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BRPI0110443B8 - etapas processuais na produção de um composto de ecteinascidina - Google Patents

etapas processuais na produção de um composto de ecteinascidina

Info

Publication number
BRPI0110443B8
BRPI0110443B8 BRPI0110443A BRPI0110443B8 BR PI0110443 B8 BRPI0110443 B8 BR PI0110443B8 BR PI0110443 A BRPI0110443 A BR PI0110443A BR PI0110443 B8 BRPI0110443 B8 BR PI0110443B8
Authority
BR
Brazil
Prior art keywords
production
bridge
procedural steps
compound
ecteinascidin compound
Prior art date
Application number
Other languages
English (en)
Inventor
Francesch Andres
Cuevas Carmen
Fernandez Carolina
Manzanares Ignacio
Luis Chicharro Jose
Jesus Martin Maria
Zarzuelo Maria
Perez Marta
Gallego Pilar
Munt Simon
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911345.8A external-priority patent/GB9911345D0/en
Priority claimed from GBGB9918178.6A external-priority patent/GB9918178D0/en
Priority claimed from GBGB9923632.5A external-priority patent/GB9923632D0/en
Priority claimed from GB0001063A external-priority patent/GB0001063D0/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of BR0110443A publication Critical patent/BR0110443A/pt
Publication of BRPI0110443B1 publication Critical patent/BRPI0110443B1/pt
Publication of BRPI0110443B8 publication Critical patent/BRPI0110443B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

"processo sintético para a produção de um composto de ecteinascidina". são fornecidos processos para preparar compostos com uma estrutura de anel fundido de fórmula (xiv). tais produtos incluem ecteinascidinas e têm uma espiroamina-1,4-ponte. o processo envolve formar uma ponte em 1,4 usando um composto de anel fundido do tipo 1-lábil, 10-hidróxi, 18-hidróxi protegido, di-6,8-en-5-ona. depois da formação da ponte em 1,4, a proteção de c-18 é removida antes da introdução da espiroamina.
BR0110443-8 1999-05-14 2001-05-15 etapas processuais na produção de um composto de ecteinascidina BRPI0110443B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB9911345.8A GB9911345D0 (pt) 1999-05-14 1999-05-14
GBGB9918178.6A GB9918178D0 (en) 2000-05-15 1999-08-02 Synthetic methods
GBGB9923632.5A GB9923632D0 (en) 1999-10-06 1999-10-06 Hemisynthetic process towards ecteinascidin and phtalscidin compounds
GB0001063A GB0001063D0 (en) 2000-01-17 2000-01-17 Hemisynthetic process towards ecteinascidin and phtalascidin
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof
GBPCT/GB00/01852 2000-05-15
PCT/GB2001/002120 WO2001087895A1 (en) 1999-05-14 2001-05-15 Synthetic process for the manufacture of an ecteinaschidin compound

Publications (3)

Publication Number Publication Date
BR0110443A BR0110443A (pt) 2003-04-08
BRPI0110443B1 BRPI0110443B1 (pt) 2018-06-26
BRPI0110443B8 true BRPI0110443B8 (pt) 2021-05-25

Family

ID=42632476

Family Applications (3)

Application Number Title Priority Date Filing Date
BRPI0010559A BRPI0010559B8 (pt) 1999-05-14 2000-05-15 processo hemissintético e compostos intermediários
BR0110443-8 BRPI0110443B8 (pt) 1999-05-14 2001-05-15 etapas processuais na produção de um composto de ecteinascidina
BRPI0110801-8 BRPI0110801B8 (pt) 1999-05-14 2001-05-15 análogos antitumorais de et-743, composição farmacêutica compreendendo os mesmos e uso dos referidos análogos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0010559A BRPI0010559B8 (pt) 1999-05-14 2000-05-15 processo hemissintético e compostos intermediários

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0110801-8 BRPI0110801B8 (pt) 1999-05-14 2001-05-15 análogos antitumorais de et-743, composição farmacêutica compreendendo os mesmos e uso dos referidos análogos

Country Status (29)

