HRP20030276B1 - Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament - Google Patents

Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Info

Publication number: HRP20030276B1
Authority: HR; Croatia
Prior art keywords: medicament; producing; production; same; crystalline monohydrate
Prior art date: 2000-10-12

Application number

HR20030276A

Other languages

English (en)

Croatian (hr)

Inventor

Banholzer Rolf

Sieger Peter

Kulinna Christian

Trunk Michael

Ludwig August Graulich Manfred

Specht Peter

Meissner Helmut

Mathes Andreas

Original Assignee

Boehringer Ingelheim Pharma Gmbh & Co. Kg.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-12

Filing date

2001-09-28

Publication date

2006-02-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20030276(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-09-28 Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg. filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg.

2005-02-28 Publication of HRP20030276A2 publication Critical patent/HRP20030276A2/hr

2006-02-28 Publication of HRP20030276B1 publication Critical patent/HRP20030276B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HR20030276A 2000-10-12 2001-09-28 Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament HRP20030276B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10050621		2000-10-12
PCT/EP2001/011225 WO2002030928A1 (de)	2000-10-12	2001-09-28	Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels

Publications (2)

Publication Number	Publication Date
HRP20030276A2 HRP20030276A2 (en)	2005-02-28
HRP20030276B1 true HRP20030276B1 (en)	2006-02-28

Family

ID=7659568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20030276A HRP20030276B1 (en)	2000-10-12	2001-09-28	Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Country Status (46)

Country	Link
EP (2)	EP1326862B1 (hu)
JP (1)	JP3764422B2 (hu)
KR (1)	KR100823860B1 (hu)
CN (2)	CN1221549C (hu)
AP (1)	AP1572A (hu)
AR (2)	AR034389A1 (hu)
AT (1)	ATE276253T1 (hu)
AU (2)	AU1499602A (hu)
BG (1)	BG66161B1 (hu)
BR (1)	BR0114584A (hu)
CA (1)	CA2425539C (hu)
CR (1)	CR6938A (hu)
CZ (1)	CZ301841B6 (hu)
DE (1)	DE50103666D1 (hu)
DK (1)	DK1326862T3 (hu)
DZ (1)	DZ3478A1 (hu)
EA (1)	EA004381B1 (hu)
EC (1)	ECSP034540A (hu)
EE (1)	EE04567B1 (hu)
EG (1)	EG24142A (hu)
ES (1)	ES2228965T3 (hu)
GE (1)	GEP20063905B (hu)
HR (1)	HRP20030276B1 (hu)
HU (1)	HU226830B1 (hu)
IL (2)	IL155335A0 (hu)
IS (1)	IS2339B (hu)
MA (1)	MA25842A1 (hu)
ME (2)	MEP40008A (hu)
MX (1)	MXPA03003221A (hu)
MY (1)	MY126931A (hu)
NO (1)	NO328465B1 (hu)
NZ (1)	NZ525733A (hu)
OA (1)	OA12403A (hu)
PE (1)	PE20020422A1 (hu)
PL (1)	PL207870B1 (hu)
PT (1)	PT1326862E (hu)
RS (1)	RS50218B (hu)
SA (1)	SA01220412B1 (hu)
SI (1)	SI1326862T1 (hu)
SK (1)	SK287009B6 (hu)
TR (1)	TR200402579T4 (hu)
TW (1)	TW589313B (hu)
UA (1)	UA74215C2 (hu)
UY (2)	UY26962A1 (hu)
WO (1)	WO2002030928A1 (hu)
ZA (1)	ZA200302500B (hu)

