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EA200201209A1 - Противоопухолевые аналоги ет-743 - Google Patents

Противоопухолевые аналоги ет-743

Info

Publication number
EA200201209A1
EA200201209A1 EA200201209A EA200201209A EA200201209A1 EA 200201209 A1 EA200201209 A1 EA 200201209A1 EA 200201209 A EA200201209 A EA 200201209A EA 200201209 A EA200201209 A EA 200201209A EA 200201209 A1 EA200201209 A1 EA 200201209A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
group
analogues
tumor
optionally protected
Prior art date
Application number
EA200201209A
Other languages
English (en)
Other versions
EA006070B1 (ru
Inventor
Кармен Куэвас
Игнасио Мансанарес
Марта Перес
Мария Хесус Мартин
Альберто Родригес
Саймон Мант
Original Assignee
Фарма Мар, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2000/001852 external-priority patent/WO2000069862A2/en
Application filed by Фарма Мар, С.А. filed Critical Фарма Мар, С.А.
Publication of EA200201209A1 publication Critical patent/EA200201209A1/ru
Publication of EA006070B1 publication Critical patent/EA006070B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Discharging, Photosensitive Material Shape In Electrophotography (AREA)

Abstract

Противоопухолевые соединения, имеющие пятичленную структуру эктеинасцидина, с конденсированными кольцами формулы (XIV). В соединениях настоящего изобретения отсутствует 1,4-мостиковая группа, обычно присутствующая в эктеинасцидинах. Указанные соединения имеют заместитель в положении С-1, выбранный из необязательно защищенной или дериватизированной аминометиленовой группы или необязательно защищенной или дериватизированной гидроксиметиленовой группы.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200201209A 2000-05-15 2001-05-15 Противоопухолевые аналоги ет-743 EA006070B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof
PCT/GB2001/002110 WO2001087894A1 (en) 1999-05-14 2001-05-15 Antitumoral analogs of et-743

Publications (2)

Publication Number Publication Date
EA200201209A1 true EA200201209A1 (ru) 2003-04-24
EA006070B1 EA006070B1 (ru) 2005-08-25

Family

ID=34855248

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200201210A EA006369B1 (ru) 2000-05-15 2001-05-15 Синтетический способ получения соединения эктеинасцидина
EA200201209A EA006070B1 (ru) 2000-05-15 2001-05-15 Противоопухолевые аналоги ет-743

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200201210A EA006369B1 (ru) 2000-05-15 2001-05-15 Синтетический способ получения соединения эктеинасцидина

Country Status (16)

Country Link
EP (3) EP1496060B1 (ru)
KR (2) KR100777464B1 (ru)
AT (2) ATE368671T1 (ru)
AU (2) AU783563B2 (ru)
DE (3) DE60107241T2 (ru)
DK (3) DK1289999T3 (ru)
EA (2) EA006369B1 (ru)
ES (2) ES2248319T3 (ru)
GB (1) GB9918178D0 (ru)
HU (1) HU228789B1 (ru)
MX (1) MXPA02010701A (ru)
NZ (2) NZ532793A (ru)
PL (2) PL203745B1 (ru)
PT (3) PT1287004E (ru)
SI (2) SI1289999T1 (ru)
UA (1) UA75597C2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1658848T3 (da) 2004-10-29 2007-11-26 Pharma Mar Sa Formuleringer omfattende ecteinascidin og et disaccharid
KR100676325B1 (ko) * 2005-03-15 2007-01-30 삼성전자주식회사 디스플레이장치
KR100676324B1 (ko) * 2005-03-15 2007-01-30 삼성전자주식회사 디스플레이장치
KR100712667B1 (ko) * 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
US9428524B2 (en) * 2010-05-25 2016-08-30 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2020105068A1 (en) * 2018-11-24 2020-05-28 Natco Pharma Limited Process for the preparation of ecteinascidin derivative and its intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
FI885726A7 (fi) * 1986-06-09 1988-12-09 Univ Of Illinois Ekteinaskidiinit 729, 743, 745, 759A, 759B ja 770
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743

Also Published As

Publication number Publication date
EP1496060A1 (en) 2005-01-12
DE60112286T2 (de) 2006-06-01
ATE300547T1 (de) 2005-08-15
KR20030005308A (ko) 2003-01-17
DK1287004T3 (da) 2005-11-28
NZ521807A (en) 2004-06-25
EA200201210A1 (ru) 2003-04-24
UA75597C2 (en) 2006-05-15
PT1496060E (pt) 2007-10-30
EP1496060B1 (en) 2007-08-01
EP1287004B1 (en) 2005-07-27
EA006070B1 (ru) 2005-08-25
HUP0300648A2 (hu) 2003-07-28
EA006369B1 (ru) 2005-12-29
PT1289999E (pt) 2005-03-31
ATE368671T1 (de) 2007-08-15
DK1289999T3 (da) 2005-03-14
KR100777464B1 (ko) 2007-11-27
SI1496060T1 (sl) 2008-06-30
AU2001256496C1 (en) 2006-08-03
EP1287004A1 (en) 2003-03-05
PL358258A1 (en) 2004-08-09
NZ532793A (en) 2004-10-29
DE60107241T2 (de) 2006-08-03
DE60107241D1 (de) 2004-12-23
EP1289999B1 (en) 2004-11-17
PT1287004E (pt) 2005-11-30
PL215769B1 (pl) 2014-01-31
KR20030031481A (ko) 2003-04-21
ES2248319T3 (es) 2006-03-16
KR100830717B1 (ko) 2008-05-20
HU228789B1 (en) 2013-05-28
AU2001256496B2 (en) 2006-02-16
HK1050193A1 (en) 2003-06-13
PL203745B1 (pl) 2009-11-30
ES2290583T3 (es) 2008-02-16
DK1496060T3 (da) 2007-12-03
EP1289999A1 (en) 2003-03-12
DE60112286D1 (de) 2005-09-01
DE60129753T2 (de) 2008-04-30
AU783563B2 (en) 2005-11-10
GB9918178D0 (en) 1999-10-06
MXPA02010701A (es) 2003-05-14
SI1289999T1 (en) 2005-06-30
HUP0300648A3 (en) 2006-05-29
DE60129753D1 (de) 2007-09-13
PL358143A1 (en) 2004-08-09
AU5649301A (en) 2001-11-26

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MK4A Patent expired

Designated state(s): BY RU