Country Link
US (3) US7241892B1 (pt)
EP (1) EP1185536B1 (pt)
JP (1) JP4445136B2 (pt)
KR (1) KR100834601B1 (pt)
CN (3) CN1229382C (pt)
AR (1) AR035842A1 (pt)
AT (1) ATE283273T1 (pt)
AU (2) AU775580B2 (pt)
BG (1) BG65896B1 (pt)
BR (3) BRPI0010559B8 (pt)
CA (2) CA2372058C (pt)
CY (1) CY1108095T1 (pt)
CZ (3) CZ303536B6 (pt)
DE (1) DE60016209T2 (pt)
DK (1) DK1185536T3 (pt)
ES (2) ES2233367T3 (pt)
HU (1) HU230646B1 (pt)
MX (1) MXPA01011631A (pt)
MY (1) MY130271A (pt)
NO (2) NO322016B1 (pt)
NZ (1) NZ515424A (pt)
PL (1) PL226890B1 (pt)
PT (1) PT1185536E (pt)
RU (1) RU2237063C9 (pt)
SI (2) SI1185536T1 (pt)
SK (2) SK287835B6 (pt)
TR (1) TR200103273T2 (pt)
UA (1) UA75333C2 (pt)
WO (3) WO2000069862A2 (pt)

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SK285069B6 (sk) 1998-05-11 2006-05-04 Pharma Mar, S. A. Zlúčeniny, ktoré sú metabolitmi ekteinascidínu 743, farmaceutické prostriedky s ich obsahom a ich použitie
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
IL152094A (en) * 2000-04-12 2011-10-31 Pharma Mar Sa History of actinacidin and pharmaceutical preparations containing them as anti-cancer substances
US7919493B2 (en) 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
IL152125A (en) * 2000-05-15 2008-04-13 Pharma Mar Sa Process for the manufacture of ecteinascidin derivatives
US6809099B2 (en) 2000-11-03 2004-10-26 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
BR0115162A (pt) * 2000-11-06 2003-10-21 Pharma Mar Sa Tratamentos antitumorais eficazes
GB0117402D0 (en) 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
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GB0229793D0 (en) * 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
US7183054B2 (en) 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds
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CA2545054A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
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DK1658848T3 (da) * 2004-10-29 2007-11-26 Pharma Mar Sa Formuleringer omfattende ecteinascidin og et disaccharid
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
KR100712667B1 (ko) 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
GB0708691D0 (en) * 2007-05-04 2007-06-13 Pharma Mar Sa Anticancer treatments a
US20090076017A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched trabectedin
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３治療のための予後分子マーカー
EP2307003A2 (en) * 2008-05-16 2011-04-13 Pharma Mar S.A. Combination therapy with pm00104 and another antitumor agent
JP2011520846A (ja) * 2008-05-16 2011-07-21 ファルマ・マール・ソシエダード・アノニマ 多発性骨髄腫の治療
WO2011048210A1 (en) 2009-10-22 2011-04-28 Pharma Mar, S.A. PDGFR-α AS RESPONSE MARKER FOR PM00104 TREATMENT
US9428524B2 (en) 2010-05-25 2016-08-30 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
TR201904459T4 (tr) 2010-11-12 2019-05-21 Pharma Mar Sa Bir mitotik inhibitör ile kombinasyon terapisi.
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN107739387B (zh) * 2017-10-16 2020-01-03 上海皓元生物医药科技有限公司 一种制备曲贝替定的关键中间体化合物的方法
CN109912629B (zh) * 2017-12-13 2021-12-24 浙江中科创越药业有限公司 天然产物Trabectedin的制备
TWI824043B (zh) 2018-10-25 2023-12-01 西班牙商瑪製藥股份有限公司 藥物抗體共軛物
CN111518110B (zh) * 2019-02-01 2023-11-03 博瑞生物医药（苏州）股份有限公司 一种海鞘素化合物及其中间体的制备方法
CN111620792B (zh) * 2019-02-28 2023-01-03 兰州大学 一种n,n-二取代氰基甲酰胺的合成方法
IL293128A (en) 2019-11-21 2022-07-01 Pharma Mar Sa Methods of treating small cell lung cancer with lurbinectedin formulations
CN116217584A (zh) * 2021-12-06 2023-06-06 南通诺泰生物医药技术有限公司 Et743及其中间体的光催化合成方法
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Also Published As

