NO20035104L - Imidazo [1.5-A] pyrimido [5,4-D] benzazepin-derivater som GABA A reseptor-modulatorer - Google Patents

Imidazo [1.5-A] pyrimido [5,4-D] benzazepin-derivater som GABA A reseptor-modulatorer

Info

Publication number: NO20035104L
Authority: NO; Norway
Prior art keywords: pyrimido; gaba; imidazo; receptor modulators; benzazepine derivatives
Prior art date: 2001-05-18

Application number

NO20035104A

Other languages

English (en)

Norwegian (no)

Other versions

NO20035104D0 (no

Inventor

Raffaello Masciadri

Andrew William Thomas

Juergen Wichmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-18

Filing date

2003-11-17

Publication date

2003-11-17

2003-11-17 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-11-17 Publication of NO20035104L publication Critical patent/NO20035104L/no

2003-11-17 Publication of NO20035104D0 publication Critical patent/NO20035104D0/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

NO20035104A 2001-05-18 2003-11-17 Imidazo [1.5-A] pyrimido [5,4-D] benzazepin-derivater som GABA A reseptor-modulatorer NO20035104D0 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01112222		2001-05-18
PCT/EP2002/005121 WO2002094834A1 (en)	2001-05-18	2002-05-08	Imidazo [1,5-a] pyrimido [5,4-d] benzazepine derivatives as gaba a receptor modulators

Publications (2)

Publication Number	Publication Date
NO20035104L true NO20035104L (no)	2003-11-17
NO20035104D0 NO20035104D0 (no)	2003-11-17

Family

ID=8177471

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20035104A NO20035104D0 (no)	2001-05-18	2003-11-17	Imidazo [1.5-A] pyrimido [5,4-D] benzazepin-derivater som GABA A reseptor-modulatorer

Country Status (37)

Country	Link
US (1)	US6686352B2 (cs)
EP (1)	EP1399448B1 (cs)
JP (1)	JP4068466B2 (cs)
KR (1)	KR100533406B1 (cs)
CN (1)	CN1230436C (cs)
AR (1)	AR033753A1 (cs)
AT (1)	ATE283857T1 (cs)
AU (1)	AU2002338898B2 (cs)
BG (1)	BG108369A (cs)
BR (1)	BR0209859A (cs)
CA (1)	CA2446903C (cs)
CZ (1)	CZ20033355A3 (cs)
DE (1)	DE60202147T2 (cs)
DK (1)	DK1399448T3 (cs)
EC (1)	ECSP034851A (cs)
ES (1)	ES2232778T3 (cs)
GT (1)	GT200200087A (cs)
HR (1)	HRP20030890A2 (cs)
HU (1)	HUP0400743A3 (cs)
IL (2)	IL158572A0 (cs)
JO (1)	JO2297B1 (cs)
MA (1)	MA27024A1 (cs)
MX (1)	MXPA03010529A (cs)
MY (1)	MY127570A (cs)
NO (1)	NO20035104D0 (cs)
NZ (1)	NZ529097A (cs)
PA (1)	PA8545201A1 (cs)
PE (1)	PE20030041A1 (cs)
PL (1)	PL366846A1 (cs)
PT (1)	PT1399448E (cs)
RU (1)	RU2287531C2 (cs)
SI (1)	SI1399448T1 (cs)
SK (1)	SK15252003A3 (cs)
TW (1)	TWI251489B (cs)
WO (1)	WO2002094834A1 (cs)
YU (1)	YU90003A (cs)
ZA (1)	ZA200308544B (cs)

