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MX2011011963A - Derivados de 7-aril-1,2,4-triazolo[4,3-a]piridina y uso como moduladores alostericos positivos de receptores de glutamato metabotropico (mglur2). - Google Patents

Derivados de 7-aril-1,2,4-triazolo[4,3-a]piridina y uso como moduladores alostericos positivos de receptores de glutamato metabotropico (mglur2).

Info

Publication number
MX2011011963A
MX2011011963A MX2011011963A MX2011011963A MX2011011963A MX 2011011963 A MX2011011963 A MX 2011011963A MX 2011011963 A MX2011011963 A MX 2011011963A MX 2011011963 A MX2011011963 A MX 2011011963A MX 2011011963 A MX2011011963 A MX 2011011963A
Authority
MX
Mexico
Prior art keywords
mglur2
triazolo
pyridine derivatives
positive allosteric
allosteric modulators
Prior art date
Application number
MX2011011963A
Other languages
English (en)
Inventor
Andres Avelino Trabanco-Suarez
Gregor James Macdonald
Jose Maria Cid-Nunez
Ana Isabel De Lucas Olivares
Original Assignee
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc
Publication of MX2011011963A publication Critical patent/MX2011011963A/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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Abstract

La presente invención se refiere a novedosos derivados de triazolo[4,3-a]piridina de Fórmula (I) (ver fórmula (I)) en donde todos los radicales son según lo definido en las reivindicaciones. Los compuestos de conformidad con la invención son moduladores alostéricos positivos del subtipo 2 receptor de glutamato metabotrópico ("mGluR2"), los cuales son útiles para el tratamiento o prevención de trastornos neurológicos y psiquiátricos con la disfunción de glutamato y enfermedades en las cuales el subtipo mGluR2 de receptores metabotrópicos está involucrado. La invención se refiere además a composiciones farmacéuticas que comprenden ese tipo de compuestos, a procesos para preparar estos compuestos y composiciones, y al uso de ese tipo de compuestos para la prevención o tratamiento de trastornos neurológicos y psiquiátricos y enfermedades en las cuales mGluR2 está involucrado.
MX2011011963A 2009-05-12 2010-05-11 Derivados de 7-aril-1,2,4-triazolo[4,3-a]piridina y uso como moduladores alostericos positivos de receptores de glutamato metabotropico (mglur2). MX2011011963A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09160064 2009-05-12
PCT/EP2010/002909 WO2010130423A1 (en) 2009-05-12 2010-05-11 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors

Publications (1)

Publication Number Publication Date
MX2011011963A true MX2011011963A (es) 2012-03-14

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MX2011011963A MX2011011963A (es) 2009-05-12 2010-05-11 Derivados de 7-aril-1,2,4-triazolo[4,3-a]piridina y uso como moduladores alostericos positivos de receptores de glutamato metabotropico (mglur2).

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US (2) US8716480B2 (es)
EP (1) EP2430021B1 (es)
JP (1) JP5707391B2 (es)
KR (1) KR20120039532A (es)
CN (1) CN102439009B (es)
AR (1) AR076860A1 (es)
AU (1) AU2010246608B2 (es)
CA (1) CA2760084C (es)
CL (1) CL2011002839A1 (es)
EA (1) EA020556B1 (es)
ES (1) ES2428401T3 (es)
HK (1) HK1166784A1 (es)
IL (1) IL215911A (es)
MX (1) MX2011011963A (es)
MY (1) MY153913A (es)
NZ (1) NZ595945A (es)
SG (1) SG175931A1 (es)
TW (1) TW201100415A (es)
WO (1) WO2010130423A1 (es)
ZA (1) ZA201107833B (es)

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TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
BRPI0817101A2 (pt) 2007-09-14 2017-05-09 Addex Pharmaceuticals Sa 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas
CA2698929C (en) 2007-09-14 2016-01-19 Addex Pharma S.A. 1,3-disubstituted-4-phenyl-1h-pyridin-2-ones
CN103342695B (zh) 2007-09-14 2015-04-22 杨森制药有限公司 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮
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