Publication number Publication date
HUP0201188A2 (en) 2002-07-29
AU4597300A (en) 2000-12-05
BRPI0110443B1 (pt) 2018-06-26
SI1185536T1 (en) 2005-06-30
NO322016B1 (no) 2006-08-07
CN1360588A (zh) 2002-07-24
BRPI0110801B8 (pt) 2021-05-25
BRPI0010559B8 (pt) 2021-05-25
AU5649601A (en) 2001-11-26
JP2002544280A (ja) 2002-12-24
AU775580B2 (en) 2004-08-05
PT1185536E (pt) 2005-04-29
KR20020021636A (ko) 2002-03-21
AR035842A1 (es) 2004-07-21
DK1185536T3 (da) 2005-04-04
WO2000069862A3 (en) 2001-03-22
BG107301A (bg) 2003-07-31
BR0110443A (pt) 2003-04-08
NO20015547D0 (no) 2001-11-13
RU2237063C9 (ru) 2008-10-10
BG65896B1 (bg) 2010-04-30
CN1441805A (zh) 2003-09-10
CA2406095C (en) 2010-02-16
DE60016209T2 (de) 2005-12-15
SK287879B6 (sk) 2012-02-03
CZ303536B6 (cs) 2012-11-21
CZ20023746A3 (cs) 2003-04-16
CZ20023751A3 (en) 2004-05-12
BR0010559A (pt) 2002-07-02
CN1440414A (zh) 2003-09-03
EP1185536A2 (en) 2002-03-13
CY1108095T1 (el) 2014-02-12
WO2001087894A1 (en) 2001-11-22
PL353002A1 (en) 2003-09-22
NO328301B1 (no) 2010-01-25
SI1287004T1 (sl) 2005-12-31
DE60016209D1 (de) 2004-12-30
SK15272002A3 (sk) 2003-06-03
CZ304973B6 (cs) 2015-02-25
CN100475822C (zh) 2009-04-08
SK16502001A3 (sk) 2002-06-04
CZ304966B6 (cs) 2015-02-18
US7241892B1 (en) 2007-07-10
ATE283273T1 (de) 2004-12-15
CZ20014102A3 (cs) 2002-06-12
NO20025186D0 (no) 2002-10-29
KR100834601B1 (ko) 2008-06-02
MXPA01011631A (es) 2002-07-30
HU230646B1 (hu) 2017-05-29
SK287835B6 (sk) 2011-12-05
WO2000069862A2 (en) 2000-11-23
US20080045713A1 (en) 2008-02-21
NO20025186L (no) 2003-01-14
CN1229382C (zh) 2005-11-30
ES2231486T3 (es) 2005-05-16
BRPI0010559B1 (pt) 2016-08-30
CA2372058C (en) 2010-10-26
US7524956B2 (en) 2009-04-28
NZ515424A (en) 2004-06-25
BR0110801A (pt) 2003-02-11
JP4445136B2 (ja) 2010-04-07
CA2406095A1 (en) 2001-11-22
ES2233367T3 (es) 2005-06-16
UA75333C2 (uk) 2006-04-17
CA2372058A1 (en) 2000-11-23
BRPI0110801B1 (pt) 2018-02-27
MY130271A (en) 2007-06-29
PL226890B1 (pl) 2017-09-29
CN1211386C (zh) 2005-07-20
TR200103273T2 (tr) 2002-04-22
RU2237063C2 (ru) 2004-09-27
US20040002602A1 (en) 2004-01-01
WO2001087895A1 (en) 2001-11-22
EP1185536B1 (en) 2004-11-24
NO20015547L (no) 2002-01-14
HK1047432A1 (en) 2003-02-21

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