CN1268316C - 片状贴附剂 - Google Patents
片状贴附剂 Download PDFInfo
- Publication number
- CN1268316C CN1268316C CNB018095615A CN01809561A CN1268316C CN 1268316 C CN1268316 C CN 1268316C CN B018095615 A CNB018095615 A CN B018095615A CN 01809561 A CN01809561 A CN 01809561A CN 1268316 C CN1268316 C CN 1268316C
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- China
- Prior art keywords
- adhesive preparation
- sheet
- weight
- form adhesive
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Abstract
本发明涉及在包含水溶性高分子、多元醇、交联剂、水和肌肤美化成分的基剂中配合清凉剂、芳香剂和/或皮脂调整剂的片状贴附剂。该片状贴附剂保持对皮肤的适度粘着性，而且对皮肤的效果和安全性、以及对身心松弛作用都优异。
Description
技术领域
本发明涉及在包含水溶性高分子、多元醇、交联剂、水和肌肤美化成分的基剂中配合清凉剂、芳香剂和/或皮脂调整剂并用于颜面贴附的片状贴附剂。
背景技术
近年，特开昭54-49334号公报公开了一种以聚丙烯酸盐、多元醇和水作为主要成分的贴附剂，其具有优异的保水性和低的剥离力。另外，特公平1-46485号公报公开了一种使用交联型含水凝胶作为基材的片状贴附剂。特开平5-295004号公报公开了一种配合天然由来的半合成成分作为保湿剂或增粘剂的贴附剂。
但是，现有的贴附剂仍存在以下问题：贴附作用不充分，容易产生贴附时的压迫感及刺痛感等不和谐的感觉，而且当片状化妆品快速发展(コスメブ—ム)时不能满足现在使用者的松弛需要。
另外，特开平8-283147号公报公开了一种作为外用剂适用于皮肤且能够产生持续性适度清凉感的水性粘着组合物。但是，该组合物仅使用诸如湿布片等作为外用剂的成分，没有完全公开作为片状贴附剂的成分。
因此，强烈期望开发出保持对皮肤的适度粘着性，而且对皮肤的效果和安全性、以及对身心松弛作用都优异的片状贴附剂。
发明简述
本发明的目的就是解决上述问题，提供一种保持对皮肤的适度粘着性，而且对皮肤的效果和安全性、以及对身心松弛作用都优异的片状贴附剂。更具体而言，根据本发明提供的片状贴附剂具有贴附作用，在使用时产生爽快的清凉感，在使用后具有持续的爽快的清凉感作用，皮脂去除作用以及皮脂抑制作用效果优异，而且由于爽快的香气和舒适的感觉具有优异的松弛效果。
本发明的发明者为解决上述问题进行了深入的研究，其结果是发现可通过在现有的贴附剂所用的各种成份中再配合加入清凉剂、芳香剂和/或皮脂调整剂来解决上述问题。
因此，本发明涉及一种片状贴附剂，其中在包含水溶性高分子、多元醇、交联剂、水和肌肤美化成份的基剂中配合清凉剂、芳香剂和/或皮脂调整剂。
另外，在本发明的片状贴附剂中，水溶性高分子是选自于以下组中的1种或者2种以上：明胶、聚丙烯酸、聚丙烯酸部分中和物、以及聚丙烯酸盐。
在本发明的片状贴附剂中，多元醇是选自于以下组中的1种或者2种以上：聚乙二醇和聚丙二醇。
在本发明的片状贴附剂中，交联剂是选自于以下组中的1种或者2种以上：水难溶性铝化合物及多官能性环氧化合物。
在本发明的片状贴附剂中，清凉剂是选自于以下组中的1种或者2种以上：薄荷油、d-樟脑、dl-樟脑、l-薄荷醇、异番薄荷醇、3-L-孟氧基丙烷-1，2-二醇、孟基吡咯烷酮羧酸酯、以及L-孟基-3-羟基-丁酸酯。
在本发明的片状贴附剂中，芳香剂是选自于以下组中的1种或者2种以上：桉油、dl-薄荷醇及丁子油。
在本发明的片状贴附剂中，皮脂调整剂是丁子油。
在本发明的片状贴附剂中，清凉剂、芳香剂和/或皮脂调整剂的配合量为基剂总重量的0.001-3重量％。
在本发明的片状贴附剂中，还配合有防腐剂。
本发明的片状贴附剂，其是以颜面作为贴附对象。
另外，在本发明的片状贴附剂中，使用后的皮脂成分量降低至使用前的40％以下。
本发明的实施方式
本发明中所用的水溶性高分子例如包括明胶、聚丙烯酸及其盐、或者其部分中和物，它们可单独或者2种以上配合使用。聚丙烯酸的盐类优选为钠、锂、钾等金属盐，其平均聚合度优选为1000-100000。这些水溶性高分子在基剂中特别优选配合明胶与聚丙烯酸部分中和物的组合。这些水溶性高分子的配合量可为3-25重量％，优选5-20重量％，更优选为5-10重量％。配合量在5重量％以下时，制剂的粘着性和凝集性、保型性、吸水能力等都下降，容易产生膏体不均匀化、操作性低下以及使用感下降的倾向，而且在未满3重量％时该倾向显著化，所以不是理想的。另外，配合量在10重量％以上时，制剂的粘着性和凝集性、保型性不足，制造中粘性也同时过度增加，容易产生膏体不均匀化、操作性低下以及使用感下降的倾向，而且在超过25重量％时该倾向显著化，所以不是理想的。