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EP2719698B1 (en)	2004-05-14	2016-10-05	Millennium Pharmaceuticals, Inc.	Methods for preparing aurora kinase inhibitors
JP5002460B2 (ja) *	2004-10-04	2012-08-15	ミレニアムファーマシューティカルズ，インコーポレイテッド	タンパク質キナーゼインヒビターとして有用なラクタム化合物
CN101084220B (zh) *	2004-10-20	2010-12-15	弗·哈夫曼-拉罗切有限公司	卤素取代的苯并二氮杂*衍生物
RU2007112940A (ru) *	2004-10-20	2008-11-27	Ф.Хоффманн-Ля Рош Аг (Ch)	Производные имидазобензодиазепина
EP1937688B1 (en) *	2005-10-11	2010-08-11	F. Hoffmann-La Roche AG	Imidazo benzodiazepine derivatives
PE20080145A1 (es) *	2006-03-21	2008-02-11	Janssen Pharmaceutica Nv	Tetrahidro-pirimidoazepinas como moduladores de trpv1
CL2007003244A1 (es)	2006-11-16	2008-04-04	Millennium Pharm Inc	Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
US8288397B2 (en)	2007-12-17	2012-10-16	Janssen Pharmaceutica Nv	Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1
CN101735211B (zh) *	2008-11-04	2012-11-14	复旦大学	2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
WO2010065134A1 (en) *	2008-12-05	2010-06-10	Millennium Pharmaceuticals, Inc.	5, 7-dihydro- 6h-pyrimido [ 5, 4-d] [ 1 ] benzazepin-6-thiones as plk inhibitors
EP2376082B1 (en)	2008-12-22	2014-03-05	Millennium Pharmaceuticals, Inc.	Combination of aurora kinase inhibitors and anti-cd20 antibodies
JO3635B1 (ar)	2009-05-18	2020-08-27	Millennium Pharm Inc	مركبات صيدلانية صلبة وطرق لانتاجها
JP2013520424A (ja)	2010-02-19	2013-06-06	ミレニアムファーマシューティカルズ，インコーポレイテッド	ナトリウム４−｛［９−クロロ−７−（２−フルオロ−６−メトキシフェニル）−５Ｈ−ピリミド［５，４−ｄ］［２］ベンゾアゼピン−２−イル］アミノ｝−２−メトキシベンゾエートの結晶形
CN101891706B (zh) *	2010-04-09	2013-05-29	复旦大学	3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CN102424670A (zh) *	2011-10-31	2012-04-25	江苏阿尔法药业有限公司	一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain
US20130303519A1 (en)	2012-03-20	2013-11-14	Millennium Pharmaceuticals, Inc.	Methods of treating cancer using aurora kinase inhibitors
WO2014153509A1 (en)	2013-03-22	2014-09-25	Millennium Pharmaceuticals, Inc.	Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase
US10329301B2 (en)	2013-12-20	2019-06-25	Agenebio, Inc.	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EA036844B1 (ru)	2015-06-19	2020-12-28	Эйджинбайо, Инк.	Производные бензодиазепина, композиции и способы для лечения когнитивного нарушения
EP3324976A4 (en)	2015-07-21	2019-03-27	Millennium Pharmaceuticals, Inc.	ADMINISTRATION OF KINASE AURORA INHIBITOR AND CHEMOTHERAPEUTIC AGENTS
BR112019012821A2 (pt)	2016-12-19	2019-11-26	Agenebio Inc	derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
JP7514534B2 (ja)	2018-06-19	2024-07-11	エージンバイオ，インコーポレイテッド	認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
CN110452172B (zh) *	2019-08-21	2021-03-26	爱斯特（成都）生物制药股份有限公司	一种苯并己内酰胺的合成方法
CN112159411A (zh) *	2020-10-15	2021-01-01	南京工业大学	一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法

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FR2607503B1 (fr) *	1986-12-02	1989-02-24	Rhone Poulenc Sante	Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
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RU2119496C1 (ru) *	1992-04-14	1998-09-27	Научно-исследовательский институт фармакологии Российской академии медицинских наук	Производные n-ацилпролилдипептидов
FR2728902B1 (fr) *	1994-12-29	1997-01-31	Synthelabo	Derives d'acide 8-oxo-5,8-dihydro-6h-dibenzo(a,g)quinolizine-13-propanoique, leur preparation et leur application en therapeutique
WO1999043682A1 (en) *	1998-02-26	1999-09-02	Neurogen Corporation	2-(het-)aryl-4-(cyclic amino substituted) heteroaryl fused pyridine derivatives, their preparation and their use as (ant-)agonists for gaba (a) brain receptors
US6177569B1 (en) *	1998-08-25	2001-01-23	Neurogen Corporation	Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
FR2783828B1 (fr)	1998-09-29	2000-11-10	Synthelabo	Derives d'acide 5,6-dihydro-4h-imidazo[1,2-a][1] benzazepine -1-acetique, leur preparation et leur application en therapeutique
BR0015420A (pt)	1999-11-12	2002-07-16	Neurogen Corp	Composto, composição farmacêutica, métodos de tratamento de uma doença ou de um distúrbio associados com agonismo patogênio, para a localização de receptores gabaa, em uma amostra de tecido, de inibição da ligação de um composto de benzodiazepina em um receptor gabaa, e de alteração da atividade de transdução de sinal de receptores gabaa, agonismo inverso ou antagonismo do receptor gabaa, uso de um composto, e , composição faramcêutica embalada
TWI239333B (en)	2000-11-16	2005-09-11	Hoffmann La Roche	Benzodiazepine derivatives as GABA A receptor modulators

