MXPA03009441A - Ciclobuteno-1,2-dionas 3,4-disustituidas como ligandos del receptor de quimocina cxc. - Google Patents

Ciclobuteno-1,2-dionas 3,4-disustituidas como ligandos del receptor de quimocina cxc.

Info

Publication number: MXPA03009441A
Authority: MX; Mexico
Prior art keywords: cxc; diones; chemokine receptor; receptor ligands; substituted cyclobutene
Prior art date: 2001-04-16

Application number

MXPA03009441A

Other languages

English (en)

Inventor

Bernd Kaiser

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-16

Filing date

2002-04-15

Publication date

2004-02-12

2002-04-15 Application filed by Schering Corp filed Critical Schering Corp

2004-02-12 Publication of MXPA03009441A publication Critical patent/MXPA03009441A/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
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- C07—ORGANIC CHEMISTRY
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- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Tropical Medicine & Parasitology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Biotechnology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Hematology (AREA)
Diabetes (AREA)
Toxicology (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)

MXPA03009441A 2001-04-16 2002-04-15 Ciclobuteno-1,2-dionas 3,4-disustituidas como ligandos del receptor de quimocina cxc. MXPA03009441A (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28402601P	2001-04-16	2001-04-16
PCT/US2002/012681 WO2002083624A1 (en)	2001-04-16	2002-04-15	3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands

Publications (1)

Publication Number	Publication Date
MXPA03009441A true MXPA03009441A (es)	2004-02-12

Family

ID=23088576

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MXPA03009441A MXPA03009441A (es)	2001-04-16	2002-04-15	Ciclobuteno-1,2-dionas 3,4-disustituidas como ligandos del receptor de quimocina cxc.

Country Status (30)

Country	Link
EP (2)	EP1818325B1 (es)
JP (3)	JP4499993B2 (es)
KR (2)	KR20100008794A (es)
CN (2)	CN1990457A (es)
AR (1)	AR035825A1 (es)
AT (2)	ATE458715T1 (es)
AU (3)	AU2002311841B2 (es)
BR (1)	BRPI0208957B8 (es)
CA (1)	CA2444031C (es)
CY (2)	CY1109908T1 (es)
CZ (1)	CZ20032831A3 (es)
DE (2)	DE60235507D1 (es)
DK (2)	DK1818325T3 (es)
EC (1)	ECSP034809A (es)
ES (2)	ES2287284T3 (es)
HU (1)	HUP0401783A3 (es)
IL (3)	IL158262A0 (es)
MX (1)	MXPA03009441A (es)
MY (2)	MY138202A (es)
NO (2)	NO330790B1 (es)
NZ (3)	NZ529551A (es)
PE (1)	PE20021084A1 (es)
PL (2)	PL207255B1 (es)
PT (2)	PT1381590E (es)
RU (1)	RU2344123C9 (es)
SI (2)	SI1381590T1 (es)
SK (1)	SK287598B6 (es)
TW (2)	TW200736196A (es)
WO (1)	WO2002083624A1 (es)
ZA (1)	ZA200307905B (es)