配合二醇类化合物作为多元醇时，其配合量为基剂总量的1-35重量％，优选5-25重量％，更优选为5-20重量％。配合量为5重量％以下时，制剂会产生粘着性和凝集性、使用前的保水性以及保型性低下，凝胶不均匀，操作性低下，使用时的使用感下降的倾向，而且不足1重量％时该倾向显著化，所以不是理想的。另外，配合量为25重量％以上时，制剂的粘着性和凝集性、使用前的保水性和保型性下降。还发现有操作性低下、使用时的使用感下降的倾向，而且超过35重量％时该倾向显著化，所以不是理想的。多元醇最优选以5-20重量％的配合量范围进行调制。再者，在多元醇中，二醇类化合物优选具有聚醚构造且平均分子量为200-600的聚乙二醇和平均分子量为500-3000的聚丙二醇等，它们可单独或者2种以上配合使用。
交联剂可以单独使用水难溶性铝化合物或多官能性环氧化合物，或2种以上配合使用。水难溶性铝化合物例如是氢氧化铝、含水硅酸铝、合成硅酸铝、高岭土、醋酸铝、乳酸铝、硬脂酸铝、无水氢氧化铝凝胶、硅酸铝镁、二羟基铝氨基乙酸盐、合成水滑石、硅酸铝镁等，可以使用其中1种或2种以上配合使用。通过使用水难溶性铝化合物，除了抑酸作用带来的皮肤刺激性的抑制效果和微量铝离子产生的皮肤收敛作用之外，还可以在初期的物性上呈现出下述功能，即作为填充剂赋予凝胶适当的强度，同时随时间变化铝离子溶出到制剂中，补偿高分子经时分解和高分子间共价键交联部位经时断裂造成的凝胶强度降低。而且，通过pH调整也可以控制其铝离子的溶出速度。
多官能性环氧化合物例如是聚乙二醇二缩水甘油醚、乙二醇二缩水甘油醚、甘油二缩水甘油醚、甘油三缩水甘油醚、丙二醇二缩水甘油醚、聚甘油聚缩水甘油醚、山梨醇聚缩水甘油醚、脱水山梨醇聚缩水甘油醚、三羟甲基丙烷聚缩水甘油醚、五赤藓醇聚缩水甘油醚、间苯二酚二缩水甘油醚、新戊二醇二缩水甘油醚等。
这些多官能性环氧化合物可以使用其中的1种或者2种以上配合使用。通过使用多官能性环氧化合物，可以得到优良的吸水性能和保型性，而且可以与具有羧基、氨基或羟基等的水溶性高分子有效地形成共价键，提高凝胶强度。这些交联剂(即、水难溶性铝化合物和/或多官能性环氧化合物)的配合量可以为0.05～20重量％，优选0.5～15重量％，更优选1～10重量％。配合量为1重量％以下时，有制剂的凝集性和保型性、吸水能力低下，制剂物性的经时稳定性低下，操作性低下，对皮肤的安全性下降，以及使用感下降的倾向，而且未满0.05重量％时该倾向显著化，所以不是理想的。另外，配合量为10重量％以上时，有粘着性、凝集性、保型性、制造中粘度过度增加，由于凝胶化而使膏体不均匀，操作性低下，对皮肤的安全性下降，以及使用感下降的倾向，而且在超过20重量％时该倾向显著化，所以不是理想的。再者，考虑到作为制剂物理性质的使用感觉和使用效果，优选组合使用水难溶性铝化合物和多官能环氧化合物。
在本发明的片状贴附剂中所使用的水是使用蒸馏水、灭菌水、天然水。水作为肌肤美化成分、保湿成分、水溶性高分子、交联剂、防腐剂等的分散、溶解剂发挥作用，对于增加肌肤美化成分和保湿剂的效果，它是特别重要的。而且，水本身也可以产生显著提高使用时和使用后的使用感，并与保湿剂一同向皮肤移行赋予湿润和张力等的效果。因此，水必须大量添加，其配合量为60～95重量％，优选65～90重量％，更优选70～85重量％。通过使制剂中含有大量的水，可以提高制剂自身的相对湿度，另外可以在使用时将大量水有效地排出到外部，结果赋予肌肤湿润，进一步通过水向外部挥发，带走气化热，赋予舒适的清凉感。水的配合量为70重量％以下时，有制剂的粘着性和使用前的保水性降低、操作性降低、使用时的使用感降低的倾向，而且未满60重量％时该倾向显著化，所以不是理想的。另外，配合量为85重量％以上时，容易损坏粘着性和凝集性，并有使用前的保型性下降的倾向，而且超过95重量％时该倾向显著化，所以不是理想的。
作为肌肤美化成分，可以使用尿囊素、娑罗果提取物(マロニエエキス)、水溶性胎盘提取物、鼠尾草提取物、曲酸(コウジ酸)、卵磷脂、氨基酸、蛋白质、糖类、激素类、胎盘提取物，或者芦荟、丝瓜(ヘチマ)和甘草等生药中的提取物，或者是维生素A、维生素C、维生素D、维生素E以及其他维生素类或它们的衍生物。其还可以是以下具有美白作用的药物：甘草亭酸二钾、盐酸苯海拉明、水杨酸苯海拉明、单宁酸苯海拉明、盐酸曲普利啶、美喹他嗪、马来酸氯苯那敏、d-马来酸氯苯那敏、富马酸氯马斯丁、盐酸异丙嗪、曲尼司特、色甘酸钠、酮替芬、芳香基硫酸酯酶B、丁苯羟酸、苄达酸、氟芬那酸丁酯、布洛芬、吲哚美辛、阿司匹林、氟比洛芬、酮洛芬、吡罗昔康、2-吡啶甲基甲芬那酸、布洛芬吡啶甲醇、5，6-脱氢花生四烯酸、5，6-亚甲基-LTA4、七叶内酯、异泽兰黄素、咖啡因酸、苯恶洛芬等，它们可单独或者2种以上组合使用。这些肌肤美化成分的配合量为0.001-10重量％，优选为0.005-5重量％，更优选为0.01-5重量％。配合量为0.005重量％以下时，则容易产生操作性下降、以及使用感和使用效果下降的倾向，而且未满0.001重量％时该倾向显著化，所以不是理想的。另外，配合量为5重量％以上时，则容易产生制剂的粘着性和凝集性、保型性欠缺，并同时容易产生膏体的不均匀性、操作性下降、安全性下降以及使用感和使用效果下降的倾向，而且在超过10重量％时该倾向显著化，所以不是理想的。
清凉剂是选自于以下组中的1种或者2种以上：薄荷油、d-樟脑、dl-樟脑、L-薄荷醇、异番薄荷醇、3-L-氧基丙烷-1，2-二醇、基吡咯烷酮羧酸酯、或者L-基-3-羟基-丁酸酯。相对于基剂总量，该清凉剂的配合量为0.0005-2.9重量％，优选为0.0005-2重量％，更优选为0.001-1重量％。
