BRPI0417958A - composto, composição farmacêutica, processo para a preparação de um sal maleato, uso de um sal maleato, e, método para produzir um efeito redutor na permeabilidade antiangiogênica e/ou vascular em um animal de sangue quente - Google Patents
composto, composição farmacêutica, processo para a preparação de um sal maleato, uso de um sal maleato, e, método para produzir um efeito redutor na permeabilidade antiangiogênica e/ou vascular em um animal de sangue quenteInfo
- Publication number
- BRPI0417958A BRPI0417958A BRPI0417958-7A BRPI0417958A BRPI0417958A BR PI0417958 A BRPI0417958 A BR PI0417958A BR PI0417958 A BRPI0417958 A BR PI0417958A BR PI0417958 A BRPI0417958 A BR PI0417958A
- Authority
- BR
- Brazil
- Prior art keywords
- maleate salt
- vascular permeability
- antiangiogenic
- warm
- compound
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, PROCESSO PARA A PREPARAçãO DE UM SAL MALEATO, USO DE UM SAL MALEATO, E, MéTODO PARA PRODUZIR UM EFEITO REDUTOR NA PERMEABILIDADE ANTIANGIOGêNICA E/OU VASCULAR EM UM ANIMAL DE SANGUE QUENTE". A presente invenção diz respeito a sal maleato AZD2171, a formas cristalinas particulares do sal maleato AZD2171, a processos par sua preparação, a composições farmacêuticas contendo-os como ingrediente ativo, a seu uso na fabricação de medicamentos para uso na produção dos efeitos de redução da permeabilidade antiangiogênica e/ou vascular em animais de sangue quente, tais como seres humanos, e a seu uso em método para o tratamento de estados de doença associados com a angiogênese e/ou a permeabilidade vascular aumentada.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0330002.7A GB0330002D0 (en) | 2003-12-24 | 2003-12-24 | Quinazoline derivatives |
| PCT/GB2004/005359 WO2005061488A1 (en) | 2003-12-24 | 2004-12-18 | Maleate salts of a quinazoline derivative useful as an antiangiogenic agent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0417958A true BRPI0417958A (pt) | 2007-03-27 |
| BRPI0417958B1 BRPI0417958B1 (pt) | 2019-02-05 |
| BRPI0417958B8 BRPI0417958B8 (pt) | 2021-05-25 |
Family
ID=30776508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0417958A BRPI0417958B8 (pt) | 2003-12-24 | 2004-12-18 | sais cristalinos de maleato de [4-((4-fluoro-2-metil-1h-indol-5-il)-6-metóxi-7-(3-(pirrolidin-1-il) propóxi) quinazolina], composição farmacêutica, processo e uso dos ditos sais cristalinos |
Country Status (33)
| Country | Link |
|---|---|
| US (6) | US20070129387A1 (pt) |
| EP (1) | EP1699782B1 (pt) |
| JP (2) | JP5009628B2 (pt) |
| KR (1) | KR101240872B1 (pt) |
| CN (2) | CN102153543B (pt) |
| AR (2) | AR046993A1 (pt) |
| AT (1) | ATE471936T1 (pt) |
| AU (1) | AU2004303590B2 (pt) |
| BR (1) | BRPI0417958B8 (pt) |
| CA (1) | CA2548662C (pt) |
| CY (1) | CY1110730T1 (pt) |
| DE (1) | DE602004027833D1 (pt) |
| DK (1) | DK1699782T3 (pt) |
| ES (1) | ES2345776T3 (pt) |
| GB (1) | GB0330002D0 (pt) |
| HK (1) | HK1095325A1 (pt) |
| HR (1) | HRP20100455T1 (pt) |
| IL (1) | IL176308A (pt) |
| MX (1) | MXPA06007191A (pt) |
| MY (1) | MY145143A (pt) |
| NO (1) | NO336613B1 (pt) |
| NZ (1) | NZ547547A (pt) |
| PL (1) | PL1699782T3 (pt) |
| PT (1) | PT1699782E (pt) |
| RS (1) | RS51387B (pt) |
| RU (1) | RU2425043C2 (pt) |
| SA (1) | SA05250464B1 (pt) |
| SI (1) | SI1699782T1 (pt) |
| TW (1) | TWI339119B (pt) |
| UA (1) | UA91332C2 (pt) |
| UY (1) | UY28702A1 (pt) |
| WO (1) | WO2005061488A1 (pt) |
| ZA (1) | ZA200605225B (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0017548B8 (pt) | 1999-02-10 | 2023-05-02 | Astrazeneca Ab | Composto |
| WO2003064413A1 (en) * | 2002-02-01 | 2003-08-07 | Astrazeneca Ab | Quinazoline compounds |
| GB0330002D0 (en) * | 2003-12-24 | 2004-01-28 | Astrazeneca Ab | Quinazoline derivatives |
| US20080113039A1 (en) * | 2004-03-23 | 2008-05-15 | Stephen Robert Wedge | Combination Therapy |
| GB0523810D0 (en) * | 2005-11-23 | 2006-01-04 | Astrazeneca Ab | Pharmaceutical compositions |
| ATE502641T1 (de) * | 2005-12-22 | 2011-04-15 | Astrazeneca Ab | Kombination aus azd2171 und pemetrexed |
| CL2007003158A1 (es) | 2006-11-02 | 2008-05-16 | Astrazeneca Ab | Procedimiento de preparacion de compuestos derivados de quinazolina o sus sales farmaceuticamente aceptables; compuestos intermediarios; procedimiento de preparacion. |