2002
- 2002-04-09 US US10/118,584 patent/US6686352B2/en not_active Expired - Fee Related
- 2002-05-08 YU YU90003A patent/YU90003A/sh unknown
- 2002-05-08 DE DE60202147T patent/DE60202147T2/de not_active Expired - Lifetime
- 2002-05-08 KR KR10-2003-7015036A patent/KR100533406B1/ko not_active Expired - Fee Related
- 2002-05-08 CA CA002446903A patent/CA2446903C/en not_active Expired - Fee Related
- 2002-05-08 PL PL02366846A patent/PL366846A1/xx not_active Application Discontinuation
- 2002-05-08 SK SK1525-2003A patent/SK15252003A3/sk unknown
- 2002-05-08 IL IL15857202A patent/IL158572A0/xx unknown
- 2002-05-08 CN CNB028101774A patent/CN1230436C/zh not_active Expired - Fee Related
- 2002-05-08 EP EP02771640A patent/EP1399448B1/en not_active Expired - Lifetime
- 2002-05-08 WO PCT/EP2002/005121 patent/WO2002094834A1/en active IP Right Grant
- 2002-05-08 JP JP2002591507A patent/JP4068466B2/ja not_active Expired - Fee Related
- 2002-05-08 ES ES02771640T patent/ES2232778T3/es not_active Expired - Lifetime
- 2002-05-08 RU RU2003136078/04A patent/RU2287531C2/ru not_active IP Right Cessation
- 2002-05-08 HU HU0400743A patent/HUP0400743A3/hu unknown
- 2002-05-08 NZ NZ529097A patent/NZ529097A/en unknown
- 2002-05-08 BR BR0209859-8A patent/BR0209859A/pt not_active IP Right Cessation
- 2002-05-08 MX MXPA03010529A patent/MXPA03010529A/es active IP Right Grant
- 2002-05-08 PT PT02771640T patent/PT1399448E/pt unknown
- 2002-05-08 DK DK02771640T patent/DK1399448T3/da active
- 2002-05-08 SI SI200230055T patent/SI1399448T1/xx unknown
- 2002-05-08 AU AU2002338898A patent/AU2002338898B2/en not_active Ceased
- 2002-05-08 CZ CZ20033355A patent/CZ20033355A3/cs unknown
- 2002-05-08 HR HR20030890A patent/HRP20030890A2/xx not_active Application Discontinuation
- 2002-05-08 AT AT02771640T patent/ATE283857T1/de not_active IP Right Cessation
- 2002-05-14 JO JO200243A patent/JO2297B1/en active
- 2002-05-15 PA PA20028545201A patent/PA8545201A1/es unknown
- 2002-05-15 TW TW091110162A patent/TWI251489B/zh not_active IP Right Cessation
- 2002-05-16 AR ARP020101805A patent/AR033753A1/es not_active Application Discontinuation
- 2002-05-16 PE PE2002000413A patent/PE20030041A1/es not_active Application Discontinuation
- 2002-05-16 GT GT200200087A patent/GT200200087A/es unknown
- 2002-05-17 MY MYPI20021808A patent/MY127570A/en unknown
2003
- 2003-10-23 IL IL158572A patent/IL158572A/en not_active IP Right Cessation
- 2003-10-31 ZA ZA200308544A patent/ZA200308544B/en unknown
- 2003-11-14 MA MA27398A patent/MA27024A1/fr unknown
- 2003-11-17 NO NO20035104A patent/NO20035104D0/no not_active Application Discontinuation
- 2003-11-17 EC EC2003004851A patent/ECSP034851A/es unknown
- 2003-11-18 BG BG108369A patent/BG108369A/bg unknown

