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HRP20210246T1 - Pripravci koji sadrže bakterijske sojeve - Google Patents

Pripravci koji sadrže bakterijske sojeve Download PDF

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Publication number
HRP20210246T1
HRP20210246T1 HRP20210246TT HRP20210246T HRP20210246T1 HR P20210246 T1 HRP20210246 T1 HR P20210246T1 HR P20210246T T HRP20210246T T HR P20210246TT HR P20210246 T HRP20210246 T HR P20210246T HR P20210246 T1 HRP20210246 T1 HR P20210246T1
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Croatia
Prior art keywords
preparation
use according
bacterial strain
treatment
disease
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HRP20210246TT
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English (en)
Inventor
George Grant
Angela Margaret PATTERSON
Imke MULDER
Seanin MCCLUSKEY
Emma RAFTIS
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4D Pharma Research Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1510469.8A external-priority patent/GB201510469D0/en
Priority claimed from GBGB1520628.7A external-priority patent/GB201520628D0/en
Priority claimed from GBGB1604566.8A external-priority patent/GB201604566D0/en
Application filed by 4D Pharma Research Limited filed Critical 4D Pharma Research Limited
Publication of HRP20210246T1 publication Critical patent/HRP20210246T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
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    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
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Claims (16)

1. Pripravak, naznačen time, da sadrži bakterijski soj vrste Parabacteroides distasonis, za uporabu u postupku liječenja ili prevencije upalnih bolesti, pri čemu postupak obuhvaća unošenje pripravka u gastrointestinalni trakt.
2. Pripravak za uporabu prema patentnom zahtjevu 1, naznačen time, da upalna bolest nije upalna bolest crijeva.
3. Pripravak za uporabu prema patentnom zahtjevu 1 ili 2, naznačen time, da je pripravak za uporabu u postupku liječenja ili prevencije upalne bolesti koja se odabire iz skupine koju čine astma; artritis; multipla skleroza; neuromyelitis optica (Devicova bolest), ankilozni spondilitis; spondiloartritis; psorijaza; sistemski eritemski lupus; kronična opstruktivna plućna bolest (KOPB); uveitis; skleritis; vaskulitis; Behcetova bolest; ateroskleroza; atopijski dermatitis; emfizem; periodontitis; alergijski rinitis; i odbacivanje alogenog presatka.
4. Pripravak za uporabu prema patentnom zahtjevu 3, naznačen time, da je pripravak za uporabu u postupku liječenja ili prevencije upalne bolesti koja se odabire iz skupine koju čine astma, artritis, multipla skleroza i uveitis.
5. Pripravak za uporabu prema patentnom zahtjevu 4, naznačen time, da je pripravak za uporabu u postupku liječenja ili prevencije astme, kao što je neutrofilna astma ili alergijska astma, gdje je opcionalno pripravak za uporabu u postupku smanjivanja neutrofilije ili eozinofilije kod liječenja astme.
6. Pripravak za uporabu prema patentnom zahtjevu 4, naznačen time, da je pripravak za uporabu u postupku liječenja ili prevencije reumatoidnog artritisa, gdje je opcionalno pripravak za uporabu u postupku smanjivanja oteklina zglobova kod reumatoidnog artritisa.
7. Pripravak za uporabu prema patentnom zahtjevu 4, naznačen time, da je pripravak za uporabu u postupku liječenja ili prevencije multiple skleroze, gdje je opcionalno pripravak za uporabu u postupku smanjivanja incidencije bolesti ili ozbiljnosti bolesti.
8. Pripravak za uporabu prema patentnom zahtjevu 4, naznačen time, da je pripravak za uporabu u postupku liječenja ili prevencije upalne bolesti dok upalna bolest jest uveitis, opcionalno time, da je pripravak za uporabu u postupku smanjivanja ili sprečavanje oštećenja mrežnice kod uveitisa.