未满0.0005重量％时，很难得到由清爽的香气和爽快的使用感产生的松弛效果。另外，超过2.9重量％时，虽然清凉效果增加，但随着清凉效果的增加，产生了皮肤刺激感增强的倾向。再者，由于会使成本中的原料价格升高，所以不是理想的。
作为芳香剂，可配合桉油、dl-薄荷醇或者丁子油中的1种或者2种以上。相对于基剂总量，芳香剂的配合量可为0.0001-2.9重量％，优选为0.0005-2重量％，更优选为0.001-1重量％。未满0.0001重量％时，不仅由清爽的香气产生的松弛效果衰减，而且与清凉剂组合所产生的协同松弛效果也衰减。另外，超过2.9重量％时，芳香性极度增强，发现有使用时不愉快的倾向。另外，由于制剂中芳香成分渗出的现象，则更容易产生粘着性下降、成本中原料价格升高的问题，所以不是理想的。
作为皮脂调整剂，可使用丁子油。其配合量可为0.00001-2.9重量％，优选为0.00001-2重量％，更优选为0.0002-1重量％。未满0.00001重量％时，不能充分地去除皮脂成分。另外，在超过2.9重量％时，很难使使用感增加，所以不是理想的。
选自于前述薄荷油、d-樟脑、dl-樟脑或l-薄荷醇中的1种或者2种以上的清凉剂和选自于桉油、dl-薄荷醇和丁子油中的1种或者2种以上的芳香剂以及作为皮脂调整剂的丁子油在基剂总量中的配合量优选在0.001-3重量％的范围内，另外这些成分的配合比在0.1-160∶0.1-110的范围内，由此调制可得到最好的效果。也就是说，清爽的香气和爽快的使用感产生松弛效果，并显著提高肌肤美化作用，因此组合清凉剂和芳香剂的配合平衡是最合适的。
另外，对于皮脂去除作用和皮脂抑制作用效果，本发明的片状贴附剂使用后的每单位面积的皮脂成分量的比例，优选为使用前的40％以下，更优选为30％以下。
除上述基剂成分外，本发明的片状贴附剂还可适当地以合适的量配合已知的防腐剂、保湿成分、抗氧剂、增粘剂、溶解剂、色素、香料、表面活性剂、紫外吸收剂、无机填充剂和pH调节剂。
防腐剂例如为对羟基苯甲酸酯(例如对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丙酯)、1，2-戊二醇、苯甲酸、苯甲酸盐、水杨酸、山梨酸、山梨酸盐、脱氢醋酸盐、4-异丙基-3-甲基苯酚、2-异丙基-5-甲基苯酚、苯酚、日柏酚、甲酚、2，4，4′-三氯-2′-羟基二苯基醚、3，4，4＇-三氯二苯脲、氯丁醇、苯扎氯铵、氯化苄乙氧铵等，可以使用其中1种或2种以上配合使用。其中优选对羟基苯甲酸酯。其配合量可为0.005～10重量％，优选0.01～5重量％，更优选0.01～1重量％。配合量为0.01重量％以下时，由于在保存中产生霉菌和细菌，使制剂腐败，而且有使用时和使用后的使用感下降的倾向，而且在未满0.005重量％时该倾向显著化，所以不是理想的。另外，配合量为1重量％以上时，制剂中的粘着性、凝集性发生微妙的变化，对于使用感有刺激和防腐剂臭产生的不愉快等的影响，而且超过10重量％时该倾向显著化，所以不是理想的。
作为保湿成分，可以配合使用以下物质中的1种或2种以上：玫瑰果提取物、柑桔提取物、柑桔果汁、黑莓提取物、猕猴桃提取物、黄瓜子提取物、栀子提取物、葡萄柚提取物、山楂提取物、山椒提取物、英国山楂提取物、欧洲杜松提取物、大棘(タイソウ)提取物、杂交樱桃(デュ—ク)提取物、番茄提取物、葡萄提取物、丝瓜提取物、梨莓果汁、苹果提取物、苹果果汁、柠檬提取物、柠檬果汁、琥珀酰酸乳酒胞外多糖水溶液、乙酰酸乳酒胞外多糖水溶液、马来酰酸乳酒胞外多糖水溶液、麦芽根提取物、蔷薇提取物、胶原、神经酰胺、透明质酸。水果提取物(果汁)还具有作为香料的效果，而且还可更高地维持作为必须成分的清凉剂和芳香剂的效果。
作为抗氧化剂，可以配合依地酸钠盐、抗坏血酸、没食子酸丙酯、丁基羟基苯甲醚、二丁基羟基甲苯、去甲二氢愈创木酸、生育酚、醋酸生育酚等。
作为增粘剂，可以配合酪蛋白、茁酶多糖、琼脂、葡聚糖、海藻酸钠、可溶性淀粉、羧基淀粉、糊精、羧甲基纤维素、羧甲基纤维素钠、甲基纤维素、乙基纤维素、羟乙基纤维素、聚乙烯醇、聚环氧乙烷、聚丙烯酰胺、聚丙烯酸、聚乙烯吡咯烷酮、羧基乙烯聚合物、聚乙烯醚、聚马来酸共聚物、甲氧基乙烯马来酸酐共聚物、异丁烯马来酸酐共聚物、聚乙烯亚胺等。
作为溶解剂，可以配合苯甲醇、焦硫代癸烷(pyrothiodecan)、薄荷油、肉豆蔻酸异丙酯、克罗它米通等。
色素优选对制剂外观没有太大的影响并与提高使用感和肌肤的活化感有关的物质，例如红色2号(苋菜红)、红色3号(赤藓红)、红色102号(新胭脂红)、红色104号之(1)(根皮红B)、红色105号之(1)(玫瑰红)、红色106号(酸性红)、黄色4号(酒石黄)、黄色5号(黄原酸盐黄FCF)、绿色3号(坚牢绿FCF)、蓝色1号(艳蓝FCF)、蓝色2号(靛胭脂)等法定色素。对色素没有特别的限定，只要不较大地影响制剂的外观，并可提高使用感和肌肤的活性化感。
作为表面活性剂，可以配合二辛基磺基琥珀酸钠、烷基硫酸酯盐、2一乙基己基烷基硫酸酯钠盐、正十二烷基苯磺酸钠等阴离子表面活性剂，十六烷基三甲基氯化铵、十八烷基二甲基苄基氯化铵、聚氧乙烯十二烷基一甲基氯化铵等阳离子表面活性剂，聚氧乙烯硬脂基醚、聚氧乙烯十三烷基醚、聚氧乙烯壬基苯基醚、聚氧乙烯辛基苯基醚、聚氧乙烯单硬脂酸酯、脱水山梨醇单硬脂酸酯、脱水山梨醇单棕榈酸酯、脱水山梨醇倍半油酸酯、聚氧乙烯脱水山梨醇单月桂酸酯、聚氧乙烯脱水山梨醇单油酸酯、甘油单硬脂酸酯、聚甘油脂肪酸酯、聚氧乙烯十八烷基胺等非离子表面活性剂。
