ATE300547T1 - Synthetisches verfahren zur herstellung von ecteinascidin-derivaten - Google Patents

Synthetisches verfahren zur herstellung von ecteinascidin-derivaten

Info

Publication number: ATE300547T1
Authority: AT; Austria
Prior art keywords: hydroxy; synthetic process; spiroamine; protecting group; bridge
Prior art date: 2000-05-15

Application number

AT01929816T

Other languages

English (en)

Inventor

Carmen Cuevas

Marta Perez

Andres Francesch

Jose Luis Chicharro

Pilar Gallego

Maria Zarzuelo

Ignacio Manzanares

Maria Jesus Martin

Simon Munt

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-15

Filing date

2001-05-15

Publication date

2005-08-15

2000-05-15 Priority claimed from PCT/GB2000/001852 external-priority patent/WO2000069862A2/en

2001-05-15 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2005-08-15 Application granted granted Critical

2005-08-15 Publication of ATE300547T1 publication Critical patent/ATE300547T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Compounds Of Unknown Constitution (AREA)
Discharging, Photosensitive Material Shape In Electrophotography (AREA)
Instruments For Viewing The Inside Of Hollow Bodies (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Pyrane Compounds (AREA)

AT01929816T 2000-05-15 2001-05-15 Synthetisches verfahren zur herstellung von ecteinascidin-derivaten ATE300547T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/GB2000/001852 WO2000069862A2 (en)	1999-05-14	2000-05-15	Hemisynthetic method and intermediates thereof
PCT/GB2001/002120 WO2001087895A1 (en)	1999-05-14	2001-05-15	Synthetic process for the manufacture of an ecteinaschidin compound

Publications (1)

Publication Number	Publication Date
ATE300547T1 true ATE300547T1 (de)	2005-08-15

Family

ID=34855248

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT04010399T ATE368671T1 (de)	2000-05-15	2001-05-15	Et-743 analoga als antitumoralverbindungen
AT01929816T ATE300547T1 (de)	2000-05-15	2001-05-15	Synthetisches verfahren zur herstellung von ecteinascidin-derivaten

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT04010399T ATE368671T1 (de)	2000-05-15	2001-05-15	Et-743 analoga als antitumoralverbindungen

Country Status (17)

Country	Link
EP (3)	EP1287004B1 (de)
KR (2)	KR100777464B1 (de)
AT (2)	ATE368671T1 (de)
AU (2)	AU2001256496C1 (de)
DE (3)	DE60112286T2 (de)
DK (3)	DK1287004T3 (de)
EA (2)	EA006369B1 (de)
ES (2)	ES2248319T3 (de)
GB (1)	GB9918178D0 (de)
HK (1)	HK1050193A1 (de)
HU (1)	HU228789B1 (de)
MX (1)	MXPA02010701A (de)
NZ (2)	NZ532793A (de)
PL (2)	PL215769B1 (de)
PT (3)	PT1287004E (de)
SI (2)	SI1289999T1 (de)
UA (1)	UA75597C2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1658848T3 (da)	2004-10-29	2007-11-26	Pharma Mar Sa	Formuleringer omfattende ecteinascidin og et disaccharid
KR100676325B1 (ko) *	2005-03-15	2007-01-30	삼성전자주식회사	디스플레이장치
KR100676324B1 (ko) *	2005-03-15	2007-01-30	삼성전자주식회사	디스플레이장치
KR100712667B1 (ko) *	2006-04-11	2007-05-02	재단법인서울대학교산학협력재단	신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
US9428524B2 (en) *	2010-05-25	2016-08-30	Pharma Mar, S.A.	Synthetic process for the manufacture of ecteinascidin compounds
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
WO2020105068A1 (en) *	2018-11-24	2020-05-28	Natco Pharma Limited	Process for the preparation of ecteinascidin derivative and its intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59225189A (ja)	1983-06-03	1984-12-18	Shionogi & Co Ltd	キノナミン誘導体およびその製造法
EP0309477B1 (de) *	1986-06-09	1991-11-06	The Board Of Trustees Of The University Of Illinois	Ekteinascidine 729, 743, 745, 759a, 759b und 770
US5721362A (en) *	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743