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US20040106794A1 (en)	2001-04-16	2004-06-03	Schering Corporation	3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
CA2462862A1 (en)	2001-10-12	2003-04-17	Schering Corporation	3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists
US8246969B2 (en)	2001-11-16	2012-08-21	Skinmedica, Inc.	Compositions containing aromatic aldehydes and their use in treatments
US6878709B2 (en)	2002-01-04	2005-04-12	Schering Corporation	3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
CN100444839C (zh) *	2002-03-18	2008-12-24	先灵公司	式(i)化合物在制备治疗化学激活物中介的疾病的药物中的应用
GB0218326D0 (en) *	2002-08-07	2002-09-11	Glaxo Group Ltd	Compounds
WO2004033440A1 (en)	2002-10-09	2004-04-22	Schering Corporation	Thiadiazoledioxides and thiadiazoleoxides as cxc- and cc-chemokine receptor ligands
GB0302094D0 (en)	2003-01-29	2003-02-26	Pharmagene Lab Ltd	EP4 receptor antagonists
ES2423800T3 (es) *	2003-03-28	2013-09-24	Novartis Vaccines And Diagnostics, Inc.	Uso de compuestos orgánicos para la inmunopotenciación
AU2004226278B2 (en)	2003-04-03	2010-07-29	Merck Patent Gmbh	Pyrrolidino-1,2-dicarboxy-1-(phenylamide)-2-(4-(3-oxo-morpholino-4-yl)-phenylamide) derivatives and related compounds for use as inhibitors of coagulation factor Xa in the treatment of thrombo-embolic diseases
MXPA05011183A (es)	2003-04-18	2005-12-14	Schering Corp	Sintesis de 2-hidroxi-n, n-dimetil- 3-[[2-[1(r) -(5-metil -2-furanil) propil]amino]-3, 4-dioxo-1 -ciclobuten-1 -il]amino] benzamida.
AU2004261459B2 (en)	2003-07-22	2008-06-26	Astex Therapeutics Limited	3, 4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators
GB0320983D0 (en) *	2003-09-08	2003-10-08	Biofocus Plc	Compound libraries
EP1664007B1 (en)	2003-09-23	2009-12-23	Fermion Oy	Preparation of quetiapine
GB0324269D0 (en)	2003-10-16	2003-11-19	Pharmagene Lab Ltd	EP4 receptor antagonists
CA2550189A1 (en)	2003-12-19	2005-07-21	Schering Corporation	Thiadiazoles as cxc- and cc- chemokine receptor ligands
MXPA06007205A (es)	2003-12-22	2006-08-31	Schering Corp	Dioxidos de isotiazol como ligandos del receptor cxc y cc-quimiocina.
ES2349788T3 (es)	2004-01-30	2011-01-11	Schering Corporation	Polimorfos cristalinos de un ligando de receptor de quimiocina cxc.
EP1742914A1 (en) *	2004-02-27	2007-01-17	Schering Corporation	Cyclobutenedione groups-containing compounds as inhibitors of hepatitis c virus ns3 serine protease
EP1634573A1 (en) *	2004-08-16	2006-03-15	The Procter and Gamble Company	2-(Amino or substituted Amino)-5,6-substituted Phenol compounds, dyeing compositions containing them, and use thereof
BRPI0514379A (pt)	2004-08-16	2008-06-10	Procter & Gamble	compostos de 2-(amino ou amino substituìdo) fenol-5, 6-substituìdo, composições para tingimento contendo os mesmos, e uso das mesmas
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Publication number	Publication date
EP1381590A1 (en)	2004-01-21
AU2010212484B2 (en)	2012-04-12
CN1990457A (zh)	2007-07-04
TWI316930B (en)	2009-11-11
BR0208957A (pt)	2004-06-22
RU2344123C9 (ru)	2009-05-20
HUP0401783A2 (hu)	2005-01-28
AU2002311841B2 (en)	2006-09-14
JP5294418B2 (ja)	2013-09-18
SK12882003A3 (sk)	2004-06-08
EP1818325A3 (en)	2008-02-13
PE20021084A1 (es)	2002-12-20
RU2344123C2 (ru)	2009-01-20
IL158262A0 (en)	2004-05-12
WO2002083624A1 (en)	2002-10-24
NZ529551A (en)	2006-02-24
SI1818325T1 (sl)	2010-06-30
HK1057538A1 (en)	2004-04-08
NO20034612L (no)	2003-12-08
IL158262A (en)	2012-05-31
CY1109989T1 (el)	2014-09-10
PT1381590E (pt)	2007-08-06
EP1818325B1 (en)	2010-02-24
NO20034612D0 (no)	2003-10-15
HUP0401783A3 (en)	2005-06-28
JP2010053151A (ja)	2010-03-11
NO330790B1 (no)	2011-07-18
CY1109908T1 (el)	2014-09-10
CZ20032831A3 (cs)	2004-03-17
CA2444031A1 (en)	2002-10-24
ZA200307905B (en)	2005-03-30
KR20100008794A (ko)	2010-01-26
BRPI0208957B1 (pt)	2018-10-09
IL201754A0 (en)	2010-06-16
AU2006203679A1 (en)	2006-09-14
SI1381590T1 (sl)	2007-10-31
PL207255B1 (pl)	2010-11-30
MY138202A (en)	2009-05-29
RU2003133448A (ru)	2005-06-10
ES2340207T3 (es)	2010-05-31
NZ560453A (en)	2009-03-31
CN1516687A (zh)	2004-07-28
KR20030092074A (ko)	2003-12-03
ATE365154T1 (de)	2007-07-15
NO20110050L (no)	2003-12-08
PL367129A1 (en)	2005-02-21
AU2010212484A1 (en)	2010-09-09
CN1289471C (zh)	2006-12-13
DK1818325T3 (da)	2010-05-31
DE60220778T2 (de)	2008-03-06
JP2009179641A (ja)	2009-08-13
PL208928B1 (pl)	2011-06-30
ES2287284T3 (es)	2007-12-16
EP1381590B1 (en)	2007-06-20
NZ543869A (en)	2007-09-28
HK1107818A1 (en)	2008-04-18
MY149050A (en)	2013-07-15
JP2004532846A (ja)	2004-10-28
KR100952531B1 (ko)	2010-04-12
CA2444031C (en)	2012-02-21
BRPI0208957B8 (pt)	2021-05-25
SK287598B6 (sk)	2011-03-04
JP4499993B2 (ja)	2010-07-14
PT1818325E (pt)	2010-05-12
ATE458715T1 (de)	2010-03-15
ECSP034809A (es)	2004-02-26
EP1818325A2 (en)	2007-08-15
TW200736196A (en)	2007-10-01
AR035825A1 (es)	2004-07-14
DE60235507D1 (de)	2010-04-08
DE60220778D1 (en)	2007-08-02
DK1381590T3 (da)	2007-10-22

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