作为紫外线吸收剂，可以配合对氨基苯甲酸、对氨基苯甲酸酯、对二甲氨基苯甲酸戊酯、水杨酸酯、氨茴酸薄荷酯、7-羟基香豆素、七叶苷、桂皮酸苯甲酯、对甲氧肉桂酸乙氧乙酯、愈疮奥、尿刊酸、2-(2-羟基-5-甲基苯基)苯并三唑、4-甲氧基二苯甲酮、2-羟基-4-甲氧基二苯甲酮、二羟苯酮、辛苯酮、二羟基二甲氧基二苯甲酮、スリソベンゾン、苯并间苯二酚、辛基二甲基对氨基苯甲酸酯、乙基己基对甲氧基肉桂酸酯等。
作为无机填充剂，可以配合氧化钛、滑石、氧化锌、含水二氧化硅、碳酸镁、磷酸氢钙、硅酸镁、硅藻土、硅酸酐、膨润土等。
作为pH调节剂，可以配合醋酸、甲酸、乳酸、酒石酸、草酸、苯甲酸、乙醇酸、苹果酸、枸橼酸、盐酸、硝酸、硫酸、氢氧化钠、氢氧化钾、甲胺、乙胺、丙胺、二甲胺、二乙胺、二丙胺、三甲胺、三乙胺、三丙胺、一甲醇胺、一乙醇胺、一丙醇胺、二甲醇胺、二乙醇胺、二丙醇胺、三甲醇胺、三乙醇胺、三丙醇胺等。
将上述各成分适当地适量配合得到的膏体的pH值最好照顾到不给皮肤带来刺激，5g膏体在蒸馏水中稀释至100g时，pH值优选为5～8，更优选为5.5～7.5，进一步优选为6～7。
另外，涂敷膏体的支持体例如是聚乙烯、聚丙烯、聚对苯二甲酸乙二醇酯、乙烯-醋酸乙烯酯共聚物、氯乙烯、聚氨酯、聚酯、聚酰胺、人造纤维、聚酯等通气性和透湿性的合成树脂薄膜、伸缩性无纺布、无纺纸、上述合成树脂制薄膜或片材与无纺布或无纺纸的层压体、脱脂棉等无纺布、布、伸缩性布、纸、玻璃纸等柔性物质，可以根据其用途适当选择本领域技术人员公知的物质。而且，通过将膏体层涂敷在柔性支持体构成的基布上，在该膏体层的表面上进一步用剥离性薄膜或纸覆盖，可以保持制剂的稳定性。另外，对于剥离纸设计割线、缝纫机眼等，制成容易剥离、容易贴付的形状，以便很容易地贴付到脸上。另外，对于基布的颜色没有特别的限定，由于是不会给制剂的外观带来太大影响并与提高使用感和肌肤的活化感有关的物质，例如白色、肤色、黄色、红色、绿色、蓝色、粉红色、浅蓝色、茶色等，优选根据需要调节浓淡。
本发明的片状贴附剂的制备方法将以片状贴附剂为代表例进行描述。片状贴附剂的制备方法是在搅拌机中将上述成分混合和/或溶解均匀，将其延展在未染色或已染色的基布上，将剥离纸贴付在其上，裁成颜面的形状。另外，适当地切掉眼、鼻、口和颌骨部分制成合适的形状，加工成容易操作的产品。另外，以用于脸上的某些部位为目的，也可以加工成以鼻为适用部位的鼻用贴附剂、以眼为适用部位的眼用贴附剂等非常适用于目的部位的形状。另外，从防止保存过程中的污染、挥发性物质蒸发等引起的效果降低等意义上考虑，片状贴附剂优选保存在密封性的袋或容器中待用。
本发明涉及一种片状贴附剂，其中在包含水溶性高分子、多元醇、交联剂、水和肌肤美化成份的基剂中配合清凉剂、芳香剂和/或皮脂调整剂。该片状贴附剂具有贴附作用，保持对皮肤的适度粘着性，而且对皮肤的效果和安全性、以及对身心的松弛作用优异。
实施例
以下结合实施例和试验例更详细地说明本发明的片状贴附剂，但是它们不能作为本发明的任何限定。
实施例1
将色素0.0015重量％分散到蒸馏水74.195重量％中，在其中加入并溶解明胶0.5重量％、水溶性胎盘提取物1重量％、对羟基苯甲酸乙酯0.1重量％后，添加薄荷油0.08195重量％、L-薄荷醇0.0035重量％、d-樟脑0.81970重量％、桉油0.08195重量％、dl-薄荷醇0.00820重量％、丁子油0.0082重量％、山梨醇聚缩水甘油醚0.2重量％，再加入聚丙烯酸部分中和物7重量％、聚乙二醇10重量％、聚丙二醇5重量％以及合成硅酸铝1重量％的混合物(表1)，并搅拌均匀。接着，将其延展在基布上使厚度达到约1.4mm，贴付薄膜。然后，裁成脸的形状，切掉眼、鼻、口和颌骨部分制成适当的形状，得到片状贴附剂。
实施例2-9
按照与实施例1相同的方法调制如表1所示的配合剂及配合量，得到片状贴附剂。其中成分(％)是指重量％。
比较例
比较例1：未配合清凉剂和芳香剂
由实施例1的处方中除去清凉剂和芳香剂，蒸馏水的配合量为75.1985重量％，其余与实施例1相同，制得片状贴附剂。
比较例2：未配合清凉剂
由实施例1的处方中除去清凉剂，蒸馏水的配合量为75.10015重量％，其余与实施例1相同，制得片状贴附剂。
比较例3：未配合芳香剂
由实施例1的处方中除去芳香剂，蒸馏水的配合量为74.29335重量％，其余与实施例1相同，制得片状贴附剂。
以上比较例1-3的成分以及实施例1-9的成分都如表1所示。
表1
| 成分(％) | 实施例 | 比较例 | ||||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 1 | 2 | 3 | |
| 薄荷油 | 0.08195 | 0.00033 | 0.0422 | 0.3104 | 0.00016 | 0.00804 | 0.00156 | 0.033 | 0.04545 | 0.08195 | ||
| d-樟脑 | 0.81970 | 0.4219 | 0.1724 | 0.00161 | 0.81970 | |||||||
| dl-樟脑 | 0.00040 | 0.2000 | 0.48232 | 0.01558 | 0.040 | 0.05456 | ||||||
| 桉油 | 0.08195 | 0.00020 | 1.6878 | 0.0062 | 0.00016 | 0.00804 | 0.00156 | 0.020 | 0.03636 | 0.08195 | ||