1999
- 1999-08-02 GB GBGB9918178.6A patent/GB9918178D0/en not_active Ceased
2001
- 2001-05-15 AU AU2001256496A patent/AU2001256496C1/en not_active Expired
- 2001-05-15 DE DE60112286T patent/DE60112286T2/de not_active Expired - Lifetime
- 2001-05-15 NZ NZ532793A patent/NZ532793A/en not_active IP Right Cessation
- 2001-05-15 EP EP01929816A patent/EP1287004B1/de not_active Expired - Lifetime
- 2001-05-15 ES ES01929816T patent/ES2248319T3/es not_active Expired - Lifetime
- 2001-05-15 EP EP01929813A patent/EP1289999B1/de not_active Expired - Lifetime
- 2001-05-15 PT PT01929816T patent/PT1287004E/pt unknown
- 2001-05-15 PL PL358258A patent/PL215769B1/pl unknown
- 2001-05-15 EA EA200201210A patent/EA006369B1/ru not_active IP Right Cessation
- 2001-05-15 DK DK01929816T patent/DK1287004T3/da active
- 2001-05-15 ES ES04010399T patent/ES2290583T3/es not_active Expired - Lifetime
- 2001-05-15 NZ NZ521807A patent/NZ521807A/en not_active IP Right Cessation
- 2001-05-15 AT AT04010399T patent/ATE368671T1/de active
- 2001-05-15 EA EA200201209A patent/EA006070B1/ru not_active IP Right Cessation
- 2001-05-15 DK DK01929813T patent/DK1289999T3/da active
- 2001-05-15 AU AU56493/01A patent/AU783563B2/en not_active Expired
- 2001-05-15 DE DE60129753T patent/DE60129753T2/de not_active Expired - Lifetime
- 2001-05-15 PL PL358143A patent/PL203745B1/pl unknown
- 2001-05-15 SI SI200130244T patent/SI1289999T1/xx unknown
- 2001-05-15 SI SI200130777T patent/SI1496060T1/sl unknown
- 2001-05-15 DE DE60107241T patent/DE60107241T2/de not_active Expired - Lifetime
- 2001-05-15 UA UA20021210093A patent/UA75597C2/uk unknown
- 2001-05-15 KR KR1020027014555A patent/KR100777464B1/ko not_active Expired - Lifetime
- 2001-05-15 HU HU0300648A patent/HU228789B1/hu unknown
- 2001-05-15 AT AT01929816T patent/ATE300547T1/de active
- 2001-05-15 DK DK04010399T patent/DK1496060T3/da active
- 2001-05-15 PT PT01929813T patent/PT1289999E/pt unknown
- 2001-05-15 KR KR1020027015168A patent/KR100830717B1/ko not_active Expired - Fee Related
- 2001-05-15 PT PT04010399T patent/PT1496060E/pt unknown
- 2001-05-15 MX MXPA02010701A patent/MXPA02010701A/es active IP Right Grant
- 2001-05-15 EP EP04010399A patent/EP1496060B1/de not_active Expired - Lifetime
2003
- 2003-03-31 HK HK03102277A patent/HK1050193A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2290583T3 (es)	2008-02-16
PT1496060E (pt)	2007-10-30
HK1050193A1 (en)	2003-06-13
AU2001256496C1 (en)	2006-08-03
DE60112286T2 (de)	2006-06-01
PL203745B1 (pl)	2009-11-30
EP1287004B1 (de)	2005-07-27
EP1496060B1 (de)	2007-08-01
KR20030005308A (ko)	2003-01-17
EA200201209A1 (ru)	2003-04-24
EA006369B1 (ru)	2005-12-29
DE60107241D1 (de)	2004-12-23
EP1289999A1 (de)	2003-03-12
SI1496060T1 (sl)	2008-06-30
DE60129753D1 (de)	2007-09-13
ES2248319T3 (es)	2006-03-16
EP1287004A1 (de)	2003-03-05
PL358258A1 (en)	2004-08-09
PT1287004E (pt)	2005-11-30
KR100830717B1 (ko)	2008-05-20
PT1289999E (pt)	2005-03-31
DK1496060T3 (da)	2007-12-03
AU2001256496B2 (en)	2006-02-16
EA200201210A1 (ru)	2003-04-24
EP1496060A1 (de)	2005-01-12
DK1289999T3 (da)	2005-03-14
DK1287004T3 (da)	2005-11-28
UA75597C2 (en)	2006-05-15
ATE368671T1 (de)	2007-08-15
AU783563B2 (en)	2005-11-10
GB9918178D0 (en)	1999-10-06
KR100777464B1 (ko)	2007-11-27
HUP0300648A3 (en)	2006-05-29
NZ521807A (en)	2004-06-25
DE60107241T2 (de)	2006-08-03
NZ532793A (en)	2004-10-29
PL215769B1 (pl)	2014-01-31
EA006070B1 (ru)	2005-08-25
SI1289999T1 (en)	2005-06-30
DE60112286D1 (de)	2005-09-01
DE60129753T2 (de)	2008-04-30
EP1289999B1 (de)	2004-11-17
MXPA02010701A (es)	2003-05-14
PL358143A1 (en)	2004-08-09
HUP0300648A2 (hu)	2003-07-28
HU228789B1 (en)	2013-05-28
KR20030031481A (ko)	2003-04-21
AU5649301A (en)	2001-11-26

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