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US7311894B2 (en)	2002-03-28	2007-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations containing an anticholinergic
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DE10317461A1 (de)	2003-04-16	2004-10-28	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
CA2544352C (en) *	2003-11-03	2013-07-16	Boehringer Ingelheim International Gmbh	Crystalline anhydrate with anticholinergic effect
CN101407514B (zh) *	2003-11-03	2013-05-29	贝林格尔.英格海姆国际有限公司	噻托铵盐、包含噻托铵盐的药物制剂及其用途
US7968717B2 (en)	2003-11-03	2011-06-28	Boehringer Ingelhein International Gmbh	Crystalline anhydrate with anticholinergic efficacy
EP2322522A1 (de) *	2003-11-03	2011-05-18	Boehringer Ingelheim International Gmbh	Neue Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
DE102004016179A1 (de) *	2004-03-30	2005-10-20	Boehringer Ingelheim Pharma	Verbindungen zur Behandlung von proliferativen Prozessen
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US7220742B2 (en)	2004-05-14	2007-05-22	Boehringer Ingelheim International Gmbh	Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
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EP1827541B1 (de) *	2004-10-21	2013-05-29	Boehringer Ingelheim International GmbH	Blister für inhalatoren
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DE102005019201A1 (de)	2006-04-19	2006-11-02	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Verbindungen zur Behandlung von entzündlichen Erkrankungen
JP5053997B2 (ja)	2005-04-28	2012-10-24	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	炎症性疾患の治療用の新規化合物
KR20080007656A (ko) *	2005-05-02	2008-01-22	베링거 인겔하임 인터내셔날 게엠베하	티오트로피움 브로마이드의 신규한 결정질 형태
EP1881980B1 (en)	2005-05-02	2012-08-22	Boehringer Ingelheim International GmbH	Novel crystalline forms of tiotropium bromide
RU2418796C2 (ru) *	2005-06-15	2011-05-20	Берингер Ингельхайм Интернациональ Гмбх	Способ получения новых солей тиотропия
DE102005030733A1 (de)	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
RU2422144C2 (ru) *	2005-08-06	2011-06-27	Бёрингер Ингельхайм Интернациональ Гмбх	Применение солей тиотропия для лечения тяжелых форм персистирующей астмы
MX2008001976A (es)	2005-08-15	2008-03-25	Boehringer Ingelheim Int	Procedimiento para la preparacion de betamimeticos.
US20070086957A1 (en)	2005-10-10	2007-04-19	Thierry Bouyssou	Combination of medicaments for the treatment of respiratory diseases
US7423146B2 (en)	2005-11-09	2008-09-09	Boehringer Ingelheim International Gmbh	Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (de)	2005-12-14	2007-06-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Mikronisierung
CA2627729A1 (en) *	2005-12-19	2007-07-05	Sicor Inc.	Novel forms of tiotropium bromide and processes for preparation thereof
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EP1847543A1 (de)	2006-04-19	2007-10-24	Boehringer Ingelheim Pharma GmbH & Co. KG	Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
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WO2011015882A2 (en)	2009-08-07	2011-02-10	Generics [Uk] Limited	Novel anhydrate
JP5658272B2 (ja)	2009-12-17	2015-01-21	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｃｃｒ２の新規アンタゴニスト及びこれらの使用
JP5632014B2 (ja)	2009-12-17	2014-11-26	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規ｃｃｒ２受容体アンタゴニスト及びこれらの使用
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JP2013526507A (ja)	2010-05-12	2013-06-24	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規ｃｃｒ２受容体アンタゴニスト、その製造方法及び薬物としてのその使用
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JP5647339B2 (ja)	2010-05-17	2014-12-24	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｃｃｒ２アンタゴニスト及びこれらの使用
JP5636094B2 (ja)	2010-05-25	2014-12-03	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｃｃｒ２受容体アンタゴニスト
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JP5959537B2 (ja)	2011-01-28	2016-08-02	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	置換ピリジニル−ピリミジン及び医薬としてのその使用
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2001
- 2001-09-28 AU AU1499602A patent/AU1499602A/xx active Pending
- 2001-09-28 HR HR20030276A patent/HRP20030276B1/xx not_active IP Right Cessation
- 2001-09-28 SI SI200130219T patent/SI1326862T1/xx unknown
- 2001-09-28 CN CNB018171435A patent/CN1221549C/zh not_active Ceased
- 2001-09-28 PT PT01983510T patent/PT1326862E/pt unknown
- 2001-09-28 IL IL15533501A patent/IL155335A0/xx active IP Right Grant
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- 2001-09-28 UA UA2003054185A patent/UA74215C2/uk unknown
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- 2001-09-28 WO PCT/EP2001/011225 patent/WO2002030928A1/de active IP Right Grant
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- 2001-09-28 EP EP04016877A patent/EP1468998A1/de not_active Withdrawn
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- 2001-09-28 BR BR0114584-3A patent/BR0114584A/pt active Pending
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2003
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Also Published As

