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BR0208957A - Ciclobuteno-1,2-dionas 3,4-dissubstituìdas como ligandos de receptor de quimiocina cxc - Google Patents

Ciclobuteno-1,2-dionas 3,4-dissubstituìdas como ligandos de receptor de quimiocina cxc

Info

Publication number
BR0208957A
BR0208957A BR0208957-2A BRPI0208957A BR0208957A BR 0208957 A BR0208957 A BR 0208957A BR PI0208957 A BRPI0208957 A BR PI0208957A BR 0208957 A BR0208957 A BR 0208957A
Authority
BR
Brazil
Prior art keywords
diones
chemokine receptor
receptor ligands
cxc chemokine
cyclobutene
Prior art date
Application number
BR0208957-2A
Other languages
English (en)
Inventor
Arthur G Taveras
Cynthia J Aki
Richard W Bond
Jianping Chao
Michael Dwyer
Johan A Ferreira
Jianhua Chao
Younong Yu
John J Baldwin
Bernd Kaiser
Ge Li
J Robert Merritt
Kingsley H Nelson Jr
Laura L Rokosz
Original Assignee
Schering Corp
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Pharmacopeia Inc filed Critical Schering Corp
Publication of BR0208957A publication Critical patent/BR0208957A/pt
Publication of BRPI0208957B1 publication Critical patent/BRPI0208957B1/pt
Publication of BRPI0208957B8 publication Critical patent/BRPI0208957B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
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    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

"CICLOBUTENO-1,2-DIONAS 3,4-DISSUBSTITUìDAS COMO LIGANDOS DE RECEPTOR DE QUIMIOCINA CXC". São compostos descritos da Fórmula (I) ou solvato ou sal farmaceuticamente aceitável destes que são úteis para o tratamento das doenças mediadas por quimiocina tal como câncer ou distúrbios inflamatórios crónicos e agudos.
BRPI0208957 2001-04-16 2002-04-15 composto, uso de um composto, composição farmacêutica e sal BRPI0208957B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28402601P 2001-04-16 2001-04-16
PCT/US2002/012681 WO2002083624A1 (en) 2001-04-16 2002-04-15 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands

Publications (3)

Publication Number Publication Date
BR0208957A true BR0208957A (pt) 2004-06-22
BRPI0208957B1 BRPI0208957B1 (pt) 2018-10-09
BRPI0208957B8 BRPI0208957B8 (pt) 2021-05-25

Family

ID=23088576

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0208957 BRPI0208957B8 (pt) 2001-04-16 2002-04-15 composto, uso de um composto, composição farmacêutica e sal

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EP (2) EP1818325B1 (pt)
JP (3) JP4499993B2 (pt)
KR (2) KR100952531B1 (pt)
CN (2) CN1990457A (pt)
AR (1) AR035825A1 (pt)
AT (2) ATE365154T1 (pt)
AU (3) AU2002311841B2 (pt)
BR (1) BRPI0208957B8 (pt)
CA (1) CA2444031C (pt)
CY (2) CY1109908T1 (pt)
CZ (1) CZ20032831A3 (pt)
DE (2) DE60220778T2 (pt)
DK (2) DK1381590T3 (pt)
EC (1) ECSP034809A (pt)
ES (2) ES2287284T3 (pt)
HK (2) HK1057538A1 (pt)
HU (1) HUP0401783A3 (pt)
IL (3) IL158262A0 (pt)
MX (1) MXPA03009441A (pt)
MY (2) MY149050A (pt)
NO (2) NO330790B1 (pt)
NZ (3) NZ543869A (pt)
PE (1) PE20021084A1 (pt)
PL (2) PL208928B1 (pt)
PT (2) PT1818325E (pt)
RU (1) RU2344123C9 (pt)
SI (2) SI1818325T1 (pt)
SK (1) SK287598B6 (pt)
TW (2) TW200736196A (pt)
WO (1) WO2002083624A1 (pt)
ZA (1) ZA200307905B (pt)

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US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
WO2003031440A1 (en) 2001-10-12 2003-04-17 Schering Corporation 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists
US8246969B2 (en) 2001-11-16 2012-08-21 Skinmedica, Inc. Compositions containing aromatic aldehydes and their use in treatments
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
NZ535314A (en) 2002-03-18 2007-08-31 Schering Corp Combination treatments for chemokine-mediated diseases
GB0218326D0 (en) * 2002-08-07 2002-09-11 Glaxo Group Ltd Compounds
AU2003288922A1 (en) 2002-10-09 2004-05-04 Pharmacopeia, Inc. Thiadiazoledioxides and thiadiazoleoxides as cxc- and cc-chemokine receptor ligands
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
EP1608369B1 (en) 2003-03-28 2013-06-26 Novartis Vaccines and Diagnostics, Inc. Use of organic compounds for immunopotentiation
ES2325077T3 (es) 2003-04-03 2009-08-25 Merck Patent Gmbh Derivados de 1-(fenilamida)-2-(4-(3-oxo-morfolin-4-il)-fenilamida) del acido pirrolidin-1,2-dicarboxilico y compuestos emparentados como inhibidores del factor de la coagulacion xa, para el tratamiento de las enfermedades tromboembolicas.
ES2338657T3 (es) 2003-04-18 2010-05-11 Schering Corporation Sintesis de 2-hydroxi-n,n-dimetil-3-((2-((1(r)-(5-metil-2-furanil)propil)amino)-3,4-dioxo-1-ciclobuten-1-il)amino)benzamida.
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