| l-薄荷醇 | 0.0035 | 0.0042 | 0.2104 | 0.00805 | 0.00015 | 0.004 | 0.0035 | |||||
| dl-薄荷醇 | 0.00820 | 0.00004 | 0.1000 | 0.00080 | 0.04545 | 0.0082 | ||||||
| 丁子油 | 0.00820 | 0.00003 | 0.8439 | 0.0006 | 0.00002 | 0.00080 | 0.03115 | 0.003 | 0.01818 | 0.0082 | ||
| 水溶性胎盘提取物 | 1 | 1 | 0.09 | 0.5 | 3 | 1 | 1 | |||||
| 尿囊素 | 0.05 | 0.1 | 0.04 | 0.5 | 0.05 | 0.1 | ||||||
| 聚乙二醇 | 10 | 15 | 5 | 15 | 5 | 1 | 10 | 10 | 10 | 10 | ||
| 聚丙二醇 | 5 | 5 | 5 | 20 | 10 | 10 | 5 | 5 | 5 | |||
| 明胶 | 0.5 | 2 | 1 | 3 | 0.7 | 3 | 1 | 5 | 0.5 | 0.5 | 0.5 | |
| 聚丙烯酸 | 2 | 10 | ||||||||||
| 聚丙烯酸钠 | 4 | 0.9 | 4 | |||||||||
| 聚丙烯酸部分中和物 | 7 | 6 | 8 | 6 | 10 | 7 | 7 | 7 | ||||
| 高岭土 | 4 | 8 | ||||||||||
| 醋酸铝 | 0.05 | 2 | ||||||||||
| 合成硅酸铝 | 1 | 2 | 4 | 1 | 1 | 1 | ||||||
| 山梨醇聚缩水甘油醚 | 0.2 | 0.05 | 0.1 | 0.2 | 0.2 | 0.2 | ||||||
| 聚乙二醇二缩水甘油醚 | 0.025 | 0.1 | ||||||||||
| 丙二醇二缩水甘油醚 | 0.02 | 0.1 | ||||||||||
| 甘油二缩水甘油醚 | 0.025 | 0.5 | ||||||||||
| 聚甘油聚缩水甘油醚 | 0.05 | 0.05 | ||||||||||
| 甘油三缩水甘油醚 | 0.08 | 0.1 | ||||||||||
| 对羟基苯甲酸甲酯 | 0.3 | 0.1 | 0.5 | 0.25 | 0.01 | |||||||
| 对羟基苯甲酸乙酯 | 0.1 | 0.05 | 0.5 | 0.1 | 0.1 | 0.1 | ||||||
| 对羟基苯甲酸丙酯 | 0.05 | 0.01 | 0.1 | 0.01 | ||||||||
| 香料 | 0.001 | 0.0001 | ||||||||||
| 色素 | 0.0015 | 0.001 | 0.003 | 0.0005 | 0.0015 | 0.0015 | 0.0015 | |||||
| 水 | 74.195 | 70.548 | 73.649 | 60 | 85 | 75 | 95 | 78.497 | 61.2794 | 75.1985 | 75.10015 | 74.29335 |
试验例
试验例1：粘着性试验
对实施例4-9的片状贴附剂进行粘着性试验，其结果示于表2中。试验使用预先在25℃、60％RH的条件下放置30分钟以上的试料，并在相同的条件下实施。首先，将试料粘着面向上地固定在水平台上。接着，使直径为20/32英寸的钢球沿以下轨迹降落到粘着面上，该轨迹是由17.35cm的高度下降并沿底边行走30cm距离而形成的正弦曲线。该钢球由接地点至到达地点的距离(cm)作为粘着力的评估标准。另外，所用钢球是诸如材质为JIS G4805(高碳铬轴用钢材)的SUJ 2、精度为JIS B1501(球轴承用钢球)的高级钢球。
表2
| 粘着力 | |
| 实施例4 | 9cm |
| 实施例5 | 10cm |
| 实施例6 | 3cm |
| 实施例7 | 12cm |
| 实施例8 | 4cm |
| 实施例9 | 15cm |
如表2所示，这些实施例表现出良好的粘着性。
试验例2：表皮中皮脂成分量的残存试验
对于实施例1、2和3以及比较例1、2和3，在使用前和使用后测定表皮中的皮脂成分的量并进行比较，其结果示于表3中。试验中，预先使受试者在25℃、60％RH的条件下停留30分钟以上，然后用(株)アミツク制造的SKICOS 301测定额的皮脂成分的量。接着，切断3cm×3cm的试料，并将其贴附在受试者的额15分钟，然后同样地测定额的皮脂成分的量。
表3
| 皮脂成分量(μg/cm2) | ||
| 使用前 | 使用后 | |
| 实施例1 | 80 | 23 |
| 实施例2 | 76 | 20 |
| 实施例3 | 82 | 21 |
| 比较例1 | 78 | 44 |
| 比较例2 | 81 | 37 |
| 比较例3 | 77 | 40 |
由表3可以看出，对于实施例1、2和3，使用后的单位面积的皮脂成分量分别为使用前的29％、26％和26％，降低至使用前的30％以下，而比较例1、2和3分别为56％、46％和52％。因此，确认实施例1、2和3与比较例1、2和3相比具有更显著的皮脂去除作用和皮脂抑制效果。
试验例3：使用感评价试验
