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DK1289999T3 - Antitumoranaloger af ET-743 - Google Patents

Antitumoranaloger af ET-743

Info

Publication number
DK1289999T3
DK1289999T3 DK01929813T DK01929813T DK1289999T3 DK 1289999 T3 DK1289999 T3 DK 1289999T3 DK 01929813 T DK01929813 T DK 01929813T DK 01929813 T DK01929813 T DK 01929813T DK 1289999 T3 DK1289999 T3 DK 1289999T3
Authority
DK
Denmark
Prior art keywords
hydroxy
spiroamine
protecting group
bridge
ecteinascidin
Prior art date
Application number
DK01929813T
Other languages
English (en)
Inventor
Ignacio Manzanares
Marta Perez
Simon Munt
Carmen Cuevas
Maria Jesus Martin
Alberto Rodriguez
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2000/001852 external-priority patent/WO2000069862A2/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of DK1289999T3 publication Critical patent/DK1289999T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D497/00Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/22Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Discharging, Photosensitive Material Shape In Electrophotography (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)
DK01929813T 2000-05-15 2001-05-15 Antitumoranaloger af ET-743 DK1289999T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof
PCT/GB2001/002110 WO2001087894A1 (en) 1999-05-14 2001-05-15 Antitumoral analogs of et-743

Publications (1)

Publication Number Publication Date
DK1289999T3 true DK1289999T3 (da) 2005-03-14

Family

ID=34855248

Family Applications (3)

Application Number Title Priority Date Filing Date
DK04010399T DK1496060T3 (da) 2000-05-15 2001-05-15 Antitumoranaloger af ET 743
DK01929813T DK1289999T3 (da) 2000-05-15 2001-05-15 Antitumoranaloger af ET-743
DK01929816T DK1287004T3 (da) 2000-05-15 2001-05-15 Syntetisk proces til fremstilling af en ecteinascidinforbindelse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK04010399T DK1496060T3 (da) 2000-05-15 2001-05-15 Antitumoranaloger af ET 743

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK01929816T DK1287004T3 (da) 2000-05-15 2001-05-15 Syntetisk proces til fremstilling af en ecteinascidinforbindelse

Country Status (17)

Country Link
EP (3) EP1289999B1 (da)
KR (2) KR100777464B1 (da)
AT (2) ATE368671T1 (da)
AU (2) AU2001256496C1 (da)
DE (3) DE60107241T2 (da)
DK (3) DK1496060T3 (da)
EA (2) EA006070B1 (da)
ES (2) ES2248319T3 (da)
GB (1) GB9918178D0 (da)
HK (1) HK1050193A1 (da)
HU (1) HU228789B1 (da)
MX (1) MXPA02010701A (da)
NZ (2) NZ521807A (da)
PL (2) PL203745B1 (da)
PT (3) PT1287004E (da)
SI (2) SI1289999T1 (da)
UA (1) UA75597C2 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1658848E (pt) 2004-10-29 2007-11-05 Pharma Mar Sa Formulações contendo ecteinascidina e um dissacarídeo
KR100676324B1 (ko) * 2005-03-15 2007-01-30 삼성전자주식회사 디스플레이장치
KR100676325B1 (ko) * 2005-03-15 2007-01-30 삼성전자주식회사 디스플레이장치
KR100712667B1 (ko) * 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
CN107033164A (zh) * 2010-05-25 2017-08-11 法马马有限公司 制备海鞘素化合物的合成方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2020105068A1 (en) * 2018-11-24 2020-05-28 Natco Pharma Limited Process for the preparation of ecteinascidin derivative and its intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
EP0309477B1 (en) * 1986-06-09 1991-11-06 The Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743

Also Published As

Publication number Publication date
EP1496060B1 (en) 2007-08-01
AU2001256496B2 (en) 2006-02-16
PL215769B1 (pl) 2014-01-31
HK1050193A1 (en) 2003-06-13
NZ521807A (en) 2004-06-25
PT1287004E (pt) 2005-11-30
EP1289999B1 (en) 2004-11-17
KR100777464B1 (ko) 2007-11-27
EA200201210A1 (ru) 2003-04-24
DK1496060T3 (da) 2007-12-03
DE60112286D1 (de) 2005-09-01
MXPA02010701A (es) 2003-05-14
HUP0300648A2 (hu) 2003-07-28
ATE300547T1 (de) 2005-08-15
PT1289999E (pt) 2005-03-31
PT1496060E (pt) 2007-10-30
EP1289999A1 (en) 2003-03-12
DE60129753D1 (de) 2007-09-13
HU228789B1 (en) 2013-05-28
EA006070B1 (ru) 2005-08-25
PL358143A1 (en) 2004-08-09
DK1287004T3 (da) 2005-11-28
DE60107241T2 (de) 2006-08-03
EP1287004A1 (en) 2003-03-05
ATE368671T1 (de) 2007-08-15
HUP0300648A3 (en) 2006-05-29
PL358258A1 (en) 2004-08-09
DE60107241D1 (de) 2004-12-23
AU2001256496C1 (en) 2006-08-03
GB9918178D0 (en) 1999-10-06
AU5649301A (en) 2001-11-26
PL203745B1 (pl) 2009-11-30
EP1496060A1 (en) 2005-01-12
KR100830717B1 (ko) 2008-05-20
ES2248319T3 (es) 2006-03-16
SI1289999T1 (en) 2005-06-30
DE60129753T2 (de) 2008-04-30
ES2290583T3 (es) 2008-02-16
NZ532793A (en) 2004-10-29
AU783563B2 (en) 2005-11-10
KR20030031481A (ko) 2003-04-21
KR20030005308A (ko) 2003-01-17
EP1287004B1 (en) 2005-07-27
EA200201209A1 (ru) 2003-04-24
SI1496060T1 (sl) 2008-06-30
DE60112286T2 (de) 2006-06-01
UA75597C2 (en) 2006-05-15
EA006369B1 (ru) 2005-12-29

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