Also Published As

Publication number	Publication date
EP1399448B1 (en)	2004-12-01
RU2003136078A (ru)	2005-05-27
JP4068466B2 (ja)	2008-03-26
CN1509289A (zh)	2004-06-30
MY127570A (en)	2006-12-29
DK1399448T3 (da)	2005-04-11
EP1399448A1 (en)	2004-03-24
ECSP034851A (es)	2003-12-24
ZA200308544B (en)	2005-01-31
CN1230436C (zh)	2005-12-07
YU90003A (sh)	2006-08-17
ES2232778T3 (es)	2005-06-01
KR20040002975A (ko)	2004-01-07
CA2446903A1 (en)	2002-11-28
HUP0400743A2 (hu)	2004-07-28
US6686352B2 (en)	2004-02-03
CA2446903C (en)	2008-12-30
PA8545201A1 (es)	2003-02-28
ATE283857T1 (de)	2004-12-15
TWI251489B (en)	2006-03-21
MXPA03010529A (es)	2004-03-02
NZ529097A (en)	2005-04-29
AU2002338898B8 (en)	2002-12-03
IL158572A (en)	2010-02-17
PL366846A1 (en)	2005-02-07
BR0209859A (pt)	2004-06-15
DE60202147T2 (de)	2005-12-01
IL158572A0 (en)	2004-05-12
BG108369A (bg)	2005-01-31
KR100533406B1 (ko)	2005-12-02
MA27024A1 (fr)	2004-12-20
PE20030041A1 (es)	2003-02-07
HK1066544A1 (en)	2005-03-24
US20030055042A1 (en)	2003-03-20
HUP0400743A3 (en)	2007-09-28
HRP20030890A2 (en)	2005-08-31
PT1399448E (pt)	2005-03-31
GT200200087A (es)	2003-06-19
AU2002338898B2 (en)	2007-03-15
SK15252003A3 (sk)	2004-08-03
RU2287531C2 (ru)	2006-11-20
WO2002094834A1 (en)	2002-11-28
AR033753A1 (es)	2004-01-07
JO2297B1 (en)	2005-09-12
CZ20033355A3 (en)	2004-07-14
JP2004531563A (ja)	2004-10-14
SI1399448T1 (en)	2005-02-28
NO20035104D0 (no)	2003-11-17
DE60202147D1 (de)	2005-01-05

Publication	Publication Date	Title
NO20035104D0 (no)	2003-11-17	Imidazo [1.5-A] pyrimido [5,4-D] benzazepin-derivater som GABA A reseptor-modulatorer
DK1686130T3 (da)	2009-04-06	Pyrrolo-[2,3-d]-pyrimidinforbindelser som immunsuppressive midler
NO2017014I1 (no)	2017-04-19	6-acetyl-8-cyclopentyl-5-metyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-on
EP1599482A4 (en)	2008-10-01	PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
DE60016615D1 (de)	2005-01-13	Pyrazolo[4,3-d]pyrimidinderivate
DK1699795T3 (da)	2007-09-10	Substituerede 8'-pyri(mi)dinyldihydrospiro[cycloalkylamin]-pyrimido[1,2-a]pyrimidin-6-onderivater
DK1430056T3 (da)	2006-02-27	Substituerede 2-pyrimidinyl - 6,7,8,9-tetrahydropyrimido-[1,2-a]pyrimidin-4-on- og 7-pyrimidinyl-2,3-dihydroimidazo [1,2-a] pyrimidin-5 (1H) onderivater mod neurodegenerative lidelser
ZA200507192B (en)	2007-03-28	Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido [1,2-A] pyrimidin-4-one derivatives
SI1608654T1 (sl)	2010-04-30	8-subst.-6,7,8,9-tetrahidropirimido(1,2-a)pirimidin-4-onski derivati
ATE269333T1 (de)	2004-07-15	2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2- a)pyrimidin-4-on- und 7-pyridinyl-2,3- dihydroimidazo(1,2-a)pyrimidin-5 1honderivate
DE50001191D1 (de)	2003-03-06	Pyrazolo[4, 3-d]pyrimidine
AU2002224115A1 (en)	2002-06-11	1,4,5,6-tetrahydroimidazo(4,5-d)diazepine derivatives or salts thereof
AU2002338922A1 (en)	2003-05-12	Pyrimido (4,5-b) indole derivatives
HK1084664A (en)	2006-08-04	Pyrazolo [1,5-a] pyrimidine derivatives
AU2002228541A1 (en)	2002-08-12	Novel forms of 2,3-dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo (1,2-a)pyridine-6-carboxamide
AU2002226861A1 (en)	2002-08-12	Novel forms of 2,3-dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo (1,2-a)pyridine-6-carboxamide
AU2002228540A1 (en)	2002-08-12	Novel forms of 2,3-dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo (1,2-a)pyridine-6-carboxamide
ZA200202763B (en)	2003-06-25	Pyrazolo [4,3-D] pyrimidine derivatives.
HK1068632A (en)	2005-04-29	Pyrazolo[1,5-a]pyrimidine compounds as antiviral agents
AU2002325550A1 (en)	2003-03-18	(1,2,4)triazolo(1,5-a)pyrimidine derivative

Legal Events

Date	Code	Title	Description
2008-11-24	FC2A	Withdrawal, rejection or dismissal of laid open patent application