对于实施例8、2、3和比较例1、2进行使用感试验。试验中，20多岁的男性30名分为使用实施例8和比较例1的组、使用实施例2和比较例2的组、以及使用实施例3和比较例3的组(各10名)，分别进行评价。给予受试者实施例和比较例的两个样品各1枚，使之分别在不同的日期使用。之后，让受试者对清凉感、有效感和松弛感等项目用非常好-完全不好5个级别进行评价。表4表示(清凉感)的试验结果，表5表示(有效感)的试验结果，而表6表示(松弛感)的试验结果。
表4：(清凉感)(人)
| 非常好 | 好 | 不确定 | 不太好 | 完全不好 | |
| 实施例8 | 7 | 3 | 0 | 0 | 0 |
| 实施例2 | 3 | 6 | 1 | 0 | 0 |
| 实施例3 | 1 | 5 | 4 | 0 | 0 |
| 比较例1 | 0 | 0 | 3 | 5 | 2 |
| 比较例2 | 0 | 1 | 7 | 2 | 0 |
| 比较例3 | 0 | 4 | 6 | 0 | 0 |
表5：(有效感)(人)
| 非常好 | 好 | 不确定 | 不太好 | 完全不好 | |
| 实施例8 | 3 | 4 | 3 | 0 | 0 |
| 实施例2 | 2 | 5 | 3 | 0 | 0 |
| 实施例3 | 4 | 4 | 2 | 0 | 0 |
| 比较例1 | 0 | 0 | 6 | 3 | 1 |
| 比较例2 | 0 | 1 | 7 | 1 | 1 |
| 比较例3 | 0 | 2 | 7 | 1 | 0 |
表6：(松弛感)(人)
| 非常好 | 好 | 不确定 | 不太好 | 完全不好 | |
| 实施例8 | 6 | 3 | 1 | 0 | 0 |
| 实施例2 | 2 | 7 | 1 | 0 | 0 |
| 实施例3 | 1 | 5 | 4 | 0 | 0 |
| 比较例1 | 0 | 0 | 3 | 4 | 3 |
| 比较例2 | 0 | 2 | 6 | 2 | 0 |
| 比较例3 | 0 | 0 | 7 | 3 | 0 |
由表4-6的结果可以看出，本发明的实施例2、3和8在使用时具有优异的清凉感、有效感和松弛感。
试验例4：皮肤安全性试验
对实施例1、2、3和比较例1、3进行皮肤安全性试验。在试验中，健康的男性和女性30名进行48小时的封闭贴布(closed patch)试验，观察剥离后经过1小时和24小时的皮肤变化程度，并以下述标准对皮肤刺激度进行评估。试验结果示于表7中。
-：皮肤没有变化
±：皮肤略微发红
+：皮肤明显发红
++：皮肤有严重的刺激
表7
| 剥离后的时间 | 评价试料 | ++ | + | ± | - | 合计(人) | 阳性率(％) |
| ±以上 | |||||||
| 1小时后 | 实施例1 | 0 | 0 | 0 | 30 | 30 | 0.0 |
| 实施例2 | 0 | 0 | 0 | 30 | 30 | 0.0 | |
| 实施例3 | 0 | 0 | 1 | 29 | 30 | 3.3 | |
| 比较例1 | 0 | 0 | 3 | 27 | 30 | 10.0 | |
| 比较例2 | 0 | 0 | 6 | 24 | 30 | 20.0 | |
| 24小时后 | 实施例1 | 0 | 0 | 0 | 30 | 30 | 0.0 |
| 实施例2 | 0 | 0 | 0 | 30 | 30 | 0.0 | |
| 实施例3 | 0 | 0 | 0 | 30 | 30 | 0.0 | |
| 比较例1 | 0 | 0 | 1 | 29 | 30 | 3.3 | |
| 比较例2 | 0 | 0 | 3 | 27 | 30 | 10.0 |
由表7的结果可以看出，本发明的实施例1-3对皮肤完全没有刺激作用。
产业上的可利用性
本发明的片状贴附剂具有适度的粘着性，使用感良好，皮肤的安全性优异。另外，对皮肤的皮脂去除作用和皮脂抑制作用、以及由清凉剂和芳香剂产生的松弛作用也优异，能够满足使用者的松弛需要。再者，本发明的片状贴附剂可以用作用于调理肌肤和美容的药物、保健品或化妆品，在产业上是非常有用的。
Claims (9)
1、一种片状贴附剂，其在包含水溶性高分子、多元醇、交联剂、水和肌肤美化成份的基剂中配合清凉剂、芳香剂和作为皮脂调整剂的丁子油。
2、如权利要求1所述的片状贴附剂，其中水溶性高分子是选自于以下组中的1种或者2种以上：明胶、聚丙烯酸、聚丙烯酸部分中和物、及聚丙烯酸盐。
3、如权利要求1所述的片状贴附剂，其中多元醇是选自于以下组中的1种或者2种以上：聚乙二醇和聚丙二醇。
4、如权利要求1所述的片状贴附剂，其中交联剂是选自于以下组中的1种或者2种以上：水难溶性铝化合物和多官能性环氧化合物。
5、如权利要求1-4之一所述的片状贴附剂，其中清凉剂是选自于以下组中的1种或者2种以上：薄荷油、d-樟脑、dl-樟脑、1-薄荷醇、异番薄荷醇、3-L-氧基丙烷-1，2-二醇、基吡咯烷酮羧酸酯、和L-基-3-羟基-丁酸酯。
6、如权利要求1-4之一所述的片状贴附剂，其中芳香剂是选自于以下组中的1种或者2种以上：桉油、dl-薄荷醇和丁子油。
7、如权利要求1-4之一所述的片状贴附剂，其中清凉剂、芳香剂和皮脂调整剂的配合量为基剂总重量的0.001-3重量％。
8、如权利要求1-4之一所述的片状贴附剂，其中还配合有防腐剂。
9、如权利要求1-4之一所述的片状贴附剂，其是以颜面作为贴附对象。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000141331 | 2000-05-15 | ||
| JP141331/2000 | 2000-05-15 | ||
