04005563A (es) 2004-12-06
EA007332B1 (ru) 2006-08-25
PT1455756E (pt) 2008-10-16
KR20040063991A (ko) 2004-07-15
AR037713A1 (es) 2004-12-01
CN1617712A (zh) 2005-05-18
HRP20040532B1 (en) 2012-09-30
CO5590887A2 (es) 2005-12-30
DK1455756T4 (en) 2016-01-04
CY1108354T1 (el) 2012-05-23
HUP0402596A2 (hu) 2005-03-29
JP2005516003A (ja) 2005-06-02
TW200301125A (en) 2003-07-01
SI1455756T2 (sl) 2016-01-29
HK1078017A1 (en) 2006-03-03
CA2469315A1 (en) 2003-06-19
HUP0402596A3 (en) 2011-05-30
US20040214746A1 (en) 2004-10-28
PL211243B6 (pl) 2023-01-23
ES2307820T3 (es) 2008-12-01
ES2307820T5 (es) 2016-01-13
DOP2002000542A (es) 2003-07-15
ATE400254T1 (de) 2008-07-15
AU2002360824B2 (en) 2008-05-08
ME00450B (me) 2011-10-10
NZ534009A (en) 2006-03-31
SI1455756T1 (sl) 2008-12-31
EP1455756A1 (en) 2004-09-15
IL162296A (en) 2013-11-28
GEP20063875B (en) 2006-07-10
IS7276A (is) 2004-05-21
EP1455756B2 (en) 2015-09-23
ZA200404012B (en) 2005-10-26
WO2003049718A1 (en) 2003-06-19
ECSP045144A (es) 2004-07-23
IL162296A0 (en) 2005-11-20
MY155911A (en) 2015-12-15
AU2002360824B8 (en) 2008-05-22
PL211243B1 (pl) 2012-04-30
UA76810C2 (uk) 2006-09-15
JP4532114B2 (ja) 2010-08-25
PE20030641A1 (es) 2003-07-23

Similar Documents

Publication Publication Date Title
NO20042905L (no) Farmasoytisk nanopartikkelpreparat av en takykinin reseptor antagonist
NO20033143L (no) Farmasoytisk preparat
NO20033343D0 (no) Farmasöytiske doseringsformer av epothiloner for oral administrasjon
NO20034689D0 (no) Farmasöytiske doseringsformer av amorf nelfinavir mesylat
ATE407125T1 (de) Pharmazeutische zusammenstellungen aus tachykinin antagonisten und einen serotonin-wiederaufname hemmer
NO20030418D0 (no) Nytt farmasöytisk preparat
EE200300284A (et) NMDA-retseptori agonisti farmatseutilised kompositsioonid
NO20032517L (no) Farmasöytisk preparat inneholdende amlodipinmaleat
DK200300344U4 (da) Farmaceutisk præparat indeholdende amlodipinmaleat
NO20033042L (no) Cyklodekstrin-inneholdende farmasöytisk preparat
NO20014738D0 (no) Tolperisonholdig farmasöytisk preparat for oral administrering
DE60329755D1 (de) Basische nichtpeptid-bradykinin-antagonisten und pharmazeutische zusammensetzungen daraus
IS8188A (is) Lyfjablanda sem felur í sér P2X7 viðtakamótlyf ogæxlisdrepboða a
NO20025805L (no) Farmasöytisk preparat
ATE370114T1 (de) Zwitterionische tachykinin-rezeptor-antagonisten
DK200300348U1 (da) Fast farmaceutisk dosisform omfattende amlodipinmaleat
NO20043007L (no) Farmasoytisk suspensjon for oral administrering
NO20033162L (no) Farmasöytisk tablett omfattende paroksetinmesylat
HK1063182A1 (en) A process for the preparation of 5-ht2a receptor antagonists and salts thereof
EP1421953A4 (en) MEDICINAL COMPOSITIONS CONTAINING AN ANGIOTENSIN II RECEPTOR ANTAGONIST
SI1390063T1 (en) Pharmaceutical dosage form of amorphous nelfinavir mesylate

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: MERCK SHARP & DOHME LLC, US

MK1K Patent expired