9. Pripravak za uporabu prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da je pripravak za uporabu kod pacijenta s povišenim IL-17-razinama ili Th17-stanicama, i/ili time, da je pripravak za uporabu u postupku smanjivanja proizvodnje IL-17 ili smanjivanja Th17-stanične diferencijacije kod liječenja ili prevencije upalne bolesti.
10. Pripravak za uporabu prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da bakterijski soj posjeduje 16s rRNA slijed koji je najmanje 95%, 96%, 97%, 98%, 99%, 99,5% ili 99,9% istovjetan sljedovima SEQ ID NO: 1, 2, 3, 4, 5, 6 ili 9, poželjno time, da bakterijski soj posjeduje 16s rRNA slijed koji je najmanje 95%, 96%, 97%, 98%, 99%, 99,5% ili 99,9% istovjetan slijedu SEQ ID NO: 9, još poželjnije pritom bakterijski soj posjeduje 16s rRNA slijed koji je predstavljen sa SEQ ID NO: 9, te najpoželjnije gdje je bakterijski soj Parabacteroides distasonis soj koji je deponiran pod pristupnim brojem NCIMB 42382.
11. Pripravak za uporabu prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da je pripravak za oralnu primjenu, i/ili time, da pripravak sadrži jednu ili više farmaceutski prihvatljivih pomoćnih tvari ili nosača, i/ili time, da se bakterijski soj liofilizira.
12. Pripravak za uporabu prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da postupak obuhvaća davanje pripravka oralno u gastrointestinalni trakt; preko sonde, kao što je nazogastrična sonda, orogastrična sonda, gastrična sonda, jejunostomska sonda (J sonda), perkutana endoskopska gastrostomija (PEG); ili kao port kateter, primjerice preko port katetera u stijenku grudnog koša; poželjno gdje postupak obuhvaća unošenje pripravka oralnim putem u gastrointestinalni trakt.
13. Prehrambeni proizvod ili pripravak cjepiva, naznačen time, da sadrži pripravak prema bilo kojem od patentnih zahtjeva 1, ili 7 do 12, za uporabu prema bilo kojem od patentnih zahtjeva 1, ili 7 do 12.
14. Pripravak, naznačen time, da sadrži bakterijski soj Parabacteroides distasonis, koji posjeduje 16s rRNA slijed koji je najmanje 99,5% istovjetan slijedu SEQ ID NO: 9, za uporabu u liječenju, pri čemu liječenje obuhvaća unošenje pripravka u gastrointestinalni trakt.
15. Pripravak za uporabu prema patentnom zahtjevu 14, naznačen time, da bakterijski soj posjeduje 16s rRNA slijed koji je najmanje 99,9% istovjetan slijedu SEQ ID NO: 9, poželjno time, da bakterijski soj posjeduje 16s rRNA slijed koji je predstavljen sa SEQ ID NO: 9, još poželjnije gdje je bakterijski soj Parabacteroides distasonis soj koji je deponiran pod pristupnim brojem NCIMB 42382.
16. Pripravak za uporabu prema patentnom zahtjevu 14 ili 15, naznačen time, da je pripravak za oralnu primjenu, i/ili time, da pripravak sadrži jednu ili više farmaceutski prihvatljivih pomoćnih tvari ili nosača, i/ili se bakterijski soj liofilizira; opcionalno gdje je pripravak za uporabu u postupku prema definiciji u bilo kojem od patentnih zahtjeva 1, ili 7 do 9.
HRP20210246TT 2015-06-15 2021-02-12 Pripravci koji sadrže bakterijske sojeve HRP20210246T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1510469.8A GB201510469D0 (en) 2015-06-15 2015-06-15 Compostions comprising bacterial strains
GBGB1520628.7A GB201520628D0 (en) 2015-11-23 2015-11-23 Compositions comprising bacterial strains
GBGB1604566.8A GB201604566D0 (en) 2016-03-17 2016-03-17 Compositions comprising bacterial strains
EP18167277.5A EP3369425B1 (en) 2015-06-15 2016-06-15 Compositions comprising bacterial strains

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HRP20210246T1 true HRP20210246T1 (hr) 2021-05-28

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HRP20192057TT HRP20192057T1 (hr) 2015-06-15 2016-06-15 Sastavi koji sadrže bakterijske sojeve
HRP20200702TT HRP20200702T1 (hr) 2015-06-15 2020-04-30 Sastavi koji sadrže bakterijske sojeve
HRP20210246TT HRP20210246T1 (hr) 2015-06-15 2021-02-12 Pripravci koji sadrže bakterijske sojeve

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