| JP141331/00 | 2000-05-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1429094A CN1429094A (zh) | 2003-07-09 |
| CN1268316C true CN1268316C (zh) | 2006-08-09 |
Family
ID=18648463
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB018095615A Expired - Fee Related CN1268316C (zh) | 2000-05-15 | 2001-05-15 | 片状贴附剂 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030133968A1 (zh) |
| EP (1) | EP1287806A4 (zh) |
| KR (1) | KR20030005338A (zh) |
| CN (1) | CN1268316C (zh) |
| AU (1) | AU5673901A (zh) |
| BR (1) | BR0110799A (zh) |
| CA (1) | CA2409478A1 (zh) |
| WO (1) | WO2001087244A1 (zh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002062312A1 (en) | 2001-02-08 | 2002-08-15 | The Procter & Gamble Company | Mask composition |
| KR100889659B1 (ko) * | 2002-05-27 | 2009-03-19 | 애경산업(주) | 피부 냉각용 조성물 |
| JP4693340B2 (ja) * | 2002-06-19 | 2011-06-01 | 昭和電工株式会社 | 含水ゲル体、該含水ゲル体の製造方法およびその用途 |
| JP3739731B2 (ja) * | 2002-07-03 | 2006-01-25 | カネボウ株式会社 | シート状パック化粧料 |
| JP2004269368A (ja) * | 2003-03-05 | 2004-09-30 | Ogawa & Co Ltd | 冷感剤組成物および該冷感剤組成物を含有する冷感化粧料 |
| US7972589B2 (en) | 2004-05-17 | 2011-07-05 | Akzo Nobel N.V. | Hair fixative film |
| JP5180434B2 (ja) * | 2005-12-28 | 2013-04-10 | 花王株式会社 | 角栓除去シート |
| JP5550863B2 (ja) * | 2008-12-18 | 2014-07-16 | ライオン株式会社 | 化粧料 |
| WO2015064681A1 (ja) * | 2013-10-30 | 2015-05-07 | ロート製薬株式会社 | 外用組成物 |
| JP2015147750A (ja) * | 2014-02-07 | 2015-08-20 | 株式会社コーセー | パック化粧料 |
| CN104436206B (zh) * | 2014-12-17 | 2018-09-21 | 广西德之然生物科技有限公司 | 一种制备退热贴采用的植物胶体材料及其制备方法 |
| EP3238717B1 (en) * | 2014-12-22 | 2019-08-28 | Hisamitsu Pharmaceutical Co., Inc. | Cataplasm |
| JP6581521B2 (ja) * | 2016-02-09 | 2019-09-25 | 三粧化研株式会社 | ピーリングパック剤 |
| CN106073982A (zh) * | 2016-06-16 | 2016-11-09 | 广州仁益医疗器械有限公司 | 阴囊医用降温贴 |
| JP7603032B2 (ja) | 2022-02-28 | 2024-12-19 | 花王株式会社 | 顔用シートマスク |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6296403A (ja) * | 1985-10-21 | 1987-05-02 | Watanabe Yakuhin Kogyo Kk | アイパツク剤 |
| CN1116900C (zh) * | 1993-05-19 | 2003-08-06 | 久光制药株式会社 | 溶剂及含有该溶剂的外用制剂 |
| JP3553174B2 (ja) * | 1995-01-09 | 2004-08-11 | 久光製薬株式会社 | シート状パック剤 |
| JP3291971B2 (ja) * | 1995-04-12 | 2002-06-17 | ライオン株式会社 | 水性粘着剤組成物及び清涼感の増強方法 |
| EP0750905B1 (en) * | 1995-06-27 | 2003-01-02 | Kao Corporation | Patch comprising water soluble adhesive sheet |