| TWI384986B (zh) * | 2007-01-17 | 2013-02-11 | Lg Life Sciences Ltd | 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物 |
| CN102265156B (zh) * | 2008-12-23 | 2014-11-05 | 默克专利有限公司 | 用于具有抗血管发生活性的抑制剂的生物标志 |
| SG179137A1 (en) * | 2009-09-25 | 2012-04-27 | Kyorin Seiyaku Kk | Maleic acid salt and crystal thereof |
| CN104379128A (zh) * | 2012-06-25 | 2015-02-25 | 拜尔健康护理有限责任公司 | 含有西地尼布的局部眼科药物组合物 |
| WO2015066584A1 (en) * | 2013-11-01 | 2015-05-07 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| US9007866B2 (en) | 2013-04-23 | 2015-04-14 | Tessera Inc. | Retention optimized memory device using predictive data inversion |
| US9458169B2 (en) * | 2013-11-01 | 2016-10-04 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CN105461698A (zh) * | 2014-09-12 | 2016-04-06 | 杭州普晒医药科技有限公司 | 西地尼布盐及其晶型、以及其制备方法和药物组合物 |
| WO2017035170A1 (en) * | 2015-08-24 | 2017-03-02 | Pliva Hrvatska D.O.O | Solid state forms of cediranib maleate |
| CN109073650A (zh) | 2016-02-15 | 2018-12-21 | 阿斯利康(瑞典)有限公司 | 包括对西地尼布进行固定的间歇给药的方法 |
| EP3509422A4 (en) | 2016-09-08 | 2020-05-20 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
| JP2019533641A (ja) | 2016-09-08 | 2019-11-21 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物の結晶形態およびその使用 |
| EP3509423A4 (en) | 2016-09-08 | 2020-05-13 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
| US10255725B2 (en) * | 2016-11-16 | 2019-04-09 | Disney Enterprises, Inc. | Augmented reality interactive experience |
| CN110817898B (zh) * | 2018-08-13 | 2021-09-03 | 中国科学院大连化学物理研究所 | 一种具有ats骨架结构的磷酸硅铝分子筛及其制备方法和应用 |
| WO2024003241A1 (en) | 2022-06-30 | 2024-01-04 | Astrazeneca Ab | Treatment for immuno-oncology resistant subjects with an anti pd-l1 antibody an antisense targeted to stat3 and an inhibitor of ctla-4 |
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| GB0330002D0 (en) * | 2003-12-24 | 2004-01-28 | Astrazeneca Ab | Quinazoline derivatives |
| GB0406446D0 (en) * | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
| GB0523810D0 (en) * | 2005-11-23 | 2006-01-04 | Astrazeneca Ab | Pharmaceutical compositions |
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2003
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2004
- 2004-12-18 WO PCT/GB2004/005359 patent/WO2005061488A1/en active Application Filing
- 2004-12-18 CN CN2011100351254A patent/CN102153543B/zh not_active Expired - Lifetime
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- 2004-12-18 CN CN2004800386656A patent/CN1898232B/zh not_active Expired - Lifetime
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- 2004-12-24 TW TW093140588A patent/TWI339119B/zh not_active IP Right Cessation
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2005
- 2005-01-29 SA SA5250464A patent/SA05250464B1/ar unknown
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2006
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- 2006-06-14 IL IL176308A patent/IL176308A/en active IP Right Grant
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2007
- 2007-01-16 HK HK07100533.7A patent/HK1095325A1/xx not_active IP Right Cessation
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2009
- 2009-12-23 US US12/646,153 patent/US8859570B2/en active Active
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2010
- 2010-08-09 CY CY20101100738T patent/CY1110730T1/el unknown
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2011
- 2011-02-03 JP JP2011021384A patent/JP2011088936A/ja active Pending
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2014
- 2014-09-18 US US14/489,721 patent/US9556151B2/en not_active Expired - Lifetime
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2016
- 2016-06-10 AR ARP160101750A patent/AR104979A2/es not_active Application Discontinuation
- 2016-09-13 US US15/264,527 patent/US9890140B2/en not_active Expired - Lifetime
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2017
- 2017-12-28 US US15/857,366 patent/US20180170913A1/en not_active Abandoned
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2019
- 2019-01-04 US US16/240,587 patent/US20190375730A1/en not_active Abandoned
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