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FR16C0016I2 - Facteur viii modifie - Google Patents

Facteur viii modifie

Info

Publication number
FR16C0016I2
FR16C0016I2 FR16C0016C FR16C0016C FR16C0016I2 FR 16C0016 I2 FR16C0016 I2 FR 16C0016I2 FR 16C0016 C FR16C0016 C FR 16C0016C FR 16C0016 C FR16C0016 C FR 16C0016C FR 16C0016 I2 FR16C0016 I2 FR 16C0016I2
Authority
FR
France
Prior art keywords
factor viii
modified factor
modified
viii
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR16C0016C
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Publication of FR16C0016I1 publication Critical patent/FR16C0016I1/fr
Application granted granted Critical
Publication of FR16C0016I2 publication Critical patent/FR16C0016I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/10—Factor VIII, AHF; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Glass Compositions (AREA)
  • Fish Paste Products (AREA)
  • Medicines Containing Plant Substances (AREA)
FR16C0016C 2000-03-10 2016-04-29 Facteur viii modifie Active FR16C0016I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/523,656 US6458563B1 (en) 1996-06-26 2000-03-10 Modified factor VIII
PCT/US2001/005076 WO2001068109A1 (en) 2000-03-10 2001-02-16 Modified factor viii

Publications (2)

Publication Number Publication Date
FR16C0016I1 FR16C0016I1 (pl) 2016-04-29
FR16C0016I2 true FR16C0016I2 (fr) 2018-11-02

Family

ID=24085870

Family Applications (1)

Application Number Title Priority Date Filing Date
FR16C0016C Active FR16C0016I2 (fr) 2000-03-10 2016-04-29 Facteur viii modifie

Country Status (36)

Country Link
US (3) US6458563B1 (pl)
EP (1) EP1280540B1 (pl)
JP (1) JP4044337B2 (pl)
KR (1) KR100485525B1 (pl)
CN (1) CN1191360C (pl)
AT (1) ATE391512T1 (pl)
AU (2) AU2001238416B2 (pl)
BE (1) BE2016C024I2 (pl)
BR (2) BRPI0109131B8 (pl)
CA (1) CA2400295C (pl)
CY (2) CY1108179T1 (pl)
CZ (1) CZ298250B6 (pl)
DE (1) DE60133541T2 (pl)
DK (1) DK1280540T3 (pl)
EE (1) EE05075B1 (pl)
ES (1) ES2304379T3 (pl)
FR (1) FR16C0016I2 (pl)
HK (1) HK1051004A1 (pl)
HU (2) HU227804B1 (pl)
IL (2) IL151371A0 (pl)
LT (1) LTC1280540I2 (pl)
LU (1) LU93049I2 (pl)
ME (1) MEP8209A (pl)
MX (1) MXPA02008798A (pl)
NL (1) NL300808I2 (pl)
NO (2) NO331935B1 (pl)
NZ (1) NZ520799A (pl)
PL (1) PL202936B1 (pl)
PT (1) PT1280540E (pl)
RS (1) RS50364B (pl)
RU (1) RU2285724C2 (pl)
SI (1) SI1280540T1 (pl)
SK (1) SK286205B6 (pl)
UA (1) UA75064C2 (pl)
WO (1) WO2001068109A1 (pl)
ZA (1) ZA200206810B (pl)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
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CA2461443C (en) * 2001-10-05 2011-07-12 Emory University Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of use
WO2003047507A2 (en) * 2001-11-30 2003-06-12 Emory University Factor viii c2 domain variants
GB0207092D0 (en) * 2002-03-26 2002-05-08 Sod Conseils Rech Applic Stable pharmaceutical composition containing factor VIII
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US7485291B2 (en) * 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
EP1636360A4 (en) * 2003-06-03 2006-11-08 Cell Genesys Inc COMPOSITIONS AND METHODS FOR ENHANCED EXPRESSION OF RECOMBINANT POLYPEPTIDES FROM A SINGLE VECTOR USING A PEPTIDE CLEAVAGE SITE
ATE368687T1 (de) * 2003-06-26 2007-08-15 Merck Patent Gmbh Thrombopoietinproteine mit verbesserten eigenschaften
US20050059023A1 (en) * 2003-09-16 2005-03-17 Cantor Thomas L. Methods and kits for monitoring resistance to therapeutic agents
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WO2007065691A2 (en) 2005-12-07 2007-06-14 Technische Universität München Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
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US7939632B2 (en) * 2006-06-14 2011-05-10 Csl Behring Gmbh Proteolytically cleavable fusion proteins with high molar specific activity
EP1935430A1 (en) * 2006-12-22 2008-06-25 CSL Behring GmbH Modified coagulation factors with prolonged in vivo half-life
US8754194B2 (en) 2006-12-22 2014-06-17 Csl Behring Gmbh Modified coagulation factors with prolonged in vivo half-life
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CN102277379B (zh) * 2011-08-18 2013-07-24 中国科学院遗传与发育生物学研究所 表达凝血因子viii的表达载体及其应用
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Also Published As

Publication number Publication date
UA75064C2 (en) 2006-03-15
BR122013026957A2 (pl) 2004-12-07
DE60133541T2 (de) 2009-05-07
BE2016C024I2 (pl) 2020-01-30
US7012132B2 (en) 2006-03-14
ME00601B (me) 2011-12-20
HK1051004A1 (en) 2003-07-18
PT1280540E (pt) 2008-06-09
CY2016011I1 (el) 2016-10-05
EE05075B1 (et) 2008-10-15
HUP0300586A2 (hu) 2003-06-28
JP2003526358A (ja) 2003-09-09
SK14392002A3 (sk) 2003-06-03
JP4044337B2 (ja) 2008-02-06
PL202936B1 (pl) 2009-08-31
EE200200510A (et) 2004-02-16
MXPA02008798A (es) 2003-04-25
ATE391512T1 (de) 2008-04-15
EP1280540A4 (en) 2004-11-03
NZ520799A (en) 2004-06-25
CA2400295A1 (en) 2001-09-20
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CZ20023346A3 (cs) 2003-01-15
BRPI0109131B8 (pt) 2021-07-06
HUS1600020I1 (hu) 2016-06-28
US6458563B1 (en) 2002-10-01
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US7122634B2 (en) 2006-10-17
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US20030068785A1 (en) 2003-04-10
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HU227804B1 (en) 2012-03-28
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BR0109131A (pt) 2004-12-07

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