| JPH10109945A (ja) * | 1996-10-04 | 1998-04-28 | Hisamitsu Pharmaceut Co Inc | 可塑剤および該可塑剤を含有する貼付剤 |
| JP3571172B2 (ja) * | 1997-04-25 | 2004-09-29 | カネボウ株式会社 | パック料 |
| JPH1129434A (ja) * | 1997-07-09 | 1999-02-02 | Kao Corp | シート状パック化粧料 |
| JP3048469U (ja) * | 1997-09-19 | 1998-05-15 | ダイヤ製薬株式会社 | 鼻パック |
| US6120792A (en) * | 1998-04-29 | 2000-09-19 | Juni; Jack E. | Medicated skin patch and method for its use |
| KR100290537B1 (ko) * | 1998-06-17 | 2001-09-17 | 차동천 | 시트형화장용팩 |
| JP4456679B2 (ja) * | 1998-07-10 | 2010-04-28 | 久光製薬株式会社 | ステロイド含有パップ剤及びその製造方法 |
| JP3902705B2 (ja) * | 1998-08-19 | 2007-04-11 | 花王株式会社 | シート状パック |
| EP0993936A3 (en) * | 1998-10-13 | 2001-08-08 | Nitto Denko Corporation | Gel sheet for cosmetics and method for producing the same |
| MY128817A (en) * | 1999-01-28 | 2007-02-28 | Hisamitsu Pharmaceutical Co | Sheet-shaped pack agent |
| TWI233810B (en) * | 1999-02-19 | 2005-06-11 | Hisamitsu Pharmaceutical Co | A paster sheet |
| WO2000056277A1 (en) * | 1999-03-18 | 2000-09-28 | Unilever Plc | Cosmetic towelettes |
| JP3991080B2 (ja) * | 1999-07-06 | 2007-10-17 | 株式会社カネボウ化粧品 | 毛穴ひきしめパック料および使用方法 |
| JP2001058920A (ja) * | 1999-08-20 | 2001-03-06 | Kao Corp | 化粧料 |
| JP3655781B2 (ja) * | 1999-08-25 | 2005-06-02 | 帝國製薬株式会社 | ビタミンｃ又はその誘導体を配合したパップ剤 |
-
2001
- 2001-05-15 CN CNB018095615A patent/CN1268316C/zh not_active Expired - Fee Related
- 2001-05-15 WO PCT/JP2001/004026 patent/WO2001087244A1/ja not_active Application Discontinuation
- 2001-05-15 US US10/276,214 patent/US20030133968A1/en not_active Abandoned
- 2001-05-15 BR BR0110799-2A patent/BR0110799A/pt not_active IP Right Cessation
- 2001-05-15 EP EP01930143A patent/EP1287806A4/en not_active Withdrawn
- 2001-05-15 AU AU56739/01A patent/AU5673901A/en not_active Abandoned
- 2001-05-15 KR KR1020027015118A patent/KR20030005338A/ko not_active Application Discontinuation
- 2001-05-15 CA CA002409478A patent/CA2409478A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001087244A1 (fr) | 2001-11-22 |
| KR20030005338A (ko) | 2003-01-17 |
| BR0110799A (pt) | 2003-02-11 |
| EP1287806A1 (en) | 2003-03-05 |
| CN1429094A (zh) | 2003-07-09 |
| CA2409478A1 (en) | 2002-12-02 |
| AU5673901A (en) | 2001-11-26 |
| US20030133968A1 (en) | 2003-07-17 |
| EP1287806A4 (en) | 2004-05-26 |
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