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ECSP12012104A - Inhibidores de virus flaviviridae - Google Patents

Inhibidores de virus flaviviridae

Info

Publication number
ECSP12012104A
ECSP12012104A ECSP12012104A ECSP12012104A EC SP12012104 A ECSP12012104 A EC SP12012104A EC SP12012104 A ECSP12012104 A EC SP12012104A EC SP12012104 A ECSP12012104 A EC SP12012104A
Authority
EC
Ecuador
Prior art keywords
inhibitors
compounds
virus flaviviridae
flaviviridae
formula
Prior art date
Application number
Other languages
English (en)
Inventor
Michael O'neil Hanrahan Clarke
William J Watkins
Eda Canales
Scoott Lazerwith
Wilard Lew
Philip Anthony Morganelli
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43538203&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12012104(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of ECSP12012104A publication Critical patent/ECSP12012104A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Se proporcionan compuestos de Fórmula I:Fórmula (I)y sales y ésteres farmacéuticamente aceptables de dichos compuestos. Los compuestos, las composiciones y los métodos proporcionados son útiles para el tratamiento de infecciones por virus Flaviviridae, en particular infecciones de hepatitis C.
ECSP12012104 2010-01-15 2012-08-13 Inhibidores de virus flaviviridae ECSP12012104A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29557610P 2010-01-15 2010-01-15
US35348110P 2010-06-10 2010-06-10

Publications (1)

Publication Number Publication Date
ECSP12012104A true ECSP12012104A (es) 2012-09-28

Family

ID=43538203

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12012104 ECSP12012104A (es) 2010-01-15 2012-08-13 Inhibidores de virus flaviviridae

Country Status (27)

Country Link
US (2) US8513298B2 (es)
EP (2) EP2523950B1 (es)
JP (2) JP5868872B2 (es)
KR (1) KR101727776B1 (es)
CN (1) CN102712633B (es)
AP (1) AP3576A (es)
AR (1) AR080001A1 (es)
AU (1) AU2011205744B2 (es)
BR (1) BR112012017382A2 (es)
CA (1) CA2785567C (es)
CL (1) CL2012001960A1 (es)
CR (1) CR20120417A (es)
EA (1) EA021196B1 (es)
EC (1) ECSP12012104A (es)
ES (1) ES2626150T3 (es)
IL (1) IL220545B (es)
MX (1) MX2012008211A (es)
NZ (1) NZ600817A (es)
PE (1) PE20130281A1 (es)
PL (1) PL2523950T3 (es)
PT (1) PT2523950T (es)
SG (2) SG182475A1 (es)
SI (1) SI2523950T1 (es)
TW (1) TWI491609B (es)
UY (1) UY33183A (es)
WO (1) WO2011088345A1 (es)
ZA (1) ZA201205248B (es)

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DK2475657T3 (da) * 2009-07-21 2013-09-23 Gilead Sciences Inc 5-Alkynylthien-2-ylcarboxylsyrer som inhibitorer af flaviviridae-vira
NZ598208A (en) 2009-09-09 2014-02-28 Gilead Sciences Inc Inhibitors of flaviviridae viruses
US8513298B2 (en) * 2010-01-15 2013-08-20 Gilead Sciences, Inc. Inhibitors of flaviviridae viruses
KR20120123678A (ko) 2010-01-15 2012-11-09 길리애드 사이언시즈, 인코포레이티드 플라비비리다에 바이러스의 억제제
EP2654900A1 (en) * 2010-12-20 2013-10-30 Gilead Sciences, Inc. Combinations for treating hcv
DE102011003295A1 (de) * 2011-01-28 2012-08-02 Kiekert Ag Kraftfahrzeugschloss
US8741946B2 (en) 2011-07-13 2014-06-03 Gilead Sciences, Inc. Inhibitors of flaviviridae viruses
PL2709613T5 (pl) 2011-09-16 2020-12-14 Gilead Pharmasset Llc Metody leczenia hcv
CN103087052A (zh) * 2011-10-31 2013-05-08 上海壹志医药科技有限公司 噻吩衍生物及其药物用途
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
NZ724616A (en) 2012-06-08 2018-06-29 Gilead Sciences Inc Macrocyclic inhibitors of flaviviridae viruses
WO2013185103A1 (en) 2012-06-08 2013-12-12 Gilead Sciences, Inc. Macrocyclic inhibitors of flaviviridae viruses
US8759544B2 (en) * 2012-08-17 2014-06-24 Gilead Sciences, Inc. Synthesis of an antiviral compound
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US8841340B2 (en) 2012-08-17 2014-09-23 Gilead Sciences, Inc. Solid forms of an antiviral compound
MY172166A (en) 2013-01-31 2019-11-15 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
CN107074904B (zh) 2014-10-23 2022-12-23 深圳华大智造科技股份有限公司 信号约束测序(scs)和用于信号约束测序的核苷酸类似物
PL3236972T3 (pl) 2014-12-26 2022-03-07 Emory University Przeciwwirusowe pochodne n4-hydroksycytydyny
BR112018072298A2 (pt) 2016-05-02 2019-02-12 Florida State University Research Foundation, Inc. tratamento de infecções pelo vírus da zika usando inibidores da alfa-glicosidase
WO2017197051A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Amine-linked c3-glutarimide degronimers for target protein degradation
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
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WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
EP3464336B1 (en) 2016-06-01 2022-03-16 Athira Pharma, Inc. Compounds
GB2581936B (en) 2017-12-07 2021-02-10 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN108096562B (zh) * 2017-12-25 2021-05-11 武汉百药联科科技有限公司 20s蛋白酶体抑制剂在制备治疗日本乙型脑炎病毒感染的药物中的用途
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

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Also Published As

Publication number Publication date
EA021196B1 (ru) 2015-04-30
AP3576A (en) 2016-02-08
US9321753B2 (en) 2016-04-26
TW201134822A (en) 2011-10-16
UY33183A (es) 2011-08-31
CA2785567C (en) 2018-03-27
NZ600817A (en) 2014-08-29
CN102712633B (zh) 2015-07-29
AR080001A1 (es) 2012-03-07
PL2523950T3 (pl) 2017-09-29
KR101727776B1 (ko) 2017-04-17
PE20130281A1 (es) 2013-03-08
AU2011205744A1 (en) 2012-07-26
JP2013517291A (ja) 2013-05-16
US20130315861A1 (en) 2013-11-28
KR20120101733A (ko) 2012-09-14
EP2523950B1 (en) 2017-03-15
US20110178129A1 (en) 2011-07-21
TWI491609B (zh) 2015-07-11
SG182475A1 (en) 2012-08-30
BR112012017382A2 (pt) 2017-12-05
ZA201205248B (en) 2013-03-27
MX2012008211A (es) 2012-08-08
SG10201500298PA (en) 2015-03-30
IL220545B (en) 2018-02-28
CR20120417A (es) 2012-11-30
WO2011088345A1 (en) 2011-07-21
SI2523950T1 (sl) 2017-06-30
US8513298B2 (en) 2013-08-20
EP3219713A1 (en) 2017-09-20
JP2016041732A (ja) 2016-03-31
CN102712633A (zh) 2012-10-03
EA201290576A1 (ru) 2013-01-30
CL2012001960A1 (es) 2012-10-26
AU2011205744B2 (en) 2015-06-25
CA2785567A1 (en) 2011-07-21
IL220545A0 (en) 2012-08-30
JP5868872B2 (ja) 2016-02-24
AP2012006414A0 (en) 2012-08-31
PT2523950T (pt) 2017-06-01
ES2626150T3 (es) 2017-07-24
EP2523950A1 (en) 2012-11-21

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