Publication number	Publication date
ATE276253T1 (de)	2004-10-15
CA2425539A1 (en)	2003-04-11
CN100519558C (zh)	2009-07-29
KR20030042008A (ko)	2003-05-27
MXPA03003221A (es)	2004-12-03
ECSP034540A (es)	2003-07-25
PE20020422A1 (es)	2002-06-28
NO328465B1 (no)	2010-02-22
PT1326862E (pt)	2004-11-30
BG107687A (bg)	2003-09-30
OA12403A (en)	2006-04-18
KR100823860B1 (ko)	2008-04-21
CN1733761A (zh)	2006-02-15
IL155335A0 (en)	2003-11-23
UY34901A (es)	2015-02-27
SI1326862T1 (en)	2005-02-28
EP1326862B1 (de)	2004-09-15
HU226830B1 (en)	2009-11-30
TW589313B (en)	2004-06-01
EP1468998A1 (de)	2004-10-20
EA004381B1 (ru)	2004-04-29
DZ3478A1 (fr)	2002-04-18
AU1499602A (en)	2002-04-22
EE04567B1 (et)	2005-12-15
HRP20030276A2 (en)	2005-02-28
EE200300171A (et)	2003-06-16
GEP20063905B (en)	2006-08-25
EG24142A (en)	2008-08-06
CR6938A (es)	2004-10-28
HK1060567A1 (en)	2004-08-13
JP2004526668A (ja)	2004-09-02
HUP0301022A3 (en)	2005-12-28
BR0114584A (pt)	2003-08-26
UY26962A1 (es)	2002-06-20
SA01220412B1 (ar)	2006-11-05
PL207870B1 (pl)	2011-02-28
DE50103666D1 (de)	2004-10-21
AU2002214996B2 (en)	2007-03-15
HUP0301022A2 (hu)	2003-10-28
JP3764422B2 (ja)	2006-04-05
MEP40008A (en)	2011-02-10
CN1221549C (zh)	2005-10-05
HK1086557A1 (zh)	2006-09-22
NZ525733A (en)	2005-01-28
AP2003002775A0 (en)	2003-03-31
SK4362003A3 (en)	2003-08-05
AP1572A (en)	2006-02-13
TR200402579T4 (tr)	2004-12-21
NO20031694L (no)	2003-04-11
IS6772A (is)	2003-04-09
CA2425539C (en)	2007-04-03
AR034389A1 (es)	2004-02-25
BG66161B1 (bg)	2011-09-30
CZ301841B6 (cs)	2010-07-07
MY126931A (en)	2006-10-31
PL366041A1 (en)	2005-01-24
MA25842A1 (fr)	2003-07-01
CN1469877A (zh)	2004-01-21
NO20031694D0 (no)	2003-04-11
UA74215C2 (uk)	2005-11-15
DK1326862T3 (da)	2004-11-22
RS50218B (sr)	2009-07-15
ZA200302500B (en)	2004-04-22
ME00243B (me)	2011-05-10
IS2339B (is)	2008-02-15
IL155335A (en)	2009-02-11
EP1326862A1 (de)	2003-07-16
EA200300457A1 (ru)	2003-10-30
YU27303A (sh)	2006-05-25
SK287009B6 (sk)	2009-09-07
AR068527A2 (es)	2009-11-18
WO2002030928A1 (de)	2002-04-18
ES2228965T3 (es)	2005-04-16

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HRP20030276B1 (en)	2006-02-28	Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
YU69902A (sh)	2005-07-19	Novi derivati piperazina
RS50140B (sr)	2009-03-25	Postupak za dobijanje perkihinina i njegova upotreba
HRP20030502B1 (en)	2011-09-30	Method for producing the anticholinergic agent tiotropium bromide
MXPA05013752A (es)	2006-03-08	Procedimiento e intermediarios para la preparacion de (1r,2s,5s)-6,6-dimetil-3-azabiciclo[3,1,0]exan-2-carboxilatos o sales de los mismos.
HUP0400333A2 (hu)	2004-12-28	Kristályos antikolinergikum, eljárás előállítására és alkalmazása gyógyszerkészítmény előállítására
AU2002214996A1 (en)	2002-06-27	Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
CY1111061T1 (el)	2015-06-11	Νεες ετεροκυκλικες ενωσεις δραστικες ως αναστολεις των βητα-λακταμασων
RS51146B (sr)	2010-10-31	Novi difenil-azetidinon sa poboljšanim fiziološkim osobinama postupak za njegovu proizvodnju,lekovi koji sadrže ovo jedinjenje i njihova upotreba
ATE399171T1 (de)	2008-07-15	Camptothecinanaloge und deren zubereitungsmethoden
YU17301A (sh)	2004-05-12	KRISTALNI OBLICI EtO2C-CH2-(R)-Cgl-Aze-Pab-OH
BG111461A (en)	2013-08-30	TECHNICAL METHOD FOR OBTAINING TROPENOL
ATE202483T1 (de)	2001-07-15	Immuntolerante prothrombinkomplex-präparation
YU30603A (sh)	2006-05-25	Derivati premošćenog piperazina
SE0102440D0 (sv)	2001-07-05	New compound
GB0212410D0 (en)	2002-07-10	Organic compounds
MY132777A (en)	2007-10-31	Inhalable formulation of a solution containing a tiotropium salt
EA200300272A1 (ru)	2003-10-30	Новые производные хиназолина, способ их получения и фармацевтические композиции, содержащие их
BR0213156A (pt)	2004-09-14	Formas cristalinas anidras de gabapentina
ATE344272T1 (de)	2006-11-15	Uridinderivate als antibiotika
AP2002002595A0 (en)	2002-09-30	Heterocyclic amide derivatives.
DE50010253D1 (de)	2005-06-09	Substituierte 1- und 2-naphthol-mannichbasen
MY127328A (en)	2006-11-30	5-amino-1-pentene-3-ol substituted derivatives
BR0211733A (pt)	2004-09-21	Sais de derivados de acido 1,2,3,4-tetrahidroquinolin-2-carboxilìco substituìdos
TR200000244T2 (tr)	2000-09-21	MCP-1 proteini üretimini azaltmada etkin bir farmasötik bileşim.

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