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CY1118729T1 - Παραγωγα 9-μεθυλ υποκατεστημενου εξαδεκαϋδροκυκλοπροπα(ε)πυρρολο(1,2-α)(1,4)διαζακυκλοπενταδεκινυλ καρβαμικου ως μη δομικοι 3 (ns3) αναστολεις πρωτεασης για την αγωγη λοιμωξεων απο ιο ηπατιτιδας c - Google Patents

Παραγωγα 9-μεθυλ υποκατεστημενου εξαδεκαϋδροκυκλοπροπα(ε)πυρρολο(1,2-α)(1,4)διαζακυκλοπενταδεκινυλ καρβαμικου ως μη δομικοι 3 (ns3) αναστολεις πρωτεασης για την αγωγη λοιμωξεων απο ιο ηπατιτιδας c

Info

Publication number
CY1118729T1
CY1118729T1 CY20171100231T CY171100231T CY1118729T1 CY 1118729 T1 CY1118729 T1 CY 1118729T1 CY 20171100231 T CY20171100231 T CY 20171100231T CY 171100231 T CY171100231 T CY 171100231T CY 1118729 T1 CY1118729 T1 CY 1118729T1
Authority
CY
Cyprus
Prior art keywords
hepatitis
exadekafdrokyklopropa
diazakyklopentadekinyl
nonstructural
pyrrolo
Prior art date
Application number
CY20171100231T
Other languages
English (en)
Inventor
Li-Qiang Sun
Eric Mull
Eric P Gillis
Michael S Bowsher
Qian Zhao
Kishore V Renduchintala
Kandhasamy Sarkunam
Pulicharla Nagalakshmi
Suresh PVK BABU
Paul Michael Scola
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1118729T1 publication Critical patent/CY1118729T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)

Abstract

Αναστολείς του ιού της ηπατίτιδας C που έχουν τον γενικό χημικό τύπο (I) αποκαλύπτονται. Συνθέσεις που περιλαμβάνουν τις ενώσεις και μέθοδοι για χρήση των ενώσεων για την αναστολή του HCV αποκαλύπτονται επίσης.
CY20171100231T 2012-10-19 2017-02-21 Παραγωγα 9-μεθυλ υποκατεστημενου εξαδεκαϋδροκυκλοπροπα(ε)πυρρολο(1,2-α)(1,4)διαζακυκλοπενταδεκινυλ καρβαμικου ως μη δομικοι 3 (ns3) αναστολεις πρωτεασης για την αγωγη λοιμωξεων απο ιο ηπατιτιδας c CY1118729T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2012/061094 WO2014062196A1 (en) 2012-10-19 2012-10-19 Hepatitis c virus inhibitors

Publications (1)

Publication Number Publication Date
CY1118729T1 true CY1118729T1 (el) 2017-07-12

Family

ID=47144142

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100231T CY1118729T1 (el) 2012-10-19 2017-02-21 Παραγωγα 9-μεθυλ υποκατεστημενου εξαδεκαϋδροκυκλοπροπα(ε)πυρρολο(1,2-α)(1,4)διαζακυκλοπενταδεκινυλ καρβαμικου ως μη δομικοι 3 (ns3) αναστολεις πρωτεασης για την αγωγη λοιμωξεων απο ιο ηπατιτιδας c

Country Status (30)

Country Link
US (1) US9499550B2 (el)
EP (1) EP2909205B1 (el)
JP (1) JP6154474B2 (el)
KR (1) KR20150074051A (el)
CN (1) CN104918941A (el)
AR (1) AR088768A1 (el)
AU (1) AU2012392557B2 (el)
BR (1) BR112015007879A2 (el)
CA (1) CA2888755A1 (el)
CY (1) CY1118729T1 (el)
DK (1) DK2909205T3 (el)
EA (1) EA025560B1 (el)
ES (1) ES2613766T3 (el)
HK (1) HK1212332A1 (el)
HR (1) HRP20161694T1 (el)
HU (1) HUE031625T2 (el)
IL (1) IL238286B (el)
LT (1) LT2909205T (el)
MA (1) MA37992B1 (el)
MX (1) MX360452B (el)
PH (1) PH12015500814A1 (el)
PL (1) PL2909205T3 (el)
PT (1) PT2909205T (el)
RS (1) RS55592B1 (el)
SG (1) SG11201502802PA (el)
SI (1) SI2909205T1 (el)
SM (2) SMT201700117T1 (el)
TW (1) TWI570125B (el)
WO (1) WO2014062196A1 (el)
ZA (1) ZA201503458B (el)

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EP2914598B1 (en) 2012-11-02 2017-10-18 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2014070964A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9643999B2 (en) * 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914614B1 (en) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9580463B2 (en) 2013-03-07 2017-02-28 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
JP2020193181A (ja) * 2019-05-30 2020-12-03 東ソー株式会社 芳香族ニトリル化合物の製造方法
WO2020247736A1 (en) * 2019-06-07 2020-12-10 University Of Massachusetts Hepatitis c virus ns3/4a protease inhibitors
CN112094229B (zh) * 2020-10-12 2022-11-22 苏州康润医药有限公司 6-（三氟甲基）异喹啉-5-醇的合成方法
CN114805204B (zh) * 2022-04-01 2023-09-15 云南师范大学 一种制备4-碘异喹啉-1(2h)-